• 자동차안전학회지
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• 제14권4호
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• pp.113-119
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• 2022

The structural safety of hydrogen buses is being evaluated for the successful introduction of hydrogen buses. The crash test methodology, for example, side impact test procedure is being discussed for hydrogen bus structure safety with a compressed hydrogen storage system located under the bus floor. Thus this study describes a new experiment method for side impact test with compressed hydrogen storage system independently based on finite element analysis instead of side impact test using full hydrogen bus. A side crash procedure of conceptual compressed hydrogen storage structure was investigated and impact simulations were performed. The finite element models of hydrogen bus, simplified structures, fuel tank system and side impact moving barrier were set up and simulation results reported model performance and result comparison of three different simplified models. Computational results and research discussion proposed the fundamental test framework for safety assessment of the compressed hydrogen storage system.

• Toxicological Research
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• 제26권4호
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• pp.285-291
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• 2010

Recently, reproductive and neurobehavioral effects of bisphenol A (BPA) have been documented, and thus a review was requested for BPA management direction by the government. Therefore, this study was performed to establish a Korean tolerable daily intake (TDI) for BPA. An expert committee, consisting of specialists in fields such as toxicology, medicine, pharmacology, and statistics, was asked to evaluate BPA health based guidance values (HbGVs). Although many toxicological studies were reviewed to select a point of departure (POD) for TDI, rat and mouse reproductive studies by Tyl et al. (2002, 2006), which were performed according to GLP standards and OECD guidelines, were selected. This POD was the lowest value determined from the most sensitive toxicological test. The POD, a NOAEL of 5 mg/kg bw/day, was selected based on its systemic toxicity as critical effects. An uncertainty factor of 100 including interspecies and intraspecies differences was applied to calculate the TDI. According to the evaluation results, a TDI of BPA for Korean was suggested at 0.05 mg/kg bw/day. In addition, the BPA exposure level based on food consumption by the Korean population was estimated as 1.509 ${\mu}g/kg$ bw/day, and the HI was evaluated at 0.03 when the TDI of 0.05 mg/kg bw/day was applied. This HI value of 0.03 indicated that hazardous effects would not be expected from BPA oral exposures. Although highly uncertain, further studies on low dose neurobehavioral effects of BPA should be performed. In addition, it is recommended that the 'as low as reasonably achievable' (ALARA) principle be applied for BPA exposure from food packaging materials in newborn infants and children.

• 자동차안전학회지
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• 제10권4호
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• pp.25-32
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• 2018

Due to the rapid increase in the number of vehicles, the physical and human losses caused by traffic accidents have become serious social problems. In the global trend, there have been active studies conducted on improving safety level of automobile in order to reduce the number of automobile accident. As a result of such research, traffic accidents continue to decline. In the case of South Korea, however, rate of death by automobile accident is 8.5 per 10,000 people and it is a seven rank among the countries in OECD (Organization for Economic Cooperation and Development). This average rate is almost double compared to average automobile accident rate per 10,000 vehicles, of other OECD countries in 2015. Consequently, many studies and policies currently have been conducted and made for increasing safety of pedestrians; however, they are only emphasizing characteristics of pedestrians and drivers. For this reason, this study suggests scenarios for establishment of test standard corresponding with domestic environment and international standard of AEB (Autonomous Emergency Braking) and conducts a real car test by scenarios by setting up a goal with a function for remaining distance after braking and then examine equation by comparing real car tests results and outcome after calculation. This is a theoretical method to predict a relative remaining distance after AEB prior to conducting a real car test for evaluation of safeness of automobile with AEB and it is expected that it solves problem of complication of real car test.

• 한방재활의학과학회지
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• 제34권3호
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• pp.89-96
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• 2024

Objectives This study is designed to evaluated the safety of peony root extract tablet in healthy male volunteers. Methods 12 healthy male volunteers were recruited, and this study was conducted by a single center. The safety was evaluated by collecting laboratory test and vital signs of volunteers. As the registration process, 12 subjects were assigned by serial number. To evaluate safety, vital signs were checked and blood samples were collected 4 times during the screening period, pre & post-administration (after 8 hours) and post-administration (after 7 days). The difference in variables was summarized by the mean±standard deviation. The normality test was carried out using the Shapiro-Wilk test and Kolmogorov-Smirnov test. When normality is fulfilled, a paired t-test is applied and the significance level was p<0.05. And the incidence of all adverse effects and serious adverse effects are shown in percentage. Results In the case of vital sign, body temperature (BT) (℃) was 0.06±0.05 ℃ (p=0.008), and there was a statistically significant difference in before and after administration. However, clinical symptoms were not occurred and BT (℃) of all subjects before and after administration showed values within the normal reference value. There was no significant difference from the control group in all other vital signs and laboratory test data. And no side-effects associated to clinical trial drugs were followed. Conclusions The peony root extract tablet was considered to be safe for healthy male volunteers.

