• Journal of Acupuncture Research
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• 제22권2호
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• pp.19-32
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• 2005

Objectives : to evaluate the analgesic effect of bee venom acupuncture on Choksamni (ST36) in the collagen-induced arthritis rats and investigate the role played by serotonergic receptor subtypes (5-HT1a, 5-HT2a) in the antinociceptive effect of bee venom acupuncture in a thermal hyperalgesia test Methods : Experiments were performed on 5 week-aged 60 male Sprague-Dawley rats according to National Institute of Health guidelines and the ethical guidelines of the International Association for the Study of Pain (IASP). Arthritis was induced with arthrogenic collagen emulsion (Bovine type II collagen ${\mu}g$ with incomplete Freund's adjuvant $100\;{\mu}g$). The onset of arthritis was considered to be present when erythema and swelling were detected in at least one joint. The thermal hyperalgesia was evaluated weekly with tail flick test in the rats of severity grade 3 without any injury at tail and foot (including inflammation, ulceration, snap). In the fourth week after first immunization, the analgesic effect of bee venom acupuncture (Choksamni, ST36) was measured with consecutive tail flick latency after intraperitoneal injection of spiroxatrine (1mg/kg) and spiperone (1mg/kg). Results : Chronic inflammatory pain was induced as time elapsed after the immunization of arthrogenic collagen and the maximum value was reached from third to fifth week. Chronic inflammatory pain induced by CIA was inhibited by bee venom acupuncture on the left ST36. The analgesic effect of bee venom acupuncture was inhibited by intraperitoneal injection of 5-HT1a antagonist spiroxatrine and 5-HT2a antagonist spiperone. Conclusions : Therefore, a conclusion. that the analgesic effect of bee venom acupuncture in the chronic inflammatory pain is partially mediated by 5-HT1a and 5-HT2a receptors can be made.

• 대한약침학회지
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• 제10권2호통권23호
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• pp.25-30
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• 2007

Objectives : Free radical metabolism seems to occupy a remarkably common position in the mechanisms of aging and aging related disease. Oxidative damage to DNA, lipids. proteins and other molecules may contribute to the development of cancer, cardiovascular disease and possibly neurodegenerative disease. This study was designed to find out whether Carthami Flos Herbal-Acupuncture Solution can scavenge Nitric Oxide(NO) or not. SNAP is NO generator. NO concentration was estimated after 2,6, 12 and 24 hrs in no treatment group, after treatment with Vit. C or 1, 10, 100${\mu}$g/m1 of Carthami Flos Herbal-Acupuncture Solution. There was no significant scavenging effect of Carthami Flos Herbal-Acupuncture Solutionon NO after 2 hrs. But there was a significant scavenging effect of Cafhami Flos Herbal-Acupuncture Solution on NO in 10${\mu}$/m1 group after 6hrs. And there was a significant scavenging effect of carthami Flos Herbal-Acupuncture Solution on NO in 1, 10${\mu}$g/ml group after 12, 24 hrs. These results suggest that Carhami Flos Herbal-Acupuncture Solution has scavenging effect on NO. This study shows that Carthami Flos Herbal-Acupuncture Solution can be used for aging related disease and further studies are required to investigate the antioxidative effects of it.

• 정보처리학회논문지:소프트웨어 및 데이터공학
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• 제5권2호
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• pp.95-106
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• 2016

생체 데이터는 사람에 따라 다르게 나타날 수 있고 사상의학과 밀접한 관계를 가지고 있다. 생체 데이터는 사람의 맥박과 혈압, 심박동 수와 과거의 병력, 노화의 정도, 체질량 지수 등을 의미하며, 이 생체 데이터는 사람의 건강상태를 판별하기 위한 기준 척도로 활용된다. 그렇기 때문에 생체 데이터는 사용하고자 하는 목적에 맞도록 가공되어야 한다. 기존 연구에서는 실시간으로 변화되고 있는 생체 데이터를 현재 시점의 스냅셧으로만 적용하고 있기 때문에 시간의 연속성이 배제되어 있다. 따라서 이 문제를 해결하기 위하여 본 논문에서는 생체 데이터들로 구성되는 Big Data 환경에서 시간의 연속성을 포함하는 생체데이터의 패턴분석 모델을 제안한다. 제안 모델은 치료와 건강증진을 위해 전자침을 사용할 때 침자리의 선정을 신중하게 결정하는데 도움을 줄 수 있다.

