• 국제초고층학회논문집
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• 제1권4호
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• pp.255-269
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• 2012

Tall buildings' implementation has often lacked urban design and architectural guidance. There are many examples of tall buildings that have been inappropriately located, designed, and built, and consequently dissatisfaction with high-rise development is wide-spread. This paper attempts to provide extensive urban and architectural guidelines in order to manage cityscape and to ensure safe and healthy living. Through recommendations on design and layout of tall buildings and open spaces the guidelines seek enhancing the visual experience, improving the microclimate conditions, and fostering active social life. These guidelines help in providing enjoyable urban experiences through the examination of spatial relationships, human scale, genius loci, perceptual characteristics, local identity, built heritage, economic activities, and social life.

• 한국전기화학회:학술대회논문집
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• 한국전기화학회 2000년도 전지기술심포지움
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• pp.51-62
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• 2000

Large plastic Li-ion (PLI) cells (25 to 28-Ah) were fabricated for an EV application. The 28-Ah cells showed high specific energy (160 Wh/kg), high specific power (526 W/g), excellent round-trip energy efficiency $(92\%)$, and low self-discharge rate ($6\%$ in 30 days). A 25-Ah cell of an earlier design showed good cycle life of up to 750 cycles at $100\%$ DOD to $80\%$ of its initial capacity, while cycle life test of a 28-Ah cell of a later design is in progress. Preliminary safety tests were also carried out using 6-Ah cells of a similar electrode design giving very encouraging results for development of a safe hish-energy density PLI battery for EV application.

• 한국동물생명공학회지
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• 제35권1호
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• pp.28-34
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• 2020

Imazosulfuron is globally considered as a relatively safe herbicide that controls plant growth by interfering with amino acid synthesis. It is stable, persists in the soil, and has low toxicity; however, studies about the toxic effects of imazosulfuron on non-targeted aquatic vertebrates are scarce. In this study, imazosulfuron was able to induce acute lethality on zebrafish embryos within 48 h. Imazosulfuron also had adverse effects on heartbeats and induced abnormal development with pericardial edema and scoliosis. Moreover, apoptosis and oxidative stress were increased by imazosulfuron in a dose-dependent manner. Thus, all our results showed that imazosulfuron has toxic effects on zebrafish embryogenesis.

• Toxicological Research
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• 제30권4호
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• pp.291-296
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• 2014

Saururus chinensis has been reported to contain compounds such as lignans, alkaloids, diterpenes, flavonoids, tannins, steroids, and lipids. Fermentation is commonly used to break down certain undesirable compounds, to induce effective microbial conversion, and to improve the potential nutraceutical values. Previous studies have reported that the fermentation process could modify naturally occurring constituents, including isoflavons, saponins, phytosterols, and phenols, and could enhance biological activities, specifically antioxidant and antimicrobial properties. The probiotic strains used for fermentation exert beneficial effects and are safe. In this study, the antioxidative effects of the Bacillus subtilis fermentation of Saururus chinensis were investigated in a rat model with Triton WR-1339-induced hyperlipidemia by comparing the measured antioxidative biological parameters of fermented Saururus chinensis extract to those of nonfermented Saururus chinensis extract. Fermentation played a more excellent role than nonfermentation in ultimately protecting the body from oxidative stress in the liver of the experimental rats with Triton WR-1339-induced hyperlipidemia.

• 식품과학과 산업
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• 제51권3호
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• pp.185-195
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• 2018

Nutrition through food is a very important life support activity for humans in maintaining a healthy life. Nevertheless, there is no absolute safe food. In the Modern Food Law, risk analysis developed as an alternative to food safety. However, the Korean Food Sanitation Act introduced risk analysis, but many problems have arisen because the right risk concept is not reflected. To solve the problem, it is necessary to reflect the exact concept of the risk. According to our Food Sanitation Act, risks are used as risk, hazard, and harmful according to the context. The study pointed out these problems and suggested a variety of comparative legal and realistic alternatives.

• 식품과학과 산업
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• 제52권4호
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• pp.346-357
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• 2019

In recent years, starch nanoparticles (SNPs) have been received much attention due to their unique characteristics different from native starch. Also, SNPs have economic and environmental advantages because they are prepared from starch, a cheap and safe natural polymer. It can be used in various industrial applications such as food additives, drug carriers, etc. SNPs have been prepared using different methods and their physiochemical, functional properties and possible industrial applications have been reported. Based on these studies, SNPs are expected to be the promising food materials and expand their utilization in many industries in the future. This review covered the overall researches on SNPs, including preparation, physicochemical and functional properties, and discussed their current and future applications including resistant starch materials.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2001년도 춘계학술대회 논문집
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• pp.899-904
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• 2001

