• Title/Summary/Keyword: Salivary gland

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How to Manage Salivary Gland Tumors (타액선 종양의 치료지침)

  • Park Yoon-Kyu
    • Korean Journal of Head & Neck Oncology
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    • v.9 no.1
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    • pp.91-97
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    • 1993
  • The salivary gland consists of major and minor glands. The major glands are parotid, submandibular and sublingual glands. The numerous minor salivary glands are located in the mucosa of the upper aerodigestive tracts. Tumors of the salivary gland are relatively uncommon, and the incidence of the salivary gland tumor among the head and neck neoplasm is approximately 3%. Surgery is the primary treatment of choice for the most tumors of the salivary glands. Author reviewed the recent reports of salivary gland neoplasms of Korea and foreign institutes and suggest the guideline of managemnt of salivary gland tumors.

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Clinical Application of $^{18}F-FDG$ PET in Salivary Gland Cancer (타액선암(Salivary Gland Cancer)에서 $^{18}F-FDG$ PET의 임상 이용)

  • Yang, You-Jung
    • Nuclear Medicine and Molecular Imaging
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    • v.42 no.sup1
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    • pp.14-16
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    • 2008
  • Salivary gland tumors are relatively rare, constituting 3% of all head and neck neoplasms. In patients with salivary gland malignancies, $^{18}F-FDG$ PET is clinically useful in initial staging, histologic grading, and monitoring after treatment. According to clinical research data hitherto, $^{18}F-FDG$ PET is expected to be an effective diagnostic tool in the management of salivary gland tumors.

A Clinical Review on 315 Cases of Major Salivary Gland Tumor (주 타액선 종양 315예의 임상적 고찰)

  • Chae Myong-Seog;Paik Nak-Whan;Kim Sang-Hyo
    • Korean Journal of Head & Neck Oncology
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    • v.15 no.2
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    • pp.205-210
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    • 1999
  • Objectives: Major salivary gland tumor mainly develops in the parotid gland and pleomorphic adenoma is a large percentage. The aim of this study is to get clinicopathologic characteristics of overall major salivary gland tumors and suggestions regarding surgical management through collective review of 315 cases. Materials and Methods: This is a clinicopathologic review of 315 cases of major salivary gland tumor who were treated surgically at Department of Surgery, Head and Neck Clinic, Pusan Paik Hospital, Inje University during the period of 18 years from 1980 to 1997. Analysis was performed regarding the incidence, classification, surgery and its complications, and survival rate of salivary gland cancer. Results : 1) Parotid gland was the most prevalent site of salivary gland tumor(78%) and submandibular gland(21%) was next in order. Benign tumors were 257cases(81%) and malignant tumors were 58 cases(19%). 2) Male to female sex ratio was 1:1.2, the most prevalent age group was 3rd decade and the second group was 4th decade. 3) Histopathologically, the most common benign salivary gland tumor was pleomorphic adenoma. Warthin's tumor was next common. Among the malignant tumors, mucoepidermoid carcinoma was most common, and the next were adenoid cystic carcinoma and acinic cell carcinoma. 4) In pleomorphic adenoma, superficial parotidectomy was performed in 129 cases, and extracapsular tumorectomy was performed in 3 cases. In non-pleomorphic benign tumor, tumorectomy was performed in 21 cases. In 40 cases of deep lobe tumor, total parotidectomy was performed in only 2 cases and deep parotidectomy was performed in 38 cases. 5) Surgical complications were facial nerve injury 19 cases, Frey syndrome 13 cases, and salivary fistula 3 cases. 6) Overall 5-year survival rate of salivary gland cancer was 63%. Conclusion: Postoperative recurrence rate is low in benign tumor, but high in cancer of salivary gland tumor. Surgical procedure should not be aggressive in benign tumor, especially in parotid tumor, but should be aggressive in malignant salivary gland tumors.

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Study on Changes in Endogenous Stem Cells in the Salivary Gland of Streptozotocin-induced Diabetic Rats

  • Jung, Bo Hyun;Lee, Hee Su;Yoo, Ki-Yeon
    • International Journal of Oral Biology
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    • v.42 no.3
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    • pp.99-106
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    • 2017
  • Type1 diabetes mellitus (DM) is generally known to be caused by destruction of insulin-producing pancreatic ${\beta}$ cells or an immune-related problem. Polydipsia is a representative symptom of DM, and it has been reported that this condition is closely related to xerostomia and is considered that hyposalivation from the salivary gland results in this phenomenon. Although various studies have reported that induction of diabetes reduces endogenous stem cells in other organs (heart, brain etc.), diabetes-related changes in endogenous stem cells in the salivary gland have not yet been well established. Therefore, in this study, to verify the change in salivary gland stem cells after diabetes, salivary gland tissues in the control and diabetes-induced groups were processed by histochemistry (Masson's trichrome staining) for morphological analysis, TUNEL assay for cell death, and immunohistochemistry (Ki-67 and c-Kit) for cell proliferation and maturation. Diabetes induced by STZ leads to vacuolization, apoptosis, and reduction in proliferating cells/salivary gland stem cells in salivary glands of rats. This result suggests that diabetes may be associated with reduction in salivary gland function such as degeneration and inhibition of regeneration in the salivary gland.

