• Korean Journal of Radiology
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• 제21권1호
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• pp.77-87
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• 2020

Objective: To assess the feasibility of simultaneous multislice-accelerated diffusion-weighted imaging (SMS-DWI) of the rectum in comparison with conventional DWI (C-DWI) in rectal cancer patients. Materials and Methods: This study included 65 patients with initially-diagnosed rectal cancer. All patients underwent C-DWI and SMS-DWI with acceleration factors of 2 and 3 (SMS2-DWI and SMS3-DWI, respectively) using a 3T scanner. Acquisition times of the three DWI sequences were measured. Image quality in the three DWI sequences was reviewed by two independent radiologists using a 4-point Likert scale and subsequently compared using the Friedman test. Apparent diffusion coefficient (ADC) values for rectal cancer and the normal rectal wall were compared among the three sequences using repeated measures analysis of variance. Results: Acquisition times using C-DWI, SMS2-DWI, and SMS3-DWI were 173 seconds, 107 seconds, (38.2% shorter than C-DWI), and 77 seconds (55.5% shorter than C-DWI), respectively. For all image quality parameters other than distortion (margin sharpness, artifact, lesion conspicuity, and overall image quality), C-DWI and SMS2-DWI yielded better results than did SMS3-DWI (Ps < 0.001), with no significant differences observed between C-DWI and SMS2-DWI (Ps ≥ 0.054). ADC values of rectal cancer (p = 0.943) and normal rectal wall (p = 0.360) were not significantly different among C-DWI, SMS2-DWI, and SMS3-DWI. Conclusion: SMS-DWI using an acceleration factor of 2 is feasible for rectal MRI resulting in substantial reductions in acquisition time while maintaining diagnostic image quality and similar ADC values to those of C-DWI.

• 한국버섯학회지
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• 제16권1호
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• pp.39-44
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• 2018

큰느타리버섯 수확 후 배지를 이용한 유기퇴비를 제조하여 퇴비 원료로서의 이용가능성에 대해 실험을 진행하였다. 퇴비의 발아능력을 검증하기 위해 오이, 무, 상추, 배추를 파종한 후 발아율과 발아지수를 측정하였으며 미강과 미생물제의 첨가비율이 높을수록 높은 발아율을 나타내는 것을 확인할 수 있었다. 오이와 무의 발아지수는 전체적으로 높았으며, 상추의 경우 SMS 100%와 미강 5% 첨가구만 발아지수 70을 넘었고 배추는 미생물제 5% 첨가구에서 가장 높은 발아지수를 나타내었다. 또한 상추를 이용하여 SMS 상토 제조비율과 생육특성을 조사하기 위해 생육시험용 상토 제조비율은 일반상토 100%와 SMS 10%, SMS 20%, SMS 30%, SMS 50%, SMS 70%, SMS 100%로 제조하여 상추묘를 이식하였다. 먼저 상토재료의 이화학성 분석을 시행하였으며 SMS 첨가량이 높을수록 질소전량이 높아지는 것을 확인할 수 있었다. 하지만 상추의 SMS 처리구와 일반상토에서의 생육정도를 비교하였을 때, 중량은 SMS 10% 43.9 g, 일반상토 46.4 g로 비슷하였으며 엽록소 함량도 SMS 10% 32.8, 일반상토 SMS 10% 32.8로 같았고 나머지도 비슷한 수치를 나타내었으나 총장에서 SMS 10% 14.6 cm, 일반상토 16.8 cm로 일반상토가 더 큰 것으로 확인되었다.

• 대한약침학회지
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• 제16권4호
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• pp.36-42
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• 2013

Objectives: Shengmaisan (SMS) is a traditional Chinese medicine prescription widely used for the treatment of diverse organs in Korea. The interstitial cells of Cajal (ICCs) are pacemaker cells that play an important role in the generation of coordinated gastrointestinal (GI) motility. We have aimed to investigate the effects of SMS in the ICCs in the mouse small intestine. Methods: To dissociate the ICCs, we used enzymatic digestions from the small intestine in a mouse. After that, the ICCs were identified immunologically by using the anti-c-kit antibody. In the ICCs, the electrophysiological whole-cell patch-clamp configuration was used to record pacemaker potentials in the cultured ICCs. Results: The ICCs generated pacemaker potentials in the mouse small intestine. SMS produced membrane depolarization with concentration-dependent manners in the current clamp mode. Pretreatment with a $Ca^{2+}$ free solution and thapsigargin, a $Ca^{2+}$-ATPase inhibitor in the endoplasmic reticulum, stopped the generation of the pacemaker potentials. In the case of $Ca^{2+}$-free solutions, SMS induced membrane depolarizations. However, when thapsigargin in a bath solution was applied, the membrane depolarization was not produced by SMS. The membrane depolarizations produced by SMS were inhibited by U-73122, an active phospholipase C (PLC) inhibitors. Furthermore, chelerythrine and calphostin C, a protein kinase C (PKC) inhibitors had no effects on SMS-induced membrane depolarizations. Conclusions: These results suggest that SMS might affect GI motility by modulating the pacemaker activity through an internal $Ca^{2+}$- and PLC-dependent and PKC-independent pathway in the ICCs.

