• Toxicological Research
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• v.18 no.1
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• pp.13-22
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• 2002

In Korea, 2,320 tonnes of acetanilide were mostly wed as intermediates for synthesis in phar-maceuticals or additives in synthesizing hydrogen peroxide, varnishes, polymers and rubber. Only small amount of 120 kg were wed as a stabilizer for hydrogen peroxide solution for hair colouring agents in 1998. Readily available environmental or human exposure data do not exist in Korea at the present time. However, potential human exposures from drinking water, food, ambient water and in work places are expected to be negligible because this chemical is produced in the closed system in only one company in Korea and the processing factory is equipped with local ventilation and air filtering system. Acetanilide could be distributed mainly to water based on EQC model. This substance is readily biodegradable and its bioaccumulation is low. Acute toxicity of acetanilide is low since the L $D_{50}$ of oral exposure in rats is 1,959 mg/kg bw. The chemical is not irritating to skin, but slightly irritating to the eyes of rabbits. horn repeated dose toxicity, the adverse effects in rats were red pulp hyperplasia of spleen, bone marrow hyperplasia of femur and decreased hemoglobin, hematocrit and mean corpuscular hemoglobin concentration. The LOAEL for repeated dose toxicity in rats was 22 mg/kg/day for both sexes. Acetanilide is not considered to be genotoxic. In a reproductive/developmental toxicity study, no treatment-related changes in precoital time and rate of copulation, impregnation, pregnancy were shown in all treated groups. The NOAELs for reproduction and developmental toxicity (off-spring toxicity) are considered to be 200 mg/kg bw/day and 67 mg/kg bw/day, respectively. Ecotoxicity data has been generated in a limited number of aquatic species of algae (72 hr- $E_{b}$ $C_{50}$; 13.5 mg/l), daphnid (48hr-E $C_{50}$ > 100 mg/l) and fish (Oryzias latipes, 96hr-L $C_{50}$; 100 mg/l). Form the acute toxicity values, the predicted no effect concentration (PNEC) of 0.135 mg/1 was derived win an assessment factor of 100. On the basis of these data, acetanilide was suggested as currently of low priority for further post-SIDS work in OECD.in OECD.D.

• Journal of Astronomy and Space Sciences
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• v.15 no.1
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• pp.119-138
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• 1998

Recently measurements of atmospheric trace gases from satellite are vigorous. So the development of its data processing algorithm is important. In this study, retrievalof vertical ozone profile from the atmospheric transmittance measured by satellite solar occultation method and its sensitivity to temperature and pressure are investigated. The measured transmittance from satellite is assumed to be given by the limb path transmittance simulated using annual averaged Umkehr data for Seoul. The limb path transmittance between wavelengths $9.89{\mu}m$ and $10.2{\mu}m$ is simulated with respect to tangent heights using the ozone data of HALOE SIDS(Hallogen Occultation Experiment Simulated Instrument Data Set) as an initial profile. Other input data such as pressure and temperature are also from HALOE SIDS. Vertical ozone profile is correctly retrieved from the measured transmittance by onion-peeling method from 50km to 11km tangent heights with the vertical resolution of 3km. The bias error of $\pm0.001$ in measured transmittance, the forced error of $\pm3K$ in each layer temperature, and the forced $\pm3%$ error in each layer pressure are assumed for sensitivity tests. These errors are based on the ADEOS/ILAS error limitation. The error in ozone amount ranges from -6.5% to +6.9% due to transmittance error, from -9.5% to +10.5% due to temperature error, and from -5.1% to +5.4% due to pressure error, respectively. The present study suggests that accurate vertical ozone profile can be retrieved from satellite solar occultation method. Accuracy of vertical temperature profile is especially important in the retrieval of vertical ozone profile.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.11a
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• pp.171-171
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• 2002

• 한국IT서비스학회:학술대회논문집
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• 2009.05a
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• pp.409-414
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• 2009

