• Title/Summary/Keyword: Salivary gland

Search Result 482, Processing Time 0.09 seconds

The Sclerotherapy of Plunging with the Use of OK-432 (OK-432를 이용한 몰입성 하마종의 경화치료)

  • Kim, Sun-Gon;Lee, Jun-Ho;Kim, Myung-Gu;Rho, Myung-Ho
    • Korean Journal of Bronchoesophagology
    • /
    • v.13 no.1
    • /
    • pp.33-38
    • /
    • 2007
  • Background and Objectives: A plunging ranula represents a mucus escape reaction occuring because of the disruption of the sublingual salivary gland. It is commonly a condition of young adults, although the reported age range is 6-43 years. There is said to be a slightly female preponderance of about 1.9:1(F:M). Surgical incision has been considered the definite treatment, but sometimes complete excision is very difficult. Non-surgical treatment of these lesions has been attempted, but the results have not been satisfactory. In this study, we present our experiences with picibanil (OK-432) sclerotherapy for a plunging ranula. Materials and Methods: We retrospectively reviewed 41 patients who have undergone sclerotherapy with picibanil for plunging ranula. Information was collected on age, sex, a number of injection, post-sclerotherapy side effect and outcome of treatment. Results: 17 patients (41.5%) showed a complete response, and 20 patients (48.7%) showed inter-mediate response. No response was seen in 4 patients (9.8%). As a side effect of intracystic OK-432 injection therapy, fever (26.8%) and pain(39.0%) were observed. However, fever and pain disappeared after several days in all cases. Conclusion: The results are showing that OK-432 injection is an effective and safe treatment for plunging ranula.

  • PDF

Novel Anticandidal Activity of a Recombinant Lampetra japonica RGD3 Protein

  • Wu, Caiping;Lu, Li;Zheng, Yuanyuan;Liu, Xin;Xiao, Rong;Wang, Jihong;Li, Qingwei
    • Journal of Microbiology and Biotechnology
    • /
    • v.24 no.7
    • /
    • pp.905-913
    • /
    • 2014
  • Lj-RGD3, an RGD (Arg-Gly-Asp) toxin protein from the salivary gland of Lampetra japonica, exhibits antifungal activity against Candida albicans. Lj-RGD3 has three RGD motifs and shows homology to histidine-rich glycoprotein. We synthesised two mutant derivatives of Lj-RGD3: Lj-26, which lacks all three RGD motifs and contains no His residues; and Lj-112, which lacks only the three RGD motifs. We investigated the effects of the wild-type and mutated toxins on a gram-positive bacterium (Escherichia coli), a gram-negative bacterium (Staphylococcus aureus), and a fungus (C. albicans). rLj-RGD3 and its mutants exhibited antifungal but not antibacterial activity, as measured by a radial diffusion assay. The C. albicans inhibition zone induced by rLj-112 was larger than that induced by the other proteins, and its inhibitory effect on C. albicans was dose-dependent. In viable-count assays, the rLj-112 MIC was $7.7{\mu}M$, whereas the MIC of the positive control (ketoconazole) was $15{\mu}M$. Time-kill kinetics demonstrated that rLj-112 effectively killed C. albicans at $1{\times}$ and $2{\times}$ MIC within 12 and 6 h, respectively. Electron microscopy analysis showed that rLj-RGD3 and rLj-112 induced C. albicans lysis. Our results demonstrate a novel anticandidal activity for rLj-RGD3 and its mutant derivatives.

Effects of Korean Red Ginseng on Dry Mouth: A Randomized, Double-Blind, Placebo-Controlled Trial

