• Journal of Environmental Science International
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• v.16 no.3
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• pp.369-376
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• 2007

This study was conducted to evaluate water quality in coastal sea of Kunsan using multivariate analysis. The analysis data in Coastal Sea of Kunsan use of surveyed data by the NFRDI from April 2000 to November 2002. Twelve water Quality parameter were determined on each sample. The results was summarized as follow ; Water quality in coastal sea of Kunsan could be explained up to 62.782% by four factors which were included in loading of nitrogen-nutrients by Keum river(24.688%), suspended solids variation (12.180%), seasonal climate variation (18.367%) and variation of DIP (10.546%). To analyze spatially and monthly variation by factor score, it was divided by inner area and outer area spatially, and spring and summer monthly. The result of time series analysis by factor score, inner area of Kunsan coastal sea(St.1 and St. 2) was the most affected by nitrogen-nutrient and suspended solids due to runoff by Keum river. It could be suggested from these results that it is important to reduce tile pollution loads from Kuem river for the control of the water quality in coastal sea of Kunsan.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.8
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• pp.1424-1429
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• 2007

This paper presents a simple and reliable one-touch type multi-immunosensing lab-on-a-chip (LOC) detecting antibodies as multi-disease markers using electrochemical method suitable for a portable point-of-care system (POCS). The multi-stacked LOC consists of a PDMS space layer for liquids loading, a PDMS valve layer with 50 im in height for the membrane, a PDMS channel layer for the fluid paths, and a glass layer for multi electrodes. For the disposable immunoassay which needs sequential flow control of sample and buffer liquids according to the designed strategies, reliable and easy-controlled on-chip operation mechanisms without any electric power are necessary. The driving forces of sequential liquids transfer are the capillary attraction force and the pneumatic pressure generated by air bladder push. These passive fluid transport mechanisms are suitable for single-use LOC module. Prior to the application of detection of the antibody as a disease marker, the model experiments were performed with anti-DNP antibody and anti-biotin antibody as target analytes. The flow test results demonstrate that we can control the fluid flow easily by using the capillary stop valve and the PDMS check valves. By the model tests, we confirmed that the proposed LOC is easily applicable to the bioanalytic immunosensors using bioelectrocatalysis.

• Journal of Preventive Medicine and Public Health
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• v.44 no.2
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• pp.93-100
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• 2011

Objectives: This study was performed to identify the socioeconomic factors, health behavior factors and dietary patterns that have an influence on the fasting blood glucose in adults. Methods: This study used data collected from the 2007, 2008, 2009 Korea National Health and Nutrition Examination Survey. The final sample included 4163 subjects who were 30-59 years old and who had completed the necessary health examinations, the health behaviors survey and nutrition survey. Results: Eleven dietary patterns emerged from the factor analysis with different factor loading. After controlling for potential confounders, multiple regression analysis of the dietary patterns showed that 'fruits', 'alcohols', and 'starchy foods' affected the fasting blood. Lower consumption of 'fruits' and higher consumption of 'alcohols' and 'starch foods' were significantly associated only with an increased risk of high blood glucose. Conclusions: In the light of the results of this study, it appears pretty likely that the risk of developing high blood glucose can be reduced by changing a person's dietary patterns.

• Journal of The Korean Dental Society of Anesthesiology
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• v.13 no.4
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• pp.167-178
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• 2013

Oxycodone is a semi-synthetic opioid synthesized from poppy-derived thebaine. It is a narcotic analgesic generally indicated for relief of moderate to severe pain. Although developed in an attempt to improve on the existing opioids, the adverse effects of oxycodone are those that are typically found in opioids. In recent years, the use of the opioid oxycodone has increased markedly and replacing morphine as the first line choice of opioid in several countries. There are formulations for oral immediate, oral extended release and intravenous use. In 2013, intravenous oxycodone was approved for marketing by Ministry of Food and Drug Safety (MFDS), with the indication of postoperative intravenous patient-controlled analgesia (IV PAC). Simulation study of oxycodone demonstrated that minimum effective analgesic concentration (MEAC) of oxycodone was most quickly reached with higher loading dose and IV PCA with background infusion, which may reduce the necessity of rescue analgesics during immediate postoperative period. Previous studies for postoperative pain management with intravenous oxycodone are limited in sample size, mostly less than 100 patients, which may not be large enough to assess safety of intravenous oxycodone. The effectiveness and tolerability of IV PCA with oxycodone should, therefore, be evaluated in large scale clinical trials in Korean populations.

• Structural Engineering and Mechanics
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• v.74 no.3
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• pp.313-323
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• 2020

Non-destructive tests are commonly used in construction industry to access the quality and strength of concrete. However, till date there is no non-destructive testing method that can be adopted to evaluate the bond condition of reinforced concrete beams. In this regard, the presented research work details the use of ultra-sonic pulse velocity test method to evaluate the bond condition of reinforced concrete beam. A detailed experimental research was conducted by testing four identical reinforced concrete beam samples. The samples were loaded in equal increments till failure and ultra-sonic pulse velocity readings were recorded along the length of the beam element. It was observed from experimentation that as the cracks developed in the sample, the ultra-sonic wave velocity reduced for the same path length. This reduction in wave velocity was used to identify the initiation, development and propagation of internal micro-cracks along the length of reinforcement. Using the developed experimental methodology, researchers were able to identify weak spots in bond along the length of the specimen. The proposed method can be adopted by engineers to access the quality of bond for steel reinforcement in beam members. This allows engineers to carryout localized repairs thereby resulting in reduction of time, cost and labor needed for strengthening. Furthermore, the methodology to apply the proposed technique in real-world along with various challenges associated with its application have also been highlighted.

