• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2002년도 하계학술대회 논문집
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• pp.314-317
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• 2002

Since the early work of Tersoff and Hamann on the theory of the scanning tunneling microscope (STM), many theoretical approaches have been developed in order to gain further physical insight into the real space image that this technique provides. In this Paper, the STM image of Carbon nanotubes (CNT's) was calculated through the theoretical study. The optimized structure of CNT's was simulated using Brenner's hydrocarbon potential. The structure of simulation is (5. 5) armchair CNT and (10. 0) zigzag CNT. Also we have used that the extended Huckel tight binding (EHTB) theory already provides a fairly good qualitative description of the main processes that control the final contrast in the STM image. we found that the shape of the calculated images is hardly dependent on the exact electronic charge distribution at the surface. The STM images are not too sensitive to the precise electronic structure but, rather, they reflect its qualitative features. As a result of the simulation, The STM images of CNT's and the electronic density distribution were investigated. It found that the EHTB theory is appropriate for STM image calculation and that the STM images are in agreement with the result of Experiment.

• The Korean Journal of Physiology and Pharmacology
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• 제23권1호
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• pp.21-28
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• 2019

Swertiamarin (STM) is an iridoid compound that is present in the Gentianaceae swertia genus. Here we investigated antiapoptotic effects of STM on carbon tetrachloride ($CCl_4$)-induced liver injury and its possible mechanisms. Adult male Sprague Dawley rats were randomly divided into a control group, an STM 200 mg/kg group, a $CCl_4$ group, a $CCl_4+STM$ 100 mg/kg group, and a $CCl_4+STM$ 200 mg/kg group. Rats in experimental groups were subcutaneously injected with 40% $CCl_4$ twice weekly for 8 weeks. STM (100 and 200 mg/kg per day) was orally given to experimental rats by gavage for 8 consecutive weeks. Hepatocyte apoptosis was determined by TUNEL assay and the expression levels of Bcl-2, Bax, and cleaved caspase-3 proteins were evaluated by western blot analysis. The expression of $TGF-{\beta}1$, collagen I, collagen III, CTGF and fibronectin mRNA were estimated by qRT-PCR. The results showed that STM significantly reduced the number of TUNEL-positive cells compared with the $CCl_4$ group. The levels of Bax and cleaved caspase-3 proteins, and $TGF-{\beta}1$, collagen I, collagen III, CTGF, and fibronectin mRNA were significantly reduced by STM compared with the $CCl_4$ group. In addition, STM markedly abrogated the repression of Bcl-2 by $CCl_4$. STM also attenuated the activation of the PI3K/Akt pathway in the liver. These results suggested that STM ameliorated $CCl_4$-induced hepatocyte apoptosis in rats.

• 한국결정학회:학술대회논문집
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• 한국결정학회 2002년도 정기총회 및 추계학술연구발표회
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• pp.7-7
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• 2002

실공간 (real space)에서 원자분해능을 보여주는 STM의 작동원리를 핵심사항을 중심으로 설명하며 또한 실제 제작 시 고려해야 하는 사항들을 구체적으로 검토한다. 반도체의 경우 전자들이 원자부근에서 국소화가 잘 되므로 STM으로 표면의 원자상을 얻기가 비교적 쉽다. 특히 실리콘은 그 물질의 중요성과 결부되어 STM으로 많이 연구되어 왔으며 다른 방법으로는 알 수 없는 독특한 결과들을 보여주었다. STM의 응용사례로써 오랫동안 수수께끼였던 Si(001) 표면에서 생기는 점결함(point defect)과 계단 (step)부근의 원자구조 및 최근의 몇 가지 연구결과에 대한 기본적인 결과들을 소개한다.

• 한국항공우주학회지
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• 제33권11호
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• pp.95-105
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• 2005

우주시스템연구실에서는 2008년 발사 예정으로 나노위성인 HAUSAT-2를 개발하고 있다. HAUSAT-2 구조-열 모델(STM)은 구조 및 열적 설계마진을 검증하기 위하여 개발한 시스템 모델이다. HAUSAT-2의 구조-열 모델을 이용하여 인증 수준의 진동시험과 열진공/평형시험을 수행하였다. 본 논문에서는 구조-열 모델의 구조해석과 진동시험의 결과를 비교하였고 이를 통해 해석조건을 변경해 재해석을 수행하였다. 인증수준의 진동시험 결과 구조-열 모델은 구조적인 손상 없이 설계 강성 요구조건을 만족하는 것을 확인하였다. 또한 구조 조립을 통해 조립성과 인터페이스를 확인하였다.

