• Proceedings of the Korean Society of Precision Engineering Conference
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• 2000.05a
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• pp.1051-1054
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• 2000

We developed the micro CSF (celebrospinal fluid) shunt valve with surface and bulk micromachining technology in polymer MEMS. This micro CSF shunt valve was formed with four micro check valves to have a membrane connected to the anchor with the four bridges. The up-down movement of the membrane made the CSF on & off and the valve characteristic such as open pressure was controlled by the thickness and shape of the bridge and the membrane. The membrane, anchor and bridge layer were made of the $O_2$ RIE (reactive ion etching) patterned Parylene thin film to be about 5~10 microns in thickness on the silicon wafer. The dimension of the rectangular nozzle is 0.2＊0.2 $\textrm{mm}^2$ and the membrane 0.45 mm in diameter. The bridge width is designed variously from 0.04 mm to 0.12 mm to control the valve characteristics. To protect the membrane and bridge in the CSF flow, we developed the packaging system for the CSF micro shunt valve with the deep RIE of the silicon wafer. Using this package, we can control the gap size between the membrane and the nozzle, and protect the bridge not to be broken in the flow. The total dimension of the assembled system is 2.5＊2.5 $\textrm{mm}^2$ in square, 0.8 mm in height. We could precisely control the burst pressure and low rate of the valve varing the design parameters, and develop the whole CSF shunt system using this polymer MEMS fabricated CSF shunt valve.

• Journal of Preventive Medicine and Public Health
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• v.27 no.2 s.46
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• pp.242-257
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• 1994

In Korea, female workforce has reached more than 40% of total working population, but the effects of work on spontaneous abortion are yet to be examined. This study as conducted to investigate the occupational effects on spontaneous abortion. Medical insurance claim data were used to examine the effects of the employment status and industry of employment on spontaneous abortion. The study population was composed of females, aged $15{\sim}44$, who were the beneficiary of medical insurance in the month of June, 1993. The working females covered by medical insurance for industrial workers, had the highest age-adjusted Spontaneous Abortion rate (SAB rate=claim frequency of spontaneous abortion/claim frequency of complication of pregnancy, childbirth and the puerperium), 6.65% whereas female dependants of medical insurance for industrial workers had the lowest age-adjusted SAB rate, 4.54%. Among industrial workers, the workers in manufacturing industry had the highest age-adjusted Spontaneous Abortion ratio(SAB ratio=claim frequency of spontaneous abortion/claim frequency of completly normal delivery), 43.2/100 whereas those in financing and service industry had age-adjusted SAB ratio, 16.2/100 and 20.5/100, respectively. The results of the study suggest the adverse effect of manufacturing Industry on reproduction. Work environments such as chemical exposures, overwork, awkard posture, and job stress should be further studied for their effects on reproductive functions of female.

• Nuclear Engineering and Technology
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• v.23 no.4
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• pp.426-437
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• 1991

The $He^{++}$ beam transport system of the SNU 1.5-MV Tandem Van de Graaff accelerator is analysed by ion optical approach. The program OPTRANS is developed to determine the optimum operating conditions of each ion optical component and to simulate ion beam transport. First order matrix formalism is used and the space charge effect is neglected. Optimum operating conditions for the transport of 0.5~3.0 MeV $He^{++}$ beam are determined by the use of the program OPTRANS. Initial ion beam omittance is assumed to be 0.5$\times$80.0 mm.mrad from the structure of the extraction electrode and the experiment of ion beam extraction. ion beam transport characteristics of each ion optical component according to the variation of the operating conditions are investigated, and operating conditions to minimize the beam size at each slit, stripping foil, and target are calculated. Optimum operating conditions obtained from the experiment of ion beam transport show a discrepancy of less than 15% compared with the calculated ones. From the simulation and experiment of ion beam trans-port, the validity of the calculated optimum operating conditions and the usefulness of the program OPTRANS are verified.

