• Title/Summary/Keyword: Salivary gland

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Trends in Saliva Research and Biomedical Clinical Applications (타액 연구의 최신 지견과 임상 응용)

  • Soyoung Park;Eungyung Lee;Jonghyun Shin;Taesung Jeong
    • Journal of the korean academy of Pediatric Dentistry
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    • v.50 no.1
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    • pp.1-12
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    • 2023
  • Function of salivary gland and saliva composition can be an indicator of individual's health status. Recently, saliva has been thought to have a high potential for usage in the biomedical field to diagnose, evaluate, and prevent systemic health due to the technological advances in analyzing and detecting small elements such as immunological and metabolic products, viruses, microorganisms, hormones in saliva. As a diagnostic specimen, saliva has some useful advantages compared to serum. Because of simple non-invasive method, saliva sampling is quite comfort for the patient, and it doesn't require specialists to collect samples. The possibility of infection during the collection process is also low. For this reason, proteins, genetic materials, and various biomarkers in saliva are actively being utilized on studying stress, microbiomics, genetics, and epigenetics. For the research on collecting big data related to systemic health, the needs on biobank has been focused. Regeneration of salivary gland based on tissue engineering has been also on advancement. However, there are still many issues to be solved, such as the standardization of sample collection, storage, and usage. This review focuses on the recent trends in the field of saliva research and highlight the future perspectives in biomedical and other applications.

Effect of irradiation on expression of clusterin in the rat salivary glands (방사선조사가 백서 타액선의 clusterin 발현에 미치는 영향)

  • O Gyu-Myeong;Choi Yong-Suk;Hwang Eui-Hwan;Lee Sang-Rae
    • Imaging Science in Dentistry
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    • v.36 no.1
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    • pp.33-40
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    • 2006
  • Purpose : To investigate clusterin expression in the acini and ductal cells of rat submandibular glands after Co-60 gamma irradiation. Materials and Methods : The male Sprague-Dawley rats weighing approximately 250 gm were divided into control and experimental groups. The experimental group was irradiated with a single absorbed dose of 2, 5, 10, and 15 Gy on the head and neck region. All the rats were sacrificed at 1, 3, 7, 14, 21, and 28 days after irradiation. The specimens including the submandibular gland were sectioned and observed using a immunohistochemical method. Results : In the 2 Gy group, clusterin expression was similar to that of the control group at 1 day after irradiation and it was observed in the striated ductal cells at 3 days after irradiation. In the 5 Gy group, clusterin expression was observed in the striated ductal cells at 1 day after irradiation and gradually increased in the 10 and 15 Gy groups. In the 15 Gy group, clusterin expression was prominent in the striated ductal cells at 1 day after irradiation, but it gradually decreased with the experimental period. The destruction of the striated ductal cells was observed in the 2 Gy group at 21 days after irradiation and in the 5, 10, and 15 Gy groups at 7 days after irradiation. The destruction of the acinar cells was observed in the 2 Gy group at 28 days after irradiation and in the 5, 10, and 15 Gy groups at 14 days after irradiation. Conclusion : Clusterin expression was induced by low doses of irradiation and it appeared to be involved in the regulation of cellular response to irradiation.

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Fine Needle Aspiration Cytology of Solid Type Adenoid Cystic Carcinoma of Buccal Mucosa - A Case Report - (뺨 점막에 발생한 충실성 선양낭성암종의 세침흡인 세포학적 소견 - 1예 보고 -)

  • Kim, Jean-A;Kim, Young-Sill;Lee, An-Hi;Shim, Sang-In;Kim, Byung-Kee;Kim, Kyoung-Mee
    • The Korean Journal of Cytopathology
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    • v.11 no.2
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    • pp.89-92
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    • 2000
  • Adenoid cystic carcinoma constitutes 4 percent of ail benign and malignant epithelial salivary gland tumors and is a highly malignant tumor of the salivary glands. The cytologic presentation in aspirates is usually characteristic with spherical clusters(balls) of small tumor cells filled with hyaline material. But in case of the poorly differentiated variety(solid type), it is difficult to differentiate from other tumors because sheets of small, fairly monotonous malignant cells, with somewhat larger and more conspicuous nuclei are only seen. The cytologic findings of fine needle aspiration of solid type adenoid cystic carcinoma of buccal mucosa in a 51-year-old man are presented. On cytologic findings, solid sheets of monotonous tumor cells with focal necrosis was noted on a hemorrhagic background and the characteristic cytologic features of adenoid cystic carcinoma was absent.

