• Biomolecules & Therapeutics
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• 제3권4호
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• pp.316-321
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• 1995

All the pharmacological studies of LB17522 described here were carried out with high doses (fifteen to sixty times of the therapeutic dose) to determine an indication of potential side effects in clinical use in terms of the acute clinical signs, cardiovascular and central nervous system. LB10522 does not produce any observable clinical signs except for the symptoms such as moist eye, skin rash, slight salivation, vomitting, and slightly reduced activity. The effects of LB10522 on the hemodynamics and cardiac function of anesthetized beagle dogs are as follows; heart rates and mean arterial blood pressure had a tendency to increase mildly, which is a normal finding in anesthetized dogs. All the animals except for one showed relatively stable respiratory rates throughout the observation period. Each animal treated with LB10522 showed slight increase in the left cardiac work and left ventricular stroke work which are mainly related to corresponding increases in cardiac output. Femoral blood flow were shown to be increased in some animals treated with LB10522. The epileptogenic activities of various cephalosporins were assessed by a direct intracerebral injection of appropriate concentration of test articles. The CD$_{50}$ values (nmol) obtained from the analysis of the dose-response data are as follows; 78.2, 175.3, 156.3, and 53.5 for cefazolin, cephaloridine, ceftazidime, and LB 10522, respectively. LB10522 seems to be equipotent with cefazolin or to be three times more potent than cephaloridine and ceftazidime in causing adverse CNS stimulation. Taken into consideration all the information obtained, LB10522 is not supposed to induce much changes in the functions examined in these studies in man at therapeutic doses.s.

• Biomolecules & Therapeutics
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• 제3권4호
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• pp.322-326
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• 1995

General pharmacology of LB20304, a quinolone antibiotic, were examined in terms of general behaviour, cardiovascular, and central nervous system. LB20304 at oral dose of 2,000 mg/kg did not induce significant behavioural changes in mice. In contrast with ciprofloxacin, LB20304 at dose of 20 mg/kg, iv. did not show any observable effects on the blood pressure in rats. Displacement of [$^3$H]muscimol binding to the rat brain synaptic membranes was measured. LB20304 was shown to be about five times less potent than ciprofloxacin in specific GABA receptor binding. Drug interaction between LB20304 and 4-biphenyl acetic acid, an active metabolite of fenbufen, was assessed in mice by measuring convulsion and/or subsequent death. A single oral pretreatment with 4-BPA at 400 mg/kg increased the incidence of convulsion and death after oral administration of ciprofloxacin at the doses of 25, 50, and 100 from zero of five to three of five, two of five, and four of five, respectively, whereas LB20304 alone or combination with 4-BPA caused neither convulsions nor death at the doses of 12.5, 25, 50, and 100 mg/kg, respectively. Quinolones-induced epileptogenic activities were assessed by a direct intracerebral injection of test articles. The CD$_{50}$ values (nmole) are as follows; 169.47, 35.36, 105.29, and 88.67 for LB20304, ciprofloxacin, of loxacin, and lomefloxacin, respectively. From these data, LB 20304 at therapeutic doses seems to be much more safe than any other quinolones tested.d.

• Biomolecules & Therapeutics
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• 제7권3호
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• pp.271-277
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• 1999

Safety evaluation of LB71350, a new HIV-1 protease inhibitor, was performed in mice, rats and dogs. For the general behavior of mice, LB71350 at an oral dose of 200 mg/kg did not show any significant effects on muscle tone and locomotor activity. In terms of central nervous system, at oral doses of 200 mg/kg and 1000 mg/kg, LB71350 inhibited acetic acid-induced pain response approximately 41% and 83% of control. respectively. At oral doses of 200 mg/kg and 500 mg/kg, it reduced the rectal body temperature in rats. Pentylenetetrazole-induced seizure in mice was slightly potentiated by oral administration of LB71350 at doses ranging from 200 mg/kg to 1000 mg/Ag. Single or five day treatment of LB71350 doubled the hexobarbital- induced sleeping time in mice at oral doses ranging from 50 mg/kg to 500 mg/kg. It did not cause any effects on gastric secretion and acidity in rat at oral doses of 200 mg/kg and 1000 mg/kg and also it did not change intestinal motility in mice up to 1000 mg/kg. Blood coagulation indices such as prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin time (TT) in rats were not affected by the treatment of LB71350 up to 500 mg/kg. LB71350 caused no significant effects on the cardiac output, stroke volume, heart rate, and mean blood pressure when infused intravenously to the anesthetized rats and dogs. Taken together, LB71350 at high oral doses caused significant pharmacological effects on the central nervous system and the hexobarbital-induced sleeping time.

