• The Korean Journal of Physiology and Pharmacology
• /
• 제23권1호
• /
• pp.21-28
• /
• 2019

Swertiamarin (STM) is an iridoid compound that is present in the Gentianaceae swertia genus. Here we investigated antiapoptotic effects of STM on carbon tetrachloride ($CCl_4$)-induced liver injury and its possible mechanisms. Adult male Sprague Dawley rats were randomly divided into a control group, an STM 200 mg/kg group, a $CCl_4$ group, a $CCl_4+STM$ 100 mg/kg group, and a $CCl_4+STM$ 200 mg/kg group. Rats in experimental groups were subcutaneously injected with 40% $CCl_4$ twice weekly for 8 weeks. STM (100 and 200 mg/kg per day) was orally given to experimental rats by gavage for 8 consecutive weeks. Hepatocyte apoptosis was determined by TUNEL assay and the expression levels of Bcl-2, Bax, and cleaved caspase-3 proteins were evaluated by western blot analysis. The expression of $TGF-{\beta}1$, collagen I, collagen III, CTGF and fibronectin mRNA were estimated by qRT-PCR. The results showed that STM significantly reduced the number of TUNEL-positive cells compared with the $CCl_4$ group. The levels of Bax and cleaved caspase-3 proteins, and $TGF-{\beta}1$, collagen I, collagen III, CTGF, and fibronectin mRNA were significantly reduced by STM compared with the $CCl_4$ group. In addition, STM markedly abrogated the repression of Bcl-2 by $CCl_4$. STM also attenuated the activation of the PI3K/Akt pathway in the liver. These results suggested that STM ameliorated $CCl_4$-induced hepatocyte apoptosis in rats.

• Journal of the Korean Electrochemical Society
• /
• 제3권2호
• /
• pp.104-108
• /
• 2000

It is very important to know the real roughness of electrode surface in electrochemistry. But it is impossible to know absolute roughness of electrode surface for various reasons. In this work, we compared the roughnesses of polycrystalline gold electrode often used in electrochemistry calculated from the images of scanning tunneling microscopy (STM) and cyclic voltammetry with those of Au (111) and HOPG. The roughness of polycrystalline gold calculated from STM image was $1.1(\pm0.1)$, that from adsorption-desorption of oxygen was $2.4(\pm0.7)$ and that from adsorption of N-docosyl-N'-methyl viologen was $1.6(\pm0.1)$.

• Proceedings of the KIEE Conference
• /
• 대한전기학회 2006년도 제37회 하계학술대회 논문집 C
• /
• pp.1390-1391
• /
• 2006

본 연구에서는 전도성 분자로 잘 알려진 4,4-Di(ethynyl phenyl) -2'-nitro-1-(thioacetyl)-benzene(nitro - benzene) 분자를 Au (111) 표면에 자기조립하고, ultra high vacuum scanning tunneling microscopy (UHV-STM)을 사용하여 STM tip과 sample 사이의 거리를 변화시키면서 전기전도 특성을 측정하였다. Au 기판제작은 연증착시스템 (Thermal Evaporation System)으로 제작하였으며, piranha 용액 ($H_{2}SO_{4}\;:\;H_{2}O_{2}$=3:1)을 사용하여 전치리한 후, 자기조립 단분자막 (SAMs)을 형성하였다. 먼저 1-octanethiol을 ethanol solution용액 1 mM/L 농도에서 24시간 동안 자기조립한 후에, ethanol를 solution 용액으로 이용하여 nitro-benzene를 0.1 nM/L 농도로 암실에서 30분간 자기조립 하였다. 자기조림 후 solution을 제거하기 위해 에탄올로 세척하여 $N_2$로 건조시켰다. 이 조건하에서 UHV-STM을 사용하여 nitro-benzene SAMs의 실시간 모폴로지의 변화에 따른 nitro-benzene의 전기전도 특성을 STM tip - SAMs - Au 기판의 수직구조로 STM tip과 nitro-benzene의 거리를 변화시키면서, tunneling current을 조사하였다. 측정 결과 Z-position 변화에 대한 tunneling current와 resistance의 변화를 확인할 수 있었다.

• The Transactions of the Korean Institute of Electrical Engineers C
• /
• 제54권2호
• /
• pp.51-54
• /
• 2005

In this work, the attempt has been made to investigate the morphology of self-assembled dipyridinium dithioacetate on Au(111) substrate by Scanning Tunneling Microscopy(STM). Also, we measured electrical properties(I-V) using Scanning Tunneling Spectroscopy(STS). Sample used in this experiment is dipyridinium dithioacetate, which contains thiol functional group, this structure that can be self-assembled easily to Au(111) substrate. The self-assembly procedure was used for two different concentrations, 0.5 mM/ml and 1 mM/ml. Dilute density of sample by 0.5 mM/ml, 1 mM/ml and observed dipyridinium dithioacetate's image by STM after self-assembled on Au(111) substrate. The structure of STM tip-SAMs-Au(111) substrate has been used measurement for electrical properties(I-V) using STS. The current-voltage(I-V) measurement result, observed negative differential resistance(NDR) properties.

