• 제목/요약/키워드: Saccharopolyspora sp. nov

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Potent in Vitro Anticancer Activity of Metacycloprodigiosin and Undecylprodigiosin from a Sponge-Derived Actinomycete Saccharopolyspora sp. nov.

  • Liu, Rui;Cui, Cheng-Bin;Duan, Lin;Gu, Qian-Qun;Zhu, Wei-Ming
    • Archives of Pharmacal Research
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    • 제28권12호
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    • pp.1341-1344
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    • 2005

  • Bioassay-guided fractionation of $CHCl_{3}$ extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs - metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL­7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.

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