• Food Science of Animal Resources
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• v.35 no.2
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• pp.164-170
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• 2015

The objective of this study was to evaluated the photoprotective effects of porcine placenta extract (PPE) on ultraviolet B (UVB)-induced oxidative stress in human keratinocytes (HaCaT) to evaluate its functional activities as a skin food ingredient. PPE prepared by subcritical water extraction was termed SPE, and subsequently digested by enzymes to prepare E-SPE. Increased intracellular reactive oxygen species (ROS) levels (192.0%) induced by UVB were decreased by SPE and E-SPE. SPE had more effective ROS scavenging activity than E-SPE treatment. UVB treatment increased expression of tissue inhibitor of metalloproteinase 1 (TIMP-1), and this elevated expression was decreased by E-SPE treatment. High-dose treatment with E-SPE (50 and 100 µg/mL) reduced TIMP-1 expression levels of UVB-C (control) to 33.5 and 34.6%, respectively. In contrast, at low SPE doses (1 and 10 µg/mL), the treatment slightly decreased TIMP- 1 expression levels to 73.3% and 71.3% of UVB-C, respectively. In conclusion, the present study demonstrated the protective effect of SPE and E-SPE against UVB damage in keratinocytes via ROS scavenging, down-regulating MMP-2 expression and up-regulating TIMP- 1 expression. This highlights the potential for SPE as an ingredient in the preparation of functional food against photoaging.

• Mass Spectrometry Letters
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• v.5 no.1
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• pp.30-33
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• 2014

A solid phase extraction (SPE) method was optimized for the quantitative analysis of perfluorooctanoic acid (PFOA) in serum using hydrophilic-lipophilic balance SPE and LC-MS/MS. Fetal bovine serums spiked with $^{13}C_8$-PFOA before or after SPE were used as test samples for evaluation of the SPE efficiency. Simultaneous evaluation of matrix effects and absolute SPE recovery for $^{13}C_8$-PFOA in serum using different sample pre-treatments and SPE conditions allowed optimization of SPE process efficiency with minimal matrix effect and decent SPE recovery. Introduction of protein precipitation as a sample pre-treatment procedure for serum samples before SPE generally decreased matrix effect in LC-MS/MS analysis and provided more stable recovery of PFOA.

• International Journal of Industrial Entomology and Biomaterials
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• v.46 no.2
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• pp.60-66
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• 2023

Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases and is more common in older and obese individuals. Silkworm male pupae exerts tonic effects by increasing testosterone secretion and the forced swimming time and muscle ratio increased in mice consuming silkworm pupae, which may be beneficial to the older population. Therefore, it will be beneficial to investigate the effects of silkworm pupal extracts (SPE) on OA. To confirm this effect, we prepared SPE in different solvents, and their ability to attenuate matrix metalloproteinases (MMPs) and inflammatory mediators (interleukin-6 [IL-6], interleukin-8 [IL-8] and tumor necrosis factor-α [TNF-α]) were evaluated in an interleukin-1β (IL-1β)-induced SW1353 human chondrosarcoma cell line. 70% ethanolic SPE outperformed the other solvents, reducing MMP-1 and MMP-3 expression by up to 53% and 13%, respectively. Further experiments were performed using 70% ethanolic SPE from three distinct pupation stages in males and females. SPE treatment alleviated MMP-1 expression (43.9-47.4%) regardless of pupation stage and sex. Among the inflammatory mediators, 70% ethanolic SPE alleviated IL-6 and TNF-α levels, and the concentrations thereof were lowest in the early-stage male SPE-treated group (43.15% and 56.74%, respectively). In conclusion, 70% ethanolic SPE may prevent IL-1β-induced osteoarthritis by inhibiting MMPs and inflammatory cytokines. Therefore, SPE is a potential therapeutic agent for the treatment of OA.