I have not seen each of the existing technology, RFID/USN technology combined with the wireless communication channel for the state of nuclear safety in real-time remote monitoring and operation system technology CARE existing radioactive accident information collected by the nuclear power and nuclear power status, 10-20 second intervals to monitor the safety network (SIDS), and nuclear power plants located on the site within 40 ㎞ radius around the 13~15 of the wind speed from the automatic weather network weather information such as rainfall and temperature every 10 minutes to collect as automatic weather network (REMDAS), Evaluation of atmospheric radiation and radiation of the bomb radiation impact assessment system to calculate the goodness (FADAS) and thicken the radiation-related information consists of real-time web technology to collect, the last robot on behalf of the human will to manage the nuclear power plant accident of the technology to prevent the concrete from the following narrative about to have.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.13 no.2
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• pp.75-80
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• 2013

Specific genetic conditions may lead to sudden unexpected deaths in infancy, such as inborn errors of fatty acid oxidation and genetic disorders of cardiac ion channels. The disease may present dramatically with severe hypoketotic hypoglycemia, Reye syndrome or sudden death, typically with a peak of frequency around 3-6 month, whilst neonatal sudden death is quite rare. When undetected, approximately 20-25% of infants will die or suffer permanent neurologic impairment as a consequence of the first acute metabolic decompensation. Meanwhile, the advent of newborn screening for metabolic diseases has revealed populations of patients with disorders of fatty acid oxidation (FAO), the most frequent of which is medium chain acyl-CoA dehydrogenase (MCAD) deficiency. Without this screening, affected individuals would likely succumb to sudden infant death syndrome (SIDS). Here we describe an overview of sudden infant death syndrome and inherited metabolic disorder.

• Environmental Analysis Health and Toxicology
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• v.16 no.3
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• pp.133-137
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• 2001

Acetanilide is a High Production Volume Chemical, which is produced about 2,300 tons/year in Korea as of 1998 survey. Most is used as an intermediate for synthesis of pharmaceuticals and dyes and the chemical is one of seven chemicals of which human and environmental risks are being assessed by National Institute of Environmental Research under the frame of OECD SIDS program. The chemical is water soluble (4 g/1 at 20$\^{C}$) and readily biodegradable (68.7％). Partition coefficiency (Log Pow) is 1.16 at 23$\^{C}$ so that the chemical has a low potential for bioaccumulation. The acute toxicities of algae, daphnia and fish are not high. The 72 hr-EｂC50 of algae is 13.5 mg/1,48 hr-EC50 of daphnia is over 100 mg/1 and 96 hr-LC50 of Oryzias latipes is over 100mg/1. Regarding the exposure, levels in air, water, soil or sediment have not been monitored or estimated so that risk evaluation of acetanilide was not possible. In this study, distribution of the chemical among environmental media was estimated using EQC model based on the chemical-physical properties. In Level I and IIof which the chemical are hypothesized in equilibrium and no transfer through the media, more than 98％ of acetanilide are estimated to be distributed in water. However, in Level Ⅲ of which non-equilibrium and intermedia transfer could be occurred, the chemical is estimated to distributed to soil as 51.8％ and water as 47.8％ as of total amount.

• Environmental Analysis Health and Toxicology
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• v.16 no.3
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• pp.139-142
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• 2001

Acetanilide is a High Production Volume Chemical, which is produced about 2,300 tons/year in Korea as of 1998 survey. Most is used as an intermediate for synthesis of pharmaceuticals and dyes, and the chemical is one of seven chemicals of which human and environmental risk are being assessed by National Institute of Environmental Research under the frame of OECD SIDS program. The Atmospheric Oxidation Program for Microsoft Windows (AOPWIN) is used to estimates the rate constant for the atmospheric, gas－phase reaction between photochemically produced hydroxyl radicals and organic chemicals. It is also used to estimates the rate constant for the gas－phase reaction between ozone and olefinic/acetylenic compounds. The rate constants estimated by the program are then used to calculate atmospheric half－lives for organic compounds based upon average atmospheric concentrations of hydroxyl radicals and ozone. AOPWIN requires only a chemical structure to make these predictions. Structures are entered into AOPWIN by SMILES (Simplified Molecular Input Line Entry System) notations. In this study, one of environmental fate/distribution of the chemical elements, photodegradation of acetanilide was estimated using AOPWIN model based on SMILES notation and chemical name data.

