• The Journal of Korean Medicine
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• v.26 no.1 s.61
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• pp.46-58
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• 2005

Objective : This study on Sipimikwanjung-tang was undertaken to evaluate its antioxidant capacities and antiperoxidation activities in rat liver tissues. Sipimikwanjung-tang which has been one of the prescriptions in sasang constitutional medicine is usually applied for the therapy of various liver diseases. It is elucidated that Sipimikwanjung-tang has antioxidants on liver tissue of rat and the cytotoxic effects on human hepatoblastoma Hep G2 cells. Methods: Sipimikwanjung-tang extract in antioxidant effects of Hep G2 cells is evaluated by MTT assay, DAPI staining, DNA fragmentation assays and FACS can analysis. Results: Sipimikwanjung-tang induced apoptosis in Hep G2 cells, and induced G1 and G2M arrest of the cell cycle as well as a significant increase in PARP and caspase-3 activity. It induced an increase in $H_2O_2$ generation and the subsequent $NF-{\kappa}B$ activation and also induced cell apoptosis through the caspase-3-dependent pathways in the low concentration of Sipimikwanjung-tang extracts. However, the high dose of Sipimikwanjung-tang extract in Hep G2 cells inhibited $TGF-{\beta}l-induced$ apoptosis via increase in cellular $H_2O_2$, formation and $NF-{\kappa}B$ activation in human hepatoblastoma Hep G2 cells. Conclusion: From this study, the possibility that Sipimikwanjung-tang extracts apply to antioxidant and apoptotic treatment of disease is revealed.

• Journal of Sasang Constitutional Medicine
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• v.16 no.2
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• pp.114-121
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• 2004

1. Objectives Hyperemesis Gravidarum is one of common symptoms clinically and caused by pregnancy. This is defined as vomiting sufficiently pernicious to produce weight loss, dehydration, acid-base imbalance. In severe case, it also leads to neurologic abnormality including confusion, gate disturbance, nystagmus. We have tried researching effect of herbal medicines, Soyangin Hyungbangsabaek-san. 2. Methods To heal the Hyperemesis Gravidarum, we used Soyangin Hyungbangsabaek-san. 3. Results Hyperemesis Gravidarum of a Soyangin patient was treated with a herb-medicine, and change of her subjective symptom & general condition was managed. 4. Conclusions The constitutional treatment with herb-medicine (Soyangin Hyungbangsabaek-san) was efficacious against Hyperemesis Gravidarum. Further study on management of this disease is needed.

• Journal of Sasang Constitutional Medicine
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• v.35 no.3
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• pp.12-28
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• 2023

Introduction This study reports case series of Soyangin patients with coldness in hands and feet using Sasang constitutional medicine approach. This study suggests a value of using constitutional medicine indicators as both prognostic and diagnostic tools. Methods Among patients who visited an outpatient clinic, 7 patients were selected based on the criteria. These selected patients were exclusively treated with herbal medicine and monitored every 2 to 4 weeks retrospectively. Results The average treatment period was 8 weeks. Patients with a favorable pattern showed the improvement within 8 weeks, while those with an unfavorable pattern required more time. Discussion This study confirms the significance of Sasang constitutional medicine approach in Soyangin exterior cold syndrome with coldness in hands and feet. It also validates the current coldness in hands and feet as meaningful diagnostic indicator of Soyangin exterior cold syndrome. Furthermore, it highlights the value of original symptoms as prognostic tools.

• Journal of Sasang Constitutional Medicine
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• v.28 no.1
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• pp.19-26
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• 2016

Objectives The purpose of this study is to investigate the concept of 'Sojeung' in Sasang Constitutional medicine. This is the first article, which focuses on the concepts of Sojeung by distinguishing symptoms, syndromes and disease.Methods Donguisusebowon and many articles were reviewed for summarizing the concepts of 'Sojeung'. We investigated the concept of 'Sojeung' from literal meaning and the difference between 'syndromes' and 'symptoms' in Traditional Chineses Medicine.Results & Conclusions By researching and discussing different meanings of Sojeung, we suggest that Sojeung has both 'symptom' and 'syndrome' meanings. Under different circumstances Sojeung refers to different meaning.

