• Clinical and Experimental Pediatrics
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• v.60 no.2
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• pp.31-37
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• 2017

Steroid 21-hydroxylase deficiency is the most prevalent form of congenital adrenal hyperplasia (CAH), accounting for approximately 95% of cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into adulthood. Adolescents and adults with CAH experience a number of complications, including short stature, obesity, infertility, tumor, osteoporosis, and reduced quality of life. Transition from pediatric to adult care and management of long-term complications are challenging for both patients and health-care providers. Psychosocial issues frequently affect adherence to glucocorticoid treatment. Therefore, the safe transition of adolescents to adult care requires regular follow-up of patients by a multidisciplinary team including pediatric and adult endocrinologists. The major goals for management of adults with 21-hydroxylase deficiency are to minimize the long-term complications of glucocorticoid therapy, reduce hyperandrogenism, prevent adrenal or testicular adrenal rest tumors, maintain fertility, and improve quality of life. Optimized medical or surgical treatment strategies should be developed through coordinated care, both during transition periods and throughout patients' lifetimes. This review will summarize current knowledge on the management of adults with CAH, and suggested appropriate approaches to the transition from pediatric to adult care.

• Journal of Welding and Joining
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• v.29 no.1
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• pp.46-51
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• 2011

TSV technology raises several reliability concerns particularly caused by thermally induced stress. In traditional package, the thermo-mechanical failure mostly occurs as a result of the damage in the solder joint. In TSV technology, however, the driving failure may be TSV interconnects. In this study, the thermomechanical reliability of TSV technology is investigated using finite element method. Thermal stress and thermal fatigue phenomenon caused by repetitive temperature cycling are analyzed, and possible failure locations are discussed. In particular, the effects of via size, via pitch and bonding pad on thermo-mechanical reliability are investigated. The plastic strain generally increases with via size increases. Therefore, expected thermal fatigue life also increase as the via size decreases. However, the small via shows the higher von Mises stress. This means that smaller vias are not always safe despite their longer life expectancy. Therefore careful design consideration of via size and pitch is required for reliability improvement. Also the bonding pad design is important for enhancing the reliability of TSV structure.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.40 no.2
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• pp.23-28
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• 2008

As well as crop cultivation, they could not avoid automatizing and using more environmental friendly process in cultivation of fruit. And also, the consumer ask more safe fruit which is produced with more clean method. This is why the usage of aid materials for fruit cultivation like as fruiting bags are increasing. Practical utilization of wax emulsion treated water repelling fruiting bags are developed continuously and it's properties is compared properties of nomal fruiting bags. The water repelling process was developed with wax emulsion coating. After the experiment of wax emulsion preparation from paraffin and DEA and/or OA in Lab. scale, the wax emulsion was manufactured on pilot scale. The wax emulsion coated paper was prepared in mill scale coater. The water repellency and properties of emulsion coated fruiting bags were evaluated and compared with that of current fruiting bags.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.40 no.6
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• pp.337-342
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• 2007

The formation of lysinoalanine (LAL) in protein recovered from the belanger's croaker, Johnius grypotus, using a pH shifting process was measured by amino acid analysis. The LAL peak was detected at 49.24 min, between phenylalanine and histidine peaks in the amino acid analyzer. LAL was not detected in the fish muscle or in protein recovered using the alkaline pH shifting process. LAL was not formed in protein recovered after storage for up to 9 hrs at pH 11, but was detected in the soluble protein fraction at pH 11, followed heating at $90\;^{\circ}C$. The myosin heavy chain decreased with storage time at pH 11. The results suggest that the alkaline shifting process for recovering fish muscle protein is safe, and that no LAL forms.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.17 no.4
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• pp.150-159
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• 2018

The present research deals with a finite element analysis and fatigue evaluation of a steam separator of a high-pressure evaporator for the Heat Recovery Steam Generator (HRSG). The fatigue during the expected life of the HRSG was evaluated according to the ASME Boiler and Pressure Vessel Code Section VIII Division 2 (ASME Code). First, based on the eight transient operating conditions prescribed for the HRSG, temperature distribution of the steam separator was analyzed by a transient thermal analysis. Results of the thermal analysis were used as a thermal load for the structural analysis and used to determine the mean cycle temperature. Next, a structural analysis for the transient conditions was carried out with the thermal load, steam pressure, and nozzle load. The maximum stress location was found to be the riser nozzle bore, and hence fatigue was evaluated at that location, as per ASME Code. As a result, the cumulative usage factor was calculated as 0.00072 (much less than 1). In conclusion, the steam separator was found to be safe from fatigue failure during the expected life.