• Bulletin of the Korean Chemical Society
• /
• 제32권1호
• /
• pp.281-285
• /
• 2011

We investigated the effects of tunneling current on scanning tunneling microscopy (STM) images of 1-octanethiol (OT) and 1-decanethiol (DT) self-assembled monolayers (SAMs). At a low tunneling current, the domain boundaries and ordered alkanethiol molecules were clearly resolved. As the tunneling current was increased at a constant bias voltage, however, the STM images showed disordered structures of the OT and DT SAMs. As the tunneling current was reduced back to low values, the ordered structures of the alkanethiol molecules reappeared. The reversibility of the process suggests that the sulfur head groups did not rearrange under any of the tunneling current conditions. On the basis of our observations, which are inconsistent with the standard model for STM imaging of molecules on metal surfaces, we consider the STM imaging mechanism in terms of a two-region tunneling junction model.

• Bulletin of the Korean Chemical Society
• /
• 제28권1호
• /
• pp.81-84
• /
• 2007

Ab initio periodic Hartree-Fock calculations with the full potential and minimum basis set are applied to interpretation of scanning tunneling microscope (STM) and atomic force microscope (AFM) images on 1TVTe2. Our results show that the simulated STM image shows asymmetry while the simulated AFM image shows the circular electron densities at the bright spots without asymmetry of electron density to agree with the experimental AFM image. The bright spots of both the STM and AFM images of VTe2 are associated with the surface Te atoms, while the patterns of bright spots of STM and AFM images are different.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
• /
• 한국전기전자재료학회 2004년도 추계학술대회 논문집 Vol.17
• /
• pp.485-488
• /
• 2004

본 연구에서는 dipyridinium dithioacetate 분자를 Au(111) 표면에 자기조립하여 STM 탐침-유기 단분자막-Au(111)기판의 수직구조로 STM 측정시스템을 이용하여, 전기적 특성을 관찰하였다. 먼저 Au(111)기판을 Piranha용액$(H_2SO_4:H_2O_2=3:1)$으로 Au 표면을 전처리 하였다. 전처리한 Au(111) 기판을 dipyridinium dithioacetate 1mol/ml 농도로 자기조립 하였으며, 자기조립막의 표면 구조를 STM으로 관찰하였다. dipyridinium dithioacetate의 전기적 특성은 STM 탐침-유기단분자막-Au(111) 기판의 수직구조로 STS를 이용하여 조사하였다. 전압과 전류 측정에서 전압이 증가함에 따라 전류가 감소하는 부성 미분저항(NDR)의 특성이 관찰 되었다. NDR 수치가 $-545\;[m\Omega/cm^2]$였고, PVCR은 1.64:1 이었다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
• /
• 한국정보통신학회 2018년도 추계학술대회
• /
• pp.461-463
• /
• 2018

In this paper, we have studied the devices needed for long distance wireless transmission of SDH network. This devices propose wireless transmission and measurement method of STM-1(basic transmission unit of SDH method) signal and 200Mbps synchronous ethernet. The synchronous clock recovery function is provided for STM-N transmission and synchronous ethernet transmission, and spare clock switching function is designed for stable synchronization. In addition, we discussed the measurement method of STM-N and synchronous Etherent communication method in wireless transmission section.

• Journal of Microbiology and Biotechnology
• /
• 제28권11호
• /
• pp.1896-1907
• /
• 2018

Salmonellosis is commonly associated with meat and poultry products, but an increasing number of Salmonella outbreaks have been attributed to contaminated vegetables and fruits. Enteric pathogens including Salmonella enterica spp. can colonize diverse produce and persist for a long time. Considering that fresh vegetables and fruits are usually consumed raw without heat treatments, Salmonella contamination may subsequently lead to serious human infections. In order to understand the underlying mechanism of Salmonella adaptation to produce, we investigated the transcriptomics of Salmonella in contact with green vegetables, namely cabbage and napa cabbage. Interestingly, Salmonella pathogenicity island (SPI)-1 genes, which are required for Salmonella invasion into host cells, were up-regulated upon contact with vegetables, suggesting that SPI-1 may be implicated in Salmonella colonization of plant tissues as well as animal tissues. Furthermore, Salmonella transcriptomic profiling revealed several genetic loci that showed significant changes in their expression in response to vegetables and were associated with bacterial adaptation to unfavorable niches, including STM14_0818 and STM14_0817 (speF/potE), STM14_0880 (nadA), STM14_1894 to STM14_1892 (fdnGHI), STM14_2006 (ogt), STM14_2269, and STM14_2513 to STM14_2523 (cbi operon). Here, we show that nadA was required for bacterial growth under nutrient-restricted conditions, while the other genes were required for bacterial invasion into host cells. The transcriptomes of Salmonella in contact with cabbage and napa cabbage provided insights into the comprehensive bacterial transcriptional response to produce and also suggested diverse virulence determinants relevant to Salmonella survival and adaptation.

• Journal of the Institute of Electronics Engineers of Korea TC
• /
• 제40권10호
• /
• pp.110-118
• /
• 2003

The paper describes a design process of the connection control function that performs overall procedures of optical network control system in the Next Generation - Synchronous Digital Hierarchy (NG-SDH) based transport system. Here, the NG-SDH means a new SDH technology that could perform automatic connection control with a granularity of VC-3 (about 50M) or VC-4 (about 150M) according to the increase and decrease of traffic, which is different from the existing technology that could perform connection control only with a granularity of a physical SDH link (STM-l, STM-4, STM-16, STM-64, STM-256 etc). The NG-SDH based connection control allows an ingress NG-SDH node to control the appropriate connection establishment process according to connection types such as Permanent Connection (PC), Soft Permanent Connection (SPC), Switched Connection (SC) over various SDH and Ethernet line cards.