The impact of PVD coatings can be summed up in practical terms: this technology historically complements the best designed tool substrates to enhance cutting performance. PVD coatings are now incorporated in 25% of all HSS tools. The functionality is to extend the machining speed range, improve wear resistance at the cutting edge, and reduce friction at chip/tool contact areas to allow easier chip evacuation. These translate to a larger safe zone, as discussed in the failure mode diagram, for better productivity and higher reliability in machining operations of the customer. PVD coatings therefore represent an enabling technology that extends the application range of cutting tools in response to modern industrial needs. PVD coatings prolong the product life cycle of HSS tools and help this "mature" material to hold its territory against the advent of the newer hardmetal and ceramic tool materials. There is a lot of competitive life left particularly in PVD coated HSS endmills, drills, threading/tapping tools. PM HSS technology further increases the possibilities.ibilities.

• 한국약용작물학회지
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• 제23권3호
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• pp.245-252
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• 2015

This study was carried out to investigate the effects of Salvia plebeia R. Br. ethanolic extract with different aspects (stem/leaf and whole plant) on differentiation and lipid accumulation in 3T3-L1 preadipocytes. The morphological changes and the degrees of lipid accumulation in 3T3-L1 cells were measured by Oil Red O staining and intra-cellular triglyceride (TG) assay. The mRNA expressions of special peroxisome proliferation activated receptor- genes (PPAR), CCAAT/ enhancer-binding protein (C/$EBP{\alpha}$), fatty acid synthase (FAS) and lipoprotein lipase (LPL) were detected by reverse transcriptase polymerase chain reaction (RT-PCR). The 50% ethanolic extracts ($100{\mu}g/mL$) of stem and leaf (SALE) and 30% ethanolic extracts (100 g/mL) of whole plant (SAE) from Salvia plebeia R. Br. were significantly attenuated lipid accumulation during adipogenesis in 3T3-L1 cells. Ethyl acetate-soluble fractions ($50{\mu}g/mL$) significantly inhibited lipid droplet accumulation in 3T3-L1 cells. In addition, SALE induced down-regulation of specific adipogenic transcriptional factors (C/$EBP{\alpha}$ and $PPAR{\gamma}$) and target genes (FAS and LPL) during adipogenesis. Salvia plebeia R. Br. may be used as a safe and efficient natural substance to manage obesity.

• 한국식품과학회지
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• 제24권2호
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• pp.122-126
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• 1992

츄잉껌의 shelf-life 예측을 위하여 유통중인 제품과 동일한 시료를 조제하여 상대습도를 달리한 저장조건에서 포장된 츄잉껌의 수증기투과율, 흡탈습곡선의 온도의존성을 고찰하고 츄잉껌의 상품적 가치를 유지하는 수분함량 $2.17{\sim}3.16%(dry\;basis)$을 기준으로 품질수명을 예측하였다. 포장된 츄잉껌 1통 (7 sticks)의 수증기 투과율은 0.00045g water/pack day mmHg였으며 25, 30 및 $40^{\circ}C$에서 얻은 등온흡습곡선의 온도의존성은 Clausius-Clapeyron 식으로 표현될 수 있었다. 서울지역 기후변동에 따른 츄잉껌 1통의 수분변화량을 simulation 시켜 위험수분함량에 도달하는 품질수명을 예측한 결과 10, 11월에 생상된 제품의 품질수명은 7개월 정도로 가장 길었고 6, 7월에 생산된 제품은 평균 40일로 나타났으며 1년중 7월의 기후가 제품 보관에 가장 큰 영향을 주었다.

• Tissue Engineering and Regenerative Medicine
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• 제15권6호
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• pp.699-709
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• 2018

BACKGROUND: Diabetes mellitus is a major health concern in current scenario which has been found to affect people of almost all ages. The disease has huge impact on global health; therefore, alternate methods apart from insulin injection are being explored to cure diabetes. Therefore, this review mainly focuses on the current status and therapeutic potential of stem cells mainly mesenchymal stem cells (MSCs) for Type 1 diabetes mellitus in preclinical animal models as well as humans. METHODS: Current treatment for Type 1 diabetes mellitus mainly includes use of insulin which has its own limitations and also the underlying mechanism of diseases is still not explored. Therefore, alternate methods to cure diabetes are being explored. Stem cells are being investigated as an alternative therapy for treatment of various diseases including diabetes. Few preclinical studies have also been conducted using undifferentiated MSCs as well as in vitro MSCs differentiated into ${\beta}$ islet cells. RESULTS: These stem cell transplant studies have highlighted the benefits of MSCs, which have shown promising results. Few human trials using stem cells have also affirmed the potential of these cells in alleviating the symptoms. CONCLUSION: Stem cell transplantation may prove to be a safe and effective treatment for patients with Type 1 diabetes mellitus.