• 대한의생명과학회지
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• 제25권4호
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• pp.313-320
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• 2019

In this study, phytochemicals extracted from sea mustard (SM) and sea mustard sporophyll (SMS) in ethanol solution have been analyzed and wound healing potential of the phytochemicals was investigated. In the phytochemical screening studies, the extract of SM and SMS includes several phytochemical compounds such as phytol, ascorbic acid, sitgmasta, fucosterol and ergosta. Cytotoxicity studies of the extract of SM and SMS with mouse macrophage RAW 264.7 cells showed on toxicity up to a high concentration of 1.0 mg/mL. Furthermore, the SM and SMS extract significantly reduces the production of nitric oxide (NO) induced lipopolysaccharide on RAW 264.7 cells with a dose-dependent manner. In addition, the extract of SM and SMS has the effect of enhancing the cell migration and invasion of fibroblast. These results demonstrate that the extract of SM and SMS could help to heal wound by reducing NO production and increasing cell migration.

• 스마트미디어저널
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• 제9권4호
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• pp.144-151
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• 2020

모바일 환경에서 의사소통은 SMS 문자로 이루어진다. SMS 문자에서 사용되는 어휘들은 일반적인 한국어 문어체 문장에서 사용되는 어휘들과 다른 부류의 어휘들이 사용될 것으로 예상할 수 있다. 예를 들어, 일반적인 문어체의 경우 문장의 시작이나 끝맺음이 올바르고 문장의 구성요소가 잘 갖추어졌지만, SMS 문자 말뭉치의 경우 구성요소를 생략 및 간략한 표현으로 대체하는 경우가 많다. 이러한 어휘 사용 특성을 분석하기 위하여, 기존에 구축된 구어체 말뭉치와 문어체 말뭉치를 사용한다. 실험에서는 구어체 말뭉치인 SMS 문자 말뭉치와 네이버 영화평 말뭉치, 그리고 문어체 말뭉치인 한국어 문어체 원시 말뭉치의 어휘사용 특성을 비교-분석한다. 말뭉치별 어휘 비교 및 분석을 위하여 품사 태그 형용사(VA)를 기준으로 하였고, 공연강도를 측정하기 위해 변별적 공연어휘소 분석 방법론을 사용하였다. 그 결과 '좋-', '죄송하-', '즐겁-' 등 감정표현 형용사들이 SMS 문자 말뭉치에서 선호되는 반면, 네이버 영화평 말뭉치에서는 평가 표현과 관련된 형용사들이 선호되는 것을 확인할 수 있었다. 이러한 과정에서 추출된 공연강도가 높은 형용사를 기준으로 감정어휘 사전을 자동 구축하기 위하여 단어 임베딩 기법을 사용하였으며, 총 343,603개의 감성어휘를 자동 구축하였다.

• 동의생리병리학회지
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• 제22권2호
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• pp.431-437
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• 2008

Sengmaek-san(Shengmai-san; SMS) is used in oriental medicine as one of the key herbal medicine for treating diverse symptoms including cardiovascular and neurological disorders. In the present study, the effects of SMS on axonal regeneration were investigated in the rat model given sciatic nerve injury. SMS treatment enhanced axonal regrowth into and the number of non-neuronal cells in the distal area after crush injury. GAP-43 protein levels were increased in the injured sciatic nerve compared to intact nerve and further upreguated by SMS treatment. GAP-43 protein was increased similarly in the dorsal root ganglion (DRG) at lumbar 4 - 6 by nerve injury and SMS treatment, suggesting GAP-43 induction at gene expression level. SMS-mediated increase in phospho-Erk1/2 protein was observed in the DRG as well as in the injured nerve implying its retrograde transport into the cell body as the process of lesion signal transmission. The present findings suggest that SMS may be involved in enhanced axonal regeneration via dynamic regulation of regeneration-associated proteins.

