• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.35 no.4
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• pp.347-352
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• 2007

This paper describes the design and implementation of PFM(Proto Flight Model, PFM) of DRE(Data Receiving Equipment, DRE) for Science and Technology Satellite 2(STSAT-2) and the results of integration performance test. DRE components are X-band receiver, DCE(Data Combine Equipment, DCE) and RAC(Receiving and Archiving Computer, RAC). DCE consists of I&Q data combiner and ECL signal distributor. RAC consists of DRC(Data Receiving Card) and ST2RAS(STSAT-2 Receiving and Archinving Software). X-band receiver receives 10Mbps QPSK I, Q satellite data and sends the data to DCE. DRC stores the I&Q combine data from DCE to RAID. The pre-processing program sorts and stores to satellite status data and payload data. The performance of DRE in the functional and space environments test satisfies the requirements of STSAT-2.

• Korean Circulation Journal
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• v.52 no.10
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• pp.737-754
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• 2022

Ischemic and reperfusion injuries of the heart underlie the pathogenesis of acute myocardial infarction (AMI) and sudden cardiac death. The mortality rate is still high and is 5-7% in patients with ST-segment elevation myocardial infarction. The review is devoted to pharmacological approaches to limitation of ischemic and reperfusion injuries of the heart. The article analyzes experimental evidence and the clinical data on the effects of P2Y₁₂ receptor antagonists on the heart's tolerance to ischemia/reperfusion in animals with coronary artery occlusion and reperfusion and also in patients with AMI. Chronic administration of ticagrelor prevented adverse remodeling of the heart. There is evidence that sphingosine-1-phosphate is the molecule that mediates the infarct-reducing effect of P2Y₁₂ receptor antagonists. It was discussed a role of adenosine in the cardioprotective effect of ticagrelor.

• Journal of Medicine and Life Science
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• v.21 no.3
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• pp.62-71
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• 2024

The incidence of diabetes is continuously increasing worldwide, resulting in a considerable socioeconomic burden. Glycemic control using traditional diabetes medications prevents microvascular complications; however, there is no objective evidence that it prevents macrovascular complications. In the 21st century, concerns have arisen that strict glycemic control and the diabetes drug rosiglitazone might increase mortality. This led the United States Food and Drug Administration to establish guidelines that require that cardiovascular outcome trials (CVOTs) with 3-point major adverse cardiovascular events (3-P MACE) as the primary endpoints be performed for new diabetes drugs. Since then, 20 CVOTs have been reported. Dipeptidyl peptidase 4 inhibitors do not increase the incidence of cardiovascular disease; however, saxagliptin increases the risk of heart failure. Sodium-glucose cotransporter inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonists (GLP-1RAs) not only have proven cardiovascular safety but also have shown results beyond expectations by reducing the incidence of cardiovascular diseases. Additionally, SGLT2is have been reported to markedly prevent heart failure and kidney disease. The reduction in 3-P MACE by GLP-1RAs was observed only with long-acting agents; long-acting GLP-1RAs also markedly reduced renal endpoints. However, no preventive effect against heart failure was observed with GLP-1RAs. The preventive effects of both drug types against cardiovascular and kidney diseases appear to be independent of glycemic control. In conclusion, based on CVOT results, it is necessary to actively prescribe SGLT2is and GLP-1RAs to prevent cardiovascular disease in patients with diabetes, regardless of glycemic control.

• Journal of Environmental Science International
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• v.17 no.11
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• pp.1295-1305
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• 2008

This study aims at the analyze of unsteady downstream flow due to dam failure along dam failure scenario and applied to Yeoncheon Dam which was collapsed August 1st 1999, using HEC-RAS simulation model. The boundary conditions of this unsteady flow simulation are that dam failure arrival time could be at 02:45 a.m. August 1st 1999 and failure duration time could be also 30 minutes. Downstream 19.5 km from dam site was simulated for unsteady flow analysis in terms of dam failure and non-failure cases. For the parameter calibration, observed data of Jeonkok station were used and roughness coefficient was applied to simulation model. The result of the peak discharge difference was 2,696 to $1,745\;m^3/sec$ along the downstream between dam failure and non-failure and also peak elevation of water level showed meanly 0.6m difference. Those results of these studies show that dam failure scenarios for the unknown failure time and duration were rational because most results were coincident with observed records. And also those results and procedure could suggest how and when dam failure occurs and downstream unsteady flow analyzes.

• Journal of Industrial Technology
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• v.22 no.A
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• pp.219-228
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• 2002

The divided channel is not often used on the river and when the installation is for the controlling of the flow quantity. The determination of the channel size is not a easy task. Model tests are examined to confirm the variation of distribution rate by the method of the channel installation and the position of the structure and the adjustment of numerical simulation is executed by the comparing of the results. This study is to execute numerical model according to installation of divided channel by using AQUADYN program, the 2nd dimension numerical model, and HEC-RAS program, the 1st dimension numerical model, by the shape of divided channel. Also, it compares with difference by method about each case.

