• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.403.1-403.1
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• 2014

In conventional far-field microscopy, two objects separated closer than approximately half of an emission wavelength cannot be resolved, because of the fundamental limitation known as Abbe's diffraction limit. During the last decade, several super-resolution methods have been developed to overcome the diffraction limit in optical imaging. Among them, super-resolution optical fluctuation imaging (SOFI) developed by Dertinger et al [1], employs the statistical analysis of temporal fluorescence fluctuations induced by blinking phenomena in fluorophores. SOFI is a simple and versatile method for super-resolution imaging. However, due to the uncontrollable blinking of fluorophores, there are some limitations to using SOFI for several applications, including the limitations of available blinking fluorophores for SOFI, a requirement of using a high-speed camera, and a low signal-to-noise ratio. To solve these limitations, we present a new approach combining SOFI with speckle pattern illumination to create illumination-induced optical fluctuation instead of blinking fluctuation of fluorophore.. This technique effectively overcome the limitations of the conventional SOFI since illumination-induced optical fluctuation is possible to control unlike blinking phenomena of fluorophore. And we present the sub-diffraction resolution image using SOFI with speckle illumination.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.10
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• pp.5047-5052
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• 2012

Introduction: Breast cancer is the most common malignancy of women in Kashmir. This study was conducted with the objective of assessing hormone receptor positivity and its correlation with age at diagnosis, tumor size, histological grade and lymph node metastasis. Materials and Methods: 132 newly diagnosed cases of invasive breast cancer diagnosed at the Department of Pathology, SKIMS, Srinagar, J&K, were included after excluding biopsies, in-situ lesions and recurrence cases. Results: Mean age of the patients was 48.2 years, 59.1% being ${\leq}50$ years of age. Mean duration of symptoms was 6.32 months. Most lesions (65.1%) were 2-5 cm and 16.7% were ${\geq}5.0$ cm in greatest dimension. The predominant (80.3%) morphology was IDC-NOS. The majority of the cases presented as grade II (52.1%) lesions and lymph node involvement was present in 65.2%. ER and PR were positive in 66.3% and 63.4% cases, respectively, increasing with rising age. High grade lesions and larger size tumors were more likely to be ER and PR negative. No correlation was found between ER/PR status and lymph node metastasis. Conclusions: ER and PR expression in breast cancers in the current study was found to be higher than studies done in India/Asia but lower than studies conducted in the West, even on Indian/Asian immigrants. Markedly lower receptor expression in Indian/Asian studies is likely due to preanalytic variables, thresholds for positivity, and interpretation criteria. American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for Immunohistochemical Testing of Estrogen and Progesterone Receptors in Breast Cancer are strongly advocated for standardization of receptor evaluation and for clinical management of breast cancer patients to provide best therapeutic options.

• Journal of Korean Association for Spatial Structures
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• v.16 no.4
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• pp.29-36
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• 2016

The objective of this research is to development of a parametric design system for membrane structures. The parametric design platform for the spatial structures has been designed and implemented. Rhino3D is used as a 3D graphic kernel and Grasshopper is introduced as a parametric modeling engine. Modeling components such as structural members, loading conditions, and support conditions are developed for structural modeling of the spatial structures. The interface module with commercial structural analysis programs is implemented. An iterative generation algorithm for design alternatives is a part of the design platform. This paper also proposes a design approach for the parametric design of Spoke Wheel membrane structures. A parametric modeling component is designed and implemented. SOFiSTik is examined to interact with the design platform as the structural analysis module. The application of the developed interface is to design optimally Spoke Wheel Shaped Ductile Membrane Structure using parametric design. It is possible to obtain objective shape by controlling the parameter using a parametric modeling designed for shape finding of spoke wheel shaped ductile membrane structure. Recently, looking at the present Construction Trends, It has increased the demand of the large spatial structure. But, It requires a lot of time for Modeling design and the Structural analysis. Finally an optimization process for membrane structures is proposed.

• CELLMED
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• v.10 no.1
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• pp.8.1-8.7
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• 2020

Aim:'Itrifal-e-Sagheer', a compound Unani formulation has been indicated in disease conditions simulating dyslipidemia. The present study was done to substantiate the efficacy of 'Itrifal-e-Sagheer' in dyslipidemia on scientific parameters. Materials and methods: A randomized, single blind, controlled, clinical trial was carried out on 30 patients of dyslipidemia who were randomly allocated into test (n = 15) or control (n = 15) groups. The test drug, Itrifal-e-Sagheer and control drug, Abana® were given to respective group for 45 days along with lifestyle modification. Results: The test drug significantly alleviated the symptoms of subjective parameters (palpitation, breathlessness and weight gain) (p<0.05). There was statistically significant reduction in lipid profile of the patients in test group (p<0.05) than control drug treatment. Conclusion: The study evidenced that Itrifal-e-Sagheer is potentially effective and safe in the treatment of dyslipidemia. However, a multicentric study with robust study design is required to generalize the results.