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Quantification of Salivary Gland Scan Image and its Correlation with Salivary Flow Rate (타액선 스캔의 정량적 분석과 타액분비율과의 상관관계에 관한 연구)

  • Kim, Sung-Hun;Kim, Youn-Joong;Chung, Sung-Chang
    • Journal of Oral Medicine and Pain
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    • v.26 no.3
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    • pp.215-224
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    • 2001
  • 서울대학교 치과병원 구강진단과에 구강건조증을 주소로 내원한 환자중 비자극 전타액 분비율이 0.2ml/min이하인 환자 40명과 구강건조증의 증상 및 징후가 없고 정상 타액분비율을 보이는 10명을 대상으로 비자극 전타액 분비율을 측정하고 타액선 스캔 검사를 실시하여 주타액선의 스캔 영상을 정량화한 후 이의 상관관계를 조사한 결과 다음과 같은 결론을 얻었다. 1. 구강건조증 환자군 및 정상 대조군에서 타액선 스캔 영상의 정량적 분석시 이하선 및 악하선 모두에서 좌우측 사이의 유의성 있는 차이가 없었다. 2. 타액선 스캔 영상의 정량적 분석시 구강건조증 환자군은 대조군에 비하여 악하선, 이하선 및 악하선의 합, 양측 악하선 합에서 유의한 차이를 보였다. 3. 대조군에서 타액선 스캔 영상의 정량적 수치와 비자극 전타액 분비율과는 유의성 있는 상관관계가 관찰되지 않았으나, 구강건조증 환자군에서는 유의성 있는 상관관계가 관찰되었다. 4. 구강건조증 환자군을 비자극성 전타액 분비율에 따라 세분하였을 때, 비자극 전타액 분비의 감소가 극심하여 그 측정이 불가능하였던 군은 대조군 및 나머지 구강건조증 환자군에 비하여 타액선 스캔 영상의 정량적 수치에서 유의한 차이를 보였다.

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Adenoid Cystic Carcinoma of the Esophagus - A case report - (식도의 선양 낭포성 암종의 치험 - 1예 보고 -)

  • Yun, Ju-Sik;Na, Kook-Joo;Song, Sang-Yun;Choi, Young-Sun;Kim, Sang-Hyung;Oh, Sang-Gi
    • Journal of Chest Surgery
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    • v.42 no.3
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    • pp.392-395
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    • 2009
  • Adenoid cystic carcinoma (ACC) commonly originates in the major salivary glands and respiratory tract, but it is extremely rare to find ACC in the esophagus. ACC of the esophagus is clinopathologically different from the salivary gland variant. It shows more aggressive malignant behavior and a very poor prognosis. We report here on the surgical and clinopathologic findings of ACC of the esophagus in a 65-year-old man, and we also include a review of the relevant medical literature.

P2X7 Receptor-mediated Membrane Blebbing in Salivary Epithelial Cells

  • Hwang, Sung-Min;Koo, Na-Youn;Choi, Se-Young;Chun, Gae-Sig;Kim, Joong-Soo;Park, Kyung-Pyo
    • The Korean Journal of Physiology and Pharmacology
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    • v.13 no.3
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    • pp.175-179
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    • 2009
  • High concentrations of ATP induce membrane blebbing. However, the underlying mechanism involved in epithelial cells remains unclear. In this study, we investigated the role of the P2X7 receptor (P2X7R) in membrane blebbing using Par C5 cells. We stimulated the cells with 5 mM of ATP for 1${\sim}$2 hrs and found the characteristics of membrane blebbing, a hallmark of apoptotic cell death. In addition, 500 ${\mu}M$ Bz-ATP, a specific P2X7R agonist, induced membrane blebbing. However, 300 ${\mu}M$ of Ox-ATP, a P2X7R antagonist, inhibited ATP-induced membrane blebbing, suggesting that ATP-induced membrane blebbing is mediated by P2X7R. We found that ATP-induced membrane blebbing was mediated by ROCK I activation and MLC phosphorylation, but not by caspase-3. Five mM of ATP evoked a biphasic $[Ca^{2+}]_i$ response; a transient $[Ca^{2+}]_i$ peak and sustained $[Ca^{2+}]_i$ increase secondary to ATP-stimulated $Ca^{2+}$ influx. These results suggest that P2X7R plays a role in membrane blebbing of the salivary gland epithelial cells.