  • Park, Jae-Woo;Lee, Beom-Joon;Bu, Young-Min;Yeo, In-Kwon;Kim, Jin-Sung;Ryu, Bong-Ha
    • Journal of Ginseng Research
    • /
    • v.34 no.3
    • /
    • pp.183-191
    • /
    • 2010
  • Dry mouth is easily neglected if not associated with oral diseases. Consequently, xerostomatic patients often use unconventional therapies. In traditional Korean medicine, Korean red ginseng (KRG) has long been used to relieve dry mouth. However, no clinical trials have investigated whether KRG actually has an effect on dry mouth. This study was performed to evaluate the efficacy of KRG for dry mouth. We enrolled 100 volunteers with no obvious oral or salivary gland diseases and divided them into KRG and placebo groups. Each group was divided into six subgroups according to age and gender. The subjects received 6 g/day of KRG or placebo for 8 weeks. The dry mouth visual analog scale (VAS), salivary flow rate, and a dry mouth-related symptom questionnaire were evaluated at baseline and at 4 and 8 weeks. KRG treatment did not show any significant differences for any of the variables. However, KRG improved the dry mouth VAS at 4 weeks and dry mouthrelated symptoms at 8 weeks in women, but not in men. Subgroup analyses revealed that KRG markedly improved the dry mouth VAS in women of menopausal age (40 to 59 years) at 4 and 8 weeks. KRG may have beneficial effects for dry mouth in women, especially those of menopausal age, but not in men. Further investigation in post- and perimenopausal women is required to elaborate on these findings.

EXPRESSIONS OF VASCULAR METASTASIS RELATED FACTORS IN MURINE ORTHOTOPIC TUMOR MODELS OF SALIVARY GLANDS (마우스에서 확립된 타액선 동위종양에서 혈관성 전이관련 인자의 발현)

  • Jang, Jae-Hyun;Kwon, Kwang-Jun;Park, Young-Wook
    • Maxillofacial Plastic and Reconstructive Surgery
    • /
    • v.29 no.6
    • /
    • pp.499-508
    • /
    • 2007
  • Background and Purpose: Some subtypes of malignant salivary gland tumors such as adenoid cystic carcinoma (ACC) frequently result in distant metastasis of vascular origin, which are main causes of treatment failure. The reasons for the affinity for vascular metastatic potential are unclear. Therefore, molecular characteristics that influence the dissemination of metastatic tumor cells are important for the design of more effective treatment of salivary ACC. Tumor angiogenesis has been known to be essential for the distant metastasis of malignant cells. So, we determined expressions of vascular metastasis related factors in orthotopic (parotid) murine models of parotid ACC and compared with those in ectopic (subcutis) tumors of athymic mice. Experimental Design: Using specimens from murine parotid (orthotopic, experimental group) and subcutaneous (ectopic, control group) tumors, which have developed via transplantation of tumor cells, originated from human parotid ACC, we performed immunohistochemical assays with anti-vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF, FGF2), matrix metalloproteinase (MMP)-9, and interleukin (IL)-8 antibodies. We also performed immunohistochemical assays with VEGF receptor (VEGFR)-1, VEGFR-2, VEGFR-3, and phosphorylated VEGFR-2. Results: Transplantation of human ACC tumor cell $(5{\times}10^5)$ into the parotid and subcutis successfully resulted in orthotopic (parotid) and ectopic (subcutaneous) tumors in athymic mice. Immunohistochemical staining demonstrated higher expression of major angiogenic factors (VEGF, bFGF, MMP-9) in the orthotopic tumors than in ectopic tumors (P<0.05). But the expression level of angiogenic receptors were same in orthotopic and ectopic tumors of parotid ACC. Conclusion: VEGF, bFGF, and MMP-9 could be a good candidates for antiangiogenic therapy for the contol of vascular metastatic lesions of salivary ACC.

Comparison of the diagnostic performance of panoramic and occlusal radiographs in detecting submandibular sialoliths