• Earthquakes and Structures
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• 제5권1호
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• pp.83-109
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• 2013

A simple damper optimization method is proposed to find optimal damper allocation for shear buildings under both target added damping ratio and interstorey drift ratio (IDR). The damping coefficients of added dampers are considered as design variables. The cost, which is defined as the sum of damping coefficient of added dampers, is minimized under a target added damping ratio and the upper and the lower constraint of the design variables. In the first stage of proposed algorithm, Simulated Annealing, Nelder Mead and Differential Evolution numerical algorithms are used to solve the proposed optimization problem. The candidate optimal design obtained in the first stage is tested in terms of the IDRs using linear time history analyses for a design earthquake in the second stage. If all IDRs are below the allowable level, iteration of the algorithm is stopped; otherwise, the iteration continues increasing the target damping ratio. By this way, a structural response IDR is also taken into consideration using a snap-back test. In this study, the effects of the selection of upper limit for added dampers, the storey mass distribution and the storey stiffness distribution are all investigated in terms of damper distributions, cost function, added damping ratio and IDRs for 6-storey shear building models. The results of the proposed method are compared with two existing methods in the literature. Optimal designs are also compared with uniform designs according to both IDRs and added damping ratios. The numerical results show that the proposed damper optimization method is easy to apply and is efficient to find optimal damper distribution for a target damping ratio and allowable IDR value.

• 한국농공학회논문집
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• 제61권5호
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• pp.89-99
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• 2019

In this study, we estimated the spatially-distributed soil moisture at the high resolution ($10m{\times}10m$) using the satellite-based Sentinel-1A/B SAR (Synthetic Aperture Radar) sensor images. The Sentinel-1A/B raw data were pre-processed using the SNAP (Sentinel Application Platform) tool provided from ESA (European Space Agency), and then the pre-processed data were converted to the backscatter coefficients. The regression equations were derived based on the relationships between the TDR (Time Domain Reflectometry)-based soil moisture measurements and the converted backscatter coefficients. The TDR measurements from the 51 RDA (Rural Development Administration) monitoring sites were used to derive the regression equations. Then, the soil moisture values were estimated using the derived regression equations with the input data of Sentinel-1A/B based backscatter coefficients. Overall, the soil moisture estimates showed the linear trends compared to the TDR measurements with the high Pearson's correlations (more than 0.7). The Sentinel-1A/B based soil moisture values matched well with the TDR measurements with various land surface conditions (bare soil, crop, forest, and urban), especially for bare soil (R: 0.885~0.910 and RMSE: 3.162~4.609). However, the Mandae-ri (forest) and Taean-eup (urban) sites showed the negative correlations with the TDR measurements. These uncertainties might be due to limitations of soil surface penetration depths of SAR sensors and complicated land surface conditions (artificial constructions near the TDR site) at urban regions. These results may infer that qualities of Sentinel-1A/B based soil moisture products are dependent on land surface conditions. Although uncertainties exist, the Sentinel-1A/B based high-resolution soil moisture products could be useful in various areas (hydrology, agriculture, drought, flood, wild fire, etc.).

• 한국임상수의학회지
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• 제37권6호
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• pp.311-316
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• 2020

Biomarkers used in dogs with heartworm disease include N-terminal pro B-type natriuretic peptide (NT-proBNP) and cardiac troponin I (cTnI), which are associated with damage to the myocardium. Pulmonary hypertension is one of the clinical signs of canine heartworm disease. The purpose of this study is to investigate the change in the concentration of each biomarker, severity of pulmonary hypertension and the correlation between biomarkers according to the severity of clinical signs. Five healthy dogs and 10 heartworm-infected dogs were recruited for the study. The heartworm-infected group was classified based on the history, clinical signs, and blood assay, thoracic radiography, and echocardiography after confirming the infection according to the results of the commercial ELISA kit (SNAP test, IDEXX Laboratories, Maine, USA). NT-proBNP was higher in the severely infected group than the control group (p < 0.05); cTnI was also higher in the severely infected group than the control group (p < 0.05). The pressure gradient of pulmonary hypertension was higher in the severe group than the mild group (p < 0.05). The severity of pulmonary hypertension was correlated with NT-proBNP (r = 0.818, p < 0.01), cTnI (r = 0.894, p < 0.01). When the correlation of the two serum values for each group was examined, a correlation was not found in the mild group (r = 0.707, p = 0.182), but a correlation was found in the severe group (r = 0.9, p < 0.05). NT-proBNP and cTnI were significantly increased and correlated with severe clinical signs. Pulmonary hypertension was significant higher in the severe group than in the mild group (p < 0.05). Evaluation of blood biomarker concentration and severity of pulmonary hypertension and referring to each correlation between these indicators may be helpful to assess the severity of the heartworm disease.

