• IMMUNE NETWORK
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• 제13권6호
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• pp.275-282
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• 2013

Influenza virus is one of the major sources of respiratory tract infection. Due to antigenic drift in surface glycoproteins the virus causes annual epidemics with severe morbidity and mortality. Although hemagglutinin (HA) is one of the highly variable surface glycoproteins of the influenza virus, it remains the most attractive target for vaccine development against seasonal influenza infection because antibodies generated against HA provide virus neutralization and subsequent protection against the virus infection. Combination of recombinant adenovirus (rAd) vector-based vaccine and mucosal administration is a promising regimen for safe and effective vaccination against influenza. In this study, we constructed rAd encoding the globular head region of HA from A/Puerto Rico/8/34 virus as vaccine candidate. The rAd vaccine was engineered to express high level of the protein in secreted form. Intranasal or sublingual immunization of mice with the rAd-based vaccine candidates induced significant levels of sustained HA-specific mucosal IgA and IgG. When challenged with lethal dose of homologous virus, the vaccinated mice were completely protected from the infection. The results demonstrate that intranasal or sublingual vaccination with HA-encoding rAd elicits protective immunity against infection with homologous influenza virus. This finding underlines the potential of our recombinant adenovirus-based influenza vaccine candidate for both efficacy and rapid production.

• Journal of Forest and Environmental Science
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• 제29권3호
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• pp.226-236
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• 2013

Recently check dam construction number have been increased by becoming known that effectiveness in the control of the landslide and debris flow. However, check dam management standards are not setting yet. Therefore, this study was carried by provide a basic data for the check dam management and inspection in the Gangwondo. The followings are the results of safety inspection on the 274 check dams, which are located in mountain streams, Gangwondo, Republic of Korea. 1. It was determined that, of 274 check dams inspected, 267 check dams (97.4%) generally had a safe condition but 7 check dams (2.6%) had a bad condition that repair and/or complementary measures are required. 2. The check dams with a bad condition had the ages greater than approximately 20 years. This result should be reflected to future stream management strategy including a timing of the specific inspection for durability of check dams. 3. Our finding suggests that the safety inspection of check dams is able to provide basic information required to maintain their own functions, and thus it should be widely applied to stream management strategy against to sediment-related disasters in the future.

• 대한토목학회논문집
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• 제34권6호
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• pp.1797-1806
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• 2014

지금까지 세계적으로 지하수 관리는 연간 지하수 함양량을 기반으로 한 안전채수량 정책에 의해 수행되어 왔다. 그러나 지하수 함양량은 시공간적으로 변동하므로 지속가능한 지하수자원을 평가하기 위해서는 동적 해석이 필요하다. 본 연구에서는 지표수-지하수 통합해석 모형인 SWAT-MODFLOW를 이용하여 경주지역의 지하수 함양량 공간분포를 산정하였다. 우리나라에서는 10년 빈도 갈수시 강수량에 함양계수를 곱하여 지역별 개발가능량을 산정하기에 본 연구에서는 기존 개발가능량을 평가하기 위해 빈도해석기법을 이용하였다. 소유역별 10년 빈도 갈수시의 지하수 함양량을 추정하는 보수적 방법을 제안하고 이를 기존 개발가능량과 비교하였다. 이같은 계산 절차를 통해 지하수 개발가능량을 산정하는 기존 절차의 한계를 합리적으로 제시할 수 있었다.

• 한국환경보건학회지
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• 제30권2호
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• pp.173-183
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• 2004

The purpose of the present study was to assess food hygiene and safety knowledge, attitudes, and practices of food-service personnel in school food-service programs and to find factors affecting their knowledge, attitudes, and practices. A self-administered questionnaire was offered to a random sample of 40 kitchen employees in elementary schools in one region of Korea, with 37 completing the survey, a response rate of 92.5%. The survey was carried out over a two-month period (April-May, 2001). Knowledge score of the employees was high with a mean/standard deviation of 4.75/0.32 on a 5.0-point scale. They had significantly lower attitude score (4.55$\pm$0.33) and practice score (4.55$\pm$0.45) compared to the score of knowledge (p＜0.05). Logistic regression analysis showed that (1) the employees＇ education level and work experience in school food-service programs affected their knowledge, (2) age, level of living, monthly income, and housing type affected their attitudes, and (3) monthly income, level of living, housing type, and work experience in school food-service programs affected their practices. Pearson＇s correlation analysis confirmed that the knowledge and attitude scores were significantly correlated (r=0.598, p＜0.001). The results indicate that the knowledge, attitude, and practice levels of the employees regarding the food hygiene and safety were better than expected, however, the results suggest a need for the adoption of approaches which take account of socio-economic and environmental influences on behavior to improve and maintain their practice level. The food-handling practices of school food-service employees need to be monitored routinely in order to ensure that safe food is served to our school children.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제41권1호
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• pp.30-36
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• 2015