• Genomics & Informatics
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• v.16 no.4
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• pp.36.1-36.3
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• 2018

Next generation sequencing (NGS), a high-throughput DNA sequencing technology, is widely used for molecular biological studies. In NGS, RNA-sequencing (RNA-Seq), which is a short-read massively parallel sequencing, is a major quantitative transcriptome tool for different transcriptome studies. To utilize the RNA-Seq data, various quantification and analysis methods have been developed to solve specific research goals, including identification of differentially expressed genes and detection of novel transcripts. Because of the accumulation of RNA-Seq data in the public databases, there is a demand for integrative analysis. However, the available RNA-Seq data are stored in different formats such as read count, transcripts per million, and fragments per kilobase million. This hinders the integrative analysis of the RNA-Seq data. To solve this problem, we have developed a web-based application using Shiny, COEX-seq (Convert a Variety of Measurements of Gene Expression in RNA-Seq) that easily converts data in a variety of measurement formats of gene expression used in most bioinformatic tools for RNA-Seq. It provides a workflow that includes loading data set, selecting measurement formats of gene expression, and identifying gene names. COEX-seq is freely available for academic purposes and can be run on Windows, Mac OS, and Linux operating systems. Source code, sample data sets, and supplementary documentation are available as well.

• Geomechanics and Engineering
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• v.24 no.1
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• pp.81-89
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• 2021

Uniaxial compression tests were conducted on sandstone-CGFB composite samples with different interface angles, and their strength, acoustic emission (AE), and failure characteristics were investigated. Three macro-failure patterns were identified: the splitting failure accompanied by local spalling failure in CGFB (Type-I), the mixed failure with small sliding failure along with the interface and Type-I failure (Type-II), and the sliding failure along with the interface (Type-III). With an increase of interface angle β measured horizontally, the macro-failure pattern changed from Type-I to Type-II, and then to Type-III, and the uniaxial compressive strength and elastic modulus generally decreased. Due to the small sliding failure along with the interface in the composite sample with β of 45°, AE events underwent fluctuations in peak values at the later post-peak failure stage. The composite samples with β of 60° occurred Type-III failure before the completion of initial compaction stage, and the post-peak stress-time curve initially exhibited a slow decrease, followed by a steep linear drop with peaks in AE events.

• Structural Monitoring and Maintenance
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• v.9 no.3
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• pp.271-287
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• 2022

This study investigates the bending behavior of a composite concrete slab roof with different methods of externally strengthing using steel plates and carbon fiber reinforced polymer (CFRP) strips. First, the concrete slab model which was reinforced with CFRP strips on the bottom surface of it is validated using experimental data, and then, using numerical modeling, 7 different models of square-shaped composite slab roofs are developed in ABAQUS software using the finite element modeling. Developed models include steel rebar reinforced concrete slab with variable thickness of CFRP and steel plates. Considering the control sample which has no external reinforcement, a set of 8 different reinforcement states has been investigated. Each of these 8 states is examined with 6 different uncertainties in terms of the properties of the materials in the construction of concrete slabs, which make 48 numerical models. In all models loading process is continued until complete failure occurs. The results from numerical investigations showed using the steel plates as an executive method for strengthening, the bending capacity of reinforced concrete slabs is increased in the ultimate bearing capacity of the slab by about 1.69 to 2.48 times. Also using CFRP strips, the increases in ultimate bearing capacity of the slab were about 1.61 to 2.36 times in different models with different material uncertainties.

• Journal of Sensor Science and Technology
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• v.32 no.2
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• pp.67-74
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• 2023

A microfluidic paper-based analytical device (µPAD) is proposed for the selective detection of ammonia in water by using the modified Berthelot reagent and a fluidic channel consisting of hollow paper. The modified Berthelot reagents were uniformly dispersed in cyclohexane and then immobilized in a detection zone of the µPAD. The loading position of the reagents and the type of a sample flow channel were optimized to achieve a sensitive ammonia detection within a short analytical time. The NH₃ µPAD exhibits a linear colorimetric response to the concentration of ammonia dissolved in water in the range of 1-100 mg L^-1, and its limit-of-detection is 1.75 mg L^-1. In addition, the colorimetric response was not influenced by the addition of 100 mg L^-1 nitrogen containing compounds (sodium nitrate, sodium nitrite, uric acid, hydroxylamine, butylamine, diethylamine) or inorganic salts (NaCl, Na₂HPO₄), presenting the enough selectivity in the detection of water-dissolved ammonia against possible interferents.

• Journal of The Korean Society of Agricultural Engineers
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• v.66 no.1
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• pp.15-24
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• 2024

Unlike artificially created homogeneous materials, the process of calculating the elastic modulus of natural soil involves the possibility of errors. Because the stress-strain behavior of soil is nonlinear, the secant modulus of elasticity is often used based on 1/2 of the stress at failure. Since soil has the property of changing its elastic modulus depending on the confining pressure, numerical analysis models that analyze its behavior inevitably include complex elements. The hyperbolic model, which relatively accurately simulates the behavior immediately after loading in soft ground, assumes that the stress-strain curve of the consolidated undrained triaxial test is hyperbolic and requires the slope of the tangent line at the starting point. However, the slope of the initial tangent in the stress-strain curve obtained from an actual triaxial test is difficult to have regularity according to changes in confining pressure. Additionally, due to the characteristics of a hyperbola, even small changes in related factors cause large changes in the hyperbola. Therefore, there is a lot of randomness in the process of calculating model parameters from the triaxial test results, which causes large differences in the results. Therefore, the method of calculating the initial elastic modulus by the consolidation test presented in this study is also used to verify the method by the triaxial test. It can be applied. However, since this study was applied to only one sample showing typical consolidation characteristics, it is necessary to check samples with various physical properties in the future.