• 비파괴검사학회지
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• 제32권5호
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• pp.545-550
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• 2012

원자력발전소 증기발생기 세관은 방사성물질이 외부로 누출되지 않도록 압력경계 역할을 하는 주요부품이다. 설비 운전기간이 증가함에 따라 이차측에서 유입된 슬러지가 증기발생기 2차측 유체 흐름을 따라 상부로 이동하면서 유체비등과 난류에 의해 세관 외면에 스케일이 부착되어 세관열화, 유로홈 막힘 및 열전달을 감소시키는 파울링을 유발하는 원인으로 작용한다. 따라서, 원전 운영자는 세관 외면에 쌓인 스케일의 두께를 확인하여 일정시점이 되면 화학세정 등의 정비를 수행한다. 본 논문에서는 보빈코일 와전류신호를 이용하여 세관 외면에 부착된 스케일 두께를 정량적으로 평가하는 기술을 개발하고자 스케일 시험편을 제작하여 스케일 두께와 와전류신호 진폭 간의 상관관계를 분석하였고, 이를 바탕으로 스케일의 두께를 정량적으로 평가하는 기법과 대량의 와전류 데이터를 평가할 수 있는 프로그램을 개발하였다.

• 한국항행학회논문지
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• 제17권3호
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• pp.279-284
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• 2013

운항의 여러 단계 중 착륙단계에서 조종사들이 많은 부담을 느낀다. 이는 조종사들이 항공기 속도를 줄이고 접지하여 완전히 정지하는 동안 착륙안전에 영향을 미치는 여러 요소가 있기 때문이다. 만일 착륙하는데 활주로길이가 충분하다면 부담이 적을 수도 있다. 그러나 항상 그런 경우만 있는 것은 아니다. 따라서 착륙성능이 제한범위 내에 있는지 아닌지를 확인할 필요가 있다. 필요착륙거리는 시험비행 조종사에 의해 실증되어진 실제착륙거리에다가 항공사의 평균적인 조종사들을 위한 여유분을 포함한 것이다. FAR의 AFM(항공기 비행규정) 인가는 건조 및 습윤 활주로에서 수동착륙을 기반으로 한다. 기타 다른 활주로 조건에서는 인가가 필요하지 않다. JAR에서는 빙설/윤활활주로에서도 정해진 여유분을 포함시키도록 규정하고 있다. 자동착륙은 인가사항이 아니므로 실제착륙거리만 제공된다. 본 논문에서는 각 활주로 조건에서 포함된 거리 여유분을 분석하고자 한다. 또한 특정한 활주로 조건에서 여유분이 규정되어 있지 않은 경우 대안을 제시하고자 한다.

• Geomechanics and Engineering
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• 제22권5호
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• pp.449-460
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• 2020

The double-lane arrangement model is frequently used in underground coal mines because it is beneficial to improve the mining efficiency of the working face. When the double-lane arrangement is used, the service time of the reserved roadway increases by twice, which causes several difficulties for the maintenance of the roadway. Given the severe non-uniform deformation of the reserved roadway in the Buertai Coal Mine, the stress distribution law in the mining area, the failure characteristics of roadway and the control effect of support resistance (SR) were systematically studied through on-site monitoring, FLAC 3D numerical simulation, mechanical model analysis. The research shows that the deformation and failure of the reserved roadway mainly manifested as asymmetrical roof sag and floor heave in the region behind the working face, and the roof dripping phenomenon occurred in the severe roof sag area. After the coal is mined out, the stress adjustment around goaf will happen to some extent. For example, the magnitude, direction, and confining pressure ratio of the principal stress at different positions will change. Under the influence of high-stress rotation, the plastic zone of the weak surrounding rock is expanded asymmetrically, which finally leads to the asymmetric failure of roadway. The existing roadway support has a limited effect on the control of the stress field and plastic zone, i.e., the anchor cable reinforcement cannot fully control the roadway deformation under given conditions. Based on obtained results, using roadway grouting and advanced hydraulic support during the secondary mining of the panel 22205 is proposed to ensure roadway safety. This study provides a reference for the stability control of roadway with similar geological conditions.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2017년도 학술발표회
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• pp.260-260
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• 2017

