• International Journal of Naval Architecture and Ocean Engineering
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• 제9권2호
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• pp.185-198
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• 2017

The application of composites as an alternative material for marine steel hatch covers is the subject of this study. Two separate approaches are considered; weight reduction approach and strengthening approach. For both approaches Finite Element Analysis (FEA) was performed using ANSYS software. Critical design parameters of the composite hatch cover and FEA are discussed in details. Regarding the weight reduction approach; steel hatch covers of a bulk carrier were replaced by composite covers and a weight reduction of 44.32% was achieved leading to many benefits including fuel saving, Deadweight Increment and lower center of gravity of the vessel. For the strengthening approach; the foremost hatch cover was strengthened to withstand 150% of the load required by IACS for safer navigation while no change in weight was made between the steel and composite covers. Results show that both approaches are feasible and advantageous.

• Archives of Pharmacal Research
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• 제25권2호
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• pp.111-136
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• 2002

The prodrug and antedrug concepts, which were developed to overcome the physical and pharmacological shortcomings of various therapeutic classes of agents, employ diametrically different metabolic transformations. The prodrug undergoes a predictable metabolic activation prior to exhibiting its pharmacological effects in a target tissue while the antedrug undergoes metabolic deactivation in the systemic circulation upon leaving a target tissue. An increased therapeutic index is the aspiration for both approaches in designing as well as evaluation criteria. The recent research endeavors of prodrugs include the gene-directed and antibody-directed enzymatic activation of a molecule in a targeted tissue, organ specific delivery, improved bioavailabilities and cellular penetration of nucleotides. As for antedrugs, emphasis in research has been based upon the design and synthesis of systemically inactive molecule by incorporating a metabolically labile functional group into an active molecule.

• 한국철도학회논문집
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• 제10권1호
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• pp.16-21
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• 2007

Along with the opening of the high speed railroad in 2004, the number of long tunnels constructed is increasing and will be continued. In this respect, the fro inside the tunnels is a main cause of drastic damages to both facilities and lives of passengers on board, especially more severe consequences are expected if the fire occurs on a train in urban area. Even though, the threat to human lives due to the increasing number of tong tunnels and increasing train operation times inside such tunnels is getting bigger, the studies to measure safety of the tunnel and to enhance the safety of passengers have not been carried out enough in Korea. Therefore, in this paper, we will use the probabilistic method to predict the average number of deaths of passengers in case of fire on a train iii tunnel, and show the potential risk to passengers which can be a guide for safer design of tunnels to be constructed.

• 한국가스학회지
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• 제14권6호
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• pp.44-50
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• 2010

내진 평가에서 동적 해석이 필요한 원심펌프에 대하여, 시간 이력 해석에 비해 간편한 스펙트럼 해석을 이용하여, 진동 응답을 산출하였다. 유한요소법에 의하여 모드 해석을 하였으며, 모드 해석 결과에 입각하여 스펙트럼 해석을 수행하였다. 스펙트럼 해석에 의해 구해진 진동 응답은 시간 이력 해석의 결과보다 보수적으로 산출되어 안전하게 설계할 수 있음을 알 수 있었다. 본 연구에서의 펌프는 IEEE 344-1987에서 요구되는 조건에 따라 내진 구조 건전성이 평가 되었다. 각 부재의 최대 응력은 허용 응력이하로 산출되었으며, 펌프는 주어진 지진 입력에 대하여 요구되는 안전 조건을 구비하고 있음이 판명되었다.

• 대한조선학회논문집
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• 제43권1호
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• pp.1-14
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• 2006

To improve maritime safety, it is very important not only to make safer design and operation but also to do proper response in case of maritime casualty. The large-scaled casualties will be caused by loss of structural strength and stability due to the progressive flooding and enlargement of damage by the effect of waves and wind. To prevent foundering and structural failure, the prediction of ship motion behavior of damaged ship in wave is necessary. This paper describes the motion behavior of damaged ship in waves through theoretical and experimental studies. A time domain theoretical model of damaged ship motions and accidental flooding, which can be applied to any type of ship or arrangement and considers the effects of flooding of compartments, has been developed. The model tests have been carried out in regular and irregular waves with different wave heights and directions in ship motion basin. Those were performed for three different damaged conditions such as engine room bottom damage, side shell damage and bow visor damage of a Ro-Ro ship. Comparison of theoretical and experimental results was performed.

• Geomechanics and Engineering
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• 제13권3호
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• pp.475-488
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• 2017

Geotechnical data contributes substantially to the cost of engineering projects due to increasing cost of site investigations. Existing information in the form of soil maps can save considerable time and expenses while deciding the scope and extent of site exploration for a proposed project site. This paper presents spatial interpolation of data obtained from soil investigation reports of different construction sites and development of soil maps for geotechnical characterization of Multan area using ArcGIS. The subsurface conditions of the study area have been examined in terms of soil type and standard penetration resistance. The Inverse Distance Weighting method in the Spatial Analyst extension of ArcMap10 has been employed to develop zonation maps at different depths of the study area. Each depth level has been interpolated as a surface to create zonation maps for soil type and standard penetration resistance. Correlations have been presented based on linear regression of standard penetration resistance values with depth for quick estimation of strength and stiffness of soil during preliminary planning and design stage of a proposed project in the study area. Such information helps engineers to use data derived from nearby sites or sites of similar subsoils subjected to similar geological process to build a preliminary ground model for a new site. Moreover, reliable information on geometry and engineering properties of underground layers would make projects safer and economical.

