• Journal of the Korean Society of Safety
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• 제15권4호
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• pp.157-162
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• 2000

A performance measurement system for safety management was suggested with which performance of a company's safety activities can be expressed rationally, and analysis of impact with performance improvement. A key of the measurement system is performance index of the safety management activities, which consists of 3 perspectives; an external perspective, an internal perspective, and a innovation & learning perspective. Every perspective consists of 18 performance indices and each indices consist of activity unit a such planning, support, implementation, evaluation and review.

• YAKHAK HOEJI
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• 제58권4호
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• pp.255-261
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• 2014

Poly-pharmacy has been on the rise because of aging of population and chronic disease. Most of drug metabolism happens in the liver by CYP isozymes and the metabolism by CYP450 enzymes. The Cytochrome P450 (CYP) is a superfamily of enzymes that catalyzes the oxidations of many endogenous and exogenous compounds. Primary human Hepatocytes (HH) are considered as the gold standard model for In vitro drug interaction studies. However, there are several limitations (cost, limited life span) for using HH cells. HepaRG cells are being used as a possible alternative. HepaRG cells were cultured in William E medium containing the positive control inducers (1A2: 10, 25, 50 ${\mu}M$ omeprazole, 2C9 and 2C19: 10 ${\mu}M$ rifampin, 3A4: 10, 25, 50 ${\mu}M$ rifampin) at $37^{\circ}C$, 5 % $CO_2$ in a humidified atmosphere. This study was to evaluate the induction of CYP isozymes (1A2, 2C9, 2C19 and 3A4) using LC-MS/MS. We evaluated the potential induction ability of Bosentan, as a drug of pulmonary artery hypertension, in HepaRG cells. For reference, dose of the Bosentan is determined to the basis of the $C_{max}$ (835 mg/ml) value. The enzyme activity demonstrated that CYP2C9 and 3A4 were induced up to 20 times by Bosentan. Like as In vivo, the enzyme activity of CYP2C9 and CYP3A4 is significantly induced in a dose-dependent by Bosentan.

• Journal of the Korean Applied Science and Technology
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• 제40권4호
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• pp.773-785
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• 2023

This study is a descriptive research conducted to identify the factors influencing patient safety management activities of geriatric hospitals nurses and use basic data to prevent patient safety accidents. Subjects were 220 nurses and data were collected by questionnaires from february 1 to 28, 2023. Data were analyzed using t-test, ANOVA, Scheffe's test, Pearson correlation coefficients and Multiple regression analysis using the SPSS 29.0 program. Patient safety motivation was positive correlated with degree of patient safety(r=.41, p<.001), and degree of patient safety was positive correlated with patient safety nursing activity(r=.18, p<.01). Degree of patient safety(𝛽=.21, p<.001) and patient safety guidelines(𝛽=.16, p<.001) were main factors that affect patient safety nursing activity, and its explanatory power was 7.5%(Adj R²=.075, p<.001). For patient safety nursing activity, it is proposed to develop and apply a education program that strengthens practical training for effective coping after safety accidents along with risk prediction training to prevent before safety accidents.

• Journal of Radiation Protection and Research
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• 제43권2호
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• pp.39-49
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• 2018

Background: A model to assess the activity concentration of agricultural products and the public ingestion dose as result of a nuclear accident is necessarily required to manage the contaminated agricultural systems by the accident, or to estimate the effects of chronic exposure due to food ingestion at a Level 3 PSA. Materials and Methods: A dynamic compartment model, which is composed of three sub-modules, namely, an agricultural plant contamination assessment model, an animal product contamination assessment model, and an ingestion dose assessment model has been developed based on Korean farming characteristics such as the growth characteristics of rice and stockbreeding. Results and Discussion: The application study showed that the present model can predict well the characteristics of the activity concentration for agricultural products and ingestion dose depending on the deposition date. Conclusion: The present model is very useful to predict the radioactivity concentration of agricultural foodstuffs and public ingestion dose as consequence of a nuclear accident. Consequently, it is expected to be used effectively as a module for the ingestion dose calculation of the Korean agricultural contamination management system as well as the Level 3 PSA code, which is currently being developed.

• Korean Journal of Environmental Agriculture
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• 제35권3호
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• pp.191-201
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• 2016

BACKGROUND: The aim of this study was to investigate the antimicrobial effects of the ethanol extracts from various medicinal herbs against plant pathogens to understand the possible the crop protection agents.METHODS AND RESULTS: Among the tested medicinal herbs, Zizyphus jujuba ethanol extract had the potent antimicrobial activity against Phytophthora capsici, Erwinia carotovorum subsp. carotovora, Pseudomonas syringae pv. syringae and Ralstonia solanacearum. The major constituents of Z. jujuba were identified to eugenol(40.45%), dodecanoic acid(18.40%), β-caryophyllene (10.05%) and isoeugenol(9.85%) by GC/MS. Eugenol and isoeugenol had strong inhibitory activity on spore germination against P. capsici and growth against E. carotovorum subsp. carotovora, P. syringae pv. syringae and R. solanacearum.CONCLUSION: In this regard, eugenol and isoeugenol were found to be responsible for the antimicrobial activity of Z. jujuba ethanol extract against plant pathogens. In addition, Z. jujuba ethanol extract, eugenol and isoeugenol can be used the potent antimicrobial agents.