• 한국지구물리탐사학회:학술대회논문집
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• 2007.06a
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• pp.267-272
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• 2007

Uiseong subbasin belonging to Kyungsang basin resulted from volcanic activity in the late Cretaceous. In this study, we carry out MT and gravity survey at the Hwasan caldera, which was formed of volcanic and abyssal rocks complex, then analyze and identify geological substructure. Potential survey such as gravity and magnetic survey has been mainly carried out in former studies, so depth information for understanding substructure was not enough. To complement a potential survey, we use MT method, which has high vertical resolution. Moreover we make a simple 2D model comparing with former study. The result of MT and gravity 2D modeling shows that this area is roughly composed of 3 layers; The bottom layer is a basement. In the second layer, intrusive rocks having high resistivity is placed along the ring faults and the sedimentary layer of low resistivity is inside caldera. The highest layer is alluvium. To comprehend the 3D structure of the Hwasan caldera, we perform 3D gravity inversion, and construct the 3D model from the result of 3D gravity inversion. MT responses are calculated by using the constructed 3D model and the 3D model of the Hwasan caldera's structure is suggested after comparing the calculated values with the observed values at MT line.

• International Journal of Aeronautical and Space Sciences
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• v.18 no.3
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• pp.545-554
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• 2017

Among various applications of the High Altitude Long Endurance (HALE) Unmanned Aerial Vehicle (UAV), this paper has a focus on the Global Positioning System (GPS) utilizing pseudolite and its improved performance, particularly during the multi-purpose missions. In a multi-purpose mission, the HALE UAV follows a specified flight trajectory for both navigation applications and missions. Some of the representative HALE missions are remote exploration, surveillance, reconnaissance, and communication relay. During these operations, the HALE UAV can also be an additional positioning signal source as it broadcast signals using pseudolite. The pseudolite signal can improve the availability, accuracy, and reliability of the GPS particularly in areas with poor signal reception, such as shadowed regions between tall buildings. The improvement in performance of navigation is validated through simulations of multi-purpose missions of the solar-powered HALE UAV in an urban canyon. The simulation includes UAV trajectory generation at stratosphere and uses actual geographical building data. The results indicate that the pseudolite-equipped HALE UAV has the potential to enhance the performance of the satellite navigation system in navigationally degraded regions even during multi-purpose operations.

• Journal of the Korea Convergence Society
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• v.12 no.9
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• pp.179-183
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• 2021

This study was carried out examine the effect of Celeriac Extract, which contains various anticancer ingredients, on the proliferation inhibition of human-derived cancer cells and the degree of inhibition. The five cell lines used in the experiment were lung cancer cells A549, prostate cancer cells DU-145, uterine cancer cells HeLa, breast cancer cells MCF-7, and liver cancer cells SNU-182. All cancer cells derived from the human body were used, and the inhibition of cancer cell proliferation with Celeriac Extract 10ug/mL, 100ug/mL, and 1000ug/mL was measured using the CCK-8 method. As a result of examining the inhibition of cancer cell proliferation, Celeriac Extract 1000ug/mL showed significant proliferation inhibition in lung cancer cells A549, prostate cancer cells DU-145, uterine cancer cells HeLa, and liver cancer cells SNU-182, and showed a concentration dependence. However, only a concentration-dependent decrease was observed in breast cancer cells MCF-7.In conclusion, it can be seen that the cell proliferation inhibition mechanisms of Celeriac Extract using various human-derived cancer cell lines provide the potential for cancer prevention and therapeutic development.

