• Asian Pacific Journal of Cancer Prevention
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• 제17권3호
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• pp.1057-1060
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• 2016

Background: The tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. Mdm2 SNIP309 is a negative regulator of 53. Therefore, this study aimed to determine the role of the Mdm2 SNIP 309 polymorphism in the gastric mucosal morphological patterns in patients with Helicobacter pylori associated gastritis. Materials and Methods: A prospective cross-sectional study was carried out from November 2014 through November 2015. Biopsy specimens were obtained from patients and infection was proven by positive histology. Gastric mucosa specimens were sent to the Molecular Genetics Unit, Institute of Medicine, Suranaree University of Technology where they were tested by molecular methods to detect the patterns of Mdm2 SNIP 309 polymorphism using the real-time PCR hybridization probe method. The results were analyzed and correlated with gastric mucosal morphological patterns by using C-NBI endoscopy. Results: A total of 300 infected patients were enrolled and gastric mucosa specimens were collected. In this study the percentage of Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous was 78% and 19 % respectively whereas Mdm2 SNIP309 G/G homozygous was 3%. Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygosity correlated with type 1 to type 3 gastric mucosal morphological patterns (P<0.01) whereas Mdm2 SNIP309 G/G homozygous correlated with type 4 and type 5 (P<0.01). Conclusions: Our study finds the frequency of Mdm2 SNIP309 G/G in a Thai population is very low, and suggests that this can explain ae Thailand enigma. Types 1 to type 3 are the most common gastric mucosal morphological patterns according to the unique genetic polymorphism of MDM2 SNIP 309 in the Thai population.

• Journal of Rhinology
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• 제60권1호
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• pp.2-10
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• 2022

Background: Although the role of human papillomavirus (HPV) in sinonasal inverted papilloma (SNIP) has been investigated, the link between HPV infection and SNIP recurrence remains controversial. This meta-analysis aimed to investigate the association between HPV infection and recurrence of SNIP. Methods: The PubMed, Web of Science, Google Scholar, and Cochrane Library databases were searched (until 16 June 2021) to collect all relevant articles. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using the fixed effects model. In addition, subgroup analysis, assessment of publication bias, and sensitivity analyses were performed. Results: Fourteen eligible articles, including 592 patients with SNIP, were included in this study. Pooled analysis revealed that HPV-positive cases exhibited a significantly higher OR of tumour recurrence than HPV-negative counterparts). A significant association between HPV infection and tumour recurrence remained stable in subgroup analyses according to the publication year of the studies. Conclusions: Our meta-analysis demonstrates that HPV infection is significantly associated with the recurrence of SNIP, suggesting the pathological role of HPV in SNIP. These results suggest that HPV infection should be considered in the management of SNIP.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7781-7784
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• 2015

Background: The commonly held view of the tumor suppressor p53 is as a regulator of cell proliferation, apoptosis and many other biological processes as well as external and internal stress responses. Mdm2 SNIP309 is a negative regulator of p 53. Therefore, this study aimed to determine the correlation between the patterns of Mdm2 SNIP 309 and the inflammation grading of Helicobacter pylori associated gastritis in a Thai population. Materials and Methods: A cross-sectional study was carried out from November 2014 through June 2015. Biopsy specimens were obtained from infected patients and infection was proved by positive histology. The gastric mucosa specimens were sent to the Molecular Genetic Unit, Institute of Medicine, Suranaree University of Technology where they were tested by molecular methods to detect the patterns of Mdm2 SNIP 309 using the real-time PCR hybridization probe method. The results were analyzed and compared with the Updated Sydney classification. Results: A total of 100 infected patients were interviewed and gastric mucosa specimens were collected. In this study the percentage of Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous was 78% and 19 % respectively whereas Mdm2 SNIP309 G/G homozygous was 3%. Mdm2 SNIP 309 T/T homozygous and Mdm2 SNIP309 G/T heterozygous correlated with mild to moderate inflammation (P<0.01) whereas Mdm2 SNIP309 G/G homozygous correlated with severe inflammation (P<0.01). Conclusions: Our study found the frequency of Mdm2 SNP309 G/G in our Thai population to be very low, and suggests that this can explain to some extent the low incidence of severe inflammation and gastric cancer changes in the Thai population. Mild to moderate inflammation are the most common pathologic gradings due to the unique genetic polymorphism of Mdm2 SNIP 309 in the Thai population.