• Proceedings of the Korea Information Processing Society Conference
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• 2012.04a
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• pp.896-899
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• 2012

일반적으로 출생 후 1세 전후의 영유아들은 신체의 발달이 온전치 않아 수면중 질식사하는 영유아 돌연사증후군(SIDS)에 이를 수 있어, 보호자의 세심한 관심이 필요하다. 더욱이 보호자가 있더라도 오히려 더 높은 질식에 의한 사망률이 늘어나고 있다. 이를 위해서, 본 논문에서는 수면시 발생할 수 있는 질식사 방지를 위한 하드웨어 장치와 이와 연계된 스마트폰 앱(App) 시스템을 설계하고 구현한다. 제안된 시스템으로써 하드웨어 장치는 초음파 거리 센서(sonsor)를 이용하여 실시간으로 뒤집힘 여부의 정보를 수집하여 무선 통신을 통해 스마트폰 앱(App)에 전달한다. 또한 스마트폰 앱 시스템은 수집된 정보를 분석 판단하여, 비정상적인 상태의 영유아에 대해 긴급 경보와 긴급 전화를 자동 호출한다. 따라서 여러 위험에 노출되어 있는 영유아들의 수면중에 뒤척이다 엎드려 자는 경우, 호흡기를 막거나 가슴압박으로 인한 질식사를 미연에 방지한다. 향후, 본 논문에서 제안된 시스템은 졸음방지나 낙상방지시스템 같은 유비쿼터스 헬스케어(ubiquitous healthcare) 환경 구현에도 적용될 수 있다.

• Journal of the Semiconductor & Display Technology
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• v.20 no.3
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• pp.1-5
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• 2021

Sleep apnea refers to a condition in which a person does not breathe during sleep, and is a dangerous symptom that blocks oxygen supply in the body, causing various complications, and the elderly and infants can die if severe. In this paper, we present an algorithm that classifies sleep breathing by analyzing the intensity of breathing with images alone in preparation for the risk of sleep apnea. Only the chest of the person being measured is set to the Region of Interest (ROI) to determine the breathing strength by the differential image within the corresponding ROI area. The adult was selected as the target of the measurement and the breathing strength was measured accurately, and the difference in breathing intensity was also distinguished using depth information. Two videos of sleeping babies also show that even microscopic breathing motions smaller than adults can be detected, which is also expected to help prevent infant death syndrome (SIDS).

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2003.05a
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• pp.150-151
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• 2003

Benzoyl peroxide is a high production volume chemical, which was produced about 1,375 tons/year in Korea as of 2001 survey. Most of them are used as initiators in polymerization, catalysts in the plastics industry, bleaching agents for flour and medication for acne vulgaris. The substance is one of the sever chemicals of which human and environmental risks are being assessed by National Institute of Environmental Research under the frame of OECD SIDS Program. It has a melting point of 104-106 $^{\circ}C$ and has solubility of 9.1 mg/1 in water at 25 $^{\circ}C$. The substance was readily biodegradable (83 % after 21days) and had toxic effects to aquatic organisms. The range of 72 hr-EbC50 (biomass) for algae was 0.07-0.44 mg/1 and 48 hr-EC50 for daphnia was 0.07-2.91 mg/1. The LC50 of acute toxicity to fish was 0.24-2.0 mg/1. Although the toxic effects of benzoyl peroxide to aquatic organisms were investigated, environmental monitoring data were not studied. In this study, distribution of the chemical among multimedia environment was estimated using EQC model based on the physical-chemical properties to evaluate the risk of benzoyl peroxide in environment. In level I, II calculation the chemical was distributed to soil (68.3 %) and water (28.7 %). In level III calculation it was primarily distributed to soil (99.9 %) and overall residence time of 3.4 years was estimated. Benzoyl peroxide could be persistent in environment.