Clinical Analysis of 114 Cases of Malignant Salivary Gland Tumors (악성 타액선 종양 114 예의 임상고찰)

  • Park Yoon-Kyu;Seel David J.;Chung Dong-Kyu
    • Korean Journal of Head & Neck Oncology
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    • v.1 no.1
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    • pp.21-34
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    • 1985
  • The authors reviewed 114 cases of malignant major and minor salivary gland tumors at Presbyterian Medical Center seen from February, 1963 to December, 1983. The results were obtained as follows; 1) Overall male and female sex ratio was 2:1. The peak age of patients with major and minor salivary gland tumor were both 5 th decade. 2) The ratio of benign and malignant tumor was 83:114. The incidence of malignancy in each group was 52% in parotid (50 patients), 75% in minor salivary gland (45 patients), 49% in submaxillary gland(18 patients) and 25% in sublingual gland (1 patient). 3) The incidence according to the anatomic primary site for minor salivary cancers was 10 cases in the nasal cavity, each 8 in the palate and the maxillary antrum, 7 in the tongue, 5 in the gum, 3 in the larynx and 2 in the buccal mucosa. 4) Adenoid cystic carcinoma was the most common cancer of minor salivary gland and malignant mixed tumor was the most common in major salivary glands, each comprising 34 cases (76%) of minor and 19 cases (28%) of major salivary gland tumors. 5) The incidence of cervical lymph node metastasis was 50% in the submaxillary gland cancers, 44% in the parotid gland cancers and 21% in malignant tumors of minor salivary glands. The highest incidence of lymph node metastasis according to histopathological classification was formed in high grade of mucoepidermoid (67%). 6) Nerve invasion was common in mucoepidermoid carcinoma. According to anatomic site, nerve invasion occurred most often in adenoid cystic carcinoma of the submaxillary gland (44%). 7) The lung was the commonest site for distant metastasis comprising 12 cases among 26 cases in which distant spread occurred. 8) The recurrence rate was 50% for major salivary gland cancer and 52% in cancer of the minor salivary gland. In accordance with pathological classification, adenocarcinoma most frequently recurred after excision. This being seen in 88% of patients undergoing definitive therapy. 9) The determinate 5 year survival rate was 78% in major salivary gland tumors, but 69% in minor salivary gland tumors.

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Expression of Type IV Collagen and Fibronectin in Salivary Gland Tumors (타액선 종양에서 제4형 교원질과 Fibronectin 발현)

  • Park Hye-Rim;Nam Eun-Sook;Sohn Jin-Hee;Shin Hyung-Shik;Park Young-Euy;Rho Young-Soo;Min Heun-Ki;Lim Hyun-Joon
    • Korean Journal of Head & Neck Oncology
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    • v.13 no.2
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    • pp.180-186
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    • 1997
  • Objectives: Salivary gland tumors pose considerable difficulty in diagnostic and prognostic assessment based on the histopathologic features alone. We studied the expression of type IV collagen and fibronectin in salivary gland tumors with special emphasis on the differential diagnostic significance. Materials and Methods: We did immunohistochemical stain on paraffin embedded tissues of 33 benign and 24 malignant salivary gland tumors using monoclonal antibody for type IV collagen and polyclonal antibody for fibronectin. Results: 1) Well preserved linear basement membrane-like staining of type IV collagen was detected in duct-cell-derived benign salivary gland tumors. But pleomorphic adenoma exhibited a heterogeneous pattern as focal augmentation and interruption. 2) In malignant tumors, type IV collagen was distributed in an irregular, interrupted manner or completely absent. Adenoid cystic carcinomas displayed a marked staining of the basal membrane associated substances in the pseudocysts. 3) The staining pattern of fibronectin was similar to that of type IV collagen execpt more dense in the stroma. 4) Salivary gland tumors which have a prominent myoepithelial cell component revealed a particular deposition of basement membrane materials adjacent to the myoepithelial cells. Conclusion: The study of the basal membrane substances may be helpful for differential diagnosis of benign and malignant salivary gland tumors and identifying special features of salivary gland tumors such as pseudocystic pattern of adenoid cystic carcinoma. Also we think that the myoepithelial cells contribute to the formation of basement membrane materials.