  • Kim, Jun Ho;Aoki, Eduardo Massaharu;Cortes, Arthur Rodriguez Gonzalez;Abdala-Junior, Reinaldo;Asaumi, Junichi;Arita, Emiko Saito
    • Imaging Science in Dentistry
    • /
    • v.46 no.2
    • /
    • pp.87-92
    • /
    • 2016
  • Purpose: The aim of this study was to assess and compare the diagnostic performance of panoramic and occlusal radiographs in detecting submandibular sialoliths. Materials and Methods: A total of 40 patients (20 cases and 20 controls) were included in this retrospective study. Cases were defined as subjects with a submandibular sialolith confirmed by computed tomography (CT), whereas controls did not have any submandibular calcifications. Three observers with different expertise levels assessed panoramic and occlusal radiographs of all subjects for the presence of sialoliths. Intraobserver and interobserver agreement were assessed using the kappa test. Sensitivity, specificity, accuracy, positive and negative predictive values, and the diagnostic odds ratio of panoramic and occlusal radiographs in screening for submandibular sialoliths were calculated for each observer. Results: The sensitivity and specificity values for occlusal and panoramic radiographs all ranged from 80% to 100%. The lowest values of sensitivity and specificity observed among the observers were 82.6% and 80%, respectively (P=0.001). Intraobserver and interobserver agreement were higher for occlusal radiographs than for panoramic radiographs, although panoramic radiographs demonstrated a higher overall accuracy. Conclusion: Both panoramic and occlusal radiographic techniques displayed satisfactory diagnostic performance and should be considered before using a CT scan to detect submandibular sialoliths.

Application and usefulness of Ultrasound sonography in dentistry (영상치의학에서 초음파영상의 진단과유용성)

  • Choi, Yong Suk;Seo, Yoo Kyung;Kang, Ju Hee;Oh, Song Hee;Kim, Gyu Tae;Hwang, Eui Hwan
    • The Journal of the Korean dental association
    • /
    • v.55 no.11
    • /
    • pp.778-788
    • /
    • 2017
  • Ultrasound sonography(US) is used to evaluate various diseases of oral and maxillofacial region including salivary glands, soft tissue and jaw lesions because of easy accessibility and no hazard of ionizing radiation. Also, US can offer dynamic study showing real-time images during diagnostic or surgical procedure. US images provide accurate information about the internal features of lesions on the jaw prior to surgical treatment. Doppler images are used to visualize the vascular distribution of the lesions and to provide additional information to enhance diagnostic value. It is necessary to evaluate the diagnostic value of US and evaluate its usefulness by looking at clinical cases using US images. Therefore, US imaging may be recommended as an assistant image in evaluating jaw lesions. US images provided accurate information about the internal structure of lesions on the jaw prior to surgical treatment, and diagnostic value was enhanced by visualizing the vascular distribution of the lesion using doppler imaging. We report the protocol and suggest the effectiveness of US for various lesions and US-guided sialography.

  • PDF

Two Cases of Inflammatory Pseudotumor in Respiratory System (호흡기계에 발생한 염증성 가성종양 2예)

  • Kim, Jae-Gwon;Jeong, Nak-Yong;Kim, Kwang-Hyun;Kim, Hee-Sun;Lee, Won-Yeon;Yong, Suk-Joong;Shin, Kye-Chul;Yang, Seok-Woo;Jeong, Soon-Hee
    • Tuberculosis and Respiratory Diseases
    • /
    • v.46 no.3
    • /
    • pp.394-401
    • /
    • 1999
  • Inflammatory pseudotumor is a infrequent, benign tumor that affects at all ages and involves the lung, gastrointestinal tract, and salivary gland. They are the most common, isolated, primary lesion of the lung in children, and usually present as circumscribed, peripheral, parenchymal tumors or endobronchial tumors, which may be usually static or increase slowly in size without causing symptoms. Surgical excision is the treatment of choice because of the location and benign nature of this lesion. The prognosis after resection is excellent. Other therapeutic modalities include radiation and steroid therapy. We experienced two cases of inflammatory pseudotumor of the lung parenchyme and endobronchus. We report these cases with a review of literatures.

