• Journal of Korean Neurosurgical Society
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• v.54 no.1
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• pp.1-7
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• 2013

Objective : This study was undertaken in the belief that the atypical antipsychotic drug quetiapine could prevent apoptosis in the penumbra region following ischemia, taking into account findings that show 5-hydroxytryptamine-2 receptor blockers can prevent apoptosis. Methods : We created 5 groups, each containing 6 animals. Nothing was done on the K-I group used for comparisons with the other groups to make sure adequate ischemia had been achieved. The K-II group was sacrificed on the 1st day after transient focal cerebral ischemia and the K-III group on the 3rd day. The D-I group was administered quetiapine following ischemia and sacrificed on the 1st day while the D-II group was administered quetiapine every day following the ischemia and sacrificed on the 3rd day. The samples were stained with the immunochemical TUNEL method and the number of apoptotic cells were counted. Results : There was a significant difference between the first and third day control groups (K-II/K-III : p=0.004) and this indicates that apoptotic cell death increases with time. This increase was not encountered in the drug groups (D-I/D-II : p=1.00). Statistical analysis of immunohistochemical data revealed that quetiapine decreased the apoptotic cell death that normally increased with time. Conclusion : Quetiapine is already in clinical use and is a safe drug, in contrast to many substances that are used to prevent ischemia and are not normally used clinically. Our results and the literature data indicate that quetiapine could help both as a neuronal protector and to resolve neuropsychiatric problems caused by the ischemia in cerebral ischemia cases.

• Journal of Advanced Navigation Technology
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• v.21 no.3
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• pp.279-286
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• 2017

The international maritime organization(IMO) has defined performance requirements for future maritime navigation through IMO resolution A.915(22) in 2001. Many DGPS systems currently providing DGPS services do not meet the performance requirements specified in IMO resolution A.915(22). The use of SBAS is considered as one of the DGPS replacement and supplementary system for coping with the increase in demand performance and providing safe positioning service. In particular, since a large amount of budget is required to rearrange the existing DGPS reference stations, a method which transmits differential corrections generated by using SBAS message has been proposed. In this paper, we compare and analyze the performance of NDGPS which is operated by the National Maritime PNT Office of the ministry of oceans and fisheries(MOF) in Korea and MSAS in Japan. Also, we verify that SBAS, as alternative and complementary system, meets the performance requirement specified in IMO resolution A.915(22).

• 한국전산유체공학회:학술대회논문집
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• 2007.04a
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• pp.83-86
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• 2007

Turbulent flow analysis is conducted around the multi-stage launch vehicle including base region and detachment motion of strap-on boosters due to resultant aerodynamic forces and gravity is simulated. Aerodynamic solution procedure is coupled with rigid body dynamics for the prediction of separation behavior. An overset mesh technique is adopted to achieve maximum efficiency in simulating relative motion of bodies and various turbulence models are implemented on the flow solver to predict the aerodynamic forces accurately. At first, some preliminary studies are conducted to show the importance of base flow for the exact prediction of detachment motion and to find the most suitable turbulence model for the simulation of launch vehicle configurations. And then, developed solver is applied to the simulation of KSR-III, a three-stage sounding rocket researched in Korea. From the analyses, after-body flow field strongly affects the separation motions of strap-on boosters. Negative pitching moment at initial stage is gradually recovered and a strap-on finally results in a safe separation, while fore-body analysis shows collision phenomena between core rocket and booster. And a slight variation of motion is observed from the comparison between inviscid and turbulent analyses. Change of separation trajectory based on viscous effects is just a few percent and therefore, inviscid analysis is sufficient for the simulation of separation motion if the study is focused only on the movement of strap-ons.

• Journal of the Korea institute for structural maintenance and inspection
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• v.16 no.6
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• pp.93-101
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• 2012

Bridge deck has a role in a comfortable and safe passage of vehicles. At the same time, it preserves upper structure against the abrasion and shearing due to impact of traffic loads in bridges or has a role to protect the plate from off adverse effect of climatic process as rain, chemicals. Currently, the total number of inspected bridges is 6,248 in the general national road and to maintain effectively, Introduction of GPR system mounted in the vehicle has been considered. In this research, the comparison and analysis of bridge deck condition on general national road has been performed with major variations of superstructure type, span lengths, located region and ages by using 'the current status of road bridge and tunnel' that is provided by MLTM(Ministry of Land, Transport and Maritime Affairs). As a result, Condition assessment grade, superstructure type, age and length were derived as a major factor to determine priority for the condition assessment.

