• Proceedings of the Korea Water Resources Association Conference
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• 2021.06a
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• pp.333-333
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• 2021

최근 전 지구적인 기후변화 및 온난화의 영향으로 태풍 및 집중호우가 빈번하게 일어나고 있으며, 이로 인한 한천범람 등 홍수재해로 인명 및 재산 피해가 크게 증가하고 있다. 우리나라에서도 태풍 및 집중호우로 인한 호수피해는 매년 발생하고 있으며, 피해 빈도와 강도가 증가하고 있는 실정이다. 이러한 현실을 고려하였을 때에 하천 인근 주민의 생명과 재산을 보호하기 위하여 실시간으로 홍수위 예측을 수행하는 것은 매우 중요하다 할 수 있다. 국내에서 수위예측을 위하여 대표적으로 저류함수모형(Storage Function Model, SFM)을 채택하고 있지만, 유역면적이 작아 홍수 도달시간이 짧은 중소하천에서는 충분한 선행시간과 정확도를 확보하기 어려운 문제점이 있다. 이는 유역면적이 작은 중소하천에서는 유역 및 기상 특성과 관련된 여러 인자 사이의 비선형성이 대하천 유역에 비해 커지는 문제점이 있기 때문이다. 본 연구에서는 위와같은 문제를 해결할 수 있도록, 수문자료와 딥러닝 기법을 적용하여 실시간으로 홍수위를 예측할 수 있는 방법론을 제시하였다. 지난 태풍 및 집중호우로 인하여 급격한 수위상승이 있던 낙동강 지류하천에 대하여 LSTM(Long-Short Term Memory) 모형 기반 실시간 수위예측 모형을 개발하였으며, 선행시간 30~180분 별로 홍수위를 예측하고 관측 수위와 비교함으로써 모형의 적용성을 검증하였다. 선행시간 180분 기준으로 영강 유역 수위예측 결과와 실제 관측치의 평균제곱근 오차는 0.29m, 상관계수는 0.92로 나타났으며, 밀양강 유역의 경우 각각 0.30m, 0.94로 나타났다. 본 연구에서 제시된 딥러닝 기반모형에 10분 단위 실시간 수문자료가 입력된다면, 다음 관측자료가 입력되기 전 홍수예측 결과가 산출되므로 실질적인 홍수예경보체계에 유용하게 사용될 수 있을 것이라 보인다. 모형에 적용할 수 있는 더욱 다양한 수문자료와 매개변수 조정을 통하여 예측결과에 대한 신뢰성을 더욱 높일 수 있다면, 기존의 저류함수모형과 연계하여 홍수대응 능력을 향상시키는데 도움이 될 수 있다.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.3
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• pp.480-486
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• 2004

Despite many therapeutic advances in the understanding of the processes in carcinogenesis, overall mortality statistics are unlikely to change until there is reorientation of the concepts for the use of natural products as new anticarcinogenic agents. In this study, we investigated the anticarcinogenic activity, antioxidant and DPPH scavenging activity of Sargassum fulvellum (SF). SF was extracted with methanol, which was further fractionated into five different types: hexane (SFMH), ethylether (SFMEE), ethyl acetate (SFMEA), butanol (SFMB) and aqueous (SFMA) partition layers. We determined the cytotoxic effect of these layers on human cancer cells by MTT assay. Among various partition layers of SF, at starting concentration of 100 $\mu\textrm{g}$/mL, SFMEE showed very high cytotoxicity which were 92, 90 and 84% and kept high throughout 5 concentration levels sparsed by 100 $\mu\textrm{g}$/mL against all three human cancer cell lines: HepG2, HT-29 and HeLa. SFMEA showed a low cytotoxicity at the beginning concentration level, but as the concentration became denser, growth inhibition effect of cancer cell lines started to increase and at 500 $\mu\textrm{g}$/mL, it hit the highest, which were 91, 96 and 98% against the same three cell lines as above. We observed QR induced effect in all fraction layers of SF. SFMEE showed similar tendensy of QR induced effect as did against cytotoxicity. The QR induced effect of SFMEE on HepG2 cells at 25 $\mu\textrm{g}$/mL concentration indicated 3 times higher than the control value of 1.0 and SFMH tended to be concentration-dependent on HepG2 cells. At 100 $\mu\textrm{g}$/mL, the QR induced effects resulted a ratio, which was 2.5 times higher than the control value. In search for antioxidation effects of SF extract and partition layer, the reducing activity on the 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging potential was sequentially screened. The SFM has similar antioxidant activity as to BHT and vitamin C groups.

