• Transactions of the Korean Society of Pressure Vessels and Piping
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• v.15 no.1
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• pp.18-27
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• 2019

The Advanced Power Reactor 1400 (APR1400) Steam Generator (SG) uses alloy 690 as a tube material and SA-508 Grade 3 Class 1 as a tubesheet material to form tube-to-tubesheet joint through hydraulic expansion process. In this paper, the residual stresses in the SG tube-to-tubesheet contact area was investigated by applying Model-Based System Engineering (MBSE) methodology and the V-model. The use of MBSE transform system description into diagrams which clearly describe the logical interaction between functions hence minimizes the risk of ambiguity. A theoretical and Finite Element Methodology (FEM) was used to assess and compare the residual stresses in the tube-to-tubesheet contact area. Additionally, the axial strength of the tube to tubesheet joint based on the pull-out force against the contact joint force was evaluated and recommended optimum autofrettage pressure to minimize residual stresses in the transition zone given. A single U-tube hole and tubesheet with ligament thickness was taken as a single cylinder and plane strain condition was assumed. An iterative method was used in FEM simulation to find the limit autofrettage pressure at which pull-out force and contact force are of the same magnitude. The joint contact force was estimated to be 20 times more than the pull-out force and the limit autofrettage pressure was estimated to be 141.85MPa.

• Nuclear Engineering and Technology
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• v.54 no.5
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• pp.1570-1578
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• 2022

During a severe accident, steam generator (SG) tubes undergo rapid changes in the pressure and temperature. Therefore, an appropriate creep model to predict a short term creep damage is essential. In this paper, a novel creep model for Alloy 690 SG tube material was proposed. It is based on the theta (θ) projection method that can represent all three stages of the creep process. The original θ projection method poses a limitation owing to its inability to represent experimental creep curves for SG tube materials for a large strain rate in the tertiary creep region. Therefore, a new modified θ projection method is proposed; subsequently, a master curve for Alloy 690 SG material is also proposed to optimize the creep model parameters, θ_i (i = 1-5). To adapt the implicit creep scheme to the finite element code, a partial derivative of incremental creep with respect to the stress is necessary. Accordingly, creep model parameters with a strictly linear relationship with the stress and temperature were proposed. The effectiveness of the model was validated using a commercial finite element analysis software. The creep model can be applied to evaluate the creep rupture behavior of SG tubes in nuclear power plants.

• Review of KIISC
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• v.33 no.4
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• pp.65-74
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• 2023

국제전기통신연합(ITU)은 국제연합(UN) 산하 정보통신기술(ICT)에 대한 전문 국제 표준화기구이다. 193개 회원국, 약 900개 기업 및 학계 멤버 등으로 구성되어 있으며, 산하에 전기통신표준화부문(ITU-T), 전기통신개발부문(ITU-D), 그리고 전파통신 부문(ITU-R) 등 3개의 부문으로 구성되어 있다[1]. ITU-T는 역할과 임무에 따라 11개의 연구반(SG, Study Group)으로 구성되어 있으며, 각 업무에 맞는 선도 그룹(Lead Study Group)을 지정하여 국제 표준을 개발하고 있다. 정보보안 분야 국제 표준은 ITU-T SG17(보안)에서 담당한다[2]. ITU-T 국제 표준화 조직은 4년 주기의 연구회기(Study Period)로 연구반 구조조정, 의장단 선출 및 표준화 추진 방향을 WTSA(World Telecommunication Standardization Assembly) 총회에서 결정한다. 다음 총회는 2024년 10월에 인도에서 열릴 예정이다. 본 논문에서는 지난 2022년 8/9월과 2023년 2/3월 스위스 제네바에서 열린 ITU-T SG17 회의에서 한국이 주도적으로 수행한 정보보호 표준화 활동 결과를 알아보고, 차기 연구회기(2025-2028)를 위한 SG17 구조조정에 대해 2023년 2/3월 SG17 회의 결과와 서신 그룹(CG, 5월-7월) 회의의 주요 결과를 중심으로 제시한다.

• Review of KIISC
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• v.34 no.4
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• pp.5-15
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• 2024

국제전기통신연합(ITU)은 국제연합(UN) 산하 정보통신기술(ICT)에 대한 국제 표준화기구이다. 193개회원국, 약 900개 기업 및 학계 멤버 등으로 구성되어 있으며, 산하에 전기통신표준화부문(ITU-T), 전기통신개발부문(ITU-D), 그리고 전파통신 부문(ITU-R) 등 3개의 부문으로 구성되어 있다[1]. ITU-T는 역할과 임무에 따라 11개의 연구반(SG, Study Group)으로 구성되어 있으며, 각 업무에 맞는 선도 그룹(Lead Study Group)을 지정하여 국제 표준을 개발하고 있다. 정보보안 분야 국제 표준은 ITU-T SG17(보안)에서 담당한다[2]. ITU-T 국제 표준화 조직은 4년 주기의 연구회기(Study Period)로 연구반 구조조정, 의장단 선출 및 표준화 추진 방향을 WTSA(World Telecommunication Standardization Assembly) 총회에서 결정한다. 다음 총회는 올해 2024년 10월에 인도 뉴델리에서 열릴 예정이다. 본 논문에서는 지난 2023년 8/9월과 2024년 2/3월 진행된 ITU-T SG17 회의에서 한국이 주도적으로 수행한 정보보호 표준화 활동 결과를 알아보고, 차기 연구회기(2025-2028) ITU-T SG17 추진 방향에 대해 2024년 7월 진행된 ITU-T SG17 E-Plenary 참석 결과를 중심으로 살펴본다.