• Clinical and Experimental Pediatrics
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• v.61 no.6
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• pp.194-199
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• 2018

Purpose: Sacral dimples are a common cutaneous anomaly in infants. Spine ultrasonography (USG) is an effective and safe screening tool for patients with a sacral dimple. The aim of this study was to determine the clinical manifestations in patients with an isolated sacral dimple and to review the management of spinal cord abnormalities identified with USG. Methods: We reviewed clinical records and collected data on admissions for a sacral dimple from March 2014 through February 2017 that were evaluated with spine USG by a pediatric radiologist. During the same period, patients who were admitted for other complaints, but were found to have a sacral dimple were also included. Results: This study included 230 infants under 6-months-old (130 males and 100 females; mean age $52.8{\pm}42.6days$). Thirty-one infants with a sacral dimple had an echogenic filum terminale, and 57 children had a filar cyst. Twenty-seven patients had a low-lying spinal cord, and only one patient was suspected of having a tethered cord. Follow-up spine USG was performed in 28 patients, which showed normalization or insignificant change. Conclusion: In this study, all but one infant with a sacral dimple had benign imaging findings. USG can be recommended in infants with a sacral dimple for its convenience and safety.

• Archives of Plastic Surgery
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• v.37 no.1
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• pp.46-51
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• 2010

Purpose: The loss of web space is caused by congenital syndactyly or acquired burn injury, trauma or surgery. Numerous surgical procedures have been described for restoration of the web space. Local flaps are usually preferred because of the easiness to perform and tolerable postoperative outcome. Among the various local flaps, the authors introduce V-M plasty for correction of web space contracture and syndactyly. Method: From March 2007 to Jun 2008, 4 patients underwent V-M plasty for correction of web space contracture and syndactyly. V-M plasty consists of 3 distinct triangular flaps. One triangular flap is designed next to the web region on the dorsal site of the hand, whereas the remaining 2 triangular flaps are placed on the volar site. The dorsal triangular flap is then placed between the volar adjacent triangular flaps. At the end of the operation, the involved fingers or toes are positioned in abduction to avoid kinking of the triangular flaps. Result: All the patients gained web functions with good esthetic appearance without any recurrence or complications. Mean follow-up was 8 months. Conclusion: V-M plasty is a safe, easy and rapid procedure to design and apply by using local tissues without the needs for a skin graft or risk of linear scarring and recurrence. The authors advise this versatile technique both in primary and recurrent cases of web space contracture and syndactyly.

• The Journal of Korean Physical Therapy
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• v.21 no.4
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• pp.65-71
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• 2009

Purpose: Transcranial direct current stimulation (tDCS) is a useful method for modulating the brain activity. This study compared the effect of continuous and interrupted tDCS using the change in the movement related cortical potential. Methods: Thirty healthy participants (male: 18 and female: 12) were assigned randomly to three groups; sham tDCS, continuous tDCS, which the current continuously flowed for 10 minutes, and interrupted tDCS, which the interrupted current flowed for 10 minutes (repetition: 4sec stimulation and 5sec rest) at an intensity of 1mA with anodal polarity. The effect of tDCS on the right primary motor area was measured from the movement related cortical potential (MRCP) before and after the experiment. MRCP consisted of the bereitshaftspotential (BP) and negative slope potential (NS) at Cz and C4. Results: Continuous and interrupted tDCS showed a significant difference in the changes in the BP, NS at Cz and C4 compared to the sham tDCS. However, there was no significant difference between the continuous tDCS and interrupted tDCS. Conclusion: The change in cortical activity by continuous and interrupted tDCS results from an improvement in the MRCP. An interrupted tDCS may be a safe and useful modality for stimulating the cortical region.

