• 대한한의학회지
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• 제26권1호
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• pp.46-58
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• 2005

Objective : This study on Sipimikwanjung-tang was undertaken to evaluate its antioxidant capacities and antiperoxidation activities in rat liver tissues. Sipimikwanjung-tang which has been one of the prescriptions in sasang constitutional medicine is usually applied for the therapy of various liver diseases. It is elucidated that Sipimikwanjung-tang has antioxidants on liver tissue of rat and the cytotoxic effects on human hepatoblastoma Hep G2 cells. Methods: Sipimikwanjung-tang extract in antioxidant effects of Hep G2 cells is evaluated by MTT assay, DAPI staining, DNA fragmentation assays and FACS can analysis. Results: Sipimikwanjung-tang induced apoptosis in Hep G2 cells, and induced G1 and G2M arrest of the cell cycle as well as a significant increase in PARP and caspase-3 activity. It induced an increase in $H_2O_2$ generation and the subsequent $NF-{\kappa}B$ activation and also induced cell apoptosis through the caspase-3-dependent pathways in the low concentration of Sipimikwanjung-tang extracts. However, the high dose of Sipimikwanjung-tang extract in Hep G2 cells inhibited $TGF-{\beta}l-induced$ apoptosis via increase in cellular $H_2O_2$, formation and $NF-{\kappa}B$ activation in human hepatoblastoma Hep G2 cells. Conclusion: From this study, the possibility that Sipimikwanjung-tang extracts apply to antioxidant and apoptotic treatment of disease is revealed.

• 대한암한의학회지
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• 제27권1호
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• pp.49-56
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• 2022

Objective: This case report represented that Korean traditional medicine therapies can make effective results for chemotherapy-induced peripheral neuropathy(CIPN) patients. Methods: A 63-year-old female patient has been diagnosed with ovarian cancer(Sertoli-Leydig cell tumor). Total excision of uterus and appendages was operated, and Bleomycin, etoposide and cisplatin combination therapy was applied. After three cycles of chemotherapy, the severe side effects of neutropenia and CIPN occurred. Chemotherapy was terminated, but numbness and tingling pains in the limbs persisted for several months. We provided Korean medicine treatments including herbal medicine, pharmacopuncture, acupuncture, moxibustion and physiotherapies. Results: After treatments, the numbness and pain were reduced from 10 to 1 in hand and 6 to 0 on the numeric rating scale(NRS). Functional assessment of cancer therapy/Gynecologic oncology group neurotoxicity (FACT/GOG-NTX) score was improved from 58 to 97. Conclusion: According to these results, Korean medicine treatments could be considered effective for CIPN. Prospective studies are needed to confirm and expand these findings.

• 사상체질의학회지
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• 제25권4호
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• pp.277-288
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• 2013

Objectives This study was aimed to propose the guideline of the diarrhea in Sasang Constitutional Medicine. Methods 1) Literature search It was investigated that the prescriptions stated the diarrhea as a main and accessory symptoms to be treated in "Donguisasangshinpyun", "Donguisusebowon Sasang Chobongwon", "Donguisusebowon Gabobon", "Donguisusebowon Sinchukbon", "Dongmuyugo" 2) Clinial paper search (1) The foreign papers were searched by using the search word with 'Sasang AND Diarrhea' in pubmed (http://www.ncbi.nlm.nih.gov/pubmed/) and The Cochrane Library(http://www.thecochranelibrary.com) (2) The domestic papers were searched by using the search word with 'Soeumin AND Diarrhea', 'Soyangin AND Diarrhea', 'Taeeumin AND Diarrhea', 'Taeyangin AND Diarrhea', 'Sasang AND Diarrhea' in NDSL (http://www.ndsl.kr), KISS(http://kiss.kstudy.com), Oasis(http://oasis.kiom.re.kr), RISS(http://www.riss.kr) (3) The extracted factors were the evaluations on the mainly complained symptom, adopted four constitutional therapy and efficacy. Results & Conclusions The guidelines for treating the diarrhea in the Four Constitutional Medicine are as follows. 1) It is to categorize the constitution. 2) The diarrhea of taeeumin is prescribed with 'A Series of Taeeumjowi-tang, Galgeunhaegi-tang, Cheongsimyeonja-tang, Sahyang-san, etc'. by classifying into cold, fever, consumption and addiction. 3) The diarrhea of soyangin is regarded as an internal disease and it is prescribed with 'Baekhaobuja-tang, Baekhaobujaijung-tang, etc'. by classifying taeeum symptom and so-yin symptom. 4) The diarrhea of soeumin is Mangeum-disease and 'Jeoryeongchajeonja-tang, Hyeongbangsabaek-san, Hwalseokgosam-tang, Hyeongbanggihwang-tang, etc'. is prescribed depending on the complication.