• Journal of Environmental Health Sciences
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• v.37 no.6
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• pp.450-459
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• 2011

Objectives: Biomarkers in urine are important in assessing exposures to environmental or occupational chemicals and for evaluateing renal function by exposure from these chemicals. Spot urine samples are needed to adjust the concentration of these biomarkers for variations in urine dilution. This study was conducted to evaluate the suitability of adjusting the urinary concentration of cadmium (uCd) and arsenic (uAs) by specific gravity (SG) and urine creatinine (uCr). Methods: We measured the concentrations of blood cadmium (bCd), uCd, uAs, uCr, SG and N-acetyl-${\beta}$-D-glucosaminidase (NAG) activity, which is a sensitive marker of tubular damage by low dose Cd exposure, in spot urine samples collected from 536 individuals. The value of uCd, uAs and NAG were adjusted by SG and uCr. Results: The uCr levels were affected by gender (p < 0.01) and muscle mass (p < 0.01), while SG levels were affected by gender (p < 0.05). Unadjusted uCd and uAs were correlated with SG (uCd: r = 0.365, p < 0.01; uAs: r = 0.488, p < 0.01), uCr (uCd: r = 0.399, p < 0.01; uAs: r = 0.484, p < 0.01). uCd and uAs adjusted by SG were still correlated with SG (uCd: r = 0.360, p < 0.01, uAs: r = 0.483, p < 0.01). uCd and uAs adjusted by uCr and modified uCr ($M_{Cr}$) led to a significant negative correlation with uCr (uCd: r = -0.367, p < 0.01; uAs: r = -0.319, p < 0.01) and $M_{Cr}$ (uCd: r = -0.292, p < 0.01; uAs: r = -0.206, p < 0.01). However, uCd and uAs adjusted by conventional SG ($C_{SG}$) were disappeared from these urinary dilution effects (uCd: r = -0.081; uAs: r = 0.077). Conclusions: $C_{SG}$ adjustment appears to be more appropriate for variations in cadmium and arsenic in spot urine.

• The Journal of Internal Korean Medicine
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• v.32 no.3
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• pp.323-333
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• 2011

Objectives : Zingberis Rhizoma (ZR) and Glycyrrihizae Radix (GR) have been widely used to prevent or treat allergic diseases. However, relatively little research has been conducted on the immune response to Senggang Gamcho-tang (SG) in a mixture of ZR and GR. The purpose of this study was to determine antiallergic effects of Senggang Gamcho-tang (SG) extracts ZR and GR on activity of murine splenocytes. Methods : This study was performed to investigate the effect of SG in mice, using in vitro experiments. Cells were treated with SG extract (1 ${\mu}g$/ml, 10 ${\mu}g$/ml and 100 ${\mu}g$/ml) plus Con A (2 ${\mu}g$/ml) and ZR (6.6 ${\mu}g$/ml and 66 ${\mu}g$/ml), GR (3.3 ${\mu}g$/ml and 33 ${\mu}g$/ml) respectively for 48 hrs. The production of IFN-${\gamma}$ and IL-4 were determined by ELISA. Results : No toxicity was found in splenocytes treated with SG extract for 48 hrs at the concentration of 0 ${\mu}g$/ml, 1 ${\mu}g$/ml, 10 ${\mu}g$/ml and 100 ${\mu}g$/ml, respectively. The production of IFN-${\gamma}$ increased to 23,968.7 pg/ml (p<0.001) while that of IL-4 significantly decreased to 14.1 pg/m l(p<0.05) only at the SG concentration of 100 ${\mu}g$/ml. With the GR concentration of 33 ${\mu}g$/ml in SG extract, the production of IFN-${\gamma}$ rose to 32,102.2 pg/ml (p<0.001) while that of IL-4 (p<0.05) declined to 34.2 pg/ml. However, there was no significant observation with regard to the effect of ZR on production of IFN-${\gamma}$ and IL-4. Conclusions : This study suggests an antiallergic effect of Senggang Gamcho-tang, which leads to the implication that SG extract may be used to enhance human immune function.

