• Bulletin of the Korean Chemical Society
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• v.18 no.8
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• pp.868-873
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• 1997

Nucleophilic substitution reactions of 1-phenylethyl chlorides (1-PEC; YC6H4CH(CH3)Cl) with phenoxides (XC6H4O-) and thiophenoxides (XC6H4S-) are investigated theoretically using the PM3 method. The Bronsted α and β values are greater for the phenoxides indicating a more advanced reaction in the transition state (TS) than for the thiophenoxides. This is supported by a greater magnitude of ρX (- 6.4 ∼ - 7.4) and ρXY (- 0.76) for the phenoxides than for the thiophenoxides (ρX = - 3.6 ∼ - 4.4 and ρXY = - 0.60). The percentage bond order changes, %Δn≠, suggest that the extents of bond making and breaking are similar for the phenoxides and hence the TS is symmetrical, but bond making is somewhat greater than bond cleavage for the thiophenoxides indicating an unsymmetrical TS. The reactions in the gas phase for both nucleophile series proceed by a SN2 mechanism with a tight TS and negative charge development on the reaction center carbon, Cα. The reactions in water investigated with model systems of benzyl and 1-phenylethyl chlorides using the Cramer-Truhlar solvation model (PM3-SM3) indicate that the reactions of 1-PEC are far more complex due to enhanced stabilization of the carbocation by the methyl substitution for a benzylic hydrogen.

• Journal of Agricultural Extension & Community Development
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• v.24 no.2
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• pp.143-154
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• 2017

Saemaul Undong (SM U) initiated in Korea in the 1970's is widely acknowledged as a successful model for rural community development, despite its limitations. This paper investigates the success factors of the SMU model and the lessons thereof for Sam Sang Model of Lao PDR, which appears ineffective over the years. Results show that land reforms, social ties among villages, strong institutional support and leadership and incentive system as well as "top-down" and "bottom-up" development approaches are among the factors that significantly contributed to the success of the SMU. However, rural development program would not be effective if residents are unwilling to participate. Therefore, to successfully achieve rural community development in Lao PDR, the government should through the Sam Sang model employ top-down and bottom-up approaches to enhance local participation and address the exact needs of the local people.

• Journal of the Korean Society of Food Science and Nutrition
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• v.13 no.1
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• pp.15-21
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• 1984

In order to ascertain the practical possibility of home made retort pouches for production of retort pouch foods in factory, two kinds of retortable pouches, i. e. 3 ply film (polyester film/Al. foil/casting polypropylene) and 4 ply film(polyester film/Al. foil/nylon/casting poll·propylene) were developed in Korea, and then, their physical properties, such as physical strength, heat resistance during thermal processing and preservability of foods and sanitary safety, were tested and compared with the foreign made pouches. The results obtained were summarized as follows. a. The physical strength of home made retort pouches in processing model foods(soybean oil 5 %, acetic acid 2%, starch 5 % and water to 100 %) was equal to that of foreign made pouches at accelerated examination condition($38^{\circ}C$, 98 % RH). But the lamination strength of home made products was a little bit superior to that of foreign made products. b. Home made retort pouches(SAMA-4 ply and SAMA-3 ply pouch) packed with rice or curry was possible to bear the thermal processing at $135^{\circ}C$ and shelf-life was one year or more at ambient temperature($20^{\circ}C$). c. Sanitary safety test showed that these home made retort pouches were acceptable comparing to the regulation recommended by the Ministry of Health and Social Affairs.

• Journal of Gastric Cancer
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• v.23 no.2
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• pp.355-364
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• 2023

Background: There are no clear guidelines to determine whether to perform D1 or D1+ lymph node dissection in early gastric cancer (EGC). This study aimed to develop a nomogram for estimating the risk of extraperigastric lymph node metastasis (LNM). Materials and Methods: Between 2009 and 2019, a total of 4,482 patients with pathologically confirmed T1 disease at 6 affiliated hospitals were included in this study. The basic clinicopathological characteristics of the positive and negative extraperigastric LNM groups were compared. The possible risk factors were evaluated using univariate and multivariate analyses. Based on these results, a risk prediction model was developed. A nomogram predicting extraperigastric LNM was used for internal validation. Results: Multivariate analyses showed that tumor size (cut-off value 3.0 cm, odds ratio [OR]=1.886, P=0.030), tumor depth (OR=1.853 for tumors with sm2 and sm3 invasion, P=0.010), cross-sectional location (OR=0.490 for tumors located on the greater curvature, P=0.0303), differentiation (OR=0.584 for differentiated tumors, P=0.0070), and lymphovascular invasion (OR=11.125, P<0.001) are possible risk factors for extraperigastric LNM. An equation for estimating the risk of extraperigastric LNM was derived from these risk factors. The equation was internally validated by comparing the actual metastatic rate with the predicted rate, which showed good agreement. Conclusions: A nomogram for estimating the risk of extraperigastric LNM in EGC was successfully developed. Although there are some limitations to applying this model because it was developed based on pathological data, it can be optimally adapted for patients who require curative gastrectomy after endoscopic submucosal dissection.