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Ultrastructural Study on the Salivary Gland of a Korean Freshwater Pulmonate, Radix auricularia coreana

  • Jeong, Kye-Heon;An, Yong-Hwan
    • The Korean Journal of Malacology
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    • v.15 no.2
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    • pp.93-104
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    • 1999
  • A histochemical and ultrastructural study on the salivary gland of a freshwater snail Radix auricularia coreana was conducted .The epithelial cells of the salivary gland are composed of 9 types of cells. Two types out of them work as frame cells supporting the epithelium and the secretory cells embedded within the epithelium Seven types of secretory cells are classifiable depend on their histochemical reactions and ultrastructures. The materials secreted by the secretory cells are neutral mucopolysaccharide, acid mucopolysaccharide, and glycogen.

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IMMUNOHISTOCHEMICAL STUDY ON EXPRESSION PATTERNS OF TUMOR GROWTH RELATED FACTORS IN SALIVARY GLAND TUMORS (타액선 종양에서 종양증식 관련인자 발현에 관한 면역조직화학적 연구)

  • Kim, Han-Seok;Kim, Soung-Min;Park, Young-Wook
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.29 no.5
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    • pp.405-416
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    • 2007
  • Objective : Lots of papers have revealed that tumor growth related factors such as EGF, EGFR, c-erbB-2 play an important role in tumorigenesis and proliferation. These factors are found in most tumors of ectodermal origin. But, documentations of tumor growth related factors on salivary gland tumors were rare. Therefore, we determined expressions of tumor growth related factors; PCNA, p53, EGF, EGFR, cerbB2(HER-2), Maspin, DMBT-1, N-Ras in representative salivary gland tumors. Materials and methods : A few types of salivary tumors were examined by immunohistochemical assays. Each antibody was applied to specimens of tumors. Specimens were composed of 5 pleomorphic adenomas (PA), 3 mucoepidermoid carcinomas (MEC), 2 adenoid cystic carcinomas (ACC) and 2 squamous cell carcinomas (SCC) from 12 patients. One specimen was selected randomly as negative control. For evaluation of staining intensity, each stained sample was divided into 5 grade; no staining, obscure, weak staining, moderate staining, strong staining. Results : Strong expressions of PCNA were found in all tumors except of PA. EGF was expressed strongly in SCC, ACC sequently. But in both PA and MEC, EGF expression was weak. EGFR and c-erbB-2 expression showed similar patterns in all salivary gland tumor tissues. P53 showed weak expression generally in all salivary gland tumors. DMBT-1 was expressed in SCC rather than in ACC or in MEC. N-Ras showed weak expressions in all salivary gland tumors except of squamous cell carcinoma. Conclusion : Taken together, tumor growth related factors were expressed in salivay tumors as well as mucosal squamous cell carcinoma. Especially EGFR and c-erbB-2 could be candidates as diagnostic markers for estimating clinical grade of salivary gland tumors. But further studies with reliable methods will be needed to confirm the results of this study.

COMPARISONS BETWEEN THE SIALOGRAPHIC AND SCINTIGRAPHIC FINDINGS IN SALIVARY GLAND DISEASE (타액선질환에 대한 타액선조영상과 스캔상의 비교연구)

  • Lee Kyung-Ho;Ahn Hyung-Kyu
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • v.17 no.1
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    • pp.185-194
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    • 1987
  • The purpose of this study was to aid in diagnosis of salivary gland disease by comparing the sialogram with the scintigram. In this study, 47 patients (52 glands) who had taken the sialography and the scintigraphy were examined. The result of two methods was compared with the clinical and operative diagnosis. The following results are obtained. 1. In inflammatory diseases of the salivary gland, the scintigraphy can be a valuable substitution for a sialography. 2. In inflammatory diseases of the salivary gland, we can get more informations in case of the combined use of the sialography and the scintigraphy. 3. In tumorous lesion of the salivary gland, the sialography is superior to the scintigraphy. But both methods are less valuable in diagnosing the extraglandular tumors.

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Fine Needle Aspiration Cytology of High Grade Neoplasm and Spindle Cell Lesion of Salivary Gland (침샘에 발생하는 고등급 악성 종양과 방추세포 병변의 세침흡인 세포소견에 대한 고찰)

  • Oh, Young-Lyun
    • The Korean Journal of Cytopathology
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    • v.16 no.2
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    • pp.75-87
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    • 2005
  • Fine needle aspiration cytology (FNAC) is a very useful tool in the preoperative diagnosis of lesions of the salivary gland. Surgical therapy of high-grade malignancies (salivary duct carcinoma, mucoepidermoid carcinoma, squamous cellcarcinoma, carcinoma ex pleomorphic adenoma, small cell carcinoma, and sebaceous carcinoma) is different from that of benign lesions or low-grade malignancies. Therefore, the recognition of high-grade malignancies is important in salivary gland FNAC. Although recognition of high-grade malignancies of the salivary gland by FNAC is not difficult, precise classification of these malignancies is often impossible. Additionally, because of its rarity, FNAC of spindle cells and mesenchymal lesions of the salivary glands is a tool that is not familiar to many cytopathologists. The characteristic cytomorphologic features of these lesions are reviewed here with a discussion of specific diagnostic problems.