• 제목/요약/키워드: Scaling Coefficient

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High-Throughput Active Compound Discovery using Correlations between Activity and Mass Profiles

  • Park, Kyu-Hwan;Yoon, Kyo-Joong;Kwon, Kyung-Hoon;Kim, Hyun-Sik
    • Mass Spectrometry Letters
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    • 제1권1호
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    • pp.13-16
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    • 2010
  • The active components in a plant extract can be represented as mass profiles. We introduce here a new, multi-compound discovery method known as Scaling of Correlations between Activity and Mass Profiles (SCAMP). In this method, a correlation coefficient is used to quantify similarities between the extract activity and mass profiles. The method was evaluated by first measuring the anti-oxidation activity of eleven fractions of an Astragali Radix extract using DPPH assays. Next, 15 T Fouriertransform ion cyclotron resonance (FT-ICR) MS was employed to generate mass profiles of the eleven fractions. A comparison of correlation coefficients indicated two compounds at m/z 285.076 and 286.076 that were strong antioxidants. Principal component analyses of these profiles yielded the same result. FT-ICR MS, which offers a mass resolving power of 500,000, was used to discern isotopic fine structures and indicated that the molecular formula corresponding to the peak at m/z 285.076 was $C_{16}H_{13}O_5$. SCAMP in combination with high-resolution MS can be applied to any type of mixture to study pharmacological activity and is a powerful tool for active compound discovery in plant extract studies.

Robust Image Hashing for Tamper Detection Using Non-Negative Matrix Factorization

  • Tang, Zhenjun;Wang, Shuozhong;Zhang, Xinpeng;Wei, Weimin;Su, Shengjun
    • Journal of Ubiquitous Convergence Technology
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    • 제2권1호
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    • pp.18-26
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    • 2008
  • The invariance relation existing in the non-negative matrix factorization (NMF) is used for constructing robust image hashes in this work. The image is first re-scaled to a fixed size. Low-pass filtering is performed on the luminance component of the re-sized image to produce a normalized matrix. Entries in the normalized matrix are pseudo-randomly re-arranged under the control of a secret key to generate a secondary image. Non-negative matrix factorization is then performed on the secondary image. As the relation between most pairs of adjacent entries in the NMF's coefficient matrix is basically invariant to ordinary image processing, a coarse quantization scheme is devised to compress the extracted features contained in the coefficient matrix. The obtained binary elements are used to form the image hash after being scrambled based on another key. Similarity between hashes is measured by the Hamming distance. Experimental results show that the proposed scheme is robust against perceptually acceptable modifications to the image such as Gaussian filtering, moderate noise contamination, JPEG compression, re-scaling, and watermark embedding. Hashes of different images have very low collision probability. Tampering to local image areas can be detected by comparing the Hamming distance with a predetermined threshold, indicating the usefulness of the technique in digital forensics.

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Development and validation of a fast sub-channel code for LWR multi-physics analyses

  • Chaudri, Khurrum Saleem;Kim, Jaeha;Kim, Yonghee
    • Nuclear Engineering and Technology
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    • 제51권5호
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    • pp.1218-1230
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    • 2019
  • A sub-channel solver, named ${\underline{S}}teady$ and ${\underline{T}}ransient$ ${\underline{A}}nalyzer$ for ${\underline{R}}eactor$ ${\underline{T}}hermal$ hydraulics (START), has been developed using the homogenous model for two-phase conditions of light water reactors. The code is developed as a fast and accurate TH-solver for coupled and multi-physics calculations. START has been validated against the NUPEC PWR Sub-channel and Bundle Test (PSBT) database. Tests like single-channel quality and void-fraction for steady state, outlet fluid temperature for steady state, rod-bundle quality and void-fraction for both steady state and transient conditions have been analyzed and compared with experimental values. Results reveal a good accuracy of solution for both steady state and transient scenarios. Axially different values for turbulent mixing coefficient are used based on different grid-spacer types. This provides better results as compared to using a single value of turbulent mixing coefficient. Code-to-code evaluation of PSBT results by the START code compares well with other industrial codes. The START code has been parallelized with the OpenMP algorithm and its numerical performance is evaluated with a large whole PWR core. Scaling study of START shows a good parallel performance.

The Radial Distribution Functions of the Scaled OSS2 Water

  • Lee, Song Hi
    • 대한화학회지
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    • 제56권6호
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    • pp.669-672
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    • 2012
  • Classical molecular dynamics (MD) simulations using a scaled OSS2 potential originally derived from ab initio calculations are used to study the radial distribution functions of water. The original OSS2 water potential is shown to represent a glassy or an ice at ambient temperature, but the diffusion coefficient increases on increasing the temperature of the system or decreasing the density. This suggests scaling the OSS2 potential. The O-O, O-H, and H-H radial distribution functions and the corresponding coordination numbers for the scaled OSS2 potential, obtained by MD simulation, are in good agreement with the experiment results and calculations for the SPC/E water potential over a range of temperatures.

시로코 홴 성능 및 공력 소음 예측에 관한 연구 (Measurement and Prediction of Aerodynamic Noise from Sirocco Fans)

  • 김경호;박계찬;이승배
    • 한국유체기계학회 논문집
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    • 제2권4호
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    • pp.57-64
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    • 1999
  • The prediction method of the performance and aerodynamic noise from a sirocco fan was developed and compared with measured data. To predict the performance of the sirocco fan, the well-known slip coefficients and various loss models were tested and applied to forward curved sirocco impellers. Using loss models proposed for both impeller and casing, the predicted performance characteristics were in good agreement with measured ones by an ANSI test plenum. Various scaling models for aerodynamic noise from the sirocco fan were evaluated and tested against measured power levels in terms of flow coefficient. It was shown that the turbulent broadband sound power from the sirocco fan can be modeled successfully by trailing edge noise.

