• Journal of Microbiology and Biotechnology
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• v.33 no.12
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• pp.1625-1634
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• 2023

Leuconostoc lactis strain DMLL10 was isolated from kimchi, a fermented vegetable, as a starter candidate through safety and technological assessments. Strain DMLL10 was susceptible to ampicillin, chloramphenicol, clindamycin, erythromycin, gentamicin, kanamycin, streptomycin, and tetracycline. It did not show any hemolytic activity. Regarding its phenotypic results related to its safety properties, genomic analysis revealed that strain DMLL10 did not encode for any toxin genes such as hemolysin found in the same genus. It did not acquire antibiotic resistance genes either. Strain DMLL10 showed protease activity on agar containing NaCl up to 3%. The genome of DMLL10 encoded for protease genes and possessed genes associated with hetero- and homo-lactic fermentative pathways for lactate production. Finally, strain DMLL10 showed antibacterial activity against seven common foodborne pathogens, although bacteriocin genes were not identified from its genome. These results indicates that strain DMLL10 is a novel starter candidate with safety, enzyme activity, and bacteriocin activity. The complete genomic sequence of DMLL10 will contribute to our understanding of the genetic basis of probiotic properties and allow for assessment of the effectiveness of this strain as a starter or probiotic for use in the food industry.

• Journal of the Korea Safety Management & Science
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• v.6 no.4
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• pp.25-37
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• 2004

Safety diagnostic indicator pointer can divide by greatly two. One is management (Software) side that one that differ with mechanical (Hardware) side that handle laying stress on equipment connected with safety manages organization and management connected with safety. Weight appropriates according to specific gravity that relevant element occupies in facilities. To give so big value in particular element in grant of weight pays attention because break balance of whole guideline and should gives. Finally, efficient safety net may see effect before self-regulation inside by minimum target establishment using AHP by government and legal, systematic countermeasure establishment for this, strict law application and each business proprietor and though activity and user's active safety activity forms harmony properly.

• International conference on construction engineering and project management
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• 2011.02a
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• pp.17-22
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• 2011

A considerable number of construction disasters occur on pathways. Safety management is usually performed on construction sites to prevent accidents in activity areas. This means that the safety management level of hazards on pathways is relatively minimized. Many researchers have noted that hazard identification is fundamental to safety management. Thus, algorithms for helping safety managers to identify hazardous areas are developed using automated data collection technology. These algorithms primarily search for potential hazardous areas by comparing workers' location logs based on a real-time location system and optimal routes based on BIM. Potential hazardous areas are filtered by identified hazardous areas and activity areas. After that, safety managers are provided with information about potential hazardous areas and can establish proper safety countermeasures. This can help to improve safety on construction sites.

• Journal of the Korea Safety Management & Science
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• v.6 no.2
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• pp.11-21
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• 2004

Objectives: The aim of this study is to determine prevalence and related factors of musculoskeletal symptoms in electronics assembly line workers. Method: A questionnaire survey was performed on 350 workers in In-chon city. The questionnaire consisted of questions on the general characteristics, work duration, working hours, hobby activity hours, housekeeping activity hours and standardized descriptions of NOISH on musculoskeletal symptoms. Result: Complaint rates of musculoskeletal symptoms by anatomical site were as follows: shoulder, 67% : neck, 40.4% : waist, 28.7% : wrist and hand, 27.1% : foot and leg, 14.4% : arm and elbow, 11.2%. Significantly higher prevalence of shoulder musculoskeletal symptom was found women than men, married than unmarried, less than 1hours housekeeping activity than over 1hours housekeeping activity. Multiple logistic regression analysis identified gender, marital status and housekeeping activity as the main affecting factors for shoulder musculoskeletal symptoms. Conclusions: The most prevalence of musculoskeletal symptoms was shoulder site. It was higher in married women and over 1hours housekeeping activity in a day. It is recommended that married women should be reduce housekeeping activity time.

• Journal of the Korea Safety Management & Science
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• v.14 no.1
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• pp.87-93
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• 2012

The purpose of this study suggests a personalized algorithm of physical activity energy expenditure prediction through comparison and analysis of individual physical activity. The research for a 3-axial accelerometer sensor has increased the role of physical activity in promoting health and preventing chronic disease has long been established. Estimating algorithm of physical activity energy expenditure was implemented by using a tri-axial accelerometer motion detector of the SVM(Signal Vector Magnitude) of 3-axis(x, y, z). A total of 10 participants(5 males and 5 females aged between 20 and 30 years). The activities protocol consisted of three types on treadmill; participants performed three treadmill activity at three speeds(3, 5, 8 km/h). These activities were repeated four weeks.

• Korean Chemical Engineering Research
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• v.54 no.6
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• pp.762-766
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• 2016

In this study, natural extract including Phellodendro namurense, Eucommia ulmides Oliv and Prunus padus were tested for antimicrobial activity and safety. Antimicrobial activity was measured by using opportunistic microbes such as Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans. As safety test, cell viability test, single dose oral toxicity test, single dose inhalation toxicity test, repeat dose inhalation toxicity test and eye irritation test were done. From antimicrobial test, natural extract showed execellent antimicrobial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, Escherichia coli. From 5 kinds of safety tests, toxicity was not observed. From experimental results, natural extract including Phellodendro namurense, Eucommia ulmides Oliv and Prunus padus showed superb safety and antimicrobial effect.