• 대한의생명과학회지
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• 제27권3호
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• pp.121-133
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• 2021

Antibody-drug conjugates (ADCs) are drawing much interest due to its great potential to be one of the important options in cancer treatments. ADCs are acting like a magic bullet which delivers cytotoxic drugs specifically to cancerous cells throughout the body, thus attacks these cells, while not harming healthy cells. ADCs are complex molecules that are composed of an antibody having targeting capability and linked-payload or cytotoxic drug killing cancerous cells. The key factors of the success in the development of ADC are selection of appropriate antibody, cytotoxic payload and linker for conjugation. Recently there was considerable progress in ADCs development, and a large number of ADCs gained US FDA approval. About 80 new ADCs are under active clinical studies. In this review we present a brief introduction of the US-FDA approved ADCs and global situation in the clinical studies of ADC pipelines. We address an overview on each component of an ADC design such as target antigens, payloads, linkers, conjugation methods, drug antibody ratio. In addition, we discuss on the trend of ADC market where global big pharmas and domestic biopharmaceutical companies are competing to develop safer and more effective ADCs.

• Journal of Information Processing Systems
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• 제15권3호
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• pp.632-644
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• 2019

The remote monitoring and warning system for dangerous chemicals is designed with the concept of the Cyber-Physical System (CPS) in this paper. The real-time perception, dynamic control, and information service of major hazards chemicals are realized in this CPS system. The CPS system architecture, the physical layer and the applacation layer, are designed in this paper. The terminal node is mainly composed of the field collectors which complete the data acquisition of sensors and video in the physical layers, and the use of application layer makes CPS system safer and more reliable to monitor the hazardous chemicals. The cloud application layer completes the risk identification and the prediction of the major hazard sources. The early intelligent warning of the major dangerous chemicals is realized and the security risk images are given in the cloud application layer. With the CPS technology, the remote network of hazardous chemicals has been completed, and a major hazard monitoring and accident warning online system is formed. Through the experiment of the terminal node, it can be proved that the terminal node can complete the mass data collection and classify. With this experiment it can be obtained the CPS system is safe and effective. In order to verify feasible, the multi-risk warning based on CPS is simulated, and results show that the system solves the problem of hazardous chemicals enterprises safety management.

• Physical Therapy Rehabilitation Science
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• 제8권2호
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• pp.86-92
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• 2019

Objective: The purpose of this study was to compare the effects of performing squats and kneeling squats on trunk and lower extremity muscle activity in persons with stroke. Design: Cross-sectional study. Methods: Ten persons with stroke (3 male and 7 female) were recruited. The subjects were instructed to randomly perform the 4 different squat conditions: squat with 30 degrees of knee flexion, squat with 60 degrees of knee flexion, squat with 90 degree of knee flexion, and the kneeling squat. During the squat performance, surface electromyograms (sEMG) was used to assess muscle activity of the erector spinae (ES), gluteus maximus (Gmax), gluteus medius (Gmed), and biceps femoris (BF) muscles. Results: Muscle activation of the ES and BF were significantly increased with the kneeling squats compared to the general squats with 30 degrees and 60 degrees of knee flexion (p<0.05), and muscle activation of the Gmax and Gmed were significantly increased with the kneeling squats compared to all other squat conditions (p<0.05). Conclusions: The results suggest that the kneeling squat is an effective exercise to strengthen the proximal muscles of the lower extremities. Rather than applying a difficult general squat to the stroke population, the kneeling squat may be applied as a safer method for training the proximal muscles.

• 디지털산업정보학회논문지
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• 제15권2호
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• pp.43-52
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• 2019

The recent technological developments of smart devices, multiple services are provided to enhance the users' quality of life including smart city, smart energy, smart car, smart healthcare, smart home, and so on. Academia and industries try to provide the users with convenient services upon seamless technological research and developments. Also, whenever and wherever a variety of services can be used without any limitation on the place and time upon connecting with different types of devices. However, security weaknesses due to integrations of multiple technological elements have been detected resulting in the leakage of user information, account hacking, and privacy leakage, threats to people's lives by device operation have been raised. In this paper, safer communication framework is suggested by device control and user authentication in the mobile network environment. After implementations of registration and authentication processes by users and devices, safe communication protocol is designed based on this. Also, renewal process is designed according to the safe control of the device. In the performance evaluation, safety was analyzed on the attack of protocol change weakness occurred in the existing system, service halt, data leakage, illegal operation control of message, and so on, which confirmed the enhanced speed approximately by 8% and 23% in the communication and verification parts, respectively, compared to the existing system.