• BMB Reports
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• v.49 no.8
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• pp.449-454
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• 2016

Stress Granules (SGs) are microscopically visible, phase dense aggregates of translationally stalled messenger ribonucleoprotein (mRNP) complexes formed in response to distinct stress conditions. It is generally considered that SG formation is induced to protect cells from conditions of stress. The precise constituents of SGs and the mechanism through which SGs are dynamically regulated in response to stress are not completely understood. Hence, it is important to identify proteins which regulate SG assembly and disassembly. In the present study, we report Neuregulin-2 (NRG2) as a novel component of SGs; furthermore, depletion of NRG2 potently inhibits SG formation. We also demonstrate that NRG2 specifically localizes to SGs under various stress conditions. Knockdown of NRG2 has no effect on stress-induced polysome disassembly, suggesting that the component does not influence early step of SG formation. It was also observed that reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress.

• Asia Pacific Journal of Corpus Research
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• v.1 no.1
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• pp.31-60
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• 2020

This paper investigates changes in relativization in Singapore English broadsheet newspapers from 1993 to 2016. One of the first diachronic studies in Singapore English (SgE), it also explores corresponding data from the diachronic Siena-Bologna (SiBol) news corpus. As SgE is in the endonormative stabilization phase in Schneider's (2007) Dynamic Model of postcolonial Englishes, divergence from British English (BrE) is to be expected. In this study, the dataset is a new Singapore English Newspaper (SEN) corpus compiled from local news articles in 1993, 2005 and 2016, and the corpus tool employed is Sketch Engine. The results reveal changes in relativization practices in SEN over the given period, many of which occur in a similar pattern as those identified in SiBol, albeit at varying rates of change. Most significant of these include a sharp decline in the which relativizer in restrictive relative clauses with non-animate antecedents, complemented by a rise in that. The change has been so rapid that although which relative clauses were more common than that clauses in 1993, that has subsequently overtaken which for both the corpora. One shift in SEN that is different from SiBol is the increase in frequency of non-restrictive relative clauses in SgE. The likely motivators for the changes in the two varieties are identified as colloquialization, densification and prescriptivism. The effect each of these factors could have had on the varieties are discussed, as well as the implications that the findings have on our understanding of the evolutionary status of SgE as a postcolonial variety.

• Journal of the Korean Society of Physical Medicine
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• v.9 no.3
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• pp.333-338
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• 2014

PURPOSE: The purpose of this study was to investigate any changes in abdominal muscle activity after curl-up and jack-knife exercisse using a sling and swiss-ball. METHODS: Sixteen asymptomatic subjects were randomly assigned into either a sling exercise group (SG) or swiss-ball exercise group (SBG). Subjects performed curl-up and jack-knife exercise using sling and swiss ball. Activity of abdominal muscles (rectus abdominis and external oblique) was assessed using surface electromyography (EMG) and normalized maximal voluntary isometric contraction (MVIC) before and after exercises. The significance of differences between the SG and the SBG was evaluated by analysis of covariance (ANCOVA). RESULTS: There was an increase in activity of all abdominal muscles after the curl-up and jack-knife exercises for 6 weeks. However, there was not a significant difference between the SG and the SBG after curl-up exercise (p>.05). There was also not a significant difference between the SG and the SBG after Jack-knife exercise (p>.05) except for the right external oblique muscle (p<.05). CONCLUSION: Exercises on an unstable surface using a sling and swiss ball are effective ways of abdominal muscle exercise.

• 한국정보통신설비학회:학술대회논문집
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• 2006.08a
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• pp.241-245
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• 2006

In the examination of Steam Generator (SG) tube in Nuclear Power Plant (NPP) Eddy Current Testing (ECT) probes play an Important role in detecting the defects. Bobbin probe and Rotating Pancake Coil (RPC) probe is usually used for the inspection of SG tube. Bobbin probe is good at high speed inspection, but ability of detection of circumferential defect is very weak. On the contrary RPC probe, which moves for inspection in the direction of axial and circumferential simultaneously, has very slow inspection speed, but it was excellent detection capability fur small cracks, which is hardly detected by bobbin probe. Many examinations of SG tube examination of NPP are achieved during short period. Therefore, solution about this must develop probe of new form for examination performance and examination time shortening of other probe. In this paper, analyzed technological present condition of Bob-bin probe and RPC probe been using in Nondestructive Testing (NDT) for SG tube defect detection and Appeared about background theory and view of developed probe newly.

• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.4 no.2
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• pp.34-39
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• 2008

Steam Generator(SG) tubes are classified as one of the key components in nuclear power plants, and they should be periodically examined by the intensified management program for the assurance and diagnosis of their structural integrity. In this study, we use the optimum analysis technique to draw the detection and categorization of bowing(BOW) signals; abnormal tube-to-tube proximity in the SG upper bundle free span area. The locations in which BOW signals are detected likely have latent degradation of ODSCC(Outer Diameter Stress Corrosion Cracking). For the sake of timely and correct detection of BOW signals and diagnosis of ODSCC, we carried out the experimental demonstrations using a reduced mock-up. And we validated the MRPC(Motorized Rotating Pancake Coil) analysis technique is better than the bobbin. Hence, it comes to conclusion that the optimum analysis technique can be a good alternative for the reliable SG tube examination.

