• Journal of Ginseng Research
• /
• v.47 no.2
• /
• pp.246-254
• /
• 2023

Background: Here, we aimed to assess the inhibitory effect of a new compound from Panax ginseng on the migration of human ovarian cancer cells and tube formation of human umbilical vein endothelial cells (HUVECs). Methods: A new compound, ginsenglactone A (1), was isolated from ginseng roots, together with seven known compounds (2-8). Spectroscopic data were used to elucidate the chemical structure of 1. The tubular structure formation in HUVECs was assessed by Mayer's hematoxylin staining. The migration of A2780 cells was evaluated using the scratch wound healing assay. Results: HUVECs treated with 1 had the statistically significant decrease in tubular structure formation compared to the HUVECs treated with compounds 2-8. This effect was enhanced by co-treatment with inhibitors for phosphatidylinositol 3-kinase (PI3K) (LY294002) and extracellular signal-regulated kinase (ERK) (U0126). Treatment with 1 decreased the expression of phosphorylation of ERK, PI3K, vascular endothelial growth factor receptor2 (VEGFR2), Akt, and mammalian target of rapamycin (mTOR). In addition, the ability of A2780 cells to cover the scratched area were also decreased. This effect was enhanced by co-treatment with U0126. Lastly, treatment with 1 decreased the phosphorylation of ERK, matrix metalloproteinase-9 (MMP-9), and MMP-2. Conclusion: These results suggest that ginsenglactone A is a potential inhibitor of HUVEC tubular structure formation and A2780 cellular migration, which may be helpful for understanding its anticancer mechanism.

• The Korean Journal of Ceramics
• /
• v.2 no.3
• /
• pp.131-136
• /
• 1996

The electrical conductivity of polycrystalline TiO2 samples was measured over the temperature range 1000°-1400℃ and from 0.21 to 10-16 atm of oxygen. Based on the excellent fit observed between the theoretically derived relatin σ3=(Aσ+B)Po2-1/2+D'σ2 and the experimental conductivity data, the nonstoichimetric defect structure of TiO2 was rationalized in terms of a defect model involving quasi-free electrons and both singly and doubly ionized oxygen vacancies. The standard enthalpy of formation for the following defect reactions in TiO2. (a) OO={{{{ { 1} over {2 } }}O2(g)+VO+e'; Δ{{{{ { H}`_{o } ^{a } }}=5.15(eV) (b) OO={{{{ { 1} over {2 } }}O2(g)+VO+2e'; Δ{{{{ { H}`_{0 } ^{ a} }}=6.30(eV) (c) VO=VO+e'; Δ{{{{ { H}`_{0 } ^{a } }}=1.15(eV) were determined from the temperature dependence of A and B obtained from the above relation and from the experimental expression between the electron mobility and temperature. The electrical conductivity of TiO2 in air below approximately 950℃ appears, on the basis of this investigation, to be impurity controlled due to the presence of aluminum rather than intrinsic conduction.

• Proceedings of the KIEE Conference
• /
• 1995.07c
• /
• pp.1391-1393
• /
• 1995

An electron gun system for the Pohang Light Source has been installed and operated successfully. The basic design parameters are acceleration voltage of 80 kV, maximum peak emission current of 5 A, minimum pulse width of 1 ns, and maximum repetition rate of 100 Hz. The gun has a triode structure and is composed of a cathode, a focusing electrode(Wehnelt), and an anode. To sustain a $5{\times}10^{-9}$Torr vacuum, a $230{\ell}/s$ Ion pump has been adopted. We adopted a control and monitoring system based on the fiber-optic technology. In this article, we present the structure and operation principle of the system with special interest on the nanosecond pulser, remote control and monitoring system.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
• /
• 2010.10a
• /
• pp.302-307
• /
• 2010

Development of light-weight high speed train (HST) based on distributed motor control with the top speed of 350 km/hr has engendered a need for abatement of the interior noise of the train cabin. The development of noise abatement measures is crucial at the design stage of the train car since the noise transmission characteristics of the car structure directly influences the cabin interior noise. Since the transmission loss measurement using the entire car structure is often not feasible, especially at the initial stages of the train development, investigation of transmission characteristics using small-scale reverberation chamber can furnish useful alternative source of predicting the noise level. In the present study, white noise is generated at source and transmission loss estimated by performing measurement of a specimen in a scaled reverberation chamber. Comparison of measured values with the previously derived numerical values show good agreement in the overall trend but appreciable quantitative differences still remain.

