• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7149-7154
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• 2013

Objective: Increasing scientific evidence suggests that common variants in the PALB2 gene may confer susceptibility to breast cancer, but many studies have yielded inconclusive results. This meta-analysis aimed to derive a more precise estimation of the relationship between PALB2 genetic variants and breast cancer risk. Methods: An extensive literary search for relevant studies was conducted in PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, CNKI and CBM databases from their inception through September 1st, 2013. A meta-analysis was performed using the STATA 12.0 software and crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Results: Six case-control studies were included with a total of 4,499 breast cancer cases and 6,369 healthy controls. Our meta-analysis reveals that PALB2 genetic variants may increase the risk of breast cancer (allele model: OR>1.36, 95%CI: 1.20~1.52, P < 0.001; dominant model: OR>1.64, 95%CI: 1.42~1.91, P < 0.001; respectively). Subgroup analyses by ethnicity indicated PALB2 genetic variants were associated with an increased risk of breast cancer among both Caucasian and Asian populations (all P < 0.05). No publication bias was detected in this meta-analysis (all P > 0.05). Conclusion: The current meta-analysis indicates that PALB2 genetic variants may increase the risk of breast cancer. Thus, detection of PALB2 genetic variants may be a promising biomarker approach.

• Journal of KIISE:Computer Systems and Theory
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• v.29 no.5
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• pp.257-264
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• 2002

In this paper, we give a detailed description of KDSM(KAIST Distributed Shared Memory) system. KDSM is implemented as a user-level library running on Linux 2.2.13, and TCP/IP is used for communication. KDSM uses page-based invalidation protocol, multiple-writer protocol, and supports HLRC(Home-based Lazy Release Consistency) memory consistency model. To evaluate performance of KDSM, we executed 4 scientific applications and compared the result to JLAJLA. The results showed that performance of KDSM almost equal to JIAJIA for 2 applications and performance of KDSM is better than JIAJIA for 2 applications.

• Journal of the Korea Computer Industry Society
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• v.8 no.4
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• pp.295-302
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• 2007

Because Mobile computing uses radio transfer communications division carrying along information terminal, internet link computer and information technology of human body effectively, when, where, who, can offer role that is center enemy of available modern technology moving and reconsider new technology to physiological sounding, and reconstruct creatively. Specially, can offer possibility that can intervene in process that motive living body change before military register symptoms are developed of disease on silver society. But, much parameters data processing, standard anger of data of that is vague. same time collection of data can lift difficulty etc.. Therefore, this research excludes time limitation constituent inflecting Mobile computing, and result that analysis experiments because is proper and Mobile nerve mechanical code Tuesday that do with bioelectricity signal method select and embody system by access that become correct analysis, is becomes model of living body signal Mobile analysis device, and person could apply Mobile living body measuring device m-HSS (mobile-Hardware-software system) that measuring is possible by scientific access.

• Proceedings of the KIEE Conference
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• 2006.07d
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• pp.2167-2168
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• 2006

Mobilecomputer of offers more fundamental role than role assistance enemy of modem technology equipment and new Information Technology can reconsider, and reconstruct creatively accuracy of physiological concept. That military register symptoms are developed of disease, before far before rehalibitation, of for possibility that can intervene in process that motive change of military register symptoms after rehalibitation. But, that many parameters become analysis target and mathematical settlement and equalization system of noted data of that is huge, same time collection of all datas can lift difficulty etc.. These main weakness puts in structural relation between elements that compose system. Therefore, dynamics research that time urea of systematic adjustment has selected method code Tuesday nerve dynamics enemy who groping of approach that become analysis point is proper and do with recycling bioelectricity signal. Nature model of do living body signal digital analysis chapter as research result could be developed and scientific foundation groping could apply HSS (Hardware-software system) by rehalibitation purpose. Special quality that isdone radish form Tuesday of bioelectricity signal formation furthermore studied, and by the result, fundamental process of bodysignal in do structure circuit form of analog - digital water supply height modelling do can.

• Journal of Korean Library and Information Science Society
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• v.47 no.4
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• pp.289-307
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• 2016

This paper introduces a software system and process model for constructing domain-specific relation extraction datasets semi-automatically. The system uses a set of terms such as genes, proteins diseases and so forth as inputs and then by exploiting massive biological interaction database, generates a set of term pairs which are utilized as queries for retrieving sentences containing the pairs from scientific databases. To assess the usefulness of the proposed system, this paper applies it into constructing a genic interaction dataset related to Alzheimer's disease domain, which extracts 3,510 interaction-related sentences by using 140 gene names in the area. In conclusion, the resulting outputs of the case study performed in this paper indicate the fact that the system and process could highly boost the efficiency of the dataset construction in various subfields of biomedical research.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2923-2928
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• 2015

Background: Gallbladder carcinoma (GBC) has been stated as an Indian disease, with the highest number of cases being reported from certain districts of northeast India, which has an ethnically distinct population. Unfortunately there are no scientific reports on the underlying molecular mechanisms associated with the pathogenesis of the disease from this region. Aim: The present study evaluated the role of differential expression of human telomerase reverse transcriptase (hTERT) in the development of gall bladder anomalies. Materials and Methods: Blood and tissue samples were collected from patients undergoing routine surgical resection for clinically proven cases of gallbladder disease {cholelithiasis (CL, n=50), cholecystitis (CS, n=40) and GBC (n=30) along with adjacent histopathologically proved non-neoplastic controls (n=15)} with informed consent. Whole blood was also collected from age and sex matched healthy controls (n=25) for comparative analysis. Differential hTERT mRNA expression was evaluated by semi-quantitative rt-PCR and real-time PCR based analysis using ${\beta}$-actin as an internal control. Evaluation of differential hTERT protein expression was studied by Western blot analysis and immunoflourescence. Statistical analysis for differential expression and co-relation was performed by SPSSv13.0 software. Results: Gallbladder anomalies were mostly prevalent in females. The hTERT mRNA and protein expression increased gradiently from normal