• Nuclear Engineering and Technology
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• v.33 no.1
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• pp.73-82
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• 2001

Pressurized water reactor(PWR) fuel rods. which are continuously supported by a spring system called a spacer grid(SG), are exposed to reactor coolant at a flow velocity of up to 6-8 m/s. It is known that the vibration of 3 fuel rod is generated by the coolant flow, a so-called flow-induced-vibration(FIV), and the relative motion induced by the FIV between the fuel rod and the SG can wear away the surface of the fuel rod, which occasionally leads to its fretting failure. It is, therefore, important to understand the vibration characteristics of the fuel rod and reflect that in its design. In this paper, vibration analyses of the fuel rod with two different SGs were performed using both analytical and experimental methods. Updating of the finite element(FE) model using the measured data was performed in order to enhance confidence in the FE model of fuel rods supported by an SG. It was found that the modal parameters are very sensitive to the spring constant of the SG.

• Nuclear Engineering and Technology
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• v.49 no.8
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• pp.1669-1679
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• 2017

Background: Steam generator (SG) is one of the significant components in the nuclear steam supply system. A variety of SGs have been designed and used in nuclear reactor systems. Every SG has advantages and disadvantages. A brief account of some of the existing SG designs is presented in this study. A high surface to volume ratio of a SG is required in small modular reactors to occupy the least space. In this paper, performance improvement for SGs of integral small modular reactor is proposed. Aims/Methods: For this purpose, cross-grooved microfins have been incorporated on the inner surface of the helical tube to enhance heat transfer. The primary objective of this work is to investigate thermal-hydraulic behavior of the proposed improvements through modeling in RELAP5-3D. Results and Conclusions: The results are compared with helical-coiled SGs being used in IRIS (International Reactor Innovative and Secure). The results show that the tube length reduces up to 11.56% keeping thermal and hydraulic conditions fixed. In the case of fixed size, the steam outlet temperature increases from 590.1 K to 597.0 K and the capability of power transfer from primary to secondary also increases. However, these advantages are associated with some extra pressure drop, which has to be compensated.

• International Journal of Oral Biology
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• v.32 no.4
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• pp.153-160
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• 2007

The superficial dorsal horn, particularly substantia gelatinosa (SG) in the spinal cord, receives inputs from small-diameter primary afferents that predominantly convey noxious sensation. Reactive oxygen species (ROS) are toxic agents that may be involved in various neurodegenerative diseases. Recent studies indicate that ROS are also involved in persistent pain through a spinal mechanism. In the present study, whole cell patch clamp recordings were carried out on SG neurons in spinal cord slice of young rats to investigate the effects of hydrogen peroxide on neuronal excitability and excitatory synaptic transmission. In current clamp condition, tert-buthyl hydroperoxide (t-BuOOH), an ROS donor, depolarized membrane potential of SG neurons and increased the neuronal firing frequencies evoked by depolarizing current pulses. When slices were pretreated with phenyl-N-tert-buthylnitrone (PBN) or ascorbate, ROS scavengers, t-BuOOH did not induce hyperexcitability. In voltage clamp condition, t-BuOOH increased the frequency and amplitude of spontaneous excitatory postsynaptic currents (sEPSCs), and monosynaptically evoked excitatory postsynaptic currents (eEPSCs) by electrical stimulation of the ipsilateral dorsal root. These data suggest that ROS generated by peripheral nerve injury can modulate the excitability of the SG neurons via pre- and postsynaptic actions.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2002.11a
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• pp.498-501
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• 2002

In this paper, we designed double gate(DG) MOSFET structure which has main gate(MG) and two side gates(SG). We have simulated using TCAD simulator. DG MOSFET have the main gate length of nm and the side gate length of 70nm. Then, we have investigated the pinch-off characteristics, drain voltage is changed from 0V to 1.5V at VMG=1.5V and VSG=3.0V. In spite of the LMG is very small, we have obtained a very good pinch-off characteristics. Therefore, we know that the DG structure is very useful at nino scale.

• Journal of International Academy of Physical Therapy Research
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• v.7 no.2
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• pp.994-998
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• 2016

The purpose of this study was to examine the effects of sensory stimulation type on the learning of the elderly. The study implemented elderly verbal learning test by evenly dividing a total of 40 elderly people into auditory stimulation followed by visual stimulation group(AVG), visual stimulation followed by auditory stimulation group(VAG), simultaneous visual and auditory stimulation group(SG), and auditory stimulation group(AG). The result are as follows. SSG showed highest results in most of the test, followed by AVG, VAG, and AG. In particular, SG showed a statistically significant difference in immediate recall total score and short delay free recall score(p<.05). In the post-hoc test results of immediate recall total score, SG showed highest score with a statistical significance. AVG showed the second highest score, followed by VAG and AG and all showed a statistic significance(p<.05).In the post-hoc test results of short delay free recall score, SG and AVG showed a statistically significantly higher score than AG(p<.05). The results suggest that simultaneous stimulation of visual and auditory sense is more effective for improving the learning of the elderly people than visual stimulation followed by auditory stimulation or auditory stimulation followed by visual stimulation.