• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.685-688
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• 2005

In the micro electrochemical machining (MECM) using ultra short pulses, the machining rate is closely related to the tool electrode area. The machining rate varies according to the machining depth or the immersion depth. When using insulated tool electrodes, those depths do not matter. In addition, micro structures with high machining depth can be fabricated because the machining characteristics do not vary with the machining depth. Another advantage of insulated electrodes is prevention of taper shape. Micro structures with high machining depth or high aspect ratio were fabricated using insulated tool electrodes.

• Proceedings of the Korea Information Processing Society Conference
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• 2015.04a
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• pp.2-5
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• 2015

가상화 기술을 기반으로 하는 클라우드 컴퓨팅 환경에서 실시간 응용들을 수행하려는 움직임이 많아지고 있다. 이 응용들의 실시간성을 보장하기 위해 리눅스의 실시간 스케줄러를 활용한 기법들이 제안되었지만, 이 기법들은 가상 머신들의 공정한 수행을 보장하지 못한다는 한계가 있다. 따라서 우리는 실시간 클라우드 환경에서 가상 머신 스케줄링의 공정성을 보장하기 위해 virtual runtime 보상 기반의 가상 머신 공정 스케줄링 기법을 제안한다. 제안된 기법은 실시간 응용으로 인해 CFS가 인지하지 못한 CPU 시간을 체크하고 이를 virtual runtime에 반영하여 가상 머신 간의 공정한 수행을 보장한다. 우리는 제안된 기법을 리눅스 커널 상에 구현하였다. 제안된 기법을 적용한 결과, 가상 머신 간의 수행시간 차이가 기존 경우보다 47% 줄어든 것을 확인하였다.

• Journal of the Society of Naval Architects of Korea
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• v.42 no.5 s.143
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• pp.506-515
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• 2005

Novel ships are commonly required iterative hull form modifications until she get reputation for new marine environment. Small FRP boats are manufactured in a identical shape with a mould. It implies that every modification step requires great time and expense which makes it difficult to improve the hull form promptly. Domestic hull form of small fishing boat of force has been evolved from the traditional hull form of developable shape. Utilizing this typical developable characteristics of small boats, ,New mouldless production method for FRP boat has been suggested and it is confirmed that the method is recommendable for a petty order of hull in evolving period of hull form development.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.2
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• pp.56.1-56.1
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• 2018

Astronomy education and research can benefit from a high performance telescope that is easily accessible in campus. Such a facility allows hands-on education of observations, small research projects, test of new instruments, and time-domian study of astronomical phenomena. Recently, SNU reconstructed a 40-year old observatory (also known as 구천문대), and established the new SNU Astronomical Observatory (SAO) on that site. On 2018 March 27, the 1-m optical telescope was successfully installed at SAO. Since then, this telescope has been producing wonderful images, with the best seeing value recorded being as small as 0.85 arcsec. This poster will give an overview of the 1-m telescope, and its performance based on test observations during the 2018A semester.

• Journal of Positioning, Navigation, and Timing
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• v.10 no.4
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• pp.271-278
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• 2021

In this paper, a tropospheric delay error was calculated by using meteorological data collect from weather station and Saastamoinen model, and an empirical variogram of the tropospheric delay in the Korean peninsula was estimated. In order to estimate the empirical variogram of the tropospheric delay according to weather condition, sunny day, rainy day, and typhoon day were selected as analysis days. Analysis results show that a maximum correlation range of the empirical variogram on sunny day was about 560 km because there is overall trend of the tropospheric delay. On the other hand, the maximum correlation range of the empirical variogram on rainy was about 150 km because the regional variation was large. Although there is regional variation when the typhoon exists, there is a trend of the tropospheric delay due to a movement of the typhoon. Therefore, the maximum correlation range of the empirical variogram on typhoon day was about 280 km which is between sunny and rainy day.