• Tuberculosis and Respiratory Diseases
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• v.44 no.1
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• pp.124-135
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• 1997

Background : Diffuse panbronchiolitis(DPB) is a disease characterized clinically by chronic cough, expectoration and dyspnea; and histologically by chronic inflammation localized mainly in the region of the respiratory bronchiole. It is prevalent in Japanese, but is known to be rare in Americans and Europians. Only a few cases in Chinese, Italians, North Americans and Koreans have been reported. It is diagnosed by characteristic clinical, radiological and pathologic features. High-resolution CT(HRCT) is known to be valuable in the study of the disease process and response to therapy in DPB. To our knowledge, there has been no correlation of its appearance on HRCT with the severity of the disease process, and radioaerosol scan(RAS) of the lung has not previously been used for the diagnosis of DPB. Method : During recent two years we have found 12 cases of DPB in Kangnam St. Mary's Hospital, Catholic University Medical College. We analysed the clinical characteristics, compared HRCT classifications with clinical stages of DPB, and determined characteristic RAS manifestations of DPB. Results : 1. The ages ranged from 31 to 83 years old(mean 54.5 years old), and male female ratio was 4:8. 75%(9/12) of patients had paranasal sinusitis, and only one patient was a smoker. 2. The patients were assigned to one of three clinical stages of DPB on the basis of clinical findings, sputum bacterology and arterial blood gas analysis. of 12 cases, 5 were in the first stage, 4 were in the second stage, and 3 were in the third stage. In most of the patients, pulmonary function tests showed marked obstructive and slight restrictive impairments. Sputum culture yielded P.aeruginosa in 3 cases of our 12 cases, K.pneumoniae in 2 cases, H.influenzae in 2 cases, and S.aureus in 2 cases. 3. Of 12 patients, none had stage I characteristics as classified on HRCT scans, 4 had slage II findings, 5 had stage III findings, and 3 had stage IV characteristics. 4. We peformed RAS in 7 of 12 patients With DPB. In 71.4% (5/7) of the patients, RAS showed mottled aerosol deposits characteristically in the transitional and intermediary airways with peripheral airspace defects, which contrasted sharply with central aerosol deposition of COPD. 5. There were significant correlations between HRCT stages and clinical stages(r= 0.614, P < 0.05), between HRCT types and Pa02(r= -0.614, P < 0.05), and between HRCT types and ESR(r= 0.618, P < 0.01). Conclusion : The HRCT classifications correspond well to the clinical stage. Therfore in the examination of patients with DPB, HRCT is useful in the evaluation of both the location and severity of the lesions. Also, RAS apears to be a convenient, noninvasive and useful diagnostic method of DPB.

• Proceedings of the Korea Water Resources Association Conference
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• 2006.05a
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• pp.467-471
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• 2006

At the current of the time, the ecologic stream is the most important concern of all the country. Daejeon metropolitan city performing the plan to secure the Daejeon cheon (stream) instream water as the 1st stage of the ecologic stream development plan for the Daejeon 3 main stream. During the performing the plan to secure the Daejeon cheon (stream) instream water, the water sources are decided to supply from Yudeng cheon and Daecheong Dam by the various water sources evaluation. For the investigation of flow and quality of instream water, I applicate the HEC-RAS and QUAL2EU. Instream water is proposed as the $10{\sim}30cm$ water depth and 2 degree water quality (lower the BOD 2.0 ppm) by the report of city. It is reasonable to the water depth objective, but the water quality objective is not reasonable because of the seasonal quality changes of supplied water. I suggest that the basin management plan include the non-point source elimination must comprised to the Daejeon ecologic stream project.

• Journal of Life Science
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• v.20 no.7
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• pp.1054-1065
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• 2010

SH21B is a natural composition composed of seven herbs: Scutellaria baicalensis Georgi, Prunus armeniaca Maxim, Ephedra sinica Stapf, Acorus gramineus Soland, Typha orientalis Presl, Polygala tenuifolia Willd and Nelumbo nucifera Gaertner (Ratio 3:3:3:3:3:2:2). In our previous study, we reported that SH21B inhibited adipogenesis and fat accumulation in 3T3-L1 cells through modulation of various regulators in the adipogenesis pathway. The aim of this study was to analyze the transcriptome profiles for the anti-adipogenic effects of SH21B in 3T3-L1 cells. Total RNAs from SH21B-treated 3T3-L1 cells were reverse-transcribed into cDNAs and hybridized to Affymetrix Mouse Gene 1.0 ST array. From microarray analyses, we identified 2,568 genes of which expressions were changed more than two-fold by SH21B, and the clustering analyses of these genes resulted in 9 clusters. Three clusters among the 9 showed down-regulation by SH21B (cluster 4, cluster 6 and cluster 9), and two clusters showed up-regulation by SH21B (cluster 7 and cluster 8) during the adipogenesis of 3T3-L1 cells. It was found that many genes related to cell proliferation and adipogenesis were included in these clusters. Clusters 4, 6 and 9 included genes which were related with adipogenesis induction and cell cycle arrest. Clusters 7 and 8 included genes related to cell proliferation as well as adipogenesis inhibition. These results suggest that the mechanisms of the anti-adipogenic effects of SH21B may be the modulation of genes involved in cell proliferation and adipogenesis.