• The World Journal of Men's Health
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• v.39 no.3
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• pp.541-549
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• 2021

Purpose: To determine if chronic administration of Jun-amino terminal kinase (JNK)-inhibitors and LIM-kinase 2 (LIMK2)-inhibitors from the immediate post-injury period in a rat model of cavernous-nerve-crush-injury could normalize cavernousveno-occlusive-function, and to compare it with phosphodiesterase type 5 (PDE5)-inhibitors. Materials and Methods: A total of 75 12-week-old male Sprague-Dawley-rats were randomized into five groups: sham-surgery (S), cavernous-nerve-crush-injury (I), cavernous-nerve-crush-injury treated with 10.0 mg/kg LIMK2-inhibitor (L) or 10.0 mg/kg JNK-inhibitor and 10.0 mg/kg LIMK2-inhibitor (J+L) or 20.0 mg/kg udenafil (P) for five-weeks. Five-weeks after surgery, dynamic-infusion-cavernosometry, histological-studies, caspase-3-activity-assay, and Western-blot were investigated. Results: Group-I had lower papaverine-response, higher maintenance-rate and higher drop-rate, compared to Group-S. Group-L, Group-J+L and Group-P showed improvement in the three dynamic-infusion-cavernosometry parameters. The papaverine-response and drop-rate in Group-J+L and Group-P recovered to sham-control level, but those in Group-L did not. Regarding apoptosis, Group-I had decreased content of α-smooth-muscle-actin, increased caspase-3 activity and increased cJun-phosphorylation. The cJun-phosphorylation improved only in Group-J+L. The α-smooth-muscle-actin content and caspase-3-activity in Group-J+L and Group-P improved, but those in Group-L were not. Regarding fibrosis, Group-I had decreased smooth muscle (SM)/collagen-ratio, increased protein-expression of fibronectin, and increased Cofilin-phosphorylation. Cofilin-phosphorylation was normalized in Group-L and Group-J+L, but not in Group-P. SM/collagen-ratio and proteinexpression of fibronectin in Group-L, Group-J+L and Group-P improved. Conclusions: Our data indicate that chronic inhibition of JNK and LIMK2 can restore cavernous-veno-occlusive-function by suppressing cavernous-apoptosis and cavernous-fibrosis, comparable to the results by PDE5-inhibitors. Chronic inhibition of JNK and LIMK2 might be a potential mechanism-specific targeted therapy for cavernous-veno-occlusive-dysfunction induced by cavernous nerve-injury.

• Korean Journal of Agricultural Science
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• v.41 no.4
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• pp.391-398
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• 2014

Identifying soil water content as a major factor for evaluating irrigation and water resource is a primary module to develop a prediction model. A variety of PTFs (Pedo-Transfer Functions) are applied in the models to estimate soil water content, the analysis techniques, however, which compare the estimated from models and the measured by instruments, are not reached at the level to demonstrate the effectiveness of the PTFs in Korea. Many soil physicians such as Eom, Peterson, Rawls, Saxton, Bruand, Baties, Tomasella & Hodnett (T&H), and Minasny, have developed analytic models using PTFs. Soil data for the analysis used soil water contents on 347 soil series (10 kPa), 358 soil series (33 kPa), 356 soil series (1,500 kPa) established by NAAS (National Academy of Agricultural Science). A coefficient of determination on soil water content at 10, 33 and 1,500 kPa was the highest as 0.5932 in EM (Eom model), 0.6744 in REM (Rawls model) and 0.6108 in REM, respectively. In conclusion, it is strongly suggested that the use of EM or REM is suitable for estimating soil water content in Korea although SM (Saxton model) has been widely used.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.9
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• pp.1240-1248
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• 2013