• Herbal Formula Science
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• v.18 no.1
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• pp.87-94
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• 2010

Objectives : To provide the information of efficacy for Sagunja-tang (Sijunzi-tang; SG), it was evaluated the anti-inflammatory effect. SG, a widely used herbal formula in tranditional Korean medicine, has been used to treat for the Boki-invigorating. In many studies, plant-derived anti-inflammatory efficacies have been investigated for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory effects of SG extract on LPS-stimulated RAW 264.7 cells. Methods : The productions of nitric oxide (NO), prostaglandin (PG)$E_2$, interleukin (IL)-6 and tumor necrosis factor (TNF)-$\alpha$ were examined in a macrophage cell line, RAW 264.7 cells, in the presence of the SG extract. RAW 264.7 cells were incubated with LPS $1\;{\mu}g/mL$ and SG extract for 18 hours. The anti-inflammatory activity of SG was investigated by carrageenin-induced paw edema in rats. The paw volume was measured at 0, 2 and 4 hours following carrageenin-induced paw edema in rats. Results : SG extract showed inhibitory effect on $PGE_2$, IL-6 and TNF-$\alpha$ by LPS-stimulated RAW 264.7 cells. But SG extract was not inhibitory effect on NO by LPS-stimulated RAW 264.7 cells. And administration of SG extract (1 g/kg) showed a reduction in carrageenin-induced paw edema on rats. Conclusions : These results suggest that SG extract has anti-inflammatory activities in vitro and in vivo models.

• Korean Journal of Microbiology
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• v.45 no.2
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• pp.126-132
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• 2009

Legionella spp. is the causative agent of Legionellosis, which induces a potentially fatal form of pneumonia. With a concentrated performance during the summer of 2008, we secured 73 isolates from the water systems of 25 wards in Seoul. We analysed serotypes, pathogenic genes (Dot/Icm), and patterns of pulsed-field gel electrophoresis (PFGE) in an attempt to confirm relationships among them. Different from the previous year's pattern (2007), among the isolates, 69 were Legionella pneumophila and 4 were Legionella spp. The serotype distribution of Legionella pneumophila was sg1 43, sg6 9, sg5 8, sg3 8, and sg2 1. The serotype for the 4 Legionella spp. was Legionella nautarum. Most of the Legionella pneumophila had several pathogenic genes. On the other hand, the 4 Legionella spp. were defective in pathogenicity in genomic terms. The PFGE patterns of the serotypes showed a tendency for diversity of Legionella pneumophila and a close correlation with genetic pathogenicity.

• The Korean Journal of Zoology
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• v.34 no.2
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• pp.148-158
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• 1991

The purpose of this research was to establish the culture condition for dissociated submandibu -lar gland (SG) cells. After trypsin digestion of SG from 3-4 weeks old mice, dissociated cells were cultured in 1OO/o fetal bovine serum-Dulbecco's modified Eagle's medium (FBS-DME) or 0.5-2% low protein serum replacement-DME (LPSR-DME) on plastic surface to form monolayer. The effects of FBS, LPSR and hormones on the growth and function of cultured SG cells were examined. SG cells dissociated by enzyme were successfully cultured and were characterized as epithelial-like cells by light and electron microscope. The maximal DNA synthesis of cultured SG cells was achieved by DME containing 5-10% FBS. The same results were obtained when the effects of LPSR on cell proliferation were examined up to a LPSR concentration of 2%. SG cells cultured in 20/o LPSR-DME expressed a population doubling time of 42.5 hrs and a saturation density of 1.2 $\times$10 5cell/cm$^2$. Dihydrotestosterone (DHT) in medium did not influence on the DNA synthesis of the cultured SG cells, but stimulated protein synthesis of the SG cells. Thyroxine (T4) stimulated protein synthesis of the SCI cells markedly in a dose-dependent fashion. EGF secretion by the cultured SG cells increased significandy by DHT and or T4 trearment. This finding indicated that secretion of EGF by the SG cells was under the control of the hormones such as androgen and thyroid hormones. It seems to be that the culture condition described here can be used as a useful tool for further research on the SCI cells.

• International Journal of Oral Biology
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• v.34 no.4
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• pp.191-197
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• 2009

Somatostatin (SST) is a known neuromodulator of the central nervous system. The substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) receives many thinmyelinated $A{\delta}$-fiber and unmyelinated C primary afferent fibers and is involved in nociceptive processing. Many studies have demonstrated that SST plays a pivotal role in pain modulation in the spinal cord. However, little is yet known about the direct effects of SST on the SG neurons of the Vc in adult mice. In our present study, we investigated the direct membrane effects of SST and a type 2 SST receptor agonist, seglitide (SEG), on the SG neurons of the Vc using a gramicidin-perforated current clamp in adult mice. The majority (53%, n = 27/51) of the adult SG neurons were hyperpolarized by SST (300 nM) but no differences were found in the hyperpolarization response rate between males and females. When SST was applied successively, the second response was smaller ($76{\pm}9.5%$, n=19), suggesting that SST receptors are desensitized by repeated application. SST-induced hyperpolarization was also maintained under conditions where presynaptic events were blocked ($75{\pm}1.0%$, n=5), suggesting that this neuromodulator exerts direct effects upon postsynaptic SG neurons. SEG was further found to induce membrane hyperpolarization of the SG neurons of the Vc. These results collectively demonstrate that SST inhibits the SG neuronal activities of the Vc in adult mice with no gender bias, and that these effects are mediated via a type 2 SST receptor, suggesting that this is a potential target for orofacial pain modulation.