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제설제 살포에 따른 콘크리트 포장의 염화물 침투특성 (Characteristics of Chloride Penetration due to Sprinkle of the Deicing Salt on the Concrete Pavement)

  • 박진호;김명유;양은익;이성태;박해균
    • 한국콘크리트학회:학술대회논문집
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    • 한국콘크리트학회 2005년도 추계 학술발표회 제17권2호
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    • pp.475-478
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    • 2005
  • Deicing salt has been generally used for traffic safety in winter, and the amount is increasing every year. However, deicing salt may induce the decrease of bond strength, surface scaling, and environmental pollution, etc. the purpose of this paper is to suggest the fundamental data on safety and durability for concrete structures through the estimation of chloride concentration profile and chloride diffusion coefficient. According to the test results, the critical chloride concentration($0.9\~1.2kg/m^3$)was measured at depth $23\~30mm$, and the limit chloride concentration($0.3kg/m^3$)was reached to depth 40mm. Also the surface chloride amount indicates 3.45kg per concrete unit weight, and the results showed the possibility of corrosion by deicing salt penetration.

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다공도 및 팽창파의 영향을 고려한 BLEED 경계조건 수치 모델링의 정확도 향상 연구 (ACCURACY IMPROVEMENT OF THE BLEED BOUNDARY CONDITION WITH THE EFFECTS OF POROSITY VARIATIONS AND EXPANSION WAVES)

  • 김광현;최요한;김종암
    • 한국전산유체공학회지
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    • 제21권1호
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    • pp.94-102
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    • 2016
  • The present paper deals with accuracy improvement of a bleed boundary condition model used to improve the performance of supersonic inlets. In order to accurately predict the amount of bleed mass flow rates, this study performs a scaling of sonic flow coefficient data for 90-degree bleed holes in consideration of Prandtl-Meyer expansion theory. Furthermore, it is assumed that porosity varies with stream-wise location of the porous bleed plate to accurately predict downstream boundary layer profiles. The bleed boundary condition model is demonstrated through Computational Fluid Dynamics(CFD) simulations of bleed flows on a flat plate with/without an oblique shock. As a result, the bleed model shows the improved accuracy of bleed mass rates and downstream boundary layer profiles.

풍향의 변화에 따른 자동차 모형 표면의 압력분포에 대한 실험적 연구 (An Experimental Study on the Pressure Distribution for the Surface of a Road Vehicle Model Subjected to Various Wind Direction)

  • 지호성;김경천;박원규
    • 한국자동차공학회논문집
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    • 제9권2호
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    • pp.84-91
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    • 2001
  • To investigate the aerodynamic characteristics of the on a road vehicle, experimenrs were performed at an Atmospheric Boundary Layer Wind Tunnel. The scaled model of an automobile with 1 : 3 scaling ratio was used. The Reynolds number based on the free stream velocity and model length was $7.93{\times}10^5$. The influence of crosswind to the stability of automobile was investigated by the pressure distribution measurements and flow visualization studies. with the variation of the angle of attack, the change in pressure coefficient depends highly on the flow separation regimes. The experimental and numerical results are compared and found to be in good agreements.

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A Review of the Topographical Causes of Gloss Variation and the Effect on Perceived Print Quality

  • MacGregor, Michael A.
    • 펄프종이기술
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    • 제32권5호
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    • pp.26-43
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    • 2000
  • It is well accepted that gloss variation deteriorates the print quality and there are various objective ways to measure this. Several studies now have shown that the coefficient of variation in the octave band passed printed gloss image has an excellent correlation with ratings by an expert panel using a magnitude estimation scaling method. The correlation improves when the gloss level is also taken into account beyond that of the COV. There is also evidence that the correlation would improve even more if the gloss spatial distribution could be better accounted for. We show that much (at least 80% and perhaps up to 90%) of the gloss distribution can be accounted for by the paper topography over a wide range of dimensions (scale). Recent work has supported the role that microroughness and multiple surface scattering play in the gloss distribution. This offers the promise of showing that even a greater amount of gloss variationcan be explained by topography.

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A size-dependent study on buckling and post-buckling behavior of imperfect piezo-flexomagnetic nano-plate strips

  • Momeni-Khabisi, Hamed;Tahani, Masoud
    • Advances in nano research
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    • 제12권4호
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    • pp.427-440
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    • 2022
  • In the present study, the nonlocal strain gradient theory is used to predict the size-dependent buckling and post-buckling behavior of geometrically imperfect nano-scale piezo-flexomagnetic plate strips in two modes of direct and converse flexomagnetic effects. The first-order shear deformation plate theory is used to analyze analytically nano-strips with simply supported boundary conditions. The nonlinear governing equations of equilibrium and associated boundary conditions are derived using the principle of minimum total potential energy with consideration of the von Kármán-type of geometric nonlinearity. A closed-form solution of governing differential equation is obtained, which is easily usable for engineers and designers. To validate the presented formulations, whenever possible, a comparison with the results found in the open literature is reported for buckling loads. A parametric study is presented to examine the effect of scaling parameters, plate slenderness ratio, temperature, the mid-plane initial rise, flexomagnetic coefficient, different temperature distributions, and magnetic potential, in case of the converse flexomagnetic effect, on buckling and post-buckling loads in detail.