This study aims to compare the performance of TRIGRS (Transient Rainfall Infiltration and Grid-based Regional Slope-stability model) and TiVaSS (Time-variant Slope Stability model) in the prediction of rainfall-induced shallow landslides. TRIGRS employs one-dimensional (1-D) subsurface flow to simulate the infiltration rate, whereas a three-dimensional (3-D) model is utilized in TiVaSS. The former has been widely used in landslide modeling, while the latter was developed only recently. Both programs are used for the spatiotemporal prediction of shallow landslides caused by rainfall. The present study uses the July 2011 landslide event that occurred in Mt. Umyeon, Seoul, Korea, for validation. The performance of the two programs is evaluated by comparison with data of the actual landslides in both location and timing by using a landslide ratio for each factor of safety class ( index), which was developed for addressing point-like landslide locations. In addition, the influence of surface flow on landslide initiation is assessed. The results show that the shallow landslides predicted by the two models have characteristics that are highly consistent with those of the observed sliding sites, although the performance of TiVaSS is slightly better. Overland flow affects the buildup of the pressure head and reduces the slope stability, although this influence was not significant in this case. A slight increase in the predicted unstable area from 19.30% to 19.93% was recorded when the overland flow was considered. It is concluded that both models are suitable for application in the study area. However, although it is a well-established model requiring less input data and shorter run times, TRIGRS produces less accurate results.

• 한국재료학회지
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• 제31권9호
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• pp.525-531
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• 2021

Carbon-encapsulated Ni catalysts are synthesized by an electrical explosion of wires (EEW) method and applied for CO₂ methanation. We find that the presence of carbon shell on Ni nanoparticles as catalyst can positively affect CO₂ methanation reaction. Ni@5C that is produced under 5 % CH₄ partial pressure in Ar gas has highest conversions of 68 % at 350 ℃ and 70 % at 400 ℃, which are 73 and 75 % of the thermodynamic equilibrium conversion, respectively. The catalyst of Ni@10C with thicker carbon layer shows much reduced activity. The EEW-produced Ni catalysts with low specific surface area outperform Ni catalysts with high surface area synthesized by solution-based precipitation methods. Our finding in this study shows the possibility of utilizing carbon-encapsulated metal catalysts for heterogeneous catalysis reaction including CO₂ methanation. Furthermore, EEW, which is a highly promising method for massive production of metal nanoparticles, can be applied for various catalysis system, requiring scaled-up synthesis of catalysts.

• 한국터널지하공간학회 논문집
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• 제20권6호
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• pp.1039-1048
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• 2018

도심지 터널공사에서는 주변 건물의 안전성을 확보하고, 민원을 최소화할 수 있는 쉴드TBM 공법이 대부분 적용되고 있다. 도심지에는 기존의 택지를 매립조성하거나 개량하는 경우가 많기 때문에 지표에서부터 암반 경계부까지는 불균질한 상태로 이루어지는 경우가 많다. 이와 같이 토사지반, 파쇄정도가 다양한 화강암지반, 핵석층, 암층과 같이 복잡한 지반 조건에서 쉴드TBM으로 터널구조물을 구축하는 경우, 각 지반조건에 따른 쉴드TBM에 나타나는 기계데이터를 분석하여 지반조건에 따른 장비부하의 특징을 비교분석하였다. 그 결과, 설계막장압을 유지하면서 굴진하고, 주기적으로 커터를 점검하여 교체하는 경우, 배토량, 추력, 커터토오크의 경향으로 지반조건의 변화를 예측할 수 있을 것으로 판단된다.

• 한국재난정보학회 논문집
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• 제15권2호
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• pp.214-222
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• 2019

연구목적: 적층형 물류창고의 랙크 내에 설치하여 화세제어 및 초기 진압이 가능한 스프링클러 헤드를 개발하고 이에 따른 성능확인 실험을 목적으로 한다. 연구방법: 살수반경과 살수패턴을 고려하여 여러가지 디플렉터를 설계하고 살수각도 및 방사 시험 및 방호성능 실험을 수행하였으며 결과를 비교 분석하였다. 연구결과: 적재물 전체 및 전면부 방호가 가능하고 최소방수량 115L/min을 가지는 최적의 헤드를 개발하였다. 결론: 개발된 헤드는 방수량 K-115, 방수압 1Bar 조건에서 1단 소화실험 결과, 적용된 화재시나리오에서 적재물품을 전부 연소시키지 않고 화재를 제어함을 확인하였다. 아울러 적재물 상단에서 디플렉터까지의 수직거리는 450mm 이격하여 가연물 외곽부분으로도 충분히 방사되도록 설치해야 한다.