• 사상체질의학회지
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• 제11권2호
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• pp.209-226
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• 1999

본 연구에서는 총 65명의 고지혈증환자를 대상으로 일반치료식과 체질치료식을 처방한 후 3주 후, 6주 후를 비교하여 그 효능을 비교하였다. 체질치료식은 영양학과 사상체질의학을 고려하여 구성되었다. 태음인의 경우를 살펴보면, 일반치료식과 체질치료식은 Serum Lipids의 항목에서 같은 수준으로 영향을 주었다. 일반치료식은 TC(6주후), TG(6주후)에서 유의한 감소(P<0.05)가 관찰되어 체질치료식보다 우수한 부분이 있었고, 체질치료식은 PL(6주후)에서 유의있는 감소(P<0.01) 가 관찰되어 일반치료식보다 우수하였다. 소양인의 경우를 살펴보면, 일반치료식에서는 변화가 없었으나 체질치료식에서는 TL(3주후 6주후), PL(3주후)에서 유의있는 감소(P<0.05)가 관찰되었다.

• 사상체질의학회지
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• 제21권3호
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• pp.216-222
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• 2009

1. Objectives: This case study described a process of the patient diagnosed as acute hepatitis A treated by medication based on the Sasang Constitutional Medicine and acupuctural theraphy and obtained improved effects about several symptoms. 2. Methods: We diagnosed the male patient with acute hepatitis A as Tae-Eumin Exterior-Cold-Disease by the Cold in the Esophagus, and administered Mahwangbalpyo-tang and Handayeolso-tang according to clinical progress. And we evaluated the results by liver function test(LFT; AST, ALT, $\gamma$-GTP ), total bilirubin level and the visual analog scale(VAS) of symptoms. 3. Results and Conclusion: Almost symptoms (except for jaundice) at the time of admission were disappeared, and also jaundice (estimated by color of scleras and color of urine) was alleviated. Also level of AST, ALT, $\gamma$-GTP and total bilirubin decreased in laboratory test. We obtained positive effects to the therapy but we considered necessities of further comparative studies with control group.

• 사상체질의학회지
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• 제17권3호
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• pp.163-171
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• 2005

1. Objectives The purpose of this study is to evaluate the effectivity of the Korean herbal medicine therapy which is based on the Sasang constitutional medicine for the Soyangin Edema Patient 2. Methods Patient who diagnosed as Soyangin by physical characteristic, posture and symptoms is evaluated with length of patient' Lt. calf, ankle, foot circumference after medication 3. Results After medicine, 1) Length of patient' Lt. calf was on the decrease from 37.2cm to 34.4cm 2) Length of patient' Lt. ankle was on the decrease from 27.8cm to 25.4cm 3) Length of patient' Lt. foot was on the decrease from 28.0cm to 25.7cm Edema of a Soyangin patient responded well to the treatment with Dojeokgangki-tang 4. Conclusions The case study shows an efficient results by using Dojeokgangki-tang in treatment of Soyangin edema patient.