Objectives: The aim of this study is to determine the incidence, location, and orientation of maxillary sinus septa in formalin embalmed cadavers. Materials and Methods: The study was conducted on 210 cadaveric heads available in our department. After taking the mid-sagittal section the specimens were opened from the medial aspect and the sinus sinus septa, their anatomical plane, location and dimensions. Results: The mean linear distance between maxillary sinus floor and its anatomical ostium was $26.76{\pm}5.21mm$ and $26.91{\pm}4.96mm$ on right and left side, respectively. A total of 59 maxillary sinus septa (28.1%) were observed in 210 maxillary specimens. Septae were most common, 33 septa (55.9%), in the middle region (between first and second molar tooth) of the sinus cavity. The maxillary sinus membrane (Schneiderian membrane) adhered tightly to the maxillary sinus and over the septae. Significantly more maxillary sinus septa were observed in edentulous maxillae in comparison to the dentate upper jaw. Conclusion: Knowledge of location of maxillary sinus ostium is mandatory for the rhinologist for drainage of secretions in maxillary sinusitis. The morphological details of maxillary sinus septa, particularly their location and anatomical planes, will guide dentists in performance of safe implant surgeries. The maxillary antrum septa of category I and II may complicate the procedure of inversion of bone plate and elevation of sinus membrane during maxillary augmentation surgeries. The category III septa observed in the sagittal plane were embedded by one of the branches of the infraorbital nerve in it, and if accidentally cut will lead to infraorbital nerve palsy in maxillary sinus surgeries.

• Imaging Science in Dentistry
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• 제39권2호
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• pp.81-87
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• 2009

Purpose: To evaluate the anteroposterior length and buccal angle of the anterior loop, and the size and location of the mental foramen using cone beam computed tomography (CBCT). Materials and Methods: 100 CBCT images from 87 adults (43 males and 44 females) ranging in age from 20 to 73 years (average 50 years) with edentulous ridge of the mandibular premolar region were obtained. Axial, sagittal, coronal images were reconstructed from Dental and Block Images of CBCT. The anteroposterior length, shape and buccal angle of the anterior loop, and the size and location of the mental foramen were calculated from reconstructed images of axial, sagittal and coronal CBCT. Results: The anteroposterior length and buccal angle of the mental canal was 4.0${\pm}$1.2mm, 37.8${\pm}$11.60$^{\circ}$respectively. The loop type with straight course was the most common shape of the mental canal. The location of the mental foramen below the apex of the lower second premolar (78%) was the most common. The maximum size of the mental foramen was 4.6${\pm}$1.0 mm in width and 3.0${\pm}$0.6 mm in height. The inner size of the mental canal was 2.6${\pm}$0.6 mm in width and 2.1 mm${\pm}$0.4 mm in height. Conclusion: CBCT is useful to evaluate the anterior loop and mental foramen of the mandibular canal. Safe guideline of 4 mm from the most anterior point of the mental foramen is recommended for implant and surgical treatment. (Korean J Oral Maxillofac Radiol 2009; 39: 81-7)

• 디지털콘텐츠학회 논문지
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• 제12권3호
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• pp.279-289
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• 2011

시각 장애인을 위한 실시간 보행보조 시스템의 안전한 보행안내와 편리한 서비스를 제공하기 위해 최신 하드웨어 기술과 소프트웨어 기술이 결합되고 있다. 이 시스템은 보행자가 원하는 목적지까지 보행할 수 있도록 장애물 검출 및 인지와 장소인식, 기호인식으로 구성된다. 본 논문에서는 보행보조 시스템의 중요한 요소 중 하나인 기호인식을 위해 지하철 역 내부에서의 기호 객체 검출 시스템을 개발하였다. 본 논문은 조명과 잡음이 존재하는 복잡한 환경으로부터 기호 객체 영역을 강건하게 검출할 수 있는 적응적인 특징맵을 제안하였다. 그리고 보행 시 객체의 이동, 회전 및 크기에 불변하도록 고속 제르니케 모멘트 특징을 이용하여 기호를 인식한다. 화살표, 화장실, 출구번호 3개의 기호를 대상으로 하며, 에이다부스트 분류기를 이용하여 기호를 학습 및 인식한다. 실험결과에서는 5000장의 기호영상 데이터 베이스의 3개의 기호에 대해 평균 87.16%의 검출율과 20 frame/sec의 처리속도를 통해 안정적이며 실시간 시스템에 적합함을 입증한다.