• Korean Journal of Veterinary Research
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• v.47 no.1
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• pp.117-125
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• 2007

Bone graft had been investigated previously to restore bone defects in orthopedics. The purpose of this study was to investigate the efficacy on new bone formation in bone autografts by treatment of implants. Cortical bone autografts were transplanted to midshaft of diaphyseal fibulae of 9 rabbits which were divided in 3 groups according to the treatment method of implants. Cortical bone implants for graft were treated with 3 different methods; freezing, freeze-drying, defat-freezing. Autografts were achieved by cross-transplantation method to bilateral fibulae of the presented rabbits after implant treatment procedures. The grafted regions of fibulae of all groups had been radiographed biweekly for 16 weeks to observe new bone formation and union between donor and recipient bone in the grafted region. Bone alkaline phosphatase (BALP) in all groups was evaluated biweekly till the end of the experiment to determine osteoblast activities. Unions of the experimental grafted regions were observed at 83% (5 of 6 cases) of freezing, 17% (1 of 6 cases) of freeze-drying and 67% (4 of 6 cases) of defat-freezing autografts, respectively. BALP was increased over 100% after 2 weeks of graft procedures in all union cases (all cases in freezing group and in defat-freezing group, and 1 of 3 in freeze-drying group, respectively), then gradually decreased from 4 th week of graft to 16 th week. In non-union cases, there is no significant variation in BALP value until the end of experiment. It is speculated that defat-freezing method of treatments of implants is more safe to preserve the osteogenic ability in autograft than freeze-drying method.

• Archives of Plastic Surgery
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• v.38 no.2
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• pp.182-188
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• 2011

Purpose: The buttocks region has been associated with allure and sex appeal for centuries. Gluteal implants enable buttocks remodeling in a way that is not possible in other methods. One of the reasons that render gluteal implant surgeries unpopular is the fear of complications, the main problems being seroma, wound dehiscence, extrusion, and a visible or palpable implant. The authors present the XYZ technique, which provides anatomical reference points to guide the intramuscular dissection procedure in a feasible and safe way, resulting in a lower complication rate. Methods: The XYZ procedure was done for buttock augmentation on 8 patients from December 2009 to June 2010. Patient's ages ranged from 27 to 44 with a mean age of 36. Seven patients were applied the 250cc sized Elastomer implants with one patient 290cc sized implant. Preoperative marking was done with the patients in the standing position. Bisection of the gluteus maximus muscle was done at the midpoint thickness to create a plane for implant insertion, which is called the sandwich plane. Results: The 8 cases were performed safely without major complications. However one patient had minor wound dehiscence, and was managed with conservative treatment. Another patient had a discomfort on the buttocks for a long time. The patients were followed up for average 6 months. All patients were satisfied with the aesthetic results. Conclusion: In performing the XYZ technique for gluteal augmentation, the surgeon must split the muscle into two equal halves with anatomical reference points to guide the muscle detachment in a symmetrical way at an adequate depth. This method provides a guideline for the surgeon in determining the ideal plane during intramuscular dissection and gives predictable results with low complication rates. Intramuscular gluteoplasty with gluteal implants offers predictable, aesthetically pleasing results without contour irregularities and only a low incidence of major complications.

• Proceedings of the Korea Water Resources Association Conference
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• 2004.05b
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• pp.134-147
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• 2004

Theses days, there are 3 prerequisites for dam building in Korea: First one is how to build the dam safe and stable from the technical points of view. Second one is how to design and construct the dam environmentally sound with the minimum change of the surrounding area of the dam site. Third one is how to activate the local economy of the surrounding area of the dam site in order to make the dam construction sustainable from the social and economical points of view. As far as technical aspects far dam building, there are hardly any problems in dam design and construction in our country. However, there are a little difficulty according to the location of the dam site. In order to fulfill the second option it is believed that a lot of effort should be made to accomplish the second task not only because that fairly large area shall be inundated with water after impounding but also because that ecological environments shall be changed due to change of water environment. Therefore, thoughtful investigation and assessment of the environmental features of the local regions have to be preceded before starting of the dam building. In order to overcome these difficulties Hantan river dam has been declared as an Eco-dam with 3 strategies and 9 activities plan at the design stage after sufficient consideration of the local identities of these region and coupled national plans for surrounding areas. Finally, Eco-tourism with the several coupled network-wise touristic courses, namely PERTH model, has been proposed after thorough analysis of the local identities by the Jahari window to make local economy being activated. Detailed descriptions for 3 strategies and 9 activities plan for declaration of Eco-dam and proposal of Eco-tourism with the network-wise touristic courses will be mentioned in the main content.