• 한국임상약학회지
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• 제15권2호
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• pp.94-99
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• 2005

The aim of this study was to evaluate the safety and efficacy of treatment of mesoglycan. This study was conducted between September 2003 and May 2004. A total of 292 patients with vascular disorders including cerebral infarction were enrolled. The patients were administered with 50-100mg of mesoglycan by an oral route everyday for eight weeks. Subjective physicians' assessments of efficacy had ratings of 'improvement', 'invariability', 'exacerbation' and 'not being able to assess'. An improvement was observed in 241 patients out of 274; 18 patients were rules out. The efficacy rate was influenced statistically significantly by the duration of therapy (p=0.0392) and daily mean drug dose (p<0.0001). The adverse events were reported in 8 patients (9 cases) out of 292 patients: skin/appendages disorders (0.7%), liver/biliary system disorders (0.7%), cardiovascular system disorders (0.7%), neurologic disorders (0.3%). respiratory disorders (0.3%) and gastrointestinal system disorders (0.3%). There showed no serious adverse events. These results indicate that mesoglycan was well tolerated and effective for the prevention of vascular disorders.

• 한국안전학회지
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• 제37권6호
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• pp.40-49
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• 2022

Simple statistical frequency based analysis, such as Pareto analysis, are widely used in conventional accident analysis. However, due to the dynamic and complex nature of construction works, many factors can simultaneously affect or involve the occurrence of accidents in construction projects. Therefore, the identification of the complex relationship between such factors is important to establish relevant and effective safety management policies and/or programs. In this study, characteristic factors and their relationships' contribution to non-fatal accidents in construction projects are analyzed using the association rule mining (ARM) technique. To this end, a total of 59,202 construction accident data are collected from 2015 to 2019 and the ARM is performed to retrieve specific relationships -named as association rules-among classified factors in the data. Characteristics of the retrieved relationships are analyzed and compared with the results of conventional Pareto analysis. Based on the results, it is found that both fall and trip are notable accident forms having characteristic relations with other factors for non-fatal accidents in construction projects. It is also found that small-scale construction, age of 50s, less than 1 month of working period, and architectural construction are important factors for non-fatal accidents in construction projects.

• 대한영양사협회학술지
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• 제14권2호
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• pp.176-185
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• 2008

The purpose of this study was to identify school dieticians' perceptions on the Potentially Hazardous Food (PHF) and the inspection of food safety and sanitation conducted by Provincial Office of Education. Questionnaires were distributed to 400 school dieticians in elementary schools in Seoul and Gyeonggi Province, and 217 responses were collected. The majority of respondents (64%) defined PHF as food that easily decays at room temperature and over half of the respondents considered Korean cooked vegetables as a PHF. In addition, 4% of respondents completely excluded PHFs from their menus. Forty five percent of the respondents selected CCP rule 7 (delivery and distribution process) and 34% selected CCP rule 6 as the most difficult of the CCP rules to follow. Also, perceptions concerning food safety inspection and sanitation were not high in terms of validity, objectivity, and reliability among the evaluation criteria. The study results suggest that PHF as well as Potentially Hazardous Menu (PHM) definitions and guidelines should be re-established in consideration of traditional Korean food culture and the preparation of Korean foods.

• 보건교육건강증진학회지
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• 제18권3호
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• pp.59-75
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• 2001