• Asian-Australasian Journal of Animal Sciences
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• 제18권9호
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• pp.1320-1325
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• 2005

A 2${\times}$3 factorial arrangement of treatments was used to determine the effects of olaquindox and cyadox on immune response of Landrace${\times}$Large-White geld piglets that had been orally given 10$^{10}$ CFU of Escherichia coli (E. coli, O$_{139}$:K$_{88}$). Factors included (1) E. coli inoculation or control, and (2) no antimicrobials, 100 mg/kg olaquindox and 100 mg/kg cyadox in the basal diet respectively. E. coli inoculums were orally administered 7 days after the diets were supplemented with olaquindox and cyadox. The effects of the two antimicrobials were assessed in terms of: (1) average daily gain (ADG), (2) systemic immune response (the number of white blood cells and lymphocytes, leukocyte bactericidal capacity, lymphocyte proliferation response to PHA, immunoglobulin concentrations, and total serous hemolytic complement activity), and (3) intestinal mucosal immunity including the number of intraepithelial lymphocytes (IELs) and immunoglobulin A secreting cells (ASCs) in the intestinal lamina propria. E. coli inoculation reduced ADG (p<0.05) during the period of d 0 to d 14 after the challenge while the antimicrobial supplementations improved ADG (p<0.01) during the experiment. ADG in cyadox-supplemented pigs was higher (p<0.05) than that in olaquindox-supplemented pigs. The antimicrobials decreased IEL and ASC counts in the jejunum and ileum (p<0.01) while E. coli inoculation caused them to increase (p<0.01). Jejunal ASCs in the cyadox-supplemented pigs were lower (p<0.05) than those in the olaquindox-supplemented. E. coli elicited increase (p<0.05) in white blood cell counts, leukocyte bactericidal capacity, lymphocyte proliferation rate, serous IgA concentrations, and serous hemolytic complement activity. The antimicrobials decreased the measured systemic immune parameters, but not significantly (p>0.05). The data suggest that olaquindox and cyadox suppress E. coli-induced immune activation, especially intestinal mucosal immune activation, which may be involved in the observed growth promotion.

• 한국안전학회지
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• 제32권2호
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• pp.98-104
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• 2017

The ultrasonic pulse velocities of pressure, shear, and Rayleigh waves ( P-, S-, and R- waves) have been used for the condition evaluation of various concrete structures, but the statistical distribution according to the wave type has not been studied clearly in view of data reliability and validity. Therefore, this study analyzed the statistical distribution of P-, S-, R-wave velocities in concrete wide beams of $800{\times}3100mm$ (width ${\times}$ length) with a thickness of 300 mm. In addition, we investigated an experimental consistency by the Kolmogorov-Smirnov goodness-of-fit test. The experimental data showed that the R-, S- and P- wave velocities in order have better statistical stability and reliability for in situ evaluation because R- and S-waves are less sensitive to confinement and boundary conditions. Also, good correlations between wave velocities and strength and modulus of elasticity were found, which indicate them as appropriate techniques for estimating the mechanical properties.

• Environmental Analysis Health and Toxicology
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• 제30권
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• pp.17.1-17.6
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• 2015

Objectives In this study, the possibility of using existing test data provided in Korea and elsewhere for the registration of chemical substances was examined. Data on 510 chemical substances that are among the first subject to registration under the "Act on the Registration and Evaluation, etc. of Chemical Substances (K-REACH)" were analyzed. Methods The possibility of using existing data from 16 reference databases was examined for 510 chemical substances notified in July 2015 as being subject to registration. Results Test data with the reliability required for the registration of chemical substances under the K-REACH constituted 48.4% of the required physicochemical characteristics, 6.5% of the required health hazards, and 9.4% of the required environmental hazards. Conclusions Some existing test data were not within the scope of this research, including data used for registration in the European Union (EU). Thus, considering that 350 of these 510 species are registered in EU Registration, Evaluation, Authorisation & Restriction of Chemicals, more test data may exist that can be utilized in addition to the data identified in this study. Furthermore, the K-REACH states that non-testing data (test results predicted through Read Across, Quantitative Structure-Activity Relationships) and the weight of evidence (test results predicted based on test data with low reliability) can also be utilized for registration data. Therefore, if methods for using such data were actively reviewed, it would be possible to reduce the cost of securing test data required for the registration of chemical substances.

