• BMB Reports
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• 제38권5호
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• pp.517-525
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• 2005

Solid phase peptide synthesis method, which was introduced by Merrifield in 1963, has spawned the concept of combinatorial chemistry. In this review, we summarize the present technologies of solid phase peptide synthesis (SPPS) that are related to combinatorial chemistry. The conventional methods of peptide library synthesis on polymer support are parallel synthesis, split and mix synthesis and reagent mixture synthesis. Combining surface chemistry with the recent technology of microelectronic semiconductor fabrication system, the peptide microarray synthesis methods on a planar solid support are developed, which leads to spatially addressable peptide library. There are two kinds of peptide microarray synthesis methodologies: pre-synthesized peptide immobilization onto a glass or membrane substrate and in situ peptide synthesis by a photolithography or the SPOT method. This review also discusses the application of peptide libraries for high-throughput bioassays, for example, peptide ligand screening for antibody or cell signaling, enzyme substrate and inhibitor screening as well as other applications.

• Archives of Pharmacal Research
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• 제28권7호
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• pp.756-760
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• 2005

Polyene macrolide amphotericin B (AmB) is the drug of choice for the treatment of disseminated fungal infections. However, because of its pronounced side effects, the drug has limited applicability. There are few interesting reports, which state that co-administration of the drug with homo-peptide of polyaspartic acid reduces the side effects of the drug. In our present study, an approach has been made to systematically synthesize low molecular weight heteropeptides consisting of L-aspartic acid and its derivative. It was hypothesized that such heteropeptides will reduce the toxic side effects of the drug by facile hydrophobic binding between the polymer and the drug. We have employed the strategy of solid phase peptide synthesis (SPPS) to synthesize low molecular weight hetero-peptides by using L-aspartic acid and benzyl-L-aspartic acid to induce the hydrophobic binding between the peptide and the drug. In future, the proposed methodology can be employed to tailor other polypeptides substituted with benzyl groups to reduce the nephrotoxicity of AmB.

• Journal of the Optical Society of Korea
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• 제15권1호
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• pp.82-89
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• 2011

In this paper, we numerically study both band-pass and band-stop plasmonic filters based on Metal-Insulator-Metal (MIM) waveguides and circular ring resonators. The band-pass filter consists of two MIM waveguides coupled to each other by a circular ring resonator. The band-stop filter is made up of an MIM waveguide coupled laterally to a circular ring resonator. The propagating modes of Surface Plasmon Polaritons (SPPs) are studied in these structures. By substituting a portion of the ring core with air, while the outer dimensions of the ring resonator are kept constant, we illustrate the possibility of red-shift in resonant wavelengths in order to tune the resonance modes of the proposed filters. This feature is useful for integrated circuits in which we have limitations on the outer dimensions of the filter structure and it is not possible to enlarge the dimension of the ring resonator to reach to longer resonant wavelengths. The results are obtained by a 2D finite-difference time-domain (FDTD) method. The introduced structures have potential applications in plasmonic integrated circuits and can be simply fabricated.

• 열처리공학회지
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• 제35권4호
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• pp.193-202
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• 2022

Manholes and underground spaces are installed to manage the buried heat transport pipes of the district heating system, and the corrosion damage of the equipment placed in this space often occurs. The purpose of this work is to identify locations with a high risk of corrosion damage in the air vent and to establish preventive measures based on precise analysis via sampling of heat transport pipes and air vents that have been used for about 30 years. The residual thickness of the air vent decreased significantly by reaching ~1.1 mm in thickness, and locations of 60~70 mm away from a transport pipe were the most vulnerable to corrosion. The energy dispersive X-ray spectroscopy (EDS) analysis was performed in the corroded oxides, and it was found that chloride ion was contained in the corrosion products. Anodic polarization tests were carried out on the air vent materials (SPPS250, SS304) with varying the amounts of chloride ions at two different temperatures (RT, 80℃). The higher concentration of chloride ions and temperature are, the lower corrosion resistances of both alloys are.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2023년도 학술발표회
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• pp.176-176
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• 2023

