• 대한기관윤리심의기구협의회지
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• 제5권1호
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• pp.21-32
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• 2023

Purspose: The purpose of this study is to examine the meaning and definition of vulnerable subjects in clinical trials in light of domestic and international regulations and guidelines, to analyze the contents of standard operation procedures (SOPs) among advanced general hospitals in Korea that conduct clinical trials, and to examine deliberation procedures for operation plans. Methods: The study examined how vulnerable research subjects were defined and described in related regulations and the classification of vulnerable research subjects presented in the IRB/HRPP SOPs of 18 clinical trial institutions, including 11 AAHRPP-accreditated general hospitals in Korea, as well as the operation of the IRB deliberation. Results: Among all domestic and international regulations and guidelines, only the The Council for International Organization of Medical Sciences (CIOMS) guidelines explain why vulnerability is related to judgments on the severity of physical, psychological, and social harm, why individuals are vulnerable, and for what reasons. However, the classification of vulnerable subjects by institutions differed from the classification by the International Conference on Harmonization-Good Clinical Practice (ICH-GCP). A total of the 16 institutions classified children and minors as vulnerable research subjects. 14 institutions classified subjects who cannot consent freely were classified as vulnerable subjects. 15 institutions classified sujects who can be affected by the organizational hierarchy were classified as vulnerable subjects. Subjects in emergency situations were regarded as vulnerable research subjects in 8 of institutions, while people in wards, patients with incurable diseases, and the economically poor including the unemployed were categorized as vulnerable research subjects in 7, 4, and 4 of institutions, respectively. Additionally, some research subjects were not classified as vulnerable by ICH-GCP but were classified as vulnerable by domestic institutions 15 of the institutions classified pregnant women and fetuses as vulnerable, 11 classified the elderly as vulnerable, and 6 classified foreigners as vulnerable. Conclution: The regulations and institutional SOPs classify subjects differently, which may affect subject protection. There is a need to improve IRBs' classifications of vulnerable research subjects. It is also necessary to establish the standards according to the differences in deliberation processes. Further, it is recommended to maintain a consistent review of validity, assessment of risk/benefit, and a review using checklists and spokeperson. The review of IRB is to be carried out in a manner that respects human dignity by taking into account the physical, psychological, and social conditions of the subjects.

• 한국과학교육학회지
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• 제18권3호
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• pp.371-382
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• 1998

개항 후 1883년에 원산학사가 설립되고, 1894년에는 갑오개혁으로 여러 가지 교육개혁이 시행되었다. 1895년 한성사범학교 관제를 시작으로 각종학교 관제의 교육과정에 과학 교과가 등장하면서 과학 교과서의 필요성이 대두되었다. 정부는 필요한 교과서률 편찬하는 한편 여러 가지 학교관련 법령을 통하여 교과서의 사용에 관한 규정을 정하였다. 1895년 소학교령에서는 "교과용서(敎科用書)는 학부(學部)의 편집(編輯)한 외(外)에도 혹학부대신(或學部大臣)의 검정(檢定)을 경(經)한 자(者)를 용(用)함"으로 규정하였고, 1906년 보통학교령에서는 "교과서(敎科書)는 학부(學部)에서 편찬(編贊)한 것과 밋 학부대신(學部大臣)의 인가(認可)를 경(經)한 것으로 함"으로 규정하였다. 이에 따르면 각급 학교에서 사용할 수 있는 교과서는 학부에서 편찬한 것이거나 학부대신의 검정을 받은 것 또는 인가를 받은 것으로 제한되었다. 교과서에 관한 정책은 1906년 일본인이 학부에 참여하면서 1908년부터 본격적으로 수행되었고, 이것은 1910년 한일합방을 위한 식민지 교육정책과 밀접하게 수행되었다고 볼 수 있다. 특히 1908년의 사립 학교령과 교과용도서검정규정, 그리고 1909년의 출판법은 교과서를 통제하는 주요 수단이었다. 한국에서 발행된 62종의 과학 교과서 중 사용금지를 당한 것은 18종인데 2종은 불인가, 13종온 검정무효 그리고 3종은 검정 무효 및 검정불허가 처분을 중복으로 받았다. 이는 과학 교과가 학부나 총독부의 검열로부터 다른 교과에 비해 상대적으로 자유로운 편이었지만 일제가 점차 교과서 통제를 강화하면서 과학 교과서에도 통제를 가하고 있었음을 나타내는 것이다.