This paper describes a switching-level operation analysis of BTB(Back-To-Back) converter for HVDC(high voltage DC) application based on MMC(modular multi-level converter). A switching-level operation analysis for BTB converter is very important to understand the converter operation in detail and check the voltage and current transients in each components. However, the development of switching-level simulation model for the actual size BTB Converter is very difficult because the MMC normally has more than 150 sub-modules for each arm. So, a switching level simulation model for the 11-level MMC-based BTB converter was developed with PSCAD/EMTDC software, which has 12 sub-modules for the positive arm and another 12 sub-modules for the negative arm. The DC-voltage balance algorithm, the circulating-current reduction algorithm, the harmonic reduction algorithm, and the redundancy operation algorithm were included in this simulation model. The developed simulation model can be utilized to analyze the MMC-based BTB converter for HVDC application in switching level and to develop the protection scheme for the MMC-based BTB converter for HVDC application.

• Journal of Wetlands Research
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• v.14 no.4
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• pp.715-723
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• 2012

The Hoelyongpo in the Naeseong River as tributary basin of the Nakdong River is broadly well-known a tourist attraction, which is made of sandy beach, and is called "Island of Inland". But Construction of the Dam was planned at upstream of river. In other words, an influx of sediment is blocked from upstream of river. In this situation, through sediment discharge coming from tributary of the Naeseong river, the whether to go ahead of sand beach of the Hoelyongpo is analyzed by using 1-D and 2-D model. The sediment discharge is estimated through ratio raw with basin area, and the instream flow requirement of river coming from dam and the flow rate and sediment coming from tributary are inputted for model. The 1-D model uses HEC-6 and the 2-D model uses SMS(RMA2 and SED2D). The analysis using the HEC-6 is performed from cross section data 10 year ago to the present cross section. Consequently, Yang equation presenting similar result to the present cross section data is determined, using this, the prediction is conducted for the cross section after 20 years. The 2-D analysis is conducted for the present cross section data. The value of distinction between a deposition and erosion with the results presented in the 1, 2-D models is occur, however, the appearance between the deposition and the erosion is similar.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.43 no.5 s.311
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• pp.48-56
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• 2006

In this paper, we proposed the high quality audio watermarking algorithm using MDCT/IMDCT (Modified DCT/Inverse Modified DCT) with psychoacoustic model. Generally, a digital audio watermark is embedding the frequency domain after frequency transform of the digital audio data but the digital audio quality is affected by watermarking. In our scheme, the digital audio data is spread with PN((Pseudo Noise) code and then audio watermark is embedded in MDCT processing that refers psychoacoustic model. In MDCT processing, according to the shape of filter bank output, the block switching selects a window sequence that has 256, 1,024 or 2,048 points interval for high quality audio. The author confirm that when watermark weight ${\alpha}$ is 2.5 below, the detection ratio of watermark is a satisfied to SDMI's(Secure Digital Music Initiative) recommendation 50% above and SM is $50{\sim}68dB$ range with mainly 4 kind of attacks(Compression, Cropping, FFT and Echo).

• Animal Bioscience
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• v.34 no.2
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• pp.163-171
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• 2021

Objective: Considering the importance of dairy farming and the negative effects of heat stress, more tolerant genotypes need to be identified. The objective of this study was to investigate the effect of heat stress via temperature-humidity index (THI) and diurnal temperature variation (DTV) in the genetic evaluations for daily milk yield of Holstein dairy cattle, using random regression models. Methods: The data comprised 94,549 test-day records of 11,294 first parity Holstein cows from Brazil, collected from 1997 to 2013, and bioclimatic data (THI and DTV) from 18 weather stations. Least square linear regression models were used to determine the THI and DTV thresholds for milk yield losses caused by heat stress. In addition to the standard model (SM, without bioclimatic variables), THI and DTV were combined in various ways and tested for different days, totaling 41 models. Results: The THI and DTV thresholds for milk yield losses was THI = 74 (-0.106 kg/d/THI) and DTV = 13 (-0.045 kg/d/DTV). The model that included THI and DTV as fixed effects, considering the two-day average, presented better fit (-2logL, Akaike information criterion, and Bayesian information criterion). The estimated breeding values (EBVs) and the reliabilities of the EBVs improved when using this model. Conclusion: Sires are re-ranking when heat stress indicators are included in the model. Genetic evaluation using the mean of two days of THI and DTV as fixed effect, improved EBVs and EBVs reliability.