  • PDF

A case report of the Pulmonary Malignant Lymphoma of the mucosa-associated lymphoid tissue(MALT) (폐에 발생한 점막-연관 림프조직(MALT) 림프종 1예)

  • Ohn, Joon-Sang;Son, Hyung-Dae;Kim, Chang-Seon;Lee, Young-Sil;Yoon, Sang-Won;Rheu, Nam-Soo;Cho, Dong-Ill
    • Tuberculosis and Respiratory Diseases
    • /
    • v.43 no.6
    • /
    • pp.1019-1027
    • /
    • 1996
  • The pulmonary lymphomas were thought to originate in specialized lymphoid tissue that is associated with bronchial mucosa(bronchus-associated lymphoid tissue(BALT)), and they were categorized as mucosa-associated lymphoid tissue(MALT) lymphoma. MALT lymphoma consists of a monoclonal population of cell, in contrast to reactive lymphoid proliferation, which consists of polyclonal cells. Lymphoma arising from MALT(=MALToma) represents a distinct clinicopathologic features. It is usually localized 10 their original site for a long time and shows much more favorable prognosis than lymphoma at other site. Some MALT lymphoma could arise simultaneously or successively in different organ or that cells from MALT lymphoma might circulate and give rise to another lymphoma by homing in the MALT of another organ, such as breast, salivary gland, stomach etc, and can be multifocally disseminated or recurred. We report a case of low-grade B-cell lymphoma of the mucosa-associated lymphoid tissue(MALT) of the lung, which was confirmed by open lung biopsy, immunohistochemistry and PCR assay.

  • PDF

Effects of Cinnamaldehyde on Salivary Gland Tissue in Xerostomia Model

  • Choi, Ja-Hyeong;Lee, Jung-Hwa;Kim, Yeon-Hwa;Hyun, Kyung-Yae;Park, Chung-Mu;Lee, Min-Kyung
    • Biomedical Science Letters
    • /
    • v.26 no.2
    • /
    • pp.93-100
    • /
    • 2020
  • Xerostomia is a relatively common oral disease that causes various problems such as pain, discomforted, tissue damage, and infection. When the activity of AQPs, which plays an important role in the microbial channel transmembrane activity in tissues, decreases saliva secretion and the oral cavity dryness occurs. In this study, we observed whether there was a change in tissue through the expression level of AQP-5 in the submandibular gland in the 4-DAMP-induced xerostomia model. First, in order to construct a xerostomia model, 4-DAMP (1 mg/kg) and 20% urethane (0.5 mL/kg) were administered intraperitoneal (i.p.) to experimental animals. To observe the changes in the submandibular gland was excised, H&E staining was performed and protein quantitation analysis was performed using the submandibular tissue to observe the changes in AQP5 protein expression involved in changes in saliva secretion. Also, cinnamaldehyde (5, 12.5, 25 and 50 mg/kg) dissolved in 20% DMSO, in distilled water for each concentration, and then orally administered at a dose of 1 mL for biopsy and protein quantitative analysis. As a result, it was observed that the submandibular tissue, a model of xerostomia was wider than the naïve group. And then western blot analysis, the expression level of AQP5 decreased in the 4-DAMP group compared to the naïve group, and the expression increased in the group administered orally with cinnamaldehyde. Therefore, administration of 4-DAMP resulted in histological changes for xerostomia, and cinnamaldehyde would be a material that can be developed by reducing xerostomia.

Clinical Value of fine Needle Aspiration Biopsy in Head and Neck Masses (두경부 종물에 대한 세침천자생검의 임상적 의의)

  • 김성근;강성호;김경래;이형석;김선곤
    • Proceedings of the KOR-BRONCHOESO Conference
    • /
    • 1993.05a
    • /
    • pp.103-103
    • /
    • 1993
  • Fine needle aspiration biopsy(FNAB) is widely used in screening of head and neck(H&N) masses because it has high accuracy and few damage. The 235 cases of FNAB were performed on patient with H&N mass at the Department of Otolaryngology, Hanyang University Hospital during 1 years, from March 1985 to February 1992. The 188 of 235 were proven histologically, clinically. The results obtained were as follows ; 1) FNAB for malignant H&N mass shows sensitivity of 81.5% specificity of 96.8%. 2) FNAB for malignant LN shows sensitivity of 86.0%, specificity of 88.9%. 3) FNAB for salivary gland shows sensitivity of 66.7%, specificity 81.8%. 4) FNAB for soft tissues, bone, and intraoral lesions shows sensitivity of 90%, specificity 95.8%. 5) FNAB for tuberculosis shows false negative of 55.2%. 6) The result of FNAB was not closely related with location or size of neck nodes.

  • PDF