• Journal of Life Science
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• v.28 no.10
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• pp.1147-1155
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• 2018

Agaricus blazei mycelial liquid culture extract (ABMLCE) promoted the production of testosterone (TS) in TM-3 mouse Leydig testis cells. Now, we report that ABMLCE containing eritadenine (EA) as a minor constituent (15.3 mg/100 g) reduced $5{\alpha}-reductase$ 2 ($5{\alpha}-R2$) enzyme activity and dihydrotestosterone (DHT) content which are key constituents for the benign prostatic hyperplasia (BPH) inductions. RWPE-1 prostate cells were grown in a Keratinocyte serum-free medium (K-SFM) containing ABMLCE (0~50 ppm), EA (0~10 ppm,), and finasteride (FS $10{\mu}M$: a positive control) in a 24-well plate for 24 hr. Supernatants collected from cell-cultured media were used for the assay of $5{\alpha}-R2$, superoxide dismutase (SOD), catalase (CAT) and cyclooxygenase-2 (COX-2) enzyme activities, and for TS, DHT, tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) and $interleukin-1{\beta}$ ($IL-1{\beta}$) contents by their assay kits. The $5{\alpha}-R2$ activity and DHT content were proportionally reduced (p<0.05) to concentrations of ABMLCE. The SOD and CAT enzyme activities were significantly (p<0.05) elevated concomitant with ABMLCE concentrations, while COX-2, $TNF-{\alpha}$ and $IL-1{\beta}$ showed reverse results (p<0.05). Similarly, the effects of EA were similar to those of ABMLCE. Efficacies of ABMLCE 50 ppm and EA 10 ppm in $5{\alpha}-R2$ and DHT reduction were similar to those of $10{\mu}M$ FS. These results suggest that ABMLCE and EA reduced $5{\alpha}-R2$ and DHT through their anti-inflammatory and anti-oxidative actions. This implies that ABMLCE containing EA could be a beneficial material in the cure of BPH in humans.

• Journal of Korean Society of Disaster and Security
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• v.15 no.1
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• pp.1-12
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• 2022

An automatic optimization technique is used to estimate the optimal parameters of the hydrologic model, and different hydrologic response results can be provided depending on objective functions. In this study, the parameters of the event-based rainfall-runoff model were estimated using various objective functions, the reproducibility of the hydrograph according to the objective functions was evaluated, and appropriate objective functions were proposed. As the rainfall-runoff model, the storage function model(SFM), which is a lumped hydrologic model used for runoff simulation in the current Korean flood forecasting system, was selected. In order to evaluate the reproducibility of the hydrograph for each objective function, 9 rainfall events were selected for the Cheoncheon basin, which is the upstream basin of Yongdam Dam, and widely-used 7 objective functions were selected for parameter estimation of the SFM for each rainfall event. Then, the reproducibility of the simulated hydrograph using the optimal parameter sets based on the different objective functions was analyzed. As a result, RMSE, NSE, and RSR, which include the error square term in the objective function, showed the highest accuracy for all rainfall events except for Event 7. In addition, in the case of PBIAS and VE, which include an error term compared to the observed flow, it also showed relatively stable reproducibility of the hydrograph. However, in the case of MIA, which adjusts parameters sensitive to high flow and low flow simultaneously, the hydrograph reproducibility performance was found to be very low.

• Korea Trade Review
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• v.42 no.5
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• pp.137-159
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• 2017

This study divides manufacturing in 18 countries including Korea, China, Japan and OECD countries into 11 areas and estimates and compares the technological efficiency of each industry. The traditional view of productivity is to increase production capacity through technological innovation or process innovation, but it is also influenced by the technological efficiency of production process. A Stochastic Frontier Production Model (SFM) is a representative method for estimating the technical efficiency of such production. First, as a result of estimating the production function by setting the output variable as total output or value-added, in both cases, the output increased significantly in all manufacturing sectors as inputs of labor, capital, and intermediate increased. On the other hand, R&D investment has a large impact on output in chemical, electronics, and machinery industries. Next, as a result of estimating the technological efficiency through the production function, when the total output is set as the output variable, the overall average of each sector is 0.8 or more, showing mostly high efficiency. However, when value-added was set, Japan had the highest level in most manufacturing sectors, while other countries were lower than the efficiency of the total output. Comparing the three countries of Korea, China and Japan, Japan showed the highest efficiency in most manufacturing sectors, and Korea was about half or one third of Japan and China was lower than Korea. However, in the food and electronics sectors, China is higher than Korea, indicating that China's production efficiency has greatly improved. As such, Korea is not able to narrow its gap with Japan relatively faster than China's rapid growth. Therefore, various policy supports are needed to promote technology development. In addition, in order to improve manufacturing productivity, it is necessary to shift to an economic structure that can raise technological efficiency as well as technology development.

• Journal of the Korea Concrete Institute
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• v.17 no.5 s.89
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• pp.811-818
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• 2005

It is well known that the fluidity and the fluidity loss of fresh concrete are affected by the kind of organic admixtures. Organic admixture can improve the properties of concrete. Sulfonated Naphthalene-Formaldehyde(SNF) Superplasticizer is used representatively, but has a problem in fluidity loss. In this study, we synthesized the Sulfonated Melamine-Formaldehyde(SMF) superplasticizer at the various synthetic conditions and compared the physical properties with SMF superplasticizer. SW superplasticizer is synthesized with four synthetic steps. Step 1 is hydroxymethylation, Step. 2 is Sulfonation, Step. 3 is Polymerization and Step. 4 is Stabilization. Synthesis of SMF superplasticizer depends on pH, temperature and reaction time. In this reaction, we changed the mole ratio of melamine to formaldehyde at 1:3, 1:4, and the amount of acid catalyst at Step. 3. After application of SMF superplasticizer and its mixture with SNF superplasticizer to cement pastes and mortars, we measured the physical properties of them at the different dosages(0.5, 1.0, 1.5 wt%) to cement. All samples including superplasticizer showed higher compressive strengths and slump, smaller pore size and porosity than CEM