• Structural Engineering and Mechanics
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• 제54권3호
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• pp.501-520
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• 2015

Presence of torsional loadings can significantly affect the flow of internal forces and deformation capacity of reinforced concrete (RC) columns. It increases the possibility of brittle shear failure leading to catastrophic collapse of structural members. This necessitates accurate prediction of the torsional behaviour of RC members for their safe design. However, a review of previously published studies indicates that the torsional behaviour of RC members has not been studied in as much depth as the behaviour under flexure and shear in spite of its frequent occurrence in bridge columns. Very few analytical models are available to predict the response of RC members under torsional loads. Softened truss model (STM) developed in the University of Houston is one of them, which is widely used for this purpose. The present study shows that STM prediction is not sufficiently accurate particularly in the post cracking region when compared to test results. An improved analytical model for RC square columns subjected to torsion with and without axial compression is developed. Since concrete is weak in tension, its contribution to torsional capacity of RC members was neglected in the original STM. The present investigation revealed that, disregard to tensile strength of concrete is the main reason behind the discrepancies in the STM predictions. The existing STM is extended in this paper to include the effect of tension stiffening for better prediction of behaviour of square RC columns under torsion. Three different tension stiffening models comprising a linear, a quadratic and an exponential relationship have been considered in this study. The predictions of these models are validated through comparison with test data on local and global behaviour. It was observed that tension stiffening has significant influence on torsional behaviour of square RC members. The exponential and parabolic tension stiffening models were found to yield the most accurate predictions.

• Earthquakes and Structures
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• 제14권6호
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• pp.615-626
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• 2018

The seismic vulnerability of Turkey is relatively high due to its active fault systems with potential to create destructive earthquakes. Thus, reducing the loss of life and property, the number of the earthquake-prone buildings and their retrofit requirements are considerably significant key issues under the scenario earthquakes. The street survey based rapid assessment (SSRA) method can be considered as a powerful tool to determine the seismic vulnerability of building stock of an earthquake-prone city/state. In this study, the seismic vulnerability of the building stock of the Kirikkale province in Turkey is aimed to be estimated adopting the street survey based rapid assessment method (SSRA). For this purpose, central 2074 existing reinforced concrete (R/C) buildings were structurally surveyed with rapid visual site screening and disadvantages such as, the existence of short-column, soft-story, heavy overhangs, pounding effect and local soil conditions were determined for obtaining the structural performance score of each. The results obtained from the study demonstrate that 11-25% of the surveyed buildings in the study region needs to be investigated through more advanced assessment methods. Besides, higher correlation between increasing story number and unsafe/safe building ratio is obtained for the buildings with soft-story parameter than that for those with heavy overhangs and short-column parameters. The conformity of the results of the current study with the previous documented cases of rapid assessment efforts in the recent earthquakes in Turkey shows that the SSRA method for the Kirikkale province performed well, and thus this methodology can be reliably used for similar settlement areas.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제40권
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• pp.15.1-15.6
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• 2018

Background: The purpose of this study was to identify the location of the antilingula, lingula, and mandibular foramen in Korean cadavers and to promote safe and accurate surgery without damage to the inferior alveolar neurovascular bundle (IANB) when performing a vertical ramus osteotomy (VRO). Methods: This study was conducted on the dried mandibles of 20 adult cadavers. Digital calipers were used to measure the distances from the anatomical reference points (antilingula, lingula, and mandibular foramen). Result: The antilingula was located at the anterior 44% and superior 31% in the ramus. The lingula was located at the anterior 55% and superior 30% in the ramus. The mandibular foramen was located at the anterior 58% and superior 46% in the ramus. Regarding the positional relationship with the antilingula, the lingula was located 0.54 mm superior and 4.19 mm posterior, and the mandibular foramen was located 6.95 mm inferior and 4.98 mm posterior. The results suggested that in order to prevent damage to the IANB, osteotomy should be performed in the posterior region of ramus at least 29% of the total horizontal length of the ramus. Conclusion: Using only the antilingula as a reference point is not guaranteed to IANB injury. However, it is still important as a helpful reference point for the surgeon in the surgical field.