The Tonle Sap is the richest and diverseness of freshwater ecosystem in Southeast Asia, receiving nurturing water flows from the Mekong and its immediate basin. In addition, the rapid development in the Tonle Sap Lake (TSL) Basin, and flood inundation may threaten the natural diversities and characteristics. The impacts of flood inundation in 11 sub-basins contributing to the Tonle Sap Lake were assessed using the Rainfall-Runoff-Inundation (RRI) model to quantify the potential magnitude and extent of the flooding. The RRI model is set up by using gauged rainfall data to simulate the information of river discharge and flood inundation of huge possible flood events. Moreover, two satellite precipitation products (SPPs), CHIRPS and GSMaP, within respectively spatial resolutions of 0.05° and 0.1°, are utilized as an input for the RRI model to simulate river discharge, flood depth, and flood extent for the great TSL Basin of Cambodia. This study used statistical indicators such as NSE, PBIAS, RSR, and R2 as crucial indices to evaluate the performance of the RRI model. Therefore, the findings of this study could provide promising guidance in hydrological modeling and the significant implications for flood risk management and disaster preparedness in the region.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2022년도 학술발표회
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• pp.143-143
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• 2022

Precipitation plays an essential role in water resources management and disaster prevention. Therefore, the understanding related to spatiotemporal characteristics of rainfall is necessary. Nowadays, highly accurate precipitation is mainly obtained from gauge observation systems. However, the density of gauge stations is a sparse and uneven distribution in mountainous areas. With the proliferation of technology, satellite-based precipitation sources are becoming increasingly common and can provide rainfall information in regions with complex topography. Nevertheless, satellite-based data is that it still remains uncertain. To overcome the above limitation, this study aims to take the strengthens of machine learning to generate a new reanalysis of precipitation data by fusion of multiple satellite precipitation products (SPPs) with gauge observation data. Several machine learning algorithms (i.e., Random Forest, Support Vector Regression, and Artificial Neural Network) have been adopted. To investigate the robustness of the new reanalysis product, observed data were collected to evaluate the accuracy of the products through Kling-Gupta efficiency (KGE), probability of detection (POD), false alarm rate (FAR), and critical success index (CSI). As a result, the new precipitation generated through the machine learning model showed higher accuracy than original satellite rainfall products, and its spatiotemporal variability was better reflected than others. Thus, reanalysis of satellite precipitation product based on machine learning can be useful source input data for hydrological simulations in ungauged river basins.

• 한국광학회지
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• 제19권6호
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• pp.429-434
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• 2008

비대칭 이중-금속 장거리 표면-플라즈몬 구조는 두 금속 사이에 위치한 코어 유전체 층의 굴절률을 임의로 선택하여도 장거리 표면-플라즈몬 모드가 존재한다는 장점이 있다. 도파로의 코어 층에 격자를 형성함으로써 플라즈몬 밴드-갭에 기초한 통신대역 파장에서의 장거리 표면-플라즈몬 파장필터를 구현하였다. Method of Line과 전달행렬방법 등을 통해 장거리 표면-플라즈몬 모드의 유효굴절률, 모드 특성, 투과도 등의 분석을 통해 설계하였으며, 도파로의 코어 층에 홀로그램 리소 방식을 이용하여 523.3 nm 주기의 브래그격자를 형성하여 파장필터를 제작하여 통신대역인 1541 nm 파장에서 대략 2 nm의 반치폭과 50 dB 이상의 파장 소광률을 확인하였다. 본 연구에서 제안한 파장필터는 표면-플라즈몬 집적회로를 구성하는 소자로써 중요한 역할을 할 것이다.