• Journal of Korean Academy of Nursing
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• v.34 no.8
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• pp.1434-1442
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• 2004

Purpose. Professional nursing ethics is a living, dynamic set of standards for nurses' professional moral behavior. Furthermore, in daily clinical nursing training, nursing students are constantly confronted with decision-making that is moral in nature. The aim of this study was to identify the perceived ethical attitudes in the clinical training process of senior nursing students using Q-methodology to offer basic strategies for nursing ethics education and thereby improve patients' care. Methods. Q-methodology provides a scientific method for identifying perception structures that exist within certain individuals or groups. Thirty-seven participants in a university rated 38 selected Q-statements on a scale of 1-9. The collected data were analyzed using pc-QUNAL software. Results. Principal component analysis identified 3 types of ethical attitudes in nursing students in Korea. The categories were labeled Sacred-life, Science-realistic and Humane-life. Sacred-life individuals think that a life belongs to an absolute power (God), not a man, and a human life is a high and noble thing. Science-realistic individuals disagreed that allowing an induced abortion or embryo (human) duplication is unethical behavior that provokes a trend, which takes the value of a life lightly; most of them took a utilitarian position with respect to ethical decisions. Humane-life individuals exhibit a tendency toward human-centered thought with respect to ethical attitudes. Conclusion. This study will be of interest to educators of students of nursing and hospital nursing administrators. Also, the findings may provide the basis for the development of more appropriate strategies to improve nursing ethics education programs.

• Journal of the Korea Computer Graphics Society
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• v.21 no.3
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• pp.36-45
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• 2015

It is important subject of research in engineering and natural science field that creating continuing high-definition image from very large volume data. The necessity of software that helps analyze useful information in data has improved by effectively showing visual image information of high resolution data with visualization technique. In this paper, we designed multi-platform visualization system based on client-server to analyze and express earth environment data effectively constructed with observation and prediction. The visualization server comprised of cluster transfers data to clients through parallel/distributed computing, and the client is developed to be operated in various platform and visualize data. In addition, we aim user-friendly program through multi-touch, sensor and have made realistic simulation image with image-based lighting technique.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.7
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• pp.4261-4265
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• 2013

Increasing scientific evidence suggests that ribonucleotide reductase M1 (RRM1) may be a powerful predictor of survival in patients with pancreatic cancer treated with adjuvant gemcitabine-based chemotherapy after operative resection, but many existing studies have yielded inconclusive results. This meta-analysis aimed to assess the prognostic role of RRM1 in predicting survival in patients with pancreatic cancer treated with gemcitabine. An extensive literature search for relevant studies was conducted on PubMed, Embase, Web of Science, Cochrane Library, and CBM databases from their inception through May 1st, 2013. This meta-analysis was performed using the STATA 12.0 software and crude hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated. Eight clinical studies were included in this meta-analysis with a total of 665 pancreatic cancer patients treated with adjuvant gemcitabine-based chemotherapy, including 373 patients in the high RRM1 expression group and 292 patients in the low RRM1 expression group. Our meta-analysis revealed that high RRM1 expression was associated with improved overall survival (OS) of pancreatic cancer patients (HR=1.56, 95%CI=0.95-2.17, P<0.001). High RRM1 expression also was linked to longer disease-free survival (DFS) than low RRM1 expression (HR=1.37, 95%CI=0.25-2.48, P=0.016). In conclusion, our meta-analysis suggests that high RRM1 expression may be associated with improved OS and DFS of pancreatic cancer patients treated with adjuvant gemcitabine-based chemotherapy. Detection of RRM1 expression may be a promising biomarker for gemcitabine response and prognosis in pancreatic cancer patients.

• Journal of Agricultural Extension & Community Development
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• v.4 no.1
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• pp.231-243
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• 1997

Objective of the study was to investigate characteristics and meanings of the agricultural extension work during the period of Japanese $rule(1906{\sim}1945)$ through historical review on the work. The agricultural extension work during the period of Japanese rule was categorized into six patterns such as agricultural extension work by (1) government agricultural administration system, (2) agricultural experiment/research institute, (3) public school, (4) through the movement of rural development(Nong-chon-Jinheung Undong), (5) pro-government private organization, and (6) pure private organization. In conclusion, the characteristics of the extension work were defined; 1) a tool and/or method for colonial rule, 2) non-democratic and top-down extension work by administration, 3) authoritative and coercive work initiated by governmental system, 4) nation wide work of cooperation with public and private organization, 5) extension work focused on production increasing food and industrial materials, and 6) extension work initiated by government system without participation of pure private organization. The meanings of the extension work were reviewed in two ways. Firstly, in macro point of view, the work has negative meaning that was utilized as a tool and/or method for Japanese colonial rule, since the extension work was implemented under the direction of agricultural policy and was also directly related to the policy of Japanese colonial government. Secondly, in micro point of view, the work has significant meaning either negative or positive such as 1) beginning of modernized extension work based on experiment and research, 2) introduction of forcible agricultural extension work, 3) inducement of distrust tendency to agricultural policy and agricultural extension work, 4) establishment of basis in hardware of agricultural extension work, 5) production of experience in software of agricultural extension work, and 6) improvement of recognition toward scientific farming and improvement of level in agricultural techniques.