It is necessary to examine from primary school children's viewpoint to perception of safety as to how they cope with a condition threatening safety at the realistic world with risky environment and whether knowledge obtained through education is transmitted to action in a correct way. For this, this study explored and analyzed children's perspective to safety felt in life, their achievement of education to safety as trainees, and their perception extent to safety. As a result of it, following conclusion could be obtained. First, as for safety on their way to school and home, the lower grade they were, the more they felt safe, but the higher they were, the more they felt uneasy, which was examined that they generally had uncomfortable mind. Second, as for whether safety education was performed or not, it was indicated that safety education was generally executed, but lower graders responded that safety education was executed, but high graders responded that it was not executed. Third, as for observance of traffic rules, it was examined lower graders kept them well, but higher graders did not do so. Fourth, as for safety of play, it was indicated lower graders wore protective equipment by parents' concern, but higher graders did not wear them since they were full of confidence counting on their capability. Fifth, as for life safety, it was indicated the area most preferentially educated from parents' viewpoint was traffic safety, and the next ones were gas and fire safety. Sixth, as for fire safety, it was indicated they did not play with fire, but higher graders compared to lower ones, played with fire as the means of curiosity and play. Thus, curricula for children's safety education executed from adults' viewpoint should be established, and assessment of children's safety education should get out of the limitation of execution of safety education to habituated action by the transmission of children's knowledge. Also it is urgent to develop programs with which to perform children;'s education at the level of children, establish and operate safety education facilities for practice education that teachers and children can receive safety education through experience by building up children's safety education related entities. And it is thought that safety should not left to only children, but their safety would be kept by developing and training safety education programs to all organizations and individuals related to safety.

• 한국건축시공학회지
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• 제20권1호
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• pp.73-81
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• 2020

최근 4차 산업 시대의 흐름에 따라 건설공사에서는 최첨단 기술의 적용으로 나날이 발전하고 있는데 반해, 건설현장에서는 지속적인 안전사고가 발생하고 있다. 본 연구의 주목적은 안전관리자 계획단계에서 수행되는 업무들의 중요도와 예방효과를 전문가 의견을 통한 IPA 분석을 활용하여 상관관계를 도출하고 안전관리에 기여할 수 있는 주요 안전 계획 업무와 개선이 필요한 업무를 파악함으로써, 궁극적으로 건설안전재해사고 발생을 줄이는 데 있다.

• 한국안전학회지
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• 제21권4호
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• pp.127-133
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• 2006

이 논문의 주요 목적은 안전 분위기를 확인하여 공장과 근로자의 안전문화 수준에 영향을 주는 변수들을 찾아내고 더 나아가 화학공장의 안전문화를 향상시킬 수 있는 영향요소를 찾는데 있다. 이 논문에 사용된 질문표는 영국의 HSE(Health and Safety Executive) 의 질문표를 근간으로 문헌 조사를 통하여 경영자와 근로자로 분류하여 개발하였다. 안전문화 수준을 확인하기 위해 빈도수 분석을 하였으며 공장규모, 사고 발생, 사고 및 상해 경험과 심각성, 그리고 고용기간 등과 같은 영향변수들은 ANOVA(Analysis of Variance) 분석을 적용하여 테스트하였다. 빈도수 분석의 결과 일반적으로 경영자와 근로자 모두가 안전문화의 수준이 높게 나타났으며 주된 문제점들로는 부적당한 안전 보건 절차와 규칙, 생산에 대한 압력, 그리고 규칙위반으로 나타났다. 또한 ANOVA 분석결과에 의하면, '고용기간'은 다른 안전 문화의 수준을 만드는 유일한 변수인 것으로 나타났다. 그리고 안전문화의 조사로부터 공장들의 안전 문화요소에 대한 주요 3가지 문제점과 안전문화수준을 발견하였으며 안전 이행 능력을 향상시킬 수 있는 2가지 영향요소를 제안하였다.

• 한국산업보건학회지
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• 제30권4호
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• pp.331-341
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• 2020

Objectives: This study was conducted to evaluate perceptions of safety and risk among Korean industrial hygienists and the change between before and after the Sewol Ferry Disaster in 2014. Two surveys with questionnaires composed of 51 questions were completed by attendees of the Korea Industrial Hygiene Association(KIHA) conference. Methods: One was conducted at the 2013 KIHA Fall Conference(N=181) and the other was from the 2014 KIHA Summer Conference(N=123). Between these two surveys was the Sewol Ferry Disaster on April 14, 2014, which was believed to seriously affect safety and risk perceptions in Korea. Results: It was revealed that industrial hygienists' awareness of safety rules strengthened after the Sewol Ferry Disaster(p<0.05). It was apparent that people over the age of 30 were more sensitive to social safety. There was no significant difference in the evaluation and attitude regarding governmental safety policy between the years of 2013 and 2014. The credibility of public organizations responsible for the disaster management system decreased. The self-evaluation of respondents' safety level also decreased. This trend shows mainly in the younger generation. It was evaluated that the overall social safety level decreased and the anxiety level increased. The score on social safety on a ±5 Likert scale was 0.68 in the 2013 survey and -0.33 in the 2014 survey(p<0.05). It was reported that the most serious threat factors for accident or disaster were 'building collapse > illegalities and corruption > side effects of radiation therapy >accidents in normal activity > occupational disease,' in order. They picked 'safety ignorance > hurry-up habits and culture > focusing on short-term benefit > easy-going attitude > insufficient safety education' for the causes of low social safety levels in 2013. In 2014, they were 'safety ignorance > easy-going attitude > focusing on short-term benefit > insufficient safety education > hurry-up habits and culture'. Conclusions: This study has some limitations because it was originally not designed to survey attitudes prior to the Sewol Ferry disaster in 2013. In addition, the survey targets are industrial hygienists who are familiar with occupational disease and injury.