• 대한전자공학회논문지TC
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• 제40권10호
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• pp.110-118
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• 2003

본 논문에서는 NG-SDH(Next Generation - Synchronous Digital Hierarchy) 기반 전송 시스템(이하 NG-SDH 시스템)에서 광네트워크 제어방식의 전반적인 절차를 수행하는 연결제어 기능에 대한 설계과정을 기술한다. 여기서 NG-SDH는 물리적인 SDH 링크 단위(STM-1, STM-4, STM-16, STM-64, STM-256 등)로만 연결제어가 가능한 기존의 기술과는 달리 트래픽량의 증감에 따라 VC-3(약 50M) 및 VC-4(약 150M) 단위의 SDH 타임슬롯을 자동으로 연결제어를 수행할 수 있는 차세대 SDH 기술을 의미한다. 이러한 NG-SDH 기반 연결제어 기능을 통해 인그레스 NG-SDH 시스템에서 다양한 SDH 및 이더넷 라인카드들의 트래픽을 프로비젼형(PC, Permanent Connection), 반교환형(SPC, Soft Permanent Connection), 그리고 교환형(SC, Switched Connection) 연결 유형에 따라 적절한 연결 설정이 이루어진다.

• 한국콘텐츠학회논문지
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• 제10권9호
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• pp.201-211
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• 2010

본 연구의 목적은 정보 디자인 유형 중에서 상대적으로 "노출 시간이 짧지만 정보 전달력이 강한 정보" 즉, STM 정보(Short-term Memorable Information)” 에 대한 사용자의 인지력을 높이기 위한 방법을 모색하는 것이다. 연구를 통해 STM 정보의 디자인 속성을 고찰하고 거시적 관점에서 디자인적 표현 방법을 다음과 같이 제안하였다. STM 정보는 기능변수의 조작, 방법, 사건, 사용 예라는 네 가지 시각화 속성을 기준으로 시각적 재현 측면에서 '이해도(Understandable)', '접근성(Accessibility)' 속성이 충족되어야 한다. 또한 사용자 조작 측면에서는 '무오류(Errorless)', '적정성(Timeliness)' 속성이 충족되어야 한다. 각 측면에서의 거시적 표현 방법으로써, 시각적 재현 측면에서 "속성이론", "인식모형", "정보 주도성(Proactivity)의 최대화", "잉여 정보의 최소화", "이중부호의 사용"을 제안했으며, 사용자 조작측면에서 "맥락효과", 일차적 독특성을 중심으로 한 "기억부호화", "정보 주사(Scanning)"의 두 가지 방법을 제안했다. 사용자 설문 인터뷰를 통해서 앞서 제안한 8가지 표현 방법의 효율성에 관한 확증 및 STM 정보에 대한 사용자 인지패턴을 발견하였다. 본 연구에서의 주요 발견점을 토대로 향후에는 노출시간별 효과적인 정보 표현 및 그에 따른 응용 방법에 관한 연구가 진행될 필요가 있다.

• 동의생리병리학회지
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• 제35권6호
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• pp.235-241
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• 2021