• Imaging Science in Dentistry
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• 제52권1호
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• pp.103-108
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• 2022

Purpose: Disc displacement can cause resorption of the head of the condyle and affect its volume. This study analysed the volume of normal condyles and those with disc displacement with reduction (DDR) in cone-beam computed tomography (CBCT) scans from the Indonesian population. Materials and Methods: This study analysed 56 condyles (26 normal and 30 with DDR) from patients who visited the Oral and Maxillofacial Radiology Unit after being referred from the Prosthodontics Unit at Dental Hospital Universitas Padjadjaran from December 2020 to February 2021. Samples were divided into 2 groups (normal and DDR left and right-side condyles) based on the DC/TMD Axis 1 form through the clinical examination results. Both sample groups were exposed to CBCT radiation. The CBCT imaging results in the Digital Imaging and Communications in Medicine format were exported to the open-source ITK-SNAP format to determine condyle volume. Volumetric data from the cortical and trabecular areas of the right or left side condyles were arranged by sex. The independent t-test was used to determine the significance of differences with IBM SPSS version 21.0. Intra- and inter-observer reliability and validity were tested before determining the volume of the condyles. Results: Normal condyles and DDR condyles showed significant differences in volume (P<0.05). Significant differences were also seen in cortical (P=0.0007) and trabecular (P=0.0045) volumes. There was a significant difference in condylar volume based on sex. Conclusion: The normal condyle volume was significantly different from the DDR condyle volume in both sexes.

• 한국의류산업학회지
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• 제24권2호
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• pp.249-259
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• 2022

To analyze recent changes in designer-specific garment composition, detail, and design elements of jackets, we classified jackets from the Paris Haute Couture Collection from 2000 S/S to 2019 F/W according to their designers and examined their characteristics. Our analysis of the jackets by Armani, Chanel, Dior, Jean-Paul Gaultier, and Valentino shows that the hour-glass silhouette was most common in Armani, Chanel, Dior, Jean-Paul Gaultier and Valentino jackets; Chanel used more straight silhouettes compared to other designers. Most jackets, regardless of the designer, had midlength waist-to-bottom, tight sleeves fitted to the body, natural shoulder shape, and solid color. Moreover, woven fabric was the most common material. Jackets with no collar were the most common for Armani, tailored collars for Dior and Jean-Paul Gaultier, and standing collars for Chanel and Valentino. For the closure method, Armani used hook-and-eye, Chanel, Jean-Paul Gaultier, Valentino used button closures, and Dior used snap closures the most. New design attempts by designers are bringing details and design elements together. In an era characterized by an abundance of designs and frequent replacement of each brand's creative designers, it is important to create and maintain a brand's unique design identity and philosophy that can meet consumers' elevated standards, which tend to be biased towards new and stimulating designs due to the development of the IT industry.

• 한국공간구조학회논문집
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• 제22권3호
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• pp.25-32
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• 2022

In this paper, the instability of the domed spatial truss structure using wood and the characteristics of the buckling critical load were studied. Hexagonal space truss was adopted as the model to be analyzed, and two boundary conditions were considered. In the first case, the deformation of the inclined member is only considered, and in the second case, the deformation of the horizontal member is also considered. The materials of the model adopted in this paper are steel and timbers, and the considered timbers are spruce, pine, and larch. Here, the inelastic properties of the material are not considered. The instability of the target structure was observed through non-linear incremental analysis, and the buckling critical load was calculated through the singularities and eigenvalues of the tangential stiffness matrix at each incremental step. From the analysis results, in the example of the boundary condition considering only the inclined member, the critical buckling load was lower when using timber than when using steel, and the critical buckling load was determined according to the modulus of elasticity of timber. In the case of boundary conditions considering the effect of the horizontal member, using a mixture of steel and timber case had a lower buckling critical load than the steel case. But, the result showed that it was more effective in structural stability than only timber was used.

• Imaging Science in Dentistry
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• 제53권3호
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• pp.221-227
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• 2023

Purpose: This study was performed to develop a linear regression model using the pulp-to-tooth volume ratio (PTVR) ratio of the maxillary canine, assessed through cone-beam computed tomography (CBCT) images, to predict chronological age (CA) in Indonesian adults. Materials and Methods: A sample of 99 maxillary canines was collected from patients between 20 and 49.99 years old. These samples were obtained from CBCT scans taken at the Universitas Padjadjaran Dental Hospital in Indonesia between 2018 and 2022. Pulp volume (PV) and tooth volume (TV) were measured using ITK-SNAP, while PTVR was calculated from the PV/TV ratio. Using RStudio, a linear regression was performed to predict CA using PTVR. Additionally, correlation and observer agreement were assessed. Results: The PTVR method demonstrated excellent reproducibility, and a significant correlation was found between the PTVR of the maxillary canine and CA(r= -0.74, P<0.01). The linear regression analysis showed an R² of 0.58, a root mean square error of 5.85, and a mean absolute error of 4.31. Conclusion: Linear regression using the PTVR can be effectively applied to predict CA in Indonesian adults between 20 and 49.99 years of age. As models of this type can be population-specific, recalibration for each population is encouraged. Additionally, future research should explore the use of other teeth, such as molars.