• Journal of KIISE:Software and Applications
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• v.31 no.11
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• pp.1543-1550
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• 2004

Modeling from images is a cost-effective means of obtaining 3D geometric models. These models can be effectively constructed from classical Structure from Motion algorithm. However, it's too difficult to reconstruct whole scenes using SFM method since general sites contain a very complex shapes and brilliant colours. To overcome this difficulty, the current paper proposes a new reconstruction method based on a moving Planar mirror. We devise the mirror posture instead of scene itself as a cue for reconstructing the geometry That implies that the geometric cues are inserted into the scene by compulsion. With this method, we can obtain the geometric details regardless of the scene complexity. For this purpose, we first capture image sequences through the moving mirror containing the interested scene, and then calibrate the camera through the mirror's posture. Since the calibration results are still inaccurate due to the detection error, the camera pose is revised using frame-correspondence of the comer points that are easily obtained using the initial camera posture. Finally, 3D information is computed from a set of calibrated image sequences. We validate our approach with a set of experiments on some complex objects.

• Development and Reproduction
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• v.12 no.1
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• pp.51-56
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• 2008

To optimize the cell culture conditions of zebrafish embryonic cells, we compared the efficiency of three types of medium, DMEM, K-NAC and D-NAC. In this study, we showed that the cells grown in K-NAC have better plating efficiency than DMEM, especially in the case of low cell seeding density. However, cells grew slower in K-NAC than those in DMEM in confluent cultures. The effect of 0.1% zebrafish embryo extracts was minimal. The presence of 1% trout serum in culture medium significantly increased the growth rate of cells(p<0.05). No difference was found at $2{\sim}3{\times}10^5$ cell seeding density(p<0.05). At $4{\sim}5{\times}10^5$ cell seeding density, cells grew better in DMEM than K-NAC (p<0.1). The results suggest that supplementation of NAC and A2P in Keratinocyte SFM may improves plating efficiency when cells are plated at low population. No difference was found for cell growth in either medium with 5%, 10% or 15% FBS supplemented (p<0.05). Cells culture in D-NAC grew significantly better than those in DMEM(p<0.05). Our results clearly showed that the use of NAC and A2P in the culture medium has a positive effect on cell growth regardless of the amount of FBS added.

• Archives of Pharmacal Research
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• v.21 no.3
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• pp.298-304
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• 1998

Retinoids are applied to not only cancer prevention but also cancer chemotherapy by stimulating differentiation of cells. We studied differentiation inducing effect of all-trans retinoic acid (ATRA) by studying proportion of high dense fractions of stem-like cells and the size of S phase fraction in cell cycle. From mammary organoids obtained from 7- to 8-week old F344 female rat mammary gland, we cultured rat mammary epithelial cells (RMEC) and treated physiological doses of $10^{-6}$, $10^{-7}$, and $10^{-8}$ M ATRA from the first day and then cultured for 4, 7, and 14 days. After that, immunostaining was performed using peanut agglutinin (PNA) and anti-Thy-1.1 monoclonal antibody (Thy-1.1) that can be used as markers of differentiation. We separated four different cell subpopulations by flow cytometry: cells negative to both reagents (B-), PNA-positive cells (PNA+), Thy-1.1-positive cells (Thy-1.1+), and cells positive to both reagents (B+). We observed continuous decreases of high dense fractions of stem-like cells (PNA+ subpopulations) for 14 days and as much decreases as high doses of ATRA, which were thought to be proportional to doses of ATRA. We labeled RMEC with bromodeoxyuridine and investigated cell cycle fractions that went through S phase. We observed a tendency of decrease of S phase fraction with time in culture, which, is thought to be related to continuous decreases of PNA+ subpopulations and inhibitory role of ATRA on cell cycle. These results suggest that physiological doses of ATRA could stimulate differentiation of RMEC and convert stem-like RMEC to differentiated cells in SFM for a relatively long period of 14 days.

• Korean Journal of Agricultural and Forest Meteorology
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• v.23 no.1
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• pp.82-88
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• 2021

Sun-induced fluorescence (SIF) retrieval using remote sensing technique has been used in an effort to understand the photosynthetic efficiency and stress condition of vegetation. Although optical devices and SIF retrieval methodologies were established in order to retrieve SIF, the SIF measurements are domestically sparse. SIF data of paddy rice w as measured in Naju, South Korea from June 10, 2020 to October 5, 2020. The SIFs based red (O2A) and far-red (O2B) w ere retrieved using a spectral fitting method and an improved Fraunhofer line depth, and photosynthetically active radiation was also produced. In addition, the SIF data was filtered considering solar zenith angle, saturation conditions, the rapid and sudden change of solar irradiance, and sun glint. The provided SIF data can help to understand a SIF product and the filtering method of SIF data can contribute to producing high-quality SIF data.