• Journal of the Korean housing association
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• v.21 no.4
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• pp.23-31
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• 2010

This study aims to examine the educational function space of university dormitories at local universities with corridor centered structure in Honam area regions based on direct and indirect parameters on the whole satisfaction of users in residential environment factors and personal characteristics. First, according to relations among parameters, educational and cultural activities of four major activities within the dormitory had indirect influences on social activities, eating and sleeping activities had no direct influence on other activities. And social activity had direct influence on the general satisfaction as an important parameter and educational and cultural activities had indirect influence on the whole satisfaction through social activities. Detailed results show that, in the first educational activities directly affecting the lighting and air conditioning facilities (0.22), safety (0.326), Territoriality (0.327), the space density (-0.167), directions (-0.166) and yeohyang having personal characteristics and the safety of the second cultural activities (0.183), Territoriality (0.361), Aesthetics (-0.13) and the personal characteristics Sex (-0.179), the direct effect, third, and erosion has a direct impact on activity The flexibility of the space factor (-0.128) and Territoriality (0.38) and the personal characteristics grade (0.172), respectively. Fourth in social activities directly affecting the pathfinding (-0.104), and parameter, education (0.388) and cultural activities (0.445), and some of the factors affecting the indirect lighting and air conditioning facilities, safety, and Territoriality, the space density, directions, grade, they could influence through educational activities to be analyzed. That is, territoriality in educational function space is the important factor that users react very sensitively in educational, eating and sleeping activities and educational function space must secure area and division considering personal and public use as the space accommodating activity which is lacking in unit residential space. Accordingly, the safety of educational function space in university dormitory is considered as the fundamental safety matter on the fire prevention, hygiene and cleanness for users in the satisfaction of educational and cultural activities.

• Journal of Korean Medicine Rehabilitation
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• v.32 no.2
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• pp.1-17
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• 2022

Objectives This study was conducted to investigate the beta-glucan & ginsenoside content, antioxidant activity, anti-inflammatory effect and safety of herbal medicine mix. Methods The marker compounds contents, antioxidant activity and safety of herbal medicine mix were tested. The contents of beta-glucan and ginsenoside Rg3 were measured, the antioxidant activity was measured using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity, anti-inflammatory and a safety test was conducted via single dose toxicity assessment. Results Analyzing the contents of marker compounds showed 362.3 mg/g of beta-glucan, and 0.4184 mg/g of ginsenoside Rg3. In the DPPH free radical scavenging activity, the IC50 of herbal medicine mix, was 0.146%. The scavenging activity of herbal medicine mix was 88.28% activity at 0.5% concentration, and 90.61% activity at 5% concentration. In the lipopolysaccharides (LPS) anti-inflammatory test, the herbal remix showed a significant decrease in tumor necrosis factor-alpha (TNF-𝛼) and interleukin-6 (IL-6) compared to the LPS-induced group. In the single dose toxicity test of herbal medicine mix, a dose of 2,000 mg/kg body weight (BW) was set at its highest capacity and observed after oral administration to female and male rats. No toxicological findings were recognized. It was observed that the resulting lethal dose can be set to 2,000 mg/kg BW or higher for both females and males. Conclusions The results of the experiment on herbal medicine mix showed that the marker compounds contents were beta-glucan and ginsenoside Rg3, that antioxidant activity was observed through the DPPH free radical scavenging activity, anti-inflammatory effect was observed through TNF-𝛼 and IL-6 measurement, and safety was confirmed through the single dose toxicity assessment.

• Journal of the Korea Convergence Society
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• v.11 no.9
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• pp.405-415
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• 2020

This cross-sectional study investigated the relationship among three factors related to patient safety activities: (1) Experiences, (2) Perceptions, and (3) Willingness to Participate. An online survey was administered to 195 people in November 2019. Participants were admitted to a general hospital within the past year. Patient safety activity experience had a significant direct effect on patient safety perception, and patient safety perception had a significant direct effect on willingness to participate. Patient safety perception thus significantly mediates the relationship between patient safety activity experience and willingness to participate. It is necessary to increase patient safety perception through publicity of and educating on patient safety activities performed by hospitals. Doing so may increase willingness to participate in patient safety activities.

• Korean Journal of Veterinary Research
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• v.46 no.4
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• pp.315-322
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• 2006

Ethanol abuse is associated with liver injury, neurotoxicity, modulation of immune responses, and increased risk for cancer, whereas moderate ethanol consumption exerts protective effects against liver injury. However, the underlying signal transduction mechanisms of insulin-like growth factors (IGFs) which play an important regulatory role in various metabolism mechanisms are not well understood. We investigated the effects of ethanol-induced p42/44 activity on IGF-I secretion, IGF-I receptor and IGFBP-1 secretion using radioimmunoassay and western blotting in primary cultured rat hepatocytes. The p42/44 activity, IGF-I secretion and IGF-I receptor activity significantly accelerated compared to control at 10 and 30 min after 200 mM ethanol treatment, but then it became suppressed at 180 min. In contrast, IGFBP-1 secretion was inhibited compared to control at 30 min after 200 mM ethanol treatment, but increased at 180 min. The IGF-I secretion, IGF-I receptor and p42/44 activity at 30 min after 200 mM ethanol treatment accelerated with increasing ethanol concentration but IGFBP-1 secretion inhibited (p<0.05). The increased IGF-I secretion, inhibited IGFBP-1 secretion and IGF-IR activity by ethanol-induced temporal p42/44 activity at 30 min after ethanol treatment was blocked by treatment with PD98059. Alcohol dehydrogenase (ADH) inhibitor, 4-methylpyramazole blocked the changes of IGF-I secretion, IGFBP-1 secretion, and IGF-IR activity by ethanol-induced p42/44 activity at 30 and 180 min. Taken together, these results suggest that ethanol is involved in the modulation of IGF-I and IGFBP-1 secretion and IGF-IR activity by p42/44 activity in primary cultured rat hepatocytes. In addition, changing of p42/44 activity by ethanol was caused with ADH.