• Journal of Animal Science and Technology
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• 제64권4호
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• pp.696-706
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• 2022

This study was conducted to evaluate the effects of dietary supplementation of Silybum marianum seed (SMS) extract on the growth performance, nutrient digestibility, fecal noxious gas emission, and hematology parameters in weaned piglets. A total of 120, 21-day-old weaned piglets ([Yorkshire × Landrace] × Duroc) were randomly assigned to 3 groups based on the average initial body weight (6.46 ± 0.45 kg). There were 8 replicate pens per treatment and 5 pigs (mixed sex) per pen. The experimental period was 42 days. Dietary groups included a basal diet, and a basal diet supplemented with 0.05% or 0.10% SMS extract. Feeding weaned piglets with SMS extract containing diet significantly increased average daily gain and average daily feed intake. Additionally, the supplementation of SMS extract had no significant effects on nutrient digestibility, serum hematology, and fecal noxious gas emission parameters. We considered that the supplementation of SMS extract had positive effects on the voluntary feed intake in weaned piglets, thus improving growth performance.

• 대한약침학회지
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• 제19권3호
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• pp.231-238
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• 2016

Objectives: This study used repeated intravenous injections of Saeng Maek San (SMS) injection in Sprague-Dawley (SD) rats to assess the toxicity and the stability of SMS. Methods: Six-week-old male and female SD rats reared by Orient bio Inc were chosen for this pilot study. They were randomly split into four groups: Group 1 (G1), the control group (0.3 mL of normal saline solution/day/animal), and Groups 2, 3 and 4 (G2, G3 and G4), the experimental groups (0.1, 0.2 and 0.3 mL/day/animal of SMS), respectively. Each animal received an intravenous injection of SMS once a day for four weeks. Clinical signs, body weight changes, and food consumption were monitored during the observation period, and urinalysis and hematology were conducted after four weeks of SMS or saline administration. Results: No deaths occurred in any of the four groups during the observation period. Compared to the control group, male and female rats in groups 3 and 4 (0.2 and 0.3 mL/animal/day) showed hemoglobinuria, but the low-dosage group (G2, 0.1 mL/animal/day) showed no significant changes in the clinical signs test. No significant changes due to SMS were observed in the experimental groups regarding body weight changes, food consumption urinalysis, or hematology. Conclusion: During this study, no mortalities were observed in any of the experimental groups and no hemoglobinuria was observed in the low dosage group (0.1 mL/animal/day) while it was intermittently observed in groups 3 and 4 (0.2 and 0.3 mL/animal/day). Thus, we suggest that the no-observed adverse-effect level (NOAEL) is 0.1 mL/animal/day in male and female SD rats.

• 한국항공운항학회지
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• 제28권4호
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• pp.182-186
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• 2020

As all flight training institutions in Korea were approved by the Ministry of Land, Infrastructure and Transport (MOLIT) as aviation training organizations (ATO), safety management based on the Aviation Safety Management System (SMS) became mandatory. However, even though safety management using SMS has become mandatory, the performance of aviation safety voluntary report, which is the core of the system, remains low compared to other countries. The current address of SMS, a ATO, is like a watermill without water. The present study is to find out why voluntary aviation safety reports, which is equivalent to water from waterwheel, is underperforming and to suggest ways to revitalize it.

• 한국콘텐츠학회논문지
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• 제7권4호
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• pp.20-29
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• 2007

전자우편은 인터넷을 이용하는 사용자들에게 중요한 커뮤니케이션의 역할을 담당하고 있다. 하지만, 원하지 않는 광고 정보를 포함한 스팸 메일, 악성코드 형태를 포함한 바이러스 메일 등 대부분이 불필요한 자료들로 인해 전자우편이 가지는 본연의 의미와는 무색하게 사용되고 있어 근본적인 측면에서 스팸 메일의 발송을 방지할 수 있는 방안에 대한 연구가 시급하다. 본 연구에서 전자우편 발송자는 SMS(Short Message Service) 방식으로 별도의 비밀 정보를 전달받고 이를 통해 Domainkey 방식에서 사용하는 개인키/공개키 쌍을 생성하도록 하였으며 기존의 PGP 방식과도 접목하여 전자우편 송신자에 대한 인증 및 메시지에 대한 암복호화 기능을 수행하는 기법을 제안한다. 제안한 기법은 메일 발송 과정에서 발신자에 대한 인증 과정을 수행하므로 스팸 메일의 발송을 방지할 수 있는 기법이다.