• 전자공학회논문지
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• 제50권9호
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• pp.164-171
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• 2013

X-선 스펙트럼 데이터는 물질의 성분과 관련이 없는 많은 양의 백그라운드 신호를 포함하고 있다. XRF는 스펙트럼에서 가우시안 형태의 피크 정보의 위치와 크기를 이용하여 시료의 성분과 함유량을 분석하며, 시료의 성분과 함유량을 정확히 분석하기 위해서는 백그라운드를 정확하게 제거하여야 한다. 백그라운드를 제거하기 위한 방법으로는 모폴로지, SNIP, 임계값 방법들이 적용되고 있으며, 구간별 임계값 방법에 대한 연구가 활발히 진행되었다. 본 논문에서 제안하는 백그라운드 제거 방법은 구간별 임계값 방법을 개선한 방법으로 구간분할과 영역분류, 백그라운드추정으로 구성된다. 제안된 방법이 백그라운드 제거에서 기존의 모폴로지 기반 방법이나 SNIP 방법에 비해 좋은 성능을 보임을 실험을 통해 검증하였다.

• 전자공학회논문지
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• 제50권8호
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• pp.238-244
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• 2013

에너지 분산형 X-선 형광(EDXRF) 분석에서 X-선 스펙트럼에 존재하는 컨티넘(continuum)의 추정 및 제거는 필수적이다. 이를 위해 일반적으로 사용되는 알고리즘들은 많은 주의가 필요하며 복잡하다. 보통 이 알고리즘들은 제약적이거나 컨티넘의 데이터나 모양에 대한 가설을 필요로 한다. 본 논문에서는 제안된 에너지 분산형 X-선 형광 스펙트럼을 위한 효율적인 배경(background) 보정 방법은 배경 모델링과 배경 보정으로 구성된다. 이 방법은 스펙트럼에서 백그라운드영역과 피크영역을 구분하는 기본 개념을 기반으로 하며 성능향상을 위하여 SNIP알고리즘을 사용한다. 스펙트럼으로부터 배경에 속하는 점들을 획득한 후 이를 기반으로 곡선 근사화를 통해 배경을 모델링한다. 이후 획득된 배경 모델을 원 스펙트럼에서 뺌으로써 배경이 보정된 스펙트럼을 얻는다. 제안된 방법은 상대적으로 적은 사전 지식을 요구하면서 기존의 몇몇 방법들에 비해 우수한 결과를 보여주었다.

• 한국산학기술학회논문지
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• 제13권5호
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• pp.2291-2297
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• 2012

X-선 스펙트럼 데이터는 물질의 성분과 관련이 없는 신호(백그라운드, 노이즈)들을 포함 하고 있다. XRF는 스펙트럼에서 가우시안 형태의 피크 위치와 크기를 이용하여 시료의 성분을 분석하며, 시료의 성분을 정확히 분석하기 위해서는 노이즈와 백그라운드를 제거 하여야 한다. 백그라운드를 제거하기 위한 방법으로는 SNIP, Threshold, Morphology 방법 등을 적용하고 있으며, Threshold 기법을 중에서 블록별로 각기 다른 임계값을 적용하는 Interval Threshold기법이 하나의 임계값을 적용하는 Level Threshold 방법보다 더 좋은 성능을 발휘한다. 본 논문에서는 Interval Threshold를 적용하기 위하여 웨이블릿을 이용하여 블록을 분리하는 알고리즘을 제안하였다.

