• Journal of Acupuncture Research
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• 제21권1호
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• pp.111-118
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• 2004

Background and purpose: Opposing-needling technique involves selecting acupoints at unaffected limb. The aim of this study was to evaluate the effect of LI4-LI11 electrical acupuncture at unaffected limb on the cerebral blood flow in ischemic stroke patients using SPECT Methods: We selected 9 ischemic stroke patients. Baseline brain SPECT was done with triple head gamma camera(MultiSPECT3, Siemens, USA) after intravenous administration of 925 MBq of Tc-99m ECD). Fifteen-minute electro-acupuncture at Hapgok(LI 4) and Gokji(LI 11) were applied on unaffected upper limb of subjects. The same dose of Tc-99m ECD was injected during the electro-acupuncture, and the second SPECT images were obtained. Using the computer software(ICON 7.1, Siemens, USA), 3 SPECT slices(upper, middle, lower) surrounding the brain lesion were selected and each slice was divided by 10-16 brain regions. Asymmetry indexes were analyzed in each brain region. We regarded$\geq$10% changes of asymmetry index between before and after electro-acupuncture as significance. Results: Seven Patients(77.8%) had significantly increased perfusion and 2(22.2%) didn't show increased perfusion in post-acupuncture scans compared to pre-acupuncture scans(baseline). The regions of CBF improvement were mostly frontal lobes and anterior temporal lobes. Conclusions: This study demonstrated that LI4-LI11 electro-acupuncture at unaffected limb increased regional cerebral blood perfusion to the corresponding brain areas in ischemic stroke patients.

• Asian Pacific Journal of Cancer Prevention
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• 제16권7호
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• pp.2889-2894
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• 2015

Background: To investigate the impact of the breast size, shape, maximum heart depth (MDH), and chest wall hypotenuse (the distance connecting middle point of the sternum and the length of lung draw on the selected transverse CT slice) on the volumetric dose to heart with whole breast irradiation (WBI) of left-sided breast cancer patients. Materials and Methods: Fifty-three patients with left-sided breast cancer undergoing adjuvant intensity-modulated radiotherapy (IMRT) were enrolled in the study. The primary breast size and shape, MHD and DCWH (chest wall hypotenuse) were contoured on radiotherapy (RT) planning CT slices. The dose data of hearts were obtained from the dose-volume histograms (DVHs). Data were analyzed by one-way analysis of variance (ANOVA), Student's t-test and linear regression analysis. Results: Breast size was independent of heart dose, whereas breast shape, MHD and DCWH were correlated with heart dose. The shapes of breasts were divided into four types, as the flap type, hemisphere type, cone type and pendulous type with heart mean dose being $491.8{\pm}234.6cGy$, $752.7{\pm}219.0cGy$, $620.2{\pm}275.7cGy$, and $666.1{\pm}238.0cGy$, respectively. The flap type of breasts shows a strong statistically reduction in heart dose, compared to others (p=0.008 for V30 of heart). DCWH and MHD were found to be the most important parameters correlating with heart dose in WBI. Conclusions: More attention should be paid to the heart dose of non-flap type patients. The MHD was found to be the most important parameter to correlate with heart dose in tangential WBI, closely followed by the DCWH, which could help radiation oncologists and physicsts evaluate heart dose and design RT plan in advance.

• 한국의학물리학회지:의학물리
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• 제9권1호
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• pp.1-9
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• 1998