• Wind and Structures
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• v.7 no.2
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• pp.107-130
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• 2004

This paper presents a time-domain approach for analyzing nonlinear random vibrations of long-span suspended cables under transversal wind. A consistent continuous model of the cable, fully accounting for geometrical nonlinearities inherent in cable behavior, is adopted. The effects of spatial correlation are properly included by modeling wind velocity fluctuation as a random function of time and of a single spatial variable ranging over cable span, namely as a one-variate bi-dimensional (1V-2D) random field. Within the context of a Galerkin's discretization of the equations governing cable motion, a very efficient Monte Carlo-based technique for second-order analysis of the response is proposed. This procedure starts by generating sample functions of the generalized aerodynamic loads by using the spectral decomposition of the cross-power spectral density function of wind turbulence field. Relying on the physical meaning of both the spectral properties of wind velocity fluctuation and the mode shapes of the vibrating cable, the computational efficiency is greatly enhanced by applying a truncation procedure according to which just the first few significant loading and structural modal contributions are retained.

• Journal of Applied Tourism Food and Beverage Management and Research
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• v.15 no.2
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• pp.57-72
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• 2004

This study is carried out to investigate the effect of any periods in the freezer and the product of value, moisture content, baking loss, specific volume loaf in manufncturing process thereof. The moisture content of the croissant slightly decreased as the periods passed in the freezer. And as passed periods frozen croissant dough dried naturally by the freezer fan. 1. As frozen periods passed croissant dough decreased moisture content and loaf volume. The volume is relation to the molsture content and croissant dough' gluten. Yeast is active but croissant dough is dried so pastry margarine's moisture vaporized little by little. 2. 1 day frozen bench time provided maximum specific loaf volume while croissant shape was unsettled, moisture content was highest. At the same dough croissant hardness had very sofi crust. 3. 1week and 2weets frozen dough had specific loaf volume and hardness with proper crust color. As the proper bench time provided best shape of croissant, color. 4. 4weeks and 8weeks frozen dough had over-al] value of croissant accelerating older product. As the same result, over Sweets frozen periods product were not available for sale and serving to customers. 5. By the sensory evaluation tests, over-all croissant as 1 week, 2weeks were significantly higher quality those than 6. 1day, 4weeks and 8weeks. Textural properties of croissant over 4weeks frozen periods so hard for every panel. According to the study, not croissant dough but also any other frozen dough(ex.Danish, brioche etc.)have to need proper bench time and 1week or 2weeks circulation making method have to given encouragement to practical pastry industry. Add to this study using only for frozen dough yeast instead of using fresh and instant

• International Journal of Industrial Entomology and Biomaterials
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• v.9 no.2
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• pp.279-281
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• 2004

Components of genetic variation were estimated for five metric traits using 24 biparental progenies (N. C. Design III) generated from F$_2$ generation of a commercial bivoltine silkworm hybrid, SH$_{6}$${\times}$NB$_4$D$_2$. Variance due to additive ($\sigma$$^2$A) and dominance ($\sigma$$^2$D) gene effects was significant for single cocoon weight and shell weight. However, magnitude of former was greater than latter indicating preponderance of additive gene action in the inheritance of these two traits. Average degree of dominance was in the range of partial dominance for all the traits. High estimates of heritability (ns) indicated operation of genes with large additive effects, hence, scope exists for improvement of present populations through a few cycles of selection.n.

• CELLMED
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• v.11 no.3
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• pp.15.1-15.9
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• 2021

The chemical constitution of a drug has been accepted as an important basis for pharmacological action in Unani medicine. Various dosage forms have been developed on this concept, such as decoctions (Joshanda), infusions (Khesanda), extract (Rub / Usara), and syrup. Zarawand Mudaharaj (ZM.) / Aristolochia rotunda L. root was subjected to extraction process using Soxhlet's apparatus by using Response Surface Methodology (RSM) to design the number of random runs of the extracts with variation in the factors of temperature, the concentration of ethanol in water, time for extraction, for optimizing and maximizing the yield concentration. The data obtained, was analyzed with regression equation and ANOVA two-way summary to interpret the interaction of the factors for yield maximization. Minitab version 18 was used to design and analyze data. Validation of the optimum conditions for maximum yield of the whole extract of ZM. Root was carried out by re-run of the extract using the optimized conditions. The maximum yield percentage thus obtained using RSM was 20.87% whereas using these optimum conditions 21.35 % yield was obtained thereby validating the method. The association between the response functions and the process variables was identified by a three-factor recorded Box-Behnken design. In the present study RSM is used because itis a cheap and affordable method to optimize maximum yield percentage which may be reliably used by researchers. The study set in the surface conditions for ZM. root extraction by the Soxhlet apparatus for maximizing the yield percentage.