• Journal of Periodontal and Implant Science
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• v.43 no.6
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• pp.251-261
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• 2013

A paradigm shift is taking place in medicine and dentistry from using synthetic implants and tissue grafts to a tissue engineering approach that uses degradable porous three-dimensional (3D) material hydrogels integrated with cells and bioactive factors to regenerate tissues such as dental bone and other oral tissues. Hydrogels have been established as a biomaterial of choice for many years, as they offer diverse properties that make them ideal in regenerative medicine, including dental applications. Being highly biocompatible and similar to native extracellular matrix, hydrogels have emerged as ideal candidates in the design of 3D scaffolds for tissue regeneration and drug delivery applications. However, precise control over hydrogel properties, such as porosity, pore size, and pore interconnectivity, remains a challenge. Traditional techniques for creating conventional crosslinked polymers have demonstrated limited success in the formation of hydrogels with large pore size, thus limiting cellular infiltration, tissue ingrowth, vascularization, and matrix mineralization (in the case of bone) of tissue-engineered constructs. Emerging technologies have demonstrated the ability to control microarchitectural features in hydrogels such as the creation of large pore size, porosity, and pore interconnectivity, thus allowing the creation of engineered hydrogel scaffolds with a structure and function closely mimicking native tissues. In this review, we explore the various technologies available for the preparation of macroporous scaffolds and their potential applications.

• Computers and Concrete
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• v.25 no.3
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• pp.245-253
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• 2020

Vibrational analysis in microtubules is examined based on the nonlocal theory of elasticity. The complete analytical formulas for wave velocity are obtained and the results reveal that the small scale effects can reduce the frequency, especially for large longitudinal wave-vector and large circumferential wave number. It is seen that the small scale effects are more significant for smaller wave length. The methods and results may also support the design and application of nano devices such as micro sound generator etc. The effects of small scale parameters can increase vibrational frequencies of the protein microtubules and cannot be overlooked in the analysis of vibrating phenomena. The results for different modes with nonlocal effect are checked.

• Computers and Concrete
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• v.25 no.3
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• pp.205-214
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• 2020

Cytoskeleton components in living cell bear large compressive force and are responsible in maintaining the cell shape. Actually these filaments are surrounded by viscoelastic media within the cell. This surrounding, viscoelastic media affects the buckling behavior of these filaments when external force is applied on these filaments by exerting continuous pressure in opposite directions to the incipient buckling of the filaments. In this article a mechanical model is applied to account the effects of this media on the buckling behavior of intermediate filaments network of cytoskeleton. The model immeasurably associates; filament's bending rigidity, adjacent system elasticity, and cytosol viscosity with buckling wavelength, buckling growth rate and buckling amplitude of the filaments.

• Structural Engineering and Mechanics
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• v.64 no.5
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• pp.527-541
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• 2017

In this work, a new hyperbolic shear deformation beam theory is proposed based on a modified couple stress theory (MCST) to investigate the bending and free vibration responses of functionally graded (FG) micro beam made of porous material. This non-classical micro-beam model introduces the material length scale coefficient which can capture the size influence. The non-classical beam model reduces to the classical beam model when the material length scale coefficient is set to zero. The mechanical material properties of the FG micro-beam are assumed to vary in the thickness direction and are estimated through the classical rule of mixture which is modified to approximate the porous material properties with even and uneven distributions of porosities phases. Effects of several important parameters such as power-law exponents, porosity distributions, porosity volume fractions, the material length scale parameter and slenderness ratios on bending and dynamic responses of FG micro-beams are investigated and discussed in detail. It is concluded that these effects play significant role in the mechanical behavior of porous FG micro-beams.

• Advances in concrete construction
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• v.9 no.5
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• pp.491-501
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• 2020

Microtubules buckle under bending and torsion and this property has been studied for free microtubules before using orthotropic elastic shell model. But as microtubules are embedded in other elastic filaments and it is experimentally showed that these elastic filaments affect the critical buckling moment and critical buckling torque of the microtubules. To prove that, we developed orthotropic Winkler like model and demonstrated that the critical buckling moment and critical buckling torque of the microtubules are orders of higher magnitude than those found for free microtubules. Our results show that Critical buckling moment is about 6.04 nNnm for which the corresponding curvature is about θ = 1.33 rad /㎛ for embedded MTs, and critical buckling torque is 0.9 nNnm for the angle of 1.33 rad/㎛. Our results well proved the experimental findings.