• Journal of Microbiology and Biotechnology
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• v.19 no.11
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• pp.1364-1368
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• 2009

Lysosomes, as a cell organelle type, are safe biological control agents that may be possible replacements for chemical antimicrobial agents because they are simply isolated from egg white. In this study, it was found that the lysosomes isolated from egg white exhibited pH-dependent antimicrobial activity, with the optimal activity found at pH 6.0. The efficiency of lysosomes in inhibiting bacterial growth and activity was evaluated over a 12-h treatment period. Seven different microorganisms were used as bacterial strains, and the lysosomes showed a significant antimicrobial effect against all strains. In addition, the antimicrobial activity was maintained for 100 days, and there did not appear to be any resistance of E. coli to the lysosomal activity up to the eighth culture. However, the lysosomes did not affect the viability of mammalian cells, suggesting the biocompatibility of lysosomes. These highly effective lysosomes have a bright future in the application of novel antimicrobial sources as a cell organelle type.

• Current Research on Agriculture and Life Sciences
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• v.31 no.1
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• pp.1-10
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• 2013

The exposure of food to ionizing radiation has been recognized as a safe and effective mode of food preservation in more than 55 countries. The benefits include eradication of insect pests, inactivation of food pathogens, extension of shelf-life, and improvement in food hygiene. Regulatory authorities around the world have emphasized the implementation of various national and international regulations to facilitate trade and development of consumers' confidence in purchasing irradiated foods. Therefore, the need for reliable irradiation detection methods has increased to enforce these regulations. At present, a number of promising analytical approaches have been developed and evaluated. Moreover, about 10 European Standards have been adopted as General CODEX Alimentarius methods for the detection of irradiated foodstuffs. However, most of these methods demand relatively expensive equipment and prolonged sample preparation. Therefore, simple and cost-effective approaches would be advantageous for rapid screening of foodstuffs. The suspected samples need to be analyzed further with more validated techniques to confirm the screening results. In this review, existing screening methods (i.e. physical, chemical, and biological) for the identification of irradiated foods have been outlined along with their principles, scopes and limitations.

• Journal of the Korean Society for Precision Engineering
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• v.33 no.11
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• pp.919-925
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• 2016

In this study, multibody dynamic and mechanical analyses were conducted for the structure of roller chain bucket elevator system. The fatigue life of the roller chain elevator system was determined under static and fatigue loadings. Results of multibody dynamic analysis suggested that the maximum contact force occurred at the drive sprocket engagement point with the roller chain due to maximum tension. Fatigue analysis results suggest that the high load roller chain system is durable and safe because its life time is more than 700,000 cycles, close to its designed value (1,000,000 cycle). However, the contact portion of plate and pin needed a safety factor. The dynamic analysis of the heavy load roller chain was conducted with a multibody dynamic analysis program. The results obtained in this study can be utilized for dynamic analysis of roller chain systems in all industries.

• Journal of Korean Society for Quality Management
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• v.45 no.4
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• pp.649-664
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• 2017

Purpose: This paper introduces the technology of prognostics for Industry 4.0 and presents its application procedure for fitness-for-service assessment of natural gas pipelines according to ISO 13374 framework. Methods: Combining data-driven approach with pipe failure models, we present a hybrid scheme for the gas pipeline prognostics. The probability of pipe failure is obtained by using the PCORRC burst pressure model and First Order Second Moment (FOSM) method. A fuzzy inference system is also employed to accommodate uncertainty due to corrosion growth and defect occurrence. Results: With a modified field dataset, the probability of failure on the pipeline is calculated. Then, its residual useful life (RUL) is predicted according to ISO 16708 standard. As a result, the fitness-for-service of the test pipeline is well-confirmed. Conclusion: The framework described in ISO 13374 is applicable to the RUL prediction and the fitness-for-service assessment for gas pipelines. Therefore, the technology of prognostics is helpful for safe and efficient management of gas pipelines in Industry 4.0.

• Journal of the East Asian Society of Dietary Life
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• v.15 no.5
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• pp.606-612
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• 2005

This study was performed to provide basic data that predict the application of Saengmaegsan(SMS) as medicinal food. SMS has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. We examined the effects of SMS on physiological function in isolated abdominal aorta and femoral artery from rabbit and measured the changes of regional cerebral hood flow(rCBF), which was continually monitored by laser-doppler flowmeter and pressure transducer in anesthetized adult Spargue-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. The contraction forces by injection of norephinephrine in isolated abdominal aorta and femoral artery were significantly decreased in each concentration of SMS treatment compared with control. rCBF was increased by SMS in a dose-dependent manner. These results suggest that SMS causes a diverse response of rCBF and arterial diameter. These mechanism in rCBF increase may be mediated by prostaglandis, cyclic GMP and adrenergic $\beta-receptor$. Also mechanism in artery contraction decrease is also mediated by prostaglandis and cyclic GMP. These results indicate that SMS can be nsed as a safe and clinically applicable as a supplementation of diet therapy for cerebral cardiovascular disease patients.