• Journal of Microbiology and Biotechnology
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• v.14 no.5
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• pp.985-990
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• 2004

Levans produced from Microbacterium laevaniformans were isolated, characterized, and fractionated by molecular weight. TLC, HPLC, and GC-MS analyses of the exopolysaccharide showed that it was a fructan-type polymer and was composed of (2,6)- and (2,1)-glycosidic linkages. $^{13}C$-NMR analysis proved that the polysaccharide was mainly a $\beta$-(2,6)-linked levan-type polysaccharide. To investigate the cytotoxicity of the acetone-precipitated levan fractions such as M1, M2, and M3, HepG2, P388D1, U937, SNU-1, and SNUC2A cell lines were screened. Among the cell lines tested, the cytotoxicity of M1- M3 fractions were detected from only SNU-1 and HepG2 cells at the dosage level of $100-800\mu\textrm{g}ml$. The M2 fraction M_r$, 80,000) at 400 $mu{g/ml}$ had the greatest cell growth inhibition (84.6%) on SNU-1, while the M1 $(M_r$, 50,000) at $800\mu\textrm{g}ml$ showed the greatest (46.32%) on HepG2. To obtain more uniform M_r$ fractions of levan, the levan was further fractionated from S1 $(M_r$ 1,000,000) to S5 $(M_r$ 10,000) using gel permeation chromatography. Again, the S1-S5 fractions had strong cytotoxicity on SNU-1 and HepG2 cell lines. The greatest inhibition effects of S4 $(M_r$ 80,000) on SNU-1 and S5 $(M_r$ 10,000) on HepG2 were shown to be 49.5% and 73.0%, respectively. The cytotoxicity of the levan fractions was more effective on SNU-1 than on HepG2. Although the relationship between the Mw and the cytotoxicity was not clear, smaller $M_r$, fractions of levan showed greater growth inhibition effect on the cancer cell lines in general. Therefore, it was indicated that a specific Mw class of levan is responsible for the effective cytotoxicity.

• Journal of Gastric Cancer
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• v.6 no.3
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• pp.132-138
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• 2006

Purpose: Dopamine is a neurotransmitter, but in the GIT, the roles of dopamine are a regulator of epithelial cell proliferation, an endogenous protective factor, and a regulator of stomach cancer cell proliferation. By using two different gastric-cancer cell lines, we assessed the effects of dopamine and dopamine receptors on the proliferation of human gastric-cancer cells. Materials and Methods: To assess the effects of dopamine and dopamine receptors on the proliferation of human gastric-cancer cells, we investigated cell proliferation and the expression of D1, D2L, and D2S receptor in two gastric-cancer cell lines, SNU 601 and KCU-C2. The effects of dopamine and dopamine receptors on the level of the cell proliferation were determined by staining with an A/H/E (acridine orange, hoechst and ethidium bromide) mixture. Results: After dopamine treatment, the cell viability was significantly decreased in SNU 601 cells (P<0.05) where the D2L receptor was absent, but not in KCU-C2 cells. After treatment with raclopride, a D2 receptor antagonist, dopamine-dose-dependent inhibition of cell proliferation was observed in SNU 601 cells (P<0.05). After treatment with SCH 23390, a D1 receptor antagonist, dopamine significantly increased ceil proliferation in KCU-C2 cells (P<0.05), but inhibited ceil proliferation in SNU 601 cells (no D2L receptor). Conclusion: The dopamine signal via the D1 or the D2S receptor inhibited proliferation of gastric-cancer cells, but that via the D2L receptor increased proliferation. These results suggest that the regulatory effects of dopamine in the gastric-cancer cell proliferation may be controlled by using dopamine receptors.

• Radiation Oncology Journal
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• v.11 no.1
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• pp.17-27
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• 1993