• Journal of The Korean Astronomical Society
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• v.51 no.6
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• pp.207-214
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• 2018

A coelostat is often used for solar observations, because it corrects the image rotation automatically by guiding sunlight into a fixed telescope with two plane mirrors. For the purposes of education and spectroscopic observation, the solar group at Seoul National University (SNU) plans to develop the SNU coelostat (SNUC) and install it in the SNU Astronomical Observatory (SAO). Requirements of the SNUC are < 1" positioning accuracy with 30 cm beam size on the entrance pupil in the compact dome. To allow for installation in the small dome, we design a compact slope type coelostat with a 45 cm primary plane mirror and a 39 cm secondary plane mirror. The motion of the SNUC is minimized by fixing the position of the slope frame. Numerical simulations of the available observational time of the designed coelostat shows that the sun can be observed ay all times from June to early August and at least three hours in other months. Since the high accuracy driving motors installed in the SNUC can be affected by external environment factors such as humidity and temperature variations, we design a prototype to test the significance of these effects. The prototype consists of a 20 cm primary plane mirror, a 1 m slope rail, a direct drive motor, a ballscrew, a linear motion guide, an AC servo motor, a reduction gear and a linear encoder. We plan to control and test the accuracy of the prototype with varying atmospheric conditions in early 2019. After testing the prototype, the SNUC will be manufactured and installed in SAO by 2020.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.47 no.8
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• pp.549-557
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• 2019

In this paper, we focus on the real-time detection method of a seismic ionospheric disturbance using Global Navigation Satellite System (GNSS) signal. First, the monitor for the detection of the seismic ionospheric disturbance is studied based on the estimated ionospheric delay using the GNSS signals. And then, the threshold for the automatic detection is computed. Moreover, to discriminate the seismic ionospheric disturbance against the other ionospheric anomalies due to other error sources such as cycle slips, the signatures of the ionospheric perturbation caused by the seismic wave is investigated. Based on the observation, the detection strategy is proposed. Using GPS observations collected from the 47 permanent stations in South Korea and Japan, the proposed real-time detection method is evaluated.

• The Journal of Korean Academy of Prosthodontics
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• v.60 no.2
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• pp.211-221
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• 2022

Implant placement may be restricted by anatomical and/or financial limitations in restoring a completely edentulous arch, or the patients' unwillingness to have extensive surgical procedures. Implant assisted removable partial dentures (IARPD) in combination with anterior fixed implant prostheses can be proposed as an alternative treatment option for the restoration of a completely edentulous arch. In this case, a 56-year-old female patient who has a fully edentulous maxilla opposed by partially edentulous mandible was treated. The treatment option for the maxilla consisted of an implant-assisted removable partial denture supported by four anterior fixed implant prostheses. The mandible was restored with 8 anterior fixed partial dentures and posterior fixed implant-supported prostheses. Long-term follow-up and supportive periodontal treatment were performed for 9 years, and the patient was satisfied with the overall appearance as well as masticatory function.

• Mass Spectrometry Letters
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• v.13 no.3
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• pp.84-94
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• 2022

Neoadjuvant chemoradiotherapy (nCRT) is a standard therapy used for locally advanced rectal cancer prior to surgery, which can more effectively reduce the locoregional recurrence rate and radiation toxicity compared to postoperative chemoradiotherapy. The response of patients to nCRT varies, and thus, robust biomarkers for predicting a pathological complete response are necessary. This study aimed to identify possible biomarkers involved in the complete response/non-response of rectal cancer patients to nCRT. Comparative proteomic analysis was performed on rectal tissue samples before and after nCRT. Proteins were extracted for label-free proteomic analysis. Western blot and real-time PCR were performed using rectal cancer cell line SNU-503 and radiation-resistant rectal cancer cell line SNU-503R80Gy. A total of 135 up- and 93 down-regulated proteins were identified in the complete response group. Six possible biomarkers were selected to evaluate the expression of proteins and mRNA in SNU-503 and SNU-503R80Gy cell lines. Lyso-phosphatidylcholine acyltransferase 2, annexin A13, aldo-ketose reductase family 1 member B1, and cathelicidin antimicrobial peptide appeared to be potential biomarkers for predicting a pathological complete response to nCRT. This study identified differentially expressed proteins and some potential biomarkers in the complete response group, which would be further validated in future studies.