• Journal of Microbiology and Biotechnology
• /
• v.26 no.1
• /
• pp.99-109
• /
• 2016

We investigated the relation between the presence of geosmin in water and the bacterial community structure within the granular activated carbon (GAC) system of water treatment plants in South Korea. GAC samples were collected in May and August of 2014 at three water treatment plants (Sungnam, Koyang, and Yeoncho in Korea). Dissolved organic carbon and geosmin were analyzed before and after GAC treatment. Geosmin was found in raw water from Sungnam and Koyang water treatment plants but not in that from Yeoncho water treatment plant. Interestingly, but not surprisingly, the 16S rRNA clone library indicated that the bacterial communities from the Sungnam and Koyang GAC systems were closely related to geosmin-degrading bacteria. Based on the phylogenetic tree and multidimensional scaling plot, bacterial clones from GAC under the influence of geosmin were clustered with Variovorax paradoxus strain DB 9b and Comamonas sp. DB mg. In other words, the presence of geosmin in water might have inevitably contributed to the growth of geosmin degraders within the respective GAC system.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.21 no.3
• /
• pp.125-135
• /
• 2017

Various seismic isolation methods are being applied to bridges and buildings to improve their seismic performance. Most seismic isolation systems are the structural seismic isolation systems. In this study, the seismic performance of geotechnical seismic isolation system capable of isolating the lower foundation of the bridge structure from ground was evaluated. The geotechnical seismic isolation system was built with teflon, and the model structure was made by adopting the similitude law. The response acceleration for sinusoidal waves of various amplitudes and frequencies and seismic waves were analyzed by performing 1-G shaking table experiments. Fixed foundation, Sliding foundation, and Rocking foundation were evaluated. The results of this study indicated that the Teflon-type seismic foundation isolation system is effective in reducing the acceleration transmitted to the superstructure subject to large input ground motion. Response spectrum of the Rocking and Sliding foundation structures moves to the long period, while that of Fixed foundation moves to short period.

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.14 no.5
• /
• pp.632-639
• /
• 2014

Mechanical stress and the vacuum level are the two main factors dominating the quality factor of a resonator operated in the vacuum range 1 mTorr to 10 Torr. This means that if the quality factor of a resonator is very insensitive to the mechanical stress in the vacuum range, it is sensitive to mainly the ambient vacuum level. In this paper, a wafer-level packaged MEMS resonator with a highly vacuum-sensitive quality factor is presented. The proposed device is characterized by a package with out-of-plane symmetry and a suspending structure with only a single anchor. Out-of-plane symmetry helps prevent deformation of the packaged device due to thermal mismatch, and a single-clamped structure facilitates constraint-free displacement. As a result, the proposed device is very insensitive to mechanical stress and is sensitive to mainly the ambient vacuum level. The average quality factors of the devices packaged under pressures of 50, 100, and 200 mTorr were 4987, 3415, and 2127, respectively. The results demonstrated the high controllability of the quality factor by vacuum adjustment. The mechanical robustness of the quality factor was confirmed by comparing the quality factors before and after high-temperature storage. Furthermore, through more than 50 days of monitoring, the stability of the quality factor was also certified.

• International Journal of Aeronautical and Space Sciences
• /
• v.17 no.3
• /
• pp.423-431
• /
• 2016

In this study, wing design optimization for long-endurance unmanned aerial vehicles (UAVs) is investigated. The fluid-structure integration (FSI) analysis is carried out to simulate the aeroelastic characteristics of a high-aspect ratio wing for a long-endurance UAV. High-fidelity computational codes, FLUENT and DIAMOND/IPSAP, are employed for the loose coupling FSI optimization. In addition, this optimization procedure is improved by adopting the design of experiment (DOE) and Kriging model. A design optimization tool, PIAnO, integrates with an in-house codes, CAE simulation and an optimization process for generating the wing geometry/computational mesh, transferring information, and finding the optimum solution. The goal of this optimization is to find the best high-aspect ratio wing shape that generates minimum drag at a cruise condition of $C_L=1.0$. The result shows that the optimal wing shape produced 5.95 % less drag compared to the initial wing shape.

• 한국정보디스플레이학회:학술대회논문집
• /
• 2004.08a
• /
• pp.605-608
• /
• 2004

A novel blue-green emitting aluminum complex was developed by employing 8-hydroxyquinoline as co-ligand for enhancement of electron transport and light emission abilities so that the electroluminescent (EL) devices do not need additional electron transport layer. The aluminum complex (PAlQ) of 8-hydroxyquinoline and ${\alpha}$-pyridoin was synthesized The structure of the PAlQ was elucidated by FT-IR, UV-Vis and XPS. The PAlQ complex showed thermal stability up to 350$^{\circ}C$ under nitrogen flow by TGA. The photoluminescence (PL) was measured from solid film of the PAlQ complex on quartz substrate. The EL device was fabricated by the vacuum deposition. The device having the structure of ITO/TPD/PAlQ/Al was studied, where N,N-bis(3-methylphenyl}-N,N'-diphenyl-benzidine (TPD) was used as a hole transporting layer. The EL device emitted a blue-green light.

• The Journal of The Korea Institute of Intelligent Transport Systems
• /
• v.6 no.2
• /
• pp.113-118
• /
• 2007

KPCS internal antenna in this paper, is designed and fabricated using the theory based on the folded monopole antenna. I propose folded monopole internal antenna which has high gain low profile structure with easy installation into the handset of mobile phone. Design frequency is 1.8 GHz that is a center frequency of Korea PCS frequency band, and the impedance variances due to change of antenna structure as a length and width are simulated. Measurements show that input VSWR range under 2:1 is 1.72 - 1.88 GHz, and radiated H-plane pattern is omnidirectional under passive state. Active sensitivities and output power of phone applied antenna are $-105\;{\sim}\;-108\;dBm$ and $22.5\;{\sim}\;23.6\;dBm$ max., respectively.