• 한국정보과학회 언어공학연구회:학술대회논문집(한글 및 한국어 정보처리)
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• 한국정보과학회언어공학연구회 2023년도 제35회 한글 및 한국어 정보처리 학술대회
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• pp.479-484
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• 2023

다중 레이블 오픈 의도 분류란 다중 의도 분류와 오픈 의도 분류가 합쳐져 오픈 도메인을 가정하고 진행하는 다중 의도 분류 문제이다. 발화 속에는 여러 의도들이 존재한다. 이때 사전에 정의된 의도 여부만을 판별하는 것이 아니라 사전에 정의되어 있는 의도에 대해서만이라도 어떤 의도인지 분류할 수 있어야 한다. 본 논문에서는 발화 속 의도 정보를 활용하여 다중 레이블 오픈 의도를 분류하는 모델을 제안한다. 먼저, 문장의 의도 개수를 예측한다. 그리고 다중 레이블 의도 분류기를 통해 다중 레이블 의도 분류를 진행하여 의도 정보를 획득한다. 획득한 의도 정보 속 다중 의도 개수와 전체 의도 개수를 비교하여 전체 의도 개수가 더 많다면 오픈 의도가 존재한다고 판단한다. 실험 결과 제안한 방법은 MixATIS의 75% 의도에서 정확도 94.49, F1 97.44, MixSNIPS에서는 정확도 86.92, F1 92.96의 성능을 보여준다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7049-7052
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• 2015

Background: Helicobacter pylori plays an important role in gastric cancer, which has a relatively low inciduence in Thailand. MDM2 is a major negative regulator of p53, the key tumor suppressor involved in tumorigenesis of the majority of human cancers. Whether its expression might explain the relative lack of gastric cancer in Thailand was assessed here. Materials and Methods: This single-center study was conducted in the northeast region of Thailand. Gastric mucosa from 100 patients with Helicobacter pylori associated gastritis was analyzed for MDM2 SNP309 using real-time PCR hybridization (light-cycler) probes. Results: In the total 100 Helicobacter pylori associated gastritis cases the incidence of SNP 309 T/T homozygous was 78 % with SNP309 G/T heterozygous found in 19% and SNP309 G/G homozygous in 3%. The result show SNP 309 T/T and SNP 309 G/T to be rather common in the Thai population. Conclusions: Our study indicates that the MDM2 SNP309 G/G homozygous genotype might be a risk factor for gastric cancer in Thailand and the fact that it is infrequent could explain to some extent the low incidence of gastric cancer in the Thai population.

• 국제초고층학회논문집
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• 제3권1호
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• pp.65-71
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• 2014

Baku, the capital of Azerbaijan, has seen a boom in construction in recent years. The old Baku city has been rapidly transforming into a new hub of high-rise buildings and lively cultural centers hosting the Euro Vision Song Contest in 2012 and European Games in 2015. A major population shift to Baku from its suburbs and the countryside has resulted in the doubling of Baku's population in the 4 years between 2009 and 2013. As of January 2013, Baku's population reached four million people, 43% of the citizens in Azerbaijan according to The State Statistical Committee of Azerbaijan. With this trend, the city needs more high-rise buildings to accommodate rapidly increasing demands for more housing and business space. Until the Azerbaijan Seismic Building Code was published in 2010 and became effective, many different seismic criteria, in terms of building codes and seismic intensities, were used for all new high-rise projects in Baku. Some designers used the SNIP (Russian) code with seismic level 9 or level 8 with 1 point penalty. Others used the Turkish code with Seismic Zone 1, UBC 97 with Zone 2 through 4, or IBC with Sa = 0.75 g through 1.0 g. The seismic intensity is now clarified with the Azerbaijan Seismic Building Code. However, the Azerbaijan Seismic Building Code is appropriate for low-rise buildings applications but may be inappropriate for high-rise project applications. This is because the code-defined response spectrum yields unrealistically conservative seismic forces for high-rise buildings with long periods, as compared to those determined by other internationally accepted building codes. This paper provides observations and recommendations for code-based seismic load assessment of high-rise buildings in the Baku area.