Sogunjung-tang (SGJT) is traditional herbal prescriptions used to treat abdominal pain. In this study, we evaluated the effect on inflammation and gastritis through SGJT formulation development. SGJT composition herbal medicine was boiled in water at 95~100℃ for 3 hours and then concentrated. Sogunjung-tang mix soft extract (STM) was prepared using pharmaceutical excipients such as purified water, sodium benzoate, β-cyclodextrin and CMC-Na. Anti-inflammatory experiment was conducted using STM and lipopolysaccharide (LPS) in RAW 264.7 cells. Cell survival was measured by MTT method. Nitric oxide (NO) was measured using griess reagents, and pro inflammatory cytokines were measured by enzyme-linked immunosorbent assay and RT-PCR. Also, we verified STM validity in acute gastritis using the ICR mouse. STM was administered oral for three days. And 150 mM HCl in 60% ethanol was oral administered 0.5 mL one hour after the last drug administration. Mice were sacrificed 1 hour after 150 mM HCl in 60% ethanol administration. The gastric mucosa was visually observed. STM were not toxic in RAW 264.7 cells. Treatment of STM inhibited the production of NO and inflammatory cytokine at the protein and mRNA levels. Also, in the acute gastritis model with the mouse, the treatment of STM improved gastric mucosal bleeding and edema. In summary, it was confirmed that the treatment of STM exerts anti-inflammatory and anti-gastritis effects. Therefore, we suggest that STM may provide a preclinical evidence for the prevention and treatment of inflammatory and gastritis diseases.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제54권2호
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• pp.51-54
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• 2005

In this work, the attempt has been made to investigate the morphology of self-assembled dipyridinium dithioacetate on Au(111) substrate by Scanning Tunneling Microscopy(STM). Also, we measured electrical properties(I-V) using Scanning Tunneling Spectroscopy(STS). Sample used in this experiment is dipyridinium dithioacetate, which contains thiol functional group, this structure that can be self-assembled easily to Au(111) substrate. The self-assembly procedure was used for two different concentrations, 0.5 mM/ml and 1 mM/ml. Dilute density of sample by 0.5 mM/ml, 1 mM/ml and observed dipyridinium dithioacetate's image by STM after self-assembled on Au(111) substrate. The structure of STM tip-SAMs-Au(111) substrate has been used measurement for electrical properties(I-V) using STS. The current-voltage(I-V) measurement result, observed negative differential resistance(NDR) properties.

• Journal of Microbiology and Biotechnology
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• 제28권11호
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• pp.1896-1907
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• 2018

Salmonellosis is commonly associated with meat and poultry products, but an increasing number of Salmonella outbreaks have been attributed to contaminated vegetables and fruits. Enteric pathogens including Salmonella enterica spp. can colonize diverse produce and persist for a long time. Considering that fresh vegetables and fruits are usually consumed raw without heat treatments, Salmonella contamination may subsequently lead to serious human infections. In order to understand the underlying mechanism of Salmonella adaptation to produce, we investigated the transcriptomics of Salmonella in contact with green vegetables, namely cabbage and napa cabbage. Interestingly, Salmonella pathogenicity island (SPI)-1 genes, which are required for Salmonella invasion into host cells, were up-regulated upon contact with vegetables, suggesting that SPI-1 may be implicated in Salmonella colonization of plant tissues as well as animal tissues. Furthermore, Salmonella transcriptomic profiling revealed several genetic loci that showed significant changes in their expression in response to vegetables and were associated with bacterial adaptation to unfavorable niches, including STM14_0818 and STM14_0817 (speF/potE), STM14_0880 (nadA), STM14_1894 to STM14_1892 (fdnGHI), STM14_2006 (ogt), STM14_2269, and STM14_2513 to STM14_2523 (cbi operon). Here, we show that nadA was required for bacterial growth under nutrient-restricted conditions, while the other genes were required for bacterial invasion into host cells. The transcriptomes of Salmonella in contact with cabbage and napa cabbage provided insights into the comprehensive bacterial transcriptional response to produce and also suggested diverse virulence determinants relevant to Salmonella survival and adaptation.

• 전기화학회지
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• 제3권2호
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• pp.104-108
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• 2000

전기화학에 있어서 전극 물질의 실제 거칠기(real roughness)를 아는 것은 매우 중요하다. 그러나 여러 가지 이유 때문에 전극 물질의 절대적인 거칠기를 아는 것은 불가능하다. 여기에서는 scanning tunneling microscopy (STM), 순환전압전류법을 이용하여 전기화학에서 자주 사용하는 다결정 금 전극의 거칠기를 구하여 Au(111), HOPG로부터 구한 거칠기와 비교해 보았다. STM으로부터 얻은 다결정 금전극의 거칠기는 $1.1(\pm0.1)$,산소의 탈착으로부터는 $2.4(\pm0.7)$, N-docosyl-N'-methyl viologen의 흡착으로부터 는 $1.6(\pm0.1)$이 얻어졌다.