정위적 방사선 수술과 신경외과적 수술분야 에서는 상호보완적인 영상정보를 얻기 위하여 컴퓨터 단층촬영 (CT), 자기공명영상 (MRI) 그리고 혈관조영촬영이 사용된다. 본 연구의 목적은 여러 영상장치와 다목적 QA(Quality Control) 팬톰을 이용하면서, 정위적 방사선수술 및 신경외과적 수술분 야에서 두경부내의 병소에 대한 모양, 크기, 위치를 정확하게 결정하기 위한 3 차원 정위 시스템을 개발하는 것이다. 목표물의 정확한 위치를 정의하기 위하여, Hitchcoke 정위 프레임과 컴퓨터 단층 촬영 (CT)/혈관 조영촬영용 위치측정 보조기구들을 3차원 공간상에 9개의 목표물을 가진 팬톰에 고정하였다. 컴퓨터 단층촬영과 혈관 조영촬영을 이용하여 얻은 기하학적 팬톰의 영상들을 이용하여, 목표물의 3차원 정위좌표를 얻기위한 알고리즘이 개발되었다. 개발된 알고리즘에 의해 계산된 목표물들의 위치는 팬톰의 절대 좌표와 비교 되었고, 각 CT 영상에서의 목표물들은 뇌혈관촬영 영상위에 상호 중첩될 수 있도록 개발 되었다. 512$\times$512 메트릭스와 2mm 슬라이스 두께를 가진 컴퓨터 단층촬영에 있어서는 1.02$\pm$0.17 mm의 평균거리오차를 보였고, 혈관 조영촬영인 경우에는 0.41$\pm$0.05mm 의 평균거리오차를 보였다. 목표물의 위치를 결정하는데 있어서 결과로 나온 정확도는 개발된 시스템이 정위적 방사선수술과 신경외과적수술을 위해 충분히 신뢰성이 있음을 확인해주었다.

• 대한두개안면성형외과학회지
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• 제10권1호
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• pp.7-13
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• 2009

Purpose: Endoscopic transnasal correction of the medial orbital fractures cannot be enable to confirm the reduction degree of orbital volume without imaging modalities. We have intended through this study to make a quantative analysis of preoperative orbital volume increment and the reduction degree of that after ethmoidal sinus packing by using CT scan. Methods: In this retrospective study, 22 patients were selected to evaluate the postoperative volume reduction, who took 2 CT scans which are pre- and postoperative under the same protocol. The postoperative CT scan was carried out in about 5 days after the operation with the packing inserted into ethmoidal sinus. The length of bony defect on each section was measured by PACS program and the area of defect was calculated by summing lengths on each section multiplied by the thickness of the section. When the outline of orbit on the slice is drawn manually with a cursor, PACS program measures the area automatically. Orbital volume was calculated from the sum of the area multiplied by the section thickness. Results: The mean dimension of fractured walls was $2.86{\pm}0.99cm^2$. The mean orbital volume of the unaffected orbits was $22.89{\pm}2.15cm^3$ and that of the affected orbits was $25.62{\pm}2.82cm^3$. The mean orbital volume increment of the affected orbits was $2.73{\pm}1.13cm^3$. After surgery, the mean orbital volume of the unaffected orbits was $22.46{\pm}2.73cm^3$ and the mean orbital volume decrease on the surgical side was $2.98{\pm}1.07cm^3$. The estimated correction rate was 118.30%. Conclusion: The orbital volume increment in fractured orbit showed linear correlation with the dimension of fractured area. The orbital volume changes after ethmoidal sinus packing also showed linear correlation with orbital volume increment in fractured orbit. This study showed the regressive linear correlation between the increment of orbital volume and the correction rate. To evaluate the maintenance of reduction state, we think that the further study should be done for comparative analysis of orbital volume change after removal of packing.

• Journal of Gastric Cancer
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• 제13권3호
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• pp.149-156
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• 2013

Purpose: Clinical stage of gastric cancer is currently assessed by computed tomography. Accurate clinical staging is important for the tailoring of therapy. This study evaluated the accuracy of clinical N staging using stomach protocol computed tomography. Materials and Methods: Between March 2004 and November 2012, 171 patients with gastric cancer underwent preoperative stomach protocol computed tomography (Jeju National University Hospital; Jeju, Korea). Their demographic and clinical characteristics were reviewed retrospectively. Two radiologists evaluated cN staging using axial and coronal computed tomography images, and cN stage was matched with pathologic results. The diagnostic accuracy of stomach protocol computed tomography for clinical N staging and clinical characteristics associated with diagnostic accuracy were evaluated. Results: The overall accuracy of stomach protocol computed tomography for cN staging was 63.2%. Computed tomography images of slice thickness 3.0 mm had a sensitivity of 60.0%; a specificity of 89.6%; an accuracy of 78.4%; and a positive predictive value of 78.0% in detecting lymph node metastases. Underestimation of cN stage was associated with larger tumor size (P<0.001), undifferentiated type (P=0.003), diffuse type (P=0.020), more advanced pathologic stage (P<0.001), and larger numbers of harvested and metastatic lymph nodes (P<0.001 each). Tumor differentiation was an independent factor affecting underestimation by computed tomography (P=0.045). Conclusions: Computed tomography with a size criterion of 8 mm is highly specific but relatively insensitive in detecting nodal metastases. Physicians should keep in mind that computed tomography may not be an appropriate tool to detect nodal metastases for choosing appropriate treatment.

