• Journal of the Korean Magnetic Resonance Society
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• v.20 no.3
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• pp.66-70
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• 2016

The replication protein A (RPA), is a heterotrimer with 70, 32 and 14 kDa subunits and plays a crucial role in DNA replication, recombination, and repair. The largest subunit, RPA70, binds to single-stranded DNA (ssDNA) and mediates interactions with many cellular and viral proteins. In this study, we performed nuclear magnetic resonance experiments on the complex of the DNA binding domain A of human RPA70 (RPA70A) with ssDNA, d(CCCCC), at various temperatures, to understand the temperature dependency of ssDNA binding affinity of RPA70A. Essential residues for ssDNA binding were conserved while less essential parts were changed with the temperature. Our results provide valuable insights into the molecular mechanism of the ssDNA binding of human RPA.

• Journal of Information Processing Systems
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• v.19 no.6
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• pp.778-790
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• 2023

Although density peak clustering can often easily yield excellent results, there is still room for improvement when dealing with complex, high-dimensional datasets. One of the main limitations of this algorithm is its reliance on geometric distance as the sole similarity measurement. To address this limitation, we draw inspiration from the information bottleneck theory, and propose a novel density peak clustering algorithm that incorporates this theory as a similarity measure. Specifically, our algorithm utilizes the joint probability distribution between data objects and feature information, and employs the loss of mutual information as the measurement standard. This approach not only eliminates the potential for subjective error in selecting similarity method, but also enhances performance on datasets with multiple centers and high dimensionality. To evaluate the effectiveness of our algorithm, we conducted experiments using ten carefully selected datasets and compared the results with three other algorithms. The experimental results demonstrate that our information bottleneck-based density peaks clustering (IBDPC) algorithm consistently achieves high levels of accuracy, highlighting its potential as a valuable tool for data clustering tasks.

• The Korean Journal of Physiology and Pharmacology
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• v.19 no.5
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• pp.451-460
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• 2015

Sirtuin 1 (SIRT1) is a mammalian $NAD^+$-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflammation and insulin resistance in dietary and genetic obesity. Macrophage-mediated inflammation contributes to insulin resistance and metabolic syndrome, however, the macrophage-specific SIRT1 function in the context of obesity is largely unknown. C57/BL6 wild type (WT) or myeloid-specific SIRT1 knockout (KO) mice were fed a high-fat diet (HFD) or normal diet (ND) for 12 weeks. Metabolic parameters and markers of hepatic steatosis and inflammation in liver were compared in WT and KO mice. SIRT1 deletion enhanced HFD-induced changes on body and liver weight gain, and increased glucose and insulin resistance. In liver, SIRT1 deletion increased the acetylation, and enhanced HFD-induced nuclear translocation of nuclear factor kappa B (NF-${\kappa}B$), hepatic inflammation and macrophage infiltration. HFD-fed KO mice showed severe hepatic steatosis by activating lipogenic pathway through sterol regulatory element-binding protein 1 (SREBP-1), and hepatic fibrogenesis, as indicated by induction of connective tissue growth factor (CTGF), alpha-smooth muscle actin (${\alpha}$-SMA), and collagen secretion. Myeloid-specific deletion of SIRT1 stimulates obesity-induced inflammation and increases the risk of hepatic fibrosis. Targeted induction of macrophage SIRT1 may be a good therapy for alleviating inflammation-associated metabolic syndrome.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.9
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• pp.3250-3265
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• 2014

Integrated WiMAX and WiFi networks is of great potential for the future due to the wider coverage of WiMAX and the high data transport capacity of WiFi. However, seamless and secure handover (HO) is one of the most challenging issues in this field. In this paper, we present a novel vertical HO authentication scheme with privacy preserving for WiMAX-WiFi heterogeneous networks. Our scheme uses ticket-based and pseudonym-based cryptographic methods to secure HO process and to achieve high efficiency. The formal verification by the AVISPA tool shows that the proposed scheme is secure against various malicious attacks and the simulation result indicates that it outperforms the existing schemes in terms of communication and computation cost.

• The Pure and Applied Mathematics
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• v.19 no.4
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• pp.337-347
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• 2012

The taxicab distance and Chinese-checker distance in the plane are practical distance notions with a wide range of applications compared to the Euclidean distance. The ${\alpha}$-distance was introduced as a generalization of these two distance functions. In this paper, we study alpha circle, trigonometry, and the area of a triangle in the plane with ${\alpha}$-distance.

• Journal of the Korean Chemical Society
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• v.49 no.5
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• pp.503-512
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• 2005

• Proceedings of the Korean Powder Metallurgy Institute Conference
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• 2006.09b
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• pp.1236-1237
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• 2006

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.71.2-71.2
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• 2015

We present the high-resolution near-infrared spectra of standard stars observed with Immersion Grating Infrared Spectrograph (IGRINS). IGRINS covers the full spectral range of H and K bands simultaneously with a high spectral resolution (R=40,000), revealing many previously undetected and/or unknown lines. In this work, we present preliminary results of spectroscopic diagnostics for stellar physical parameters. Our ultimate goal is to provide a library of near-infrared spectra of standard stars, which covers all spectral types and luminosity classes, with a high-resolution and high signal to noise ratio ($SNR{\geq}200$).

• Proceedings of the Korean Vacuum Society Conference
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• 2012.02a
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• pp.427-427
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• 2012

Ferroelectric-gate field effect transistor based memory using a nanowire as a conducting channel offers exceptional advantages over conventional memory devices, like small cell size, low-voltage operation, low power consumption, fast programming/erase speed and non-volatility. We successfully fabricated ferroelectric nonvolatile memory devices using both n-type and p-type Si nanowires coated with organic ferroelectric poly(vinylidene fluoride-trifluoroethylene) [P(VDF-TrFE)] via a low temperature fabrication process. The devices performance was carefully characterized in terms of their electrical transport, retention time and endurance test. Our p-type Si NW ferroelectric memory devices exhibit excellent memory characteristics with a large modulation in channel conductance between ON and OFF states exceeding $10^5$; long retention time of over $5{\times}10^4$ sec and high endurance of over 105 programming cycles while maintaining ON/OFF ratio higher $10^3$. This result offers a viable way to fabricate a high performance high-density nonvolatile memory device using a low temperature fabrication processing technique, which makes it suitable for flexible electronics.

• Journal of the Korean Data and Information Science Society
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• v.23 no.6
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• pp.1173-1181
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• 2012

In order to suggest the basic resources of mathematics education to the specialized high school, we investigate the attitude of students about mathematics education. Questionnaires survey was carried on 654 students and we use the statistical analysis such as chi-square test, gamma, generalized linear model, Anova, regression. Several result can be derived from the questionnaire analysis. There are differences between the general and specialized high school students in the interest, pre-learning ability etc. The specialized school students think the usefulness of mathematics more importantly, while the general school students think more closely related to their course.