• 사상체질의학회지
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• 제21권1호
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• pp.53-62
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• 2009

1. Objectives The purpose of this study is to find the ground why constitution must be classified into 4 types. 2. Methods I analysed the basic presuppositions to class 4 Type Constitution in Sasang Constitutional Medicine(SCM). And I connected the presuppositions with other theories from the viewpoint of directional properties of human body. 3. Results and Conclusions The most important presupposition to class 4 Type Constitution and apply to clinical therapy in SCM is that there is native strength and weakness of lung's Exhale Dispersing Qi, liver's Inhale Gathering Qi, spleen's Ascending Yin Qi and kidney's Descending Yang Qi. If there is superior tendency of Qi flow direction in human body, 6 directions(upward, downward, forward, backward, outward and inward) will be remarkable. But, in embryonic period, the outer skin is originated from the back(ectoderm) and the alimentary canal is from the front(endoderm). Therefore 4 directions(upward, downward, outward and inward) will be more remarkable, and those directions are included in the former presupposition.

• 사상체질의학회지
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• 제32권2호
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• pp.80-95
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• 2020

Introduction This study is the first case report to observe a significant improvement of clinical symptoms of both Recurrent Aphthous Stomatitis(RAS) and pompholyx treating with modified Palmulgunja-tang for Soeum-type. Case presentation A 37-year-old female patient complained of pain by ulcers on her mouth and tongue, and of itching caused by vesicles on her palms and soles was diagnosed with RAS, pompholyx, and, especially moderate pattern of 'Congestive Hyperpsychotic symptomatology' according to the theory of Sasang Constitutional Medicine(SCM). During inpatient and outpatient treatment, she took modified Palmulgunja-tang, and was treated with acupuncture, moxibustion, and cupping therapy. The effectiveness of these therapies was assessed with subjective Neumeral Rating Scale(NRS) and Dyshidotic Eczema Area and Severity Index(DASI). Conclusion After the treatment according to the theory of SCM, NRS, and DASI score about RAS and pompoholyx was decreased, and the general condition of the patient also has improved.

• 사상체질의학회지
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• 제29권1호
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• pp.50-58
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• 2017

Objective Insomnia is a common symptom among cerebral infarction patients. The purpose of this study is to report a case which showed sypmtoms improvement after treatment with Hyeongbangsabaek-san. Method To evaluate the results of this treatment, Insomnia severity index(ISI), Pittsburgh sleep quality index(PSQI), Korean version of Beck depression inventory(K-BDI), Sleep dairy results were measured. Result The patient who suffered from severe insomnia after cerebral infarction attack was treated by Hyeongbangsabaek-san and acupuncture therapy for about 3 weeks. She refused to take Western medicine for insomnia, and after treated with Hyeongbangsabaek-san and acupuncture, her sleep quality showed improvement. Conclusion This study suggests that using Sasang constitutuional medical treatment is effective for Soyangin patient with insomnia after cerebral infarction attack.

• 사상체질의학회지
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• 제23권2호
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• pp.254-262
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• 2011

1. Objectives: We report a case of Soeumin tidal fever patient presenting with pelvic pain who was successfully treated with Sasang therapy. The purpose of this case is to report that a Soeumin patients with tidal fever and pelvic pain who improved with Sasang Constitutional treatment 2. Methods: We treated a female Soeumin patient presenting with tidal fever and pelvic pain. We prescribed Palmulgunja-tang(八物君子湯) for her symptoms. Body temperature and physical symptoms were measured to assess improvement. 3. Results: The Soeumin patient's fever and pain improved with a dramatic drop in the highest body temperature from $39.1^{\circ}C$ to $36.6^{\circ}C$. Activities of daily living(ADL) improved from bed ridden to independently ambulatory state. 4. Conclusions: This case study shows that Palmulgunja-tang was in effective treating tidal fever and pain in this Soeumin patient.