• Journal of Sasang Constitutional Medicine
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• v.30 no.1
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• pp.7-13
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• 2018

Objectives On the point of modern preventive medicine, Sasang Constitutional Meidicine(SCM) has the thoughts of preventive medicine. Modern preventive medicine has the three dimensional prevention; primary, secondary and tertiary prevention. The preventive thoughts of SCM concerning three dimensional prevention have been investigated in this article. Method Materials and references were collected about the prevention of SCM. Lee Jema's books such as Donguisusebowon, Gyeokchigo and Donguisusebowon Chobonguen were included. Result and Conclusions As the primary prevention of SCM, Regimen according to ages, explanation according to health index as Myeongmaeksilsu(命脈實數), moderation of four ruinous causes such as intoxication, seduction, opulence and authority, adequate social life and control of 4 kinds of emotions(sorrow, anger, joy and pleasure) are included. As the secondary prevention of SCM, explanation according to disease index, fragile Organs and frequently acquired diseases according to constitutions are included. As the tertiary prevention of SCM, rehabilitation for the stroke patients according to constitutions is included. In conclusion, SCM has all of 3 dimensional prevention methods although that might be applied with modern considerate modification.

• Journal of Sasang Constitutional Medicine
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• v.12 no.2
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• pp.201-209
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• 2000

Intestinal tuberculosis is an chronic infectious disease and occur insidiously. 29-years-old woman who has abdominal pain and diarrhea is admitted and we have diagnosed her as Soeumin and treated by east and west integrated therapy. The results is as following, first Pyobyung(表病) and Ribyung(裏病) occur anytime without development of a disease(傳變), second Byungjeung(病證) is occured according to Sojeung(素證), third we decide the severity of Byungjeung(病證) in according to the shape and period of stool, forth we find that Byungjeung(病證) is change from Teaeumjeung(太陰證) to Soeumjeung(少陰證) during west medical therapy

• Journal of Sasang Constitutional Medicine
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• v.35 no.1
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• pp.1-13
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• 2023

Objectives This paper was to compare and analyze the contents of 『Dongeuisasang Geumnangbogyeol(東醫四象錦囊寶訣)』 with previously published books on Sasang medicine. Methods 『Dongeuisasang Geumnangbogyeol(東醫四象錦囊寶訣)』 was compared and analyzed with the previously published 『Dongeuisasangsinpyeon(東醫四象新編)』 and 『Dongeuisusebowon(東醫壽世保元)』. Results and Conclusions 『Dongeuisasang Geumnangbogyeol(東醫四象錦囊寶訣)』 is a book related to Sasang medicine, written by the author Park Byeong-Gil in 1961 and published by Haenglim Seowon in 1961. Mainly, the contents of 『Dongeuisasangsinpyeon(東醫四象新編)』 were transcribed, but it is meaningful in that he recorded the body shape of Sasang constitution and the prescriptions he experienced clinically. 18 Taeumin prescriptions, 43 Soeumin prescriptions, and 13 Soyangin prescriptions were recorded, and it could be seen that in the Taeeumin prescriptions, the brain-nervous system disease was recorded, and in Soeumin prescriptions and Soyangin prescriptions, digestive system diseases were mainly recorded.