• 대한화학회지
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• 제42권3호
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• pp.251-265
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• 1998

15세기 초부터 약 70-80년간 활동한 광주 충효동 가마터에서 출토된 분청과 백자 60여점을 위치와 층위에 따라 8그룹으로 나누어 성분을 분석하였다. 태토의 경우 XRF로 주성분을, 그리고 ICP-MS로 미량성분을 분석하였으며, 유약은 EPMA를 사용하여 주성분을 분석하였다. SPPS 프로그램을 이용한 주성분분석법으로 성분분석 결과를 통계분석한 결과, 위치와 층위별로 뚜렷한 차이를 보였는데, 초기에 만들어진 $CHE_2$의 최상급의 분청태토는 $Al_2O_3$함량이 높고, $Fe_2O_3,\;TiO_2$가 낮았으며, 시기가 늦어질수록 질이 떨어져 $Al_2O_3$는 낮고, Fe_2O_3,\;TiO_2,$ CaO등이 높았다. 백자의 태토는 연질백자나 경질백자 모두 시기에 관계없이 30% 이상의 높은 $Al_2O_3$함량을 나타내었다. 분청유악은 라임계열이고, 백자유약은 알칼리라임계열이었다. 분청 20편에 대한 미량성분 조사에서는 1호가마에서 생산된 CHE2와 2호가마에서 생산된 CHW3-L이 같은 흙을 가지고 만들었을 것으로 추정되어 이 두 가마가 거의 동시에 운영되었음을 추정할 수 있었다.

• 한국융합학회논문지
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• 제9권5호
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• pp.99-104
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• 2018

본 연구의 목적은 일부 치위생(학)과 학생들을 대상으로 임상실습 감정노동과 자아존중감이 직업정체감에 미치는 융합적 요인을 조사하고자 실시하였다. 전남지역에 소재한 대학 3개교에 재학 중인 치위생(학)과 학생 205명의 자료를 사용하였다. 수집된 모든 자료는 SPPS 12.0 통계프로그램을 이용하여 분석하였다. 자아존중감과 직업정체감은 양의 관계(r=0.366, p<0.01)를 보였지만 임상실습 감정노동과 직업정체감은 음의 관계(r=-0.213, p<0.01)로 나타났다. 치위생(학)과 학생들의 직업정체감에 영향을 미치는 융합 요인은 전공만족도(${\beta}=0.434$), 자아존중감(${\beta}=0.236$) 그리고 임상실습 감정노동(${\beta}=-0.199$)이었다. 설명력은 34.6%의 영향력을 보였다. 따라서 치위생(학)과 학생들의 직업정체감 향상을 위하여 전공 만족도와 자아존중감을 증진시키고 임상실습 시 경험하는 감정노동 관리를 위한 프로그램 개발이 필요하리라 사료된다.

• Journal of the Optical Society of Korea
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• 제20권1호
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• pp.130-134
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• 2016

The influence of Au/Ni-based contact formed on a lightly-doped (7.3×1017cm−3, Zn-doped) InGaAsP layer for electrical compensation of surface plasmon polariton (SPP) propagation under various rapid thermal annealing (RTA) conditions has been studied. The active control of SPP propagation is realized by electrically pumping the InGaAsP multiple quantum wells (MQWs) beneath the metal planar waveguide. The metal planar film acts as the electric contact layer and SPP waveguide, simultaneously. The RTA process can lower the metal-semiconductor electric contact resistance. Nevertheless, it inevitably increases the contact interface morphological roughness, which is detrimental to SPP propagation. Based on this dilemma, in this work we focus on studying the influence of RTA conditions on electrical control of SPPs. The experimental results indicate that there is obvious degradation of electrical pumping compensation for SPP propagation loss in the devices annealed at 400℃ compared to those with no annealing treatment. With increasing annealing duration time, more significant degradation of the active performance is observed even under sufficient current injection. When the annealing temperature is set at 400℃ and the duration time approaches 60s, the SPP propagation is nearly no longer supported as the waveguide surface morphology is severely changed. It seems that eutectic mixture stemming from the RTA process significantly increases the metal film roughness and interferes with the SPP signal propagation.