Polymorphous low-grade adenocarcinoma on hard palate: case report (구개부에 발생한 다형성 저등급 선암종의 치험례)

  • Shin, Young-Min;Choi, So-Young;Kim, Jin-Wook;Byeon, Ki-Jung;Kim, Chin-Soo
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.37 no.1
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    • pp.72-76
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    • 2011
  • Polymorphous low-grade adenocarcinomas (PLGA) are distinctive salivary gland neoplasms with a propensity to arise from the minor salivary glands. The most frequent location of PLGA is the palate, even though other locations have been described. Previously used terms for PLGA include lobular carcinoma and terminal duct carcinoma. Although the frequency of the tumor is unknown, the recognition of PLGA as an individual tumor has increased with the establishment of specific histopathological criteria characterizing the PLGA. The first choice of treatment is a wide surgical excision including the subjacent bone if necessary. The prognosis is generally good and the recurrence rate ranges from 17% and 22%. Distant metastases is unusual (9%) but occur mainly in the regional lymph nodes. This is a case report of a 67 year old female patient with PLGA who was treated with a wide excision by layers (2 stage) of the lesion including the surrounding bone. We present this case with a review of the relevant literature.

Effectiveness of a Solid Sialogogue to Stimulate Salivation in MR Sialography (자기공명 타액선조영검사 시 고체 타액분비 촉진제의 유용성)

  • Choi, Kwanwoo;Lee, Hobeom;Na, Sara;Son, Soonyong;Yoo, Beonggyu
    • Journal of the Korean Society of Radiology
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    • v.10 no.8
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    • pp.577-582
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    • 2016
  • This study is aimed to prove that a solid sialogogue can improve the defects of the liquid one and substitute it with no differences in the signal intensity. From January to August 2016, 60 patients with no salivary gland diseases were enrolled. The patients were divided into two groups as follows; a group with a liquid sialogogue and the other group with a solid sialogogue. MR images were acquired and signal intensities of the parotid glands were compared. As a result, the signal intensities of liquid and solid sialogogues showed no statistically significant differences($59.42{\pm}15.74$ and $61.80{\pm}13.99$, respectively) In conclusion, a solid sialogogue was verified to have no signal intensity differences from the liquid one while it could improve the defects of the liquid sialogogue.

Application and usefulness of Ultrasound sonography in dentistry (영상치의학에서 초음파영상의 진단과유용성)

  • Choi, Yong Suk;Seo, Yoo Kyung;Kang, Ju Hee;Oh, Song Hee;Kim, Gyu Tae;Hwang, Eui Hwan
    • The Journal of the Korean dental association
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    • v.55 no.11
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    • pp.778-788
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    • 2017
  • Ultrasound sonography(US) is used to evaluate various diseases of oral and maxillofacial region including salivary glands, soft tissue and jaw lesions because of easy accessibility and no hazard of ionizing radiation. Also, US can offer dynamic study showing real-time images during diagnostic or surgical procedure. US images provide accurate information about the internal features of lesions on the jaw prior to surgical treatment. Doppler images are used to visualize the vascular distribution of the lesions and to provide additional information to enhance diagnostic value. It is necessary to evaluate the diagnostic value of US and evaluate its usefulness by looking at clinical cases using US images. Therefore, US imaging may be recommended as an assistant image in evaluating jaw lesions. US images provided accurate information about the internal structure of lesions on the jaw prior to surgical treatment, and diagnostic value was enhanced by visualizing the vascular distribution of the lesion using doppler imaging. We report the protocol and suggest the effectiveness of US for various lesions and US-guided sialography.

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A Case of Amylase Producing Small Cell Lung Cancer (아밀라제를 생성하는 소세포성 폐암 1예)

  • Lee, Han-Min;Song, Young-Gu;Park, Tae-Byung;Hwang, Sung-Chul;Lee, Yi-Hyeong;Hahn, Myung-Ho;Yim, Hyun-Ee
    • Tuberculosis and Respiratory Diseases
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    • v.44 no.3
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    • pp.661-668
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    • 1997
  • The majority of lung cancers associated with hyperamylasemia are adenocarcinomas. Here we report an unusual case of a 54-year-old male patient who complained of dyspnea, anterior chest wall discomfort and facial edema for one month, presenting with a huge mediastinal mass and hyperamylasemia complicated by pericardial effusion. Histological evaluation of mediastinal mass revealed small cell carcinoma and pericardium showed nonspecific inflammation with fibrosis. The serum amylase had an electrophoretic mobility similar to that of salivary gland enzyme. There were no evidence of a salivary or pancreatic causes of hyperamylasemia. After chemotherapy, parenchymal lung lesions improved and hyperamylasemia disappeared. For the management of pericardial effusion, a pericardial window was formed. We concluded that the striking increase in serum amylase was due to the ectopic production of this enzyme by the tumor.

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