• 자동차안전학회지
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• 제14권1호
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• pp.6-13
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• 2022

The Ministry of Land, Infrastructure and Transport (MoLIT) and the Korean Automobile Testing and Research Institute (KATRI) are supporting the development of Lv.3 automated vehicle (hereinafter, AV) technology by constructing an automated driving pilot city (as known as K-City) equipped with total 5 evaluation environments (urban, motorway, suburban, community road, and autonomous parking facility) which is a test bed exclusively for AV (2017~2018). An upgrade project is in a progress to materialize harsh environments such as bad weather (rain, fog, etc.) and reproduction of communication jamming (GPS blocking, etc.) with the purpose of supporting the development of Lv.4 connected & automated vehicle (hereinafter, CAV) technology (2019~2022). We intend to proactively establish a national level standard for CAV test-bed and test road requirements, test method, etc. for establishment of a road map for the construction of the test bed which is being promoted step by step and analyze and, when required, benchmark the case of China that has announced and is utilizing it. Through this, we plan to define standardized requirements (evaluation facility, evaluation system, etc.) on the test bed for the development of Lv.4/4+ CAV technology and utilize the same for the design and construction of a test bed, establishment of a road map for the construction of a real car-based test environment related to the support for autonomous driving service substantiation, etc. through provision of an evaluation environment utilizing K-City, and the establishment of a K-City upgrade strategies, etc.

• 한국식품위생안전성학회지
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• 제31권5호
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• pp.327-334
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• 2016

본 연구는 "축산물의 가공기준 및 성분규격"에 기준규격은 설정되어 있지 않으나, 국제 기준과의 조화를 위해 규격 신설 검토 대상 성분인 비오틴의 분석법을 마련하고자 수행하였다. 조제유류에 미량으로 함유된 비오틴함량 분석을 위해 선택성과 정밀성이 뛰어난 LC-MS/MS를 이용한 분석법을 확립하고 시중에 유통중인 제품을 대상으로 적용성을 검토하였다. 비오틴 표준품을 이용하여 LC-MS/MS를 이용한 기기분석조건을 확립하고, 식품의 기준 및 규격 분석법을 참고로 0.01 M 인산이수소칼륨(pH 4.8) 용액을 이용하여 시료중의 비오틴을 추출하여 분석하였다. 분석법 검증은 특이성, 직선성, 검출한계 및 정량한계, 정확성, 정밀성에 대해 수행되었다. 5~60 ng/mL의 농도범위에서 $R^2=0.999$ 이상의 우수한 직선성을 확인할 수 있었으며, LOD와 LOQ는 각각 0.10, 0.31 ng/mL 이었다. CRM (NIST SRM 1849a) 및 표준물질 첨가법을 이용하여 정확성을 검토하였으며, CRM에서 103%, 조제분유에서 101~104%, 조제우유에서 99~101%의 회수율을 확인할 수 있었다. 정밀성을 검토한 결과 시료 채취량에 따른 상대표준편차가 조제분유 0.4~0.9%, 조제우유1.4~1.6%로 확인하였으며, 실험일자에 따른 재현성은 조제분유에서 1.3%, 조제우유에서 1.2%로 확인하였다. 본 연구에서 확립된 분석법을 적용하여 조제분유 39건, 조제우유 3건, 성장기용조제분유 23건 등 국내 유통중인 조제유류 65건에 대해 적용성 검토를 실시한 결과 전체시료에서 분석이 용이하였으며, 모두 표시기준에 적합함을 확인하였다.

• 한국수소및신에너지학회논문집
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• 제23권4호
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• pp.330-336
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• 2012

FCEV uses 250 ~ 450 V instead of using 12 V battery. High voltage vehicle can cause electric shock, fire and explosion accident. Therefore, it has potential factors that can cause hazard of safety for users. United states of America and Europe legislate regulations such as ECE R100, FMVSS 305 for regulating electrical safety during driving or after collision. The company manufacturing high voltage components must do advanced R&D about Method for improving and confirming the safety of high voltage. We develop the specific hardware components of high voltage wiring system for the power train system and power supply system of Hyundai Motors FCEV. This paper shows test method of insulative performance for securing the electrical safety of high voltage components such as power cable, connectors and buss-bar, and proposals the guide line value for human safety of FCEV according to the test result of our development components.