• Preventive Nutrition and Food Science
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• v.19 no.1
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• pp.1-4
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• 2014

Excessive ethanol intake is known to induce a number of physiological symptoms, including headache, dizziness and vertigo. In this study, we investigated the attenuation effect of sprouted peanut extract (SPE) on ethanol-induced hangover in male Sprague-Dawley rats. The animals were divided into five groups: the control group, which was administered ethanol only; the ethanol plus SPE experimental groups, which were administered ethanol and 100, 200, or 400 mg SPE/kg b.w.; and the positive control group, which was administered ethanol plus DAWN808$^{(R)}$, a commercial product. SPE-suspended water was delivered to rats via gavage 15 h and 30 min before the administration of ethanol. Blood was collected from the tail 0, 1, 3, and 5 h after ethanol administration. The results showed that serum ethanol concentrations were significantly lower in SPE treated groups than in the control group. Furthermore, hepatic alcohol and acetaldehyde dehydrogenase activities were enhanced by SPE in a dose dependent manner. These results suggest that SPE could be useful in attenuating hangover after alcohol consumption.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.2
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• pp.97.1-97.1
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• 2011

In this study we have examined the probability of solar proton events (SPEs) and their peak fluxes depending on flare (flux, longitude and impulsive time) and CME parameters (linear speed, longitude, and angular width). For this we used the NOAA SPE list and their associated flare data from 1976 to 2006 and CME data from 1997 to 2006. We find that about 3.5% (1.9% for M-class and 21.3% for X-class) of the flares are associated with SPEs. It is also found that this fraction strongly depends on longitude; for example, the fraction for $30W^{\circ}$ < L < $90W^{\circ}$ is about three times larger than that for $30^{\circ}E$ < L < $90^{\circ}E$. The SPE probability with long duration (${\geq}$ 0.3 hours) is about 2 (X-class flare) to 7 (M-class flare) times larger than that for flares with short duration (< 0.3 hours). In case of halo CMEs with V ${\geq}$ 1500km/s, 36.1% are associated with SPEs but in case of partial halo CME ($120^{\circ}$ ${\leq}$ AW < $360^{\circ}$) with 400 km/s ${\leq}$ V < 1000 km/s, only 0.9% are associated with SPEs. The relationships between X-ray flare peak flux and SPE peak flux are strongly dependent on longitude and impulsive time. The relationships between CME speed and SPE peak flux depend on longitude as well as direction parameter. From this study, we suggest a new SPE forecast method with three-steps: (1) SPE occurrence probability prediction according to the probability tables depending on flare and CME parameters, (2) SPE flux prediction from the relationship between SPE flux and flare (or CME) parameters, and (3) SPE peak time.

• Korean Journal of Food Science and Technology
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• v.24 no.3
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• pp.247-250
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• 1992

Effects of free alkali and moisture on sucrose polyesters (SPE)-possible non calorie fat substitute-synthesis were investigated using a model system composed of sodium oleate, sucrose, potassium carbonate and methyl oleate. Trace amounts of free alkali in sodium oleate were found to interefere with SPE synthesis. When free alkali content in sodium oleate was varied gradually from 0% to 5%(w/w), the yield of SPE production was reduced from 92% to 45.5%. The moisture absorbed in sodium oleate, sucrose and potassium carbonate during storage also interefered with SPE synthesis. The yield (92%) of SPE production with dried ($105^{\circ}C$.6 hrs) reactants and catalysts was higher than that (89%) of SPE production with non-dried. Soybean oil fatty acid sodium soaps (FASS) not containing free alkali could be manufactured with slightly less than molar ratio of sodium hydroxide to soybean oil fatty acid methyl esters (FAME). Practically, 91.7% yield of soybean oil SPE production was outcomed by minimizing free alkali and moisture which were remaining in sucrose, potassium carbonate, soybean oil FASS and soybean oil FAME.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.33.2-33.2
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• 2010