• Journal of Dairy Science and Biotechnology
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• 제38권1호
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• pp.37-44
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• 2020

The antimicrobial activity of the ethanol extract of Hibiscus sabdariffa L. (Roselle) powder against various food-borne pathogens was tested using the lawn diffusion assay. The results showed that the ethanol extract exhibited antimicrobial activities against Staphylococcus aureus (total inhibition), Salmonella enteritidis (partial inhibition), Listeria monocytogenes (partial inhibition), Escherichia coli (partial inhibition), Cronobacter sakazakii (partial inhibition), and Bacillus cereus (partial inhibition). Therefore, it is strongly recommended that Hibiscus sabdariffa L. (Roselle) should be considered for use as a natural food-grade additive for the inhibition of various food-borne pathogens, including both gram-positive and gram-negative pathogens, and the improvement of the overall quality of various dairy products, including milk.

• Korean Journal of Fisheries and Aquatic Sciences
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• 제45권4호
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• pp.303-306
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• 2012

Anti-angiogenesis therapy is one of the most promising strategies for the treatment of cancer. We investigated the anti-angiogenesis activity of an extract from the ark shell Scapharca subcrenata and attempted to purify the active compounds. The crude extract of the ark shell inhibited the proliferation of human vein endothelial cells (HUVEC-1) and tube formation by human dermal microvascular endothelial cells (HMEC-1). The methanol extract of the viscera of the ark shell showed activity. The ark shell extract acts as an angiogenesis inhibitor and could be developed further as a health substance, functional food, and anticancer agent.

• Journal of the Korea Safety Management & Science
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• 제26권2호
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• pp.79-86
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• 2024

Scientific exploration of how occupational health risks relate with occupational illnesses are essential for mitigating health-related issues in industries. This study analyzed the risk scores obtained by occupational health risk assessments at 3,172 manufacturing companies and examined their effects on occupational illness. Statistical analyses revealed that companies with an occupational health manager (scored 89.1 out of 100) had significantly higher activity scores of health management compared to those without (78.2). However, companies with a history of occupational illness (79.1) or those classified as high-risk industries (85.2) had significantly lower activity scores than their counterparts (81.7, 87.3). In addition, regression analyses using factor analysis showed that latent risk factors such as cardiovascular disease/job stress, health management, and musculoskeletal problem significantly influenced the risk of occupational illness. The activity factors such as health management, work environment management, and regulatory complaisance significant impacted the reduction of occupational illness. The findings of this study can be used to improve the occupational health risk assessment method and utilized in effectively managing occupational risks in industries.

• Journal of the Korean Society of Clothing and Textiles
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• 제39권3호
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• pp.419-432
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• 2015

This paper examines the protective clothing satisfaction rate of riot policemen. The protective clothing currently in use is the version that underwent enhancement and was distributed in 2009. This version underwent significant enhancements compared to the protective clothing introduced in 1996 in terms of safety and body fitness; however, there is room for further enhancement in terms of activity, thermal comfort and easiness. In this research, a questionnaire survey was conducted on 386 riot policemen working at the Seoul Riot Police Station to study their use of protective clothing and satisfaction rate. The survey questions included safety, activity and body fitness in terms of functionality and comfort as well as easiness and design in terms of wearing comfort. Activity scored the lowest (2.89) in terms of functionality as well as comfort (2.40) that scored the lowest in terms of wearing comfort. It is concluded that, in order to correct deficiencies, the weight of protective clothing must be reduced and design changes must be made to eliminate unnecessary areas in clothing and facilitate faster dressing/undressing. In addition, it is strongly recommended that shock absorption materials be inserted only in vital areas in order to enhance thermal comfort.

• The Transactions of The Korean Institute of Electrical Engineers
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• 제62권9호
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• pp.1335-1342
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• 2013

Subway is electrified railway system nowadays, in which liquid dielectric transformers have been widely used, though mold type transformers are replacing it. The transformers supplies large electric power and have innate hazards causing accidents under operation. A number of researcher have carried out on failures of it and have oriented to identify transformer's failure causes and how to maintain it healthy state. The transformer failures can cause serious accidents which can provoke economic loss and leads persons to kill. In this paper, we carried out a safety activity to reveal hazards and to estimate risk of subway liquid dielectric transformers using FMEA, HAZOP and What-if methods. In case of installing safety devices in oil immersed transformer, we tried to evaluate an effect on a subsystem's failure rate. We proposed how to design subsystem failure rate and safety device failure rates.