• 대한한의학회지
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• 제31권2호
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• pp.48-63
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• 2010

Objectives: Yonnyuniksoogobon-dan (Yan Nian Yi Shou Gu Ben Dan 延年益壽固本丹) is composed of 11 herbs (Polygoni Mutiflori Radix, Lycii Radicis Cortex, Polia, Rehmanniae Radix, Rehmanniae Radix Preparat, Asparagi Radix, Liriopis Tuber, Lycii Fructus, Acori Graminei Rhizoma, Angelicae Acutiloba Radix, and Pini Folium) based on Yonryunggobon-dan (Yan Ling Gu Ben Dan 延齡固本丹) and Yonnyuniksoobulrho-dan (Yan Nian Yi Shou Bu Lao Dan 延年益壽不老丹). This study evaluated hair growth promoting effect of Yonnyuniksoogobon-dan on the shaved C57BL/6 mice. Methods: Yonnyuniksoogobon-dan was treated by oral administration (Sample I) and oral administration plus skin application (Sample II) once a day for 12 days. Hair regrowth was photographically and histologically determined during the experimental period. Hair growth cycle related factors (EGF, TGF-${\beta}1$) and vascular factors (VEGF, iNOS) were also determined with immunohistochemistry. Results: 1. On gross observation of hair regrowth, Sample I and Sample II groups demonstrated acceleration of hair regrowth. 2. The hair regrowth index of the Sample I group increased significantly from 7 days (P<0.05) to 12 days (P<0.01) after the shave while that of the Sample II group significantly increased at 12 days (P<0.05). 3. On histological observation, both Sample I and Sample II groups demonstrated histological improvement and increases of number and diameter of the hair follicles. 4. EGF expressions on the root sheath of hair follicles were up-regulated in both Sample I and Sample II groups. 5. TGF-${\beta}1$ expressions on the root sheath of hair follicles were not regulated in Sample I or Sample II groups. 6. VEGF expressions in the surrounding tissues of hair follicles were up-regulated in both Sample I and Sample II groups. 7. iNOS expressions in the surrounding tissues of hair follicles were down-regulated in both Sample I and Sample II groups. Conclusions: These results suggest that Yonnyuniksoogobon-dan has hair growth-promoting activity and these effects relate to up-regulations of EGF and VEFG expressions and down-regulations of TGF-${\beta}1$ and iNOS expressions on hair roots.

• 유통과학연구
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• 제14권5호
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• pp.51-57
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• 2016

Purpose - In the year of 2015 and 2016, one of the items that got attention in CES was a drone. It has been 100 years since a drone emerged, but most were used for military purposes. As its use became diverse as of 2010, it got attention of the general public. In Korea, it was in 2011 that a drone was known to the public through an aerial video shooting for television program. This study tried to come up with suggestions by comparing domestic with overseas cases, and tried to consider the related technologies and systems with applying the role of drones in logistics service. Research design, data, and methodology - The overseas cases were regarded as drone's logistical purpose. The Prime Air service by US Amazon is still not commercialized and under pre-testing due to Federal Aviation Regulations, although it started in 2013. In Germany, DHL succeeded in delivering service testing which is called Parcelcopter, but it is not commercialized yet. Other than these, there are more attempts to prepare logistics service in China with Taobao, in France with Geopost's test, and in Africa. In Korea, CJ Korea Express tested delivery with a self-developed drone Results - In order to study for utilizing drones for logistics as the prerequisites, some overseas and domestic cases, which are currently considered, were reviewed. Also, the technologies and institutional requirements to commercialize drones for logistical purpose were reviewed. The reasons for using drones in logistics is to ensure the price competitiveness by reducing cost. The empirical test also will be needed because drone pilot areas are designated by ministry of land, infrastructure and transport. Conclusions - In order to utilize drones in logistics and foster the industry, this study would like to suggest the followings. First of all, size of drones for logistics needs to be fixed and their operating system should be standardized. Centralized investment resources are needed through standardization to ensure the market occupancy. Secondly, it is necessary to get the converged businesses that do research, develop and commercialize drones with the investment of private sector. Example can be found in Korea aerospace Industries. We can respond to the rapid growth of the market with intensive investing by integrating the private sector investment. Thirdly, institutional arrangements are needed to be established quickly. In the case of high-technologies like drones, institutional support often does not follow the rapid development of the technology. The problems can be found in securing drones-only airspace, creating drone-specialized pilot's license, matters related to remote controller and complementary regulations for drones in Aviation Act. If these regulations are not prepared or complemented at the right timing, technologies cannot be commercialized even though the development is completed. Fourthly, there is a need to secure the transparency regarding possible privacy and personal information protection problem while operating drones. Finally, in order to foster this new industry, government should focus on supporting R&D more in the long term than short term outcomes.

• 대한조선학회논문집
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• 제53권6호
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• pp.503-513
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• 2016

In order to reduce the green-house gas exhaustion, International Maritime Organization (IMO) has been reinforcing carbon gas regulations. Due to the regulations, a lot of competitions for designing Eco ship in the shipbuilding industry are progressing now. It is faced with the necessity of reducing hull weight by combining automated systems for optimal compartment arrangement with hull structural design. Most researches on optimum structural design method have been consistently in progress and applied to minimize weight and cost of mid-ship section in preliminary ship design stage based on analytical structural analysis method on fixed compartment arrangement. In order to reduce design period and to improve international technical competitiveness by shortening the period of hull structural design and enhancing design accuracy, it has been felt necessity to combine optimized compartment arrangement with optimum design of ship structure based on the international regulations and rules. So in this study, the automated design algorithm for longitudinal members has been developed to combine automated algorithm of compartment arrangement with hull structural design system for oil tanker. The SeaTrust-Hullscan software developed by Korean Register is used to perform ship structural design for mother ship and selected design cases. The effect of weight reduction is verified with comparison of ship weight between mother ship and the cases suggested in this study.

