• 제목/요약/키워드: SFKLRY-$NH_2$

검색결과 1건 처리시간 0.016초

The Safety Evaluation of a Potent Angiogenic Activator, Synthetic Peptide (SFKLRY-NH2) for the Skin Application

  • Kim, Dong-Ha;Lim, Yun-Young;Kim, Hyeong-Mi;Kim, So-Young;Kim, Beom-Joon;Park, Sung-Gil;Lee, Tae-Hoon;Cho, Soo-Muk
    • Toxicological Research
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    • 제28권1호
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    • pp.51-56
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    • 2012
  • A novel synthetic hexapeptide (SFKLRY-$NH_2$) that displays angiogenic activity has been identified by positional scanning of a synthetic peptide combinatorial library (PS-SPCL). This study was carried out to investigate the irritation of the SFKLRY-$NH_2$ on the skin. The tests were performed on the basis of Korea Food and Drug Administration (KFDA) guidelines. In results, cell toxicity is not appeared for SFKLRY-$NH_2$ in HaCaT cells and B16