• Proceedings of the Korean Society of Toxicology Conference
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• 2002.05a
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• pp.138-138
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• 2002

In recent years, the safety of sunscreens has been challenged based on the reports of its adverse effect on users; dermatitis, allergic contact dermatitis, photoallergic contact dermatitis. To investigate a correlation between sun protection factor (SPF) and the safety of sunscreens, we measured in vitro SPF index using homosalate as a standard and examined the toxicity tests on cosmetics; primary and cumulative skin irritation tests, ocular irritation test, and skin sensitization test.(omitted)

• Proceedings of the Korean Society of Toxicology Conference
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• 2002.11b
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• pp.195-195
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• 2002

In recent years, the safety of sunscreens has been challenged based on the reports of its adverse effect on users; dermatitis, allergic contact dermatitis, photoallergic contact dermatitis. To investigate a correlation between sun protection factor (SPF) and the safety of sunscreens, we measured in vitro SPF index using homosalate as a standard and examined the toxicity tests on cosmetics; primary skin irritation tests, ocular irritation test, and skin sensitization test.(omitted)

• Journal of Auto-vehicle Safety Association
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• v.4 no.1
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• pp.5-11
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• 2012

This paper discusses the evaluation of the safety impact of the Adaptive Cruise Control (ACC) system in Korea. To evaluate the safety impact, this paper suggests an analysis method by using the test scenario and field operational test data. The test scenario is composed to represent the main component factor of the ACC system and ACC related accident situation such as rear-end collision, lane-change, and road-curvature, etc. Also, from the field operation test data, the system's potential to increase the safety can be measured ideally. Besides, field operational testdata was used to revise the expected safety impact value as Korean road conditions. By using the proposed evaluation method, enhanced safety impact of the ACC system can be estimated scientifically.

• YAKHAK HOEJI
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• v.57 no.3
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• pp.205-212
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• 2013

Dissolution test has been performed to control drug quality and to predict in vivo drug release profile of solid dosage forms, so there's a drift towards setting dissolution test instead of disintegration test. However, some solid dosage forms in Korea Pharmaceutical Codex (KPC) are not established the dissolution test yet, so these monographs are necessary to set the specification of dissolution test. In this study, we developed the specification and test method of dissolution test for itopride hydrochloride tablets and tiropramide hydrochloride tablets which are not established the dissolution test yet. According to the "Manual for Guideline Application for Validation of Analytical Procedures" and "Guidelines on Specification of Dissolution test for Oral dosage form" of Korean Pharmacopoeia (KP), we validated and established each development method. Based on the preliminary dissolution profile, we set the dissolution condition(paddle apparatus, pH 1.2 media, 50 rpm). For this condition, we performed the main dissolution test to determine the specification (45 min, 85%). Finally, we validated each analytical method by specificity, linearity, accuracy and precision. These developed methods will be included the next supplement of KPC and also contributed to the quality control of medicines.

• Journal of Auto-vehicle Safety Association
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• v.11 no.4
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• pp.39-49
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• 2019

Autonomous vehicle is a car which drives itself without any human interaction. SAE provides technical definitions for autonomous and international standards for test evaluation. Accordingly, automobile industry is actively researching development and evaluation of various ADAS (Advanced Driver Assistance Systems), : representative technology of autonomous technology. Recently, ADAS is in the commercialization level such as ACC, LKAS, AEB, and HDA etc. And it also has issues about safety evaluation. The purpose of HDA in ADAS is reduced the driving load on highway. It has a function which can maintain lane keeping and control distance from forward vehicle. This function is evaluated to be useful for accident prevention. Therefore, this paper proposes the safety evaluation scenario of HDA, considering the domestic highway design criteria and the situation that may arise on the actual highway. We compared and analyzed the data acquired through simulation and actual vehicle test. And verified the reliability of the proposed safety evaluation scenario. The verified result is expected safety evaluation of HDA is possible even under the bad condition, which cannot be tested.

• Korean Journal of Pharmacognosy
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• v.41 no.2
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• pp.136-140
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• 2010

This study was carried out to utilize non-toxic solvents instead of harmful solvents for the TLC(Thin Layer Chromatography) identification test of herbal medicines. It is recommended not to use harmful solvent such as chloroform at a viewpoint of clean analysis. In this study, we revised the identification test of 10 items in the Korea Pharmacopoeia(KP) and the Korean Herbal Pharmacopoeia(KHP) such as Cornus officinalis S. containing the harmful solvents on the developing solvent and established identification test that is utilized non-toxic solvents by HPTLC(High Performance Thin Layer Chromatography).