• Clinical and Experimental Vaccine Research
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• 제12권3호
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• pp.193-208
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• 2023

One of the most significant medical advancements in human history is the development of vaccines. Progress in vaccine development has always been greatly influenced by scientific human innovation. The main objective of vaccine development would be to acquire sufficient evidence of vaccine effectiveness, immunogenicity, safety, and/or quality to support requests for marketing approval. Vaccines are biological products that enhance the body's defenses against infectious diseases. From the first smallpox vaccine to the latest notable coronavirus disease 2019 nasal vaccine, India has come a long way. The development of numerous vaccines, driven by scientific innovation and advancement, combined with researcher's knowledge, has helped to reduce the global burden of disease and mortality rates. The Drugs and Cosmetics Rules of 1945 and the New Drugs and Clinical Trials Rules of 2019 specify the requirements and guidelines for CMC (chemistry, manufacturing, and controls) for all manufactured and imported vaccines, including those against coronavirus infections. This article provides an overview of the regulation pertaining to the development process, registration, and approval procedures for vaccines, particularly in India, along with their brief history.

• 한국임상약학회지
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• 제18권1호
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• pp.18-27
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• 2008

This study investigated social relief schemes for serious adverse drug reactions in foreign countries and deduced lessons and implications for Korea to implement the scheme. A social relief scheme for serious adverse drug reactions provides reliefs for diseases and such health effects as disabilities or deaths that were caused by adverse reactions to pharmaceuticals prescribed at hospitals and clinics as well as those purchased at pharmacies notwithstanding their proper use. The US and the UK do not have specific relief schemes for adverse drug reactions but apply rules of strict liability or negligence. New Zealand and Nordic countries provide no-fault compensation schemes for health effects or injuries caused by medical treatments or medicinal products. Japan and Taiwan have operated the schemes since 1980 and 2000, respectively. In designing the scheme in Korea, we suggested that cases eligible for relief be confined to serious adverse reactions such as death or disability and then extended to diseases. It is desirable to encourage the reporting system of adverse drug reactions and quality use of medicines for the relief scheme to work efficiently.

• 보건의료산업학회지
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• 제7권1호
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• pp.119-131
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• 2013

The purpose of this study is to analyze contents on media about the problems of long-term care facilities. For achieving this purpose, we reviewed 'KINDS(http://www.kinds.or.kr/)' from July, 2008 to May, 2012 which was an synthetic newspaper and TV news searching system. Among 320 articles, we finally analyzed 72 articles: 218 articles were duplicated and 30 articles did not directly related or were not objective. The results were divided with seven parts: 'long-term care facilities', 'employee' 'health care and accidents', 'providing and management of service', 'meals related problems', 'maltreatment of client', 'disorders & unfairness long-term care benefit. Among these seven parts, we could confirm specific and major problems, which were lack of safety management, incompleteness facilities & equipments, shortage of long-term care manpower, insufficient service providing low quality of service, hiding money from elderly's accounts, and providing some money to get national subsidies. For resolving these problems, the long-term service guidelines must be prepared and the related facilities must cooperate each other for providing high quality of service. In addition, the efficient systems must be made to find out long-term care problems and unfairness of service providing and strict management rules or sanctions must be needed.