We have investigated a relationship among the solar proton events (SPEs), coronal mass ejections (CMEs) and solar flares during the solar cycle 23 (1997-2006). Using 63 SPE dataset, we found that SPE rise time, duration time, and decrease times depend on CME speed and SPE peak intensity depends on the CME earthward direction parameter as well as CME speed and x-ray flare intensity. While inspecting the relation between SPE peak intensity and the CME earthward direction parameter, we found that there are two groups: first group consists of large 6 SPEs (> 10,000 pfu at >10 MeV proton channel of GOES satellite) and shows a very good correlation (cc=0.65) between SPE peak intensity and CME earthward direction parameter. The second group has a relatively weak SPE peak intensity and shows poor correlation between SPE peak intensity and the CME earthward direction parameter (cc=0.01). By investigating characteristics of 6 SPEs in the first group, we found that there are special common conditions of the extremely large proton events (group 1); (1) all the SPEs are associated with very fast halo CME (>1400km/s), (2) they are almost located at disk region, (3) they also accompany large flare (>M7), (4) all they are preceded by another wide CMEs, and (5) they all show helmet streamer nearby the main CME. In this presentation, we will give details of the energy spectra of the 6 SPE events from the ERNE/HED aboard the Solar and Heliospheric Observatory (SOHO), and onset time comparison among the SPE, flare, type II burst, and CME.

• Journal of the Korea institute for structural maintenance and inspection
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• v.17 no.4
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• pp.57-65
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• 2013

The development of the oil refining industry has resulted in an annual 120 million tons of sulphur, which is a by-product of the desulphurization process. To exploit this abundance, the applications of sulphur must be expanded. as excellent durability of reuse of leftover sulphur which has high potential for utilization in construction materials, the study is actively in progress. Meanwhile, there has been active research on semi-rigid pavements that draw on the strengths and overcome the weaknesses of asphalt and concrete pavements. Acrylate is used to prevent cracking but involves a high cost, thus, an alternative material is required. As such, this study presents methods on the reuse of leftover sulphur and examines the engineering performance of grout containing sulfur polymer emulsion (SPE) for use in semi-rigid pavements. Our analysis shows that grout in which 30% of acrylate is replaced with SPE has superior properties in terms of time of flow and strength compared to regular grout. However, performance declined when more than 50% of acrylate was replaced by SPE, indicating that the optimum replacement level is 30%. Through SEM analysis, we found that grout with utra harding cement in this study at three hours had similar hydration properties to that of Type 1 Ordinary Portland Cement (OPC) at seven days, and maintained the properties regardless of grout containing SPE. OPC and grout with a replacement level of 30% displayed similar levels of chloride invasion resistance, whereas grout without SPE was far less resistant. Within the scope of this paper, the optimum replacement level of acrylate with SPE was found to be 30% in consideration of various properties such as time of flow, strength, and chloride invasion resistance.

• Journal of Astronomy and Space Sciences
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• v.26 no.4
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• pp.479-486
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• 2009

We studied the solar proton events (SPEs) associated with coronal mass ejections (CMEs) during the solar cycle 23 (1997-2006). Using 63 SPE dataset, we investigated the relationship among SPE, flare, and CME, and found that (1) SPE rise time and duration time depend on CME speed and the earthward direction parameter of the CME, and (2) the SPE peak intensity depends on CME speed and X-ray Flare intensity. While inspecting the relation between SPE peak intensity and the direction parameter, we found there are two groups: first group consists of large six SPEs (> 10,000 pfu at > 10 MeV proton channel of GOES satellite) and shows strong correlation (cc = 0.65) between SPE peak intensity and CME direction parameter. The second group has a weak intensity and shows poor correlation between SPE peak intensity and the direction parameter (cc = 0.01). By investigating characteristics of the first group, we found that all the SPEs are associated with very fast halo CME (> 1400km/s) and also they are mostly located at central region and within ${\pm}20^{\circ}$ latitude and ${\pm}30^{\circ}$ longitude strip.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.13 no.3
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• pp.1-6
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• 1999

SpeROD, the optical design program. is developed far specular reflectors of fluorescent luminaries. SpeROD can save much tirre when to design specular reflectors. SpeROD calculates conditions 2-dimensionally. The conditions for designing reflectors considered in this program are the intensity distribution, reflector type, and Tangent Spiral Design method. Using SpeROD, uniform intensity distribution type and bat-wing type reflectors are simulated in this paper, and alrrnn(T8) diarreter fluorescent lamp and lmnm width reflector are used for the setting. The sarre setting was simulated in FIElD, the intensity distribution prediction program. and the' result represented the intensity distribution and the efficacy simulated in SpeROD were satisfactory.actory.