• Journal of Auto-vehicle Safety Association
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• v.9 no.1
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• pp.6-12
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• 2017

Regulation for the testing and operation of automated vehicles on public roadways has been recently developed all over the world. For example, the licensing standards and the evaluation technology for automated vehicles have been proposed in California, Nevada and EU. But specific safety evaluation scenarios for automated vehicles have not been proposed yet. This paper presents safety evaluation scenarios for extraordinary service permission of automated vehicles on highways. A total of seven scenarios are selected in consideration of safety priority and real traffic situation. Six scenarios are relevant with lane keeping and one scenario is relevant with lane change. All scenarios are developed based on existing ADAS evaluation scenarios and repeated simulation of automated vehicle algorithm. Safety evaluation factors as well as scenarios are developed. The safety factors are based on existing ADAS ISO requirements, ADAS safety factors and current traffic regulations. For the scenarios, a hunter vehicle is needed in addition to automated vehicle evaluated. The hunter vehicle performs multiple roles like preceding vehicle, cut-in vehicle and so on. The hunter vehicle is also automated vehicle equipped with high performance GPS, radar and Lidar. All the scenarios can be implemented by driving a lap on a KATRI ITS test track. These scenarios and safety evaluation factors are investigated via both a computer simulation and an experimental vehicle test on the test track. The experimental vehicle test was conducted with two automated vehicles, which are the evaluated vehicle and the hunter vehicle.

• Journal of the Korean Society for Precision Engineering
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• v.32 no.7
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• pp.591-595
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• 2015

The roller rig tester for safety performance evaluation of wheel derailment is a test facility which can give the test load condition to the test wheel, similar to the actual dynamic condition in actual running condition. This study describes the evaluation result on the durability of the resilient wheel equipped with the ring damper and the damping material, and installed in the half part of a full scaled bogie in combination with the primary spring when it rotates under the dynamic condition. The evaluation result on durability of resilient wheel after load test of 2 million cycles shows that the safety of wheel is not affected by the applied load in visual inspection and nondestructive test, however, in the bolt used for fastening the ring damper to the wheel the loosening was found. Accordingly the use of self-locking nut and washer is recommended.

• Toxicological Research
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• v.33 no.1
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• pp.43-48
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• 2017

With ultraviolet and visible light exposure, some pharmaceutical substances applied systemically or topically may cause phototoxic skin irritation. The major factor in phototoxicity is the generation of reactive oxygen species (ROS) such as singlet oxygen and superoxide anion that cause oxidative damage to DNA, lipids and proteins. Thus, measuring the generation of ROS can predict the phototoxic potential of a given substance indirectly. For this reason, a standard ROS assay (ROS assay) was developed and validated and provides an alternative method for phototoxicity evaluation. However, negative substances are over-predicted by the assay. Except for ultraviolet A (UVA), other UV ranges are not a major factor in causing phototoxicity and may lead to incorrect labeling of some non-phototoxic substances as being phototoxic in the ROS assay when using a solar simulator. A UVA stimulator is also widely used to evaluate phototoxicity in various test substances. Consequently, we identified the applicability of a UVA simulator to the ROS assay for photoreactivity. In this study, we tested 60 pharmaceutical substances including 50 phototoxins and 10 non-phototoxins to predict their phototoxic potential via the ROS assay with a UVA simulator. Following the ROS protocol, all test substances were dissolved in dimethyl sulfoxide or sodium phosphate buffer. The final concentration of the test solutions in the reaction mixture was 20 to $200{\mu}M$. The exposure was with $2.0{\sim}2.2mW/cm^2$ irradiance and optimization for a relevant dose of UVA was performed. The generation of ROS was compared before and after UVA exposure and was measured by a microplate spectrophotometer. Sensitivity and specificity values were 85.7% and 100.0% respectively, and the accuracy was 88.1%. From this analysis, the ROS assay with a UVA simulator is suitable for testing the photoreactivity and estimating the phototoxic potential of various test pharmaceutical substances.

• Journal of the Korean Society of Safety
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• v.38 no.3
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• pp.61-68
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• 2023

This study performed a structural performance evaluation of a system scaffolding for elevator installation work developed in previous studies. The structural performance was evaluated via a structural test conducted to apply the working load specified in the design standard. The deflection of the horizontal member and the stress of each member constituting the system scaffolding were measured. Consequently, the structural safety evaluation including structural behavior and required performance was performed using the deflection and stresses measured from the structural test. The structural test and safety evaluation results based on the heavy working load corresponding to the design load indicated that the deflection, which is the performance criterion of the horizontal member, did not exceed the allowable value. Further, each member's stress, which is a safety evaluation indicator, did not exceed the allowable strength for both horizontal and vertical members with bending behavior and fordable bracing with tensile behavior, while also satisfying the required safety factor. In addition, the results confirmed the safety against deformation, partial damage, and destruction owing to excessive and maximum load. Therefore, the system scaffolding developed in this study satisfies both the structural performance and safety required by the design standards; thus, it can be applied to elevator installation work sites.