• 한국가구학회지
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• 제24권1호
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• pp.33-41
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• 2013

As professional postnatal care systems have been rapidly supplied, there is sharp increase of postnatal care centers without legal regulations for a mother and a infant. For the quick recovery of mothers, newborn infants that have weaker immune systems are being managed in group in the postnatal care centers. Recently, the attention of the postnatal care centers has been growing because the problem of pneumonia which led to result in a casuality in a infant unit was happen. So, this research analyzed the indoor environment of infant unit through measuring formaldehyde, carbon dioxide, intensity of illumination. As a result of the data, infant units showed higher concentration of formaldehyde and carbon dioxide than Indoor Air Quality Control Law. Moreover, infant units was measured higher intensity of illumination than the range of optimum illumination for infants.

• 한국가구학회지
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• 제24권1호
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• pp.70-78
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• 2013

Indoor air quality control has been strengthened within childcare facilities and welfare communities for the elderly and infirm. I have researched the indoor air quality of kids caf$\acute{e}$s. The quality was determined by the measurement of $CO_2$ and HCHO, and the result was used in understanding of the current status of indoor air quality control. The higher level of $CO_2$ and HCHO were found in the playground area where children use compared to the area for guardians in kids caf$\acute{e}$s. And the more people in the caf$\acute{e}$s, the more $CO_2$ and HCHO were generated. It is judged that kids furniture produce harmful substances for children. Hence, the government regulations for kids caf$\acute{e}$s should be improved by reinforcing the indoor air quality control, considering that the main customers are children not adults.

• KIEAE Journal
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• 제12권4호
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• pp.105-110
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• 2012

Recently, all of the world are facing with a serious environmental crisis of global warming due to excessive energy consumptions. The Korean Government, taking over 97% of dependence on foreign energy, has made various efforts on reducing energy and greenhouse gas emission under the motto of "Low-Carbon Green Growth". Since the building sector takes 24% of domestic energy consumption, many design standards and regulations on saving energy in new buildings have been established. However, applications of energy saving designs and techniques on the remodeling process at deteriorated buildings including educational ones have been lack. Under a situation where the number of deteriorated schools accounts for up to 50%, this paper evaluated the performances of factors for reducing energy at deteriorated middle school buildings through an energy simulation tool on a standard school model. As a result, among factors of insulation, window's SHGC, southern louver, indoor setup temperature, and system efficiency, all other factors except window's SHGC and southern louver proved contribute to reduce energy at deteriorated middle school buildings, compared with the baseline energy consumption.

• KIEAE Journal
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• 제12권2호
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• pp.111-116
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• 2012

Faced with the international issue of environmental problems from global warming and energy consumption, the Korean Government has made many efforts on reducing energy and $CO_2$ emission under the motto of "Low-Carbon Green Growth". In order to reduce energy in the building sector, severe design standards and regulations on saving energy in new buildings have been established. Now, it is necessary to focus on deteriorated buildings where applications of energy saving designs and techniques have been insufficient, for maximizing energy saving in the building sector. Specially, it is very important to reduce energy through the remodeling process at deteriorated school buildings which were built over 20 years ago and sharply changed into the excessive energy consumption structure from new educational curricula. Thus, this paper examined the effects of potential factors to reduce energy at deteriorated elementary school buildings using the energy simulation on the Visual DOE 4.0 program. Among applied factors of insulations, southern louver, window's SHGC, indoor setup temperature, and system efficiency, all factors except window's SHGC turned out contribute to reduce energy at the deteriorated elementary school buildings, compared with the baseline energy performance.

• KIEAE Journal
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• 제11권6호
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• pp.127-132
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• 2011

Since the late 20th century, countries of the world have made every effort to solve environmental problems due to global warming. The Korean Government has also made various efforts on reducing energy and $CO_2$ emission under the motto of "Low-Carbon Green Growth". In order to achieve the goal to reduce energy in the construction field, severe design standards and regulations on saving energy in new buildings have been established. However, for maximizing the reduction of energy in buildings, it is time to focus on deteriorated buildings where applications of energy saving designs and techniques have been insufficient. Especially, there are little guidelines and researches on reducing energy through remodeling at deteriorated school buildings which were built over 20 years ago. This paper suggests the priority of factors to reduce energy on the remodeling process at deteriorated school buildings using the AHP(Analytic Hierarchy Process) method. For applying the AHP method, the survey of staffs in the Education Offices and board members in the Korea Institute of Ecological Architecture and Environment was conducted via e-mail. As a result, factors of insulation, daylighting, system control, and windows turned out important in the energy reducing remodeling process at deteriorated school buildings, while factors of artificial lighting, solar heating, ventilation, and system did relatively unimportant.