• Journal of Sasang Constitutional Medicine
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• v.13 no.2
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• pp.110-123
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• 2001

1. Purpose This study is intended to catch the expasion of theory of Sasang Constitutional Medicine through Dongyi-Soose-Bowon Chopanbon with Sasang-Yihak-Chobonguen and Dongyi-Soose-Bowon Gapobon 2. Method I studied the archive of prescription and medicines concerned in the Dongyi-Soose-Bowon Chopanbon with Sasang-Yihak-Chobonguen and Dongyi-Soose-Bowon Gapobon 3. Result and conclusion 1. The principle which select the Sasang-in Prescription in Dongmuyugo is Hyung-Choei-Eik-Mi(馨臭液味) and Seung-Gang-Gae- Hap(升降開闔) 2. The same Medicine in Dongyi-Soose-Bowon Chopanbon and Sasang-Yihak-Chobonguen and Dongyi-Soose-Bowon Gapobon is 27 and this medicines are the principle medicine in the Taiyin Disease 3. The same Herb-Medication in the Sasang-Yihak-Chobonguen and Dongyi-Soose-Bowon Gapobon is 4 and the concept in the Sasang-Yihak-Chobonguen is succeded to Dongyi-Soose-Bowon Gapobon 4. The same Herb-Medication in the Dongyi-Soose-Bowon Gapobon and Dongyi-Soose-Bowon Chopanbon is 7 and the Change between the Dongyi-Soose-Bowon Gapobon and Dongyi-Soose-Bowon Chopanbon is the cognition between the Pyozeung(表證) and Lizeung(裏證) in the disease 5. There is no same Herb-Medication in that three books. This result can prove that the Dongyi-Soose-Bowon Chopanbon's New Herb-Medication(新定方) was made in the last stage of Sassng-Yihak

• Journal of Sasang Constitutional Medicine
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• v.14 no.1
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• pp.1-9
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• 2002

We analyzed 44 and 16 types of herbal medicines for Taeumin and Taeyangin, clinically applied in Dongyisoosebowon. In order to discover the standard of herbal classification for the Sasang constitutions, four concepts of Sasang Medicine were applied. These included 'Sadangron (theory of four groups)', 'Seungganggaehap (ascending-descending and gathering-dispersing)', 'Pyorihanyoul (exterior-interior and hot-cold)',and 'Hyungchiaekmi (fragrance, smell, bodily fluid and taste)'. According to these analyzing methods of herbal properties, we have reached the following conclusions: Herbal medicines for 'Taeumin' are characterized by opening energetics that reinforce dispersing Qi. The 'Exterior cold disease' is treated with herbs that ventilate the lungs and disperse dampness in three ways: by moistening the lungs, by releasing exterior, and by resolving dampness. The 'Interior heat disease' is treated with herbs that clear the liver and disperse heat in two ways. One by clearing liver heat through dispersing damp-heat of the small intestine and the other by opening orifices. Herbal medicines for Taeyangin are characterized by those that gather energy inward. They include herbs that treat beriberi, dystrophy of the extremities and vomiting, as well as, fish, shellfish, fruits and vegetable.

• Journal of Sasang Constitutional Medicine
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• v.13 no.3
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• pp.1-7
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• 2001

We analyzed 45 types of herbal medicines for Soyangin, clinically applied in Dongyisoosebowon. In order to discover the standard of herbal classification for the Sasang constitutions, four concepts of Sasang Medicine were applied. These included 'Sadangron(theory of four groups)', 'Seungganggaehap(ascending-descending and gathering-dispersing)', 'Pyorihanyoul(exterior-interior and hot-cold)', and 'Hyungchiaekmi(fragrance, smell, bodily fluid and taste)'. According to these analyzing methods of herbal properties, we have reached the following conclusions: Herbal medicines for 'Soyangin' are characterized by descending energetics that reinforce the Yin Qi. The 'Exterior cold disease' is treated with herbs that descend the "Exterior Yin" in five ways: by releasing exterior, by resolving dampness, by clearing and transforming heat phlegm, by clearing heat, and by settling and calming the spirit. The 'Interior heat disease' is treated with herbs that raise the "Interior Yang" in three ways: by tonifying kidney Yin, by clearing heat, and by clearing heat and purging.