To investigate the relationship between radiosensitivity and postirradiation recovery in human cancer cells, a study was performed using human cancer cell lines-A549, CaSki, SNU-C5 and PCI-13. For the study of radiosensitivity, single doses of 2, 4, 6, 8, 10, 12, and 14 Gy were given and for postirradiation recovery, two fractions of 4 Gy were separated with a time interval of 0, 0.5, 1, 1.5, 2, 2.5, 3, 4, 5, or 6 hours. Surviving fraction was estimated using colony forming ability. Surviving fractions at 2 Gy (SF2) were 0.496 (0.570-0.412) for A549, 0.496 (0.660-0.332) for CaSki, 0.386 (0.576-0.216) for SNU-C5, and 0.185 (0.247-0.123) for PCI-13. By statistical analysis the SF2 of PCI-13 was lower significantly than those of others (p<0.05). This difference was also observed at 4, 6 and 8 Gy dose levels. At 6 and 8 Gy the surviving fractions of SNU-C5 were also lower significantly than A549 and CaSki (p<0.05). By the analysis with linear quadratic model, the values of ${\alpha}$ for A549, CaSki, SNU-C5 and PCI-13 were 0.3016, 0.3212, 0.4327 and 0.8423, respectively, and those of ${\beta}$ were 0.02429, 0.02009, 0.03349 and 0.00059, respectively. So, the value of ${\alpha}$ showed increasing tendency with decreasing SF2. By the multitarget single hit model the values of Do for A549, CaSki, SUN-C5 and PCI-13 were 1.97, 1.97, 1.46 and 0.81, respectively, and those of n were 1.53, 1.50, 1.56 and 2.28, respectively. So, the value of Do decreased with decreasing SF2. Post-irradiation recovery reached plateau at around 2 hours. Recovery ratio at plateau phase ranged from 1.2 to 4.2; the value were 1.2 for PCI-13, 3.2 for CaSki, 3.3 for SNU-C5, and 4.2 for A549. Recovery rate well correlated with SF2, and increased with increasing Do and decreasing ${\alpha}$. According to above results, the intrinsic radiosensitivity was quite different among the tested cell lines; PCI-13 was the most sensitive and A549 and CaSki was similar. This difference of radiosensitivity is thought to be partly due to the difference in amount of postirradiation recovery. By linear quadratic model the difference of ${\alpha}$ values was very high, and by multitarget single hit model the difference of Do value was significantly high among four cell lines.

• Journal of the Korean Society of Food Science and Nutrition
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• v.35 no.10
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• pp.1427-1433
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• 2006

The antioxidant activity, nitrite scavenging effect, and angiotensine I-converting enzyme inhibiting activity of solvent extracts of soybean isoflavone were investigated. Also anticarcinogenic activities of them were examined by MTT assay using human cancer cell line. Isoflavone aglycones showed relatively high antioxidant activity in order of glycitein, genistein, and daidzein. Methanol extract of soybean actively scavenged free radicals and was shown excellent nitrite scavenging effect. Glycitein and methanol extract of soybean inhibited the growth of human cancer cell such as stomach carcinoma (SNU-1) and colon carcinoma (SNU-C4) effectively. Genistein, daidzein and methanol extracts of soybean inhibited the growth of cancer cell such as stomach carcinoma (SNU-1), but had weak activities to colon carcinoma (SNU-C4). To applicate the soybean isoflavone as an enhancer for food quality and processibility, the stabilities on heat and pH of isolated isoflavone, isoflavone in soybean flour and isoflavone concentrate of soybean were investigated. Stability of isoflavone concentrate of soybean was decreased in pH extreme (below 3, above 8) during sterilization, but isoflavone in soybean flour showed higher stability in all pH range. All kinds of isoflavone tested in this study were very stable during the heat treatment.

• Journal of The Korean Society of Grassland and Forage Science
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• v.40 no.4
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• pp.244-250
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• 2020

This study investigated the effects of silage additives on rumen fermentation characteristics of rye silage. Rye was harvested at ripening stage and treated with different additives in quadruplicate following: without additive (control), with either lactic acid bacteria inoculant (LAB), formic acid (FA), or Ca-formate (Ca-FA). Overall, ensiling characteristics of FA and Ca-FA silages contained 4-fold more (P<0.05) butyrate and 2-fold more (P<0.05) NH3-N concentration (% total nitrogen) than those of control and LAB silages. Cows fed LAB silage showed a diurnal trend with the highest values of propionate concentration compared to the control at 1, 2 and 3 hr after feeding. In contrast, FA and Ca-FA silages increased the proportion of butyrate significantly (P<0.05) at all sampling times compared to control and LAB silage. In conclusion, Forage rye treated with FA or Ca-FA showed different fermentation characteristics during ensilage and in the rumen compared to LAB silage. Further studies are needed to evaluate whether different fermentation characteristics in the rumen between LAB and FA silages had effect on partitioning of nutrients between milk production and body tissue.