• 대한인간공학회지
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• 제33권5호
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• pp.395-405
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• 2014

Objective: The aim of this study is to investigate 1) somatotopic arrangement of the second and third fingers in SI area 2) difference of neural activation in the SI area produced by stimulation with different frequencies 3) correlation between the intensity of tactile perception by different stimulus intensity and the level of brain activation measurable by means of fMRI. Background: Somatosensory cortex can obtain the information of environmental stimuli about "where" (e.g., on the left palm), "what" (e.g., a book or a dog), and "how" (e.g., scrub gently or scrub roughly) to organism. However, compared to visual sense, the neural mechanism underlying the processing of specific electrotactile stimulus is still unknown. Method: 10 right-handed subjects participated in this study. Non-painful electrotactile stimuli were delivered to two different finger tips of right hand. Functional brain images were collected from 3.0T MRI using the single-shot EPI method. The scanning parameters were as follows: TR and TE were 3000, 35ms, respectively, flip angle 60, FOV $24{\times}24cm$, matrix size $64{\times}64$, slice thickness 4mm (no gap). SPM5 was used to analyze the fMRI data. Results: Significant activations produced by the stimulation were found in the SI, SII, the subcentral gyrus, the precentral gyrus, and the insula. In all participants, statistically significant activation was observed in the contralateral SI area and the bilateral SII areas by the stimulation on the fingers but ipsilaterally dominant. The SI area representing the second finger generally located in the more lateral and inferior side than that of the third finger across all the subjects. But no difference in brain area was found for the stimulation of the fingers by different frequencies. And two typical patterns were observed on the relationship between the perceived psychological intensity and the amount of voxels in the primary sensory cortex during the stimulation. Conclusion: It was possible to discriminate the representation sites in the SI by electrotactile stimulation of digit2 and digit3. But we could not find the differences of the brain areas according to different stimulation frequencies from 3 to 300Hz. Application: The results of the study can provide a deeper understanding of somatosensory cortex and offer the information for tactile display for blinds.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2001년도 제6차 학술대회 초록집
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• pp.137-137
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• 2001

Purpose： The purpose of this study was to identify cerebral cortices related with sexual arousal fro visual sexual stimulation in healthy males using BOLD-based functional MR imaging Method： Sixteen male volunteers with sexually potent(mean age：24) were examined for thi study. Functional MRI was performed on a 1.5T MR scanner(GE Signa Horizon) with birdcage-type head coil. In this study, blood oxygenation level dependent(BOLD) technique was utilized to create fMR image reflecting local brain activities. The BOLD-based fMRI d were obtained from 7 oblique planes using gradient-echo EPI with $90^{\circ}$flip angle, 50ms TE 6000ms TR, $26cm{\times}26$ cm FOV, $128{\times}128$ matrix, and 10mm slice thickness. The sexual stimulation paradigm consisted of two alternating periods of rest and activati and it began with a 1 minute rest, followed by a 2 minute stimulation by a documentary a erotic video film. Brain activation maps were generated by cross-correlation of imag acquired during rest and activation periods. The index of activation was used to compare t number of pixels activated by each task in each volunteer, where the significance of th differences was evaluated by using Students t-test.

• 한국식품영양학회지
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• 제19권4호
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• pp.358-365
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• 2006