• Computers and Concrete
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• v.25 no.5
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• pp.411-425
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• 2020

In this paper, the shell material has been taken as functionally graded material and their material quantity is located by the exponential volume fraction law. Moreover, the impact of ring supports around the shell circumference has been examined for their various positions along the shell axial length. These rings support restraints the radial displacement in the transverse direction. While the axial modal deformation functions have been estimated by characteristic beam functions and nature of materials used for construction of cylindrical shells. The fundamental natural frequency of cylindrical shell of parameter versus ratios of length- and height-to-radius for a wide range has been reported and investigated through the study. In addition, by increasing height-to-radius ratio resulting frequencies also increase and frequencies decrease on ratio of length-to-radius. Though the trends of frequency values of both ratios are converse to each other with three different boundary conditions. Also it is examined the position of ring supports with length-to radius ratio, height-to-radius ratio and varying the exponent of volume fraction. MATLAB software package has been utilized for extracting shell frequency spectra. The obtained results are confirmed by comparing with available literature.

• Advances in nano research
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• v.8 no.4
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• pp.307-322
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• 2020

In this article, free vibration of double-walled carbon nanotubes (DWNT) based on nonlocal Kelvin's model have been investigated. For this purpose, a nonlocal Kelvin's model is established to observe the small scale effect. The wave propagation is employed to frame the governing equations as eigenvalue system. The influence of nonlocal parameter subjected to different end supports has been overtly examined. The new set of inner and outer tubes radii investigated in detail against aspect ratio. The influence of boundary conditions via nonlocal parameter is shown graphically. Due to small scale effect fundamental frequency ratio decreases as length to diameter ratio increases. Small scale effect becomes negligible on all end supports for the higher values of aspect ratio. With the smaller inner tube radius double-walled CNT behaves more sensitive towards nonlocal parameter. The results generated furnish the evidence regarding applicability of nonlocal model and also verified by earlier published literature.

• Advances in materials Research
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• v.8 no.3
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• pp.155-177
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• 2019

In this paper, a new displacement based high-order shear deformation theory is introduced for the static response of functionally graded sandwich plate with new definition of porosity distribution taking into account composition and the scheme of the sandwich plate. Unlike any other theory, the number of unknown functions involved is only four, as against five in case of other shear deformation theories. The theory presented is variationally consistent, has strong similarity with classical plate theory in many aspects, does not require shear correction factor, and gives rise to transverse shear stress variation such that the transverse shear stresses vary parabolically across the thickness satisfying shear stress free surface conditions. Material properties of FGM layers are assumed to vary continuously across the plate thickness according to either power-law or sigmoid function in terms of the volume fractions of the constituents. The face layers are considered to be FG across each face thickness while the core is made of a ceramic homogeneous layer. Governing equations are derived from the principle of virtual displacements. The closed-form solution of a simply supported rectangular plate subjected to sinusoidal loading has been obtained by using the Navier method. Numerical results are presented to show the effect of the material distribution, the sandwich plate geometry and the porosity on the deflections and stresses of FG sandwich plates. The validity of the present theory is investigated by comparing some of the present results with other published results.

• Steel and Composite Structures
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• v.19 no.3
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• pp.521-546
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• 2015

A new refined hyperbolic shear and normal deformation beam theory is developed to study the free vibration and buckling of functionally graded (FG) sandwich beams under various boundary conditions. The effects of transverse shear strains as well as the transverse normal strain are taken into account. Material properties of the sandwich beam faces are assumed to be graded in the thickness direction according to a simple power-law distribution in terms of the volume fractions of the constituents. The core layer is still homogeneous and made of an isotropic material. Equations of motion are derived from Hamilton's principle. Analytical solutions for the bending, free vibration and buckling analyses are obtained for simply supported sandwich beams. Illustrative examples are given to show the effects of varying gradients, thickness stretching, boundary conditions, and thickness to length ratios on the bending, free vibration and buckling of functionally graded sandwich beams.

• Geomechanics and Engineering
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• v.11 no.5
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• pp.671-690
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• 2016

This work presents a static flexure analysis of laminated composite plates by utilizing a higher order shear deformation theory in which the stretching effect is incorporated. The axial displacement field utilizes sinusoidal function in terms of thickness coordinate to consider the transverse shear deformation influence. The cosine function in thickness coordinate is employed in transverse displacement to introduce the influence of transverse normal strain. The highlight of the present method is that, in addition to incorporating the thickness stretching effect (${\varepsilon}_z{\neq}0$), the displacement field is constructed with only 5 unknowns, as against 6 or more in other higher order shear and normal deformation theory. Governing equations of the present theory are determined by employing the principle of virtual work. The closed-form solutions of simply supported cross-ply and angle-ply laminated composite plates have been obtained using Navier solution. The numerical results of present method are compared with those of the classical plate theory (CPT), first order shear deformation theory (FSDT), higher order shear deformation theory (HSDT) of Reddy, higher order shear and normal deformation theory (HSNDT) and exact three dimensional elasticity theory wherever applicable. The results predicted by present theory are in good agreement with those of higher order shear deformation theory and the elasticity theory. It can be concluded that the proposed method is accurate and simple in solving the static bending response of laminated composite plates.