두께 1 mm의 감자 절편을 분자량 200에서 6000까지의 PEG용액에 침지했을 때 PEG의 분자량이 작을 수록 초기 탈수 속도가 빨랐으나 최종 탈수량은 PEG 분자량이 클수록 증가하여 PEG 6000인 경우 초기수분의 약 80%까지 탈수되었다. 감자절편을 저분자 용액인 NaCl, PEG400 용액에 침지한 경우, 조직의 뒤틀림 현상은 나타나지 않고 plasmolysis가 일어나면서 탈수와 부피가 감소되는 반면, PEG 600 용액에 침지시부터 조직의 뒤틀림 현상이 동반된 탈수 현상이 나타났으며, 고분자 용액인 PEG 4000 용액에 침지한 경우 cytonhysis 현상을 동반한 탈수와 부피 감소가 더욱 분명하게 관찰되었다. 초기 탈수 속도는 저분자 용액에 침지 시 더 빨랐으나 최종 탈수량은 고분자용액에 침지 시 더 컸으며 탈수량이 역전되는 시기는 cytorrhysis가 일어나는 시기와 일치하였다. 따라서 고분자 용질의 고농도 용액에 시료를 침지하면 용질의 함침량은 적게 하면서 탈수량을 증가시킬 수 있음을 알 수 있었다.

• 한국축산식품학회지
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• 제23권1호
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• pp.70-74
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• 2003

국민소득의 증가와 수입자유화에 따라 치즈 소비량도 매년 증대되어 1991년 8천 5백톤에서 2001년에는 5만 3천여톤으로 10년간 6배 이상의 소비증대를 나타내었으며, 같은 기간 신선한 치즈(H.S. 0406.10.1000)의 수입량도 2톤, 3만 달러에서 2만톤, 4천 9백만 달러로 양으로는 만 배, 금액으로는 1,600여배 증가하였다. 또한, 가공 치즈에 있어서도 1991년 4,790톤에서 2001년 24,973톤으로 5.2배의 소비증가를 나타내었으나 성분규격 및 분류체계는 적절하지 못하게 규정되어 있다. 자연치즈의 경우 정의에 따라 총고형분이 유고형분과 차이가 없을 것으로 생각되며, 한 종의 연성치즈를 제외하고는 모두 규격을 만족시켰으나 유고형분 함량에 따라 '생치즈'와 '연성치즈'가 구별되지는 않았다. 따라서, CODEX의 규정을 참조하여 지방을 제외한 성분중 수분함량(MFFB)에 따라 초경질, 경질, 반경질, 연질로 구분하는 것이 치즈의 조직적 특성을 고려할 때 적절하리라 생각되며, 건물중 지방함량에 따라 60% 이상을 '고지방', 25∼60%를 '중지방', 25% 이하를 '저지방'으로 분류하는 것이 바람직하리라 생각된다. 가공치즈는 소비자의 기호에 따라 다양한 제품이 개발되고 있으며 앞으로도 더욱 소비확대가 기대되는 제품으로서, 유고형분 15∼34% 제품을 '치즈가공품'으로 분류하여 규정하는 것이 가공치즈의 개발 및 소비촉진을 위해 필요하다고 생각된다.

• 전자공학회논문지
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• 제53권4호
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• pp.37-47
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• 2016

광폭입력함수 전용 멀티플렉서가 슬라이스 구조에 포함되는 상용 FPGA의 현실적 제약 조건을 학계의 대표적 논리 표현 방식인 AIG (And-Inverter Graph)를 근간으로 개발된 FPGA 매핑 알고리즘에 적용하였다. AIG를 LUT (Look-Up Table)으로 매핑할 때 중간 구조로서 컷을 열거하는 데 이들 중에서 멀티플렉서를 인식해 낸 후 이들이 매핑될 때 지연 시간 및 면적을 복잡도 증가 없이 계산하도록 하였다. 이 때 트리 형성 전제 조건인 대칭성과 단수 제약 요건도 검사하도록 하였다. 또한, 멀티플렉서 트리의 루트 위치를 RTL 코드에서 찾아내고 이를 보조 출력 형태로 AIG에 추가하도록 하였다. 이 위치에서 섀넌확장을 통해 멀티플렉서 트리 구조를 의도적으로 합성한 후 최적 AIG에 겹치도록 하는 접근 방법을 최초로 제안하였다. 이때 무손실 합성을 가능하게 하는 FRAIG 방식이 응용되었다. 두 가지 프로세서에 대해 제안된 접근 방법과 기법들을 적용하여 약 13~30%의 면적 감소 및 최대 32%까지의 지연 시간 단축을 달성하였다. AIG 트리에 특정 구조를 의도적으로 주입시키는 접근 방법은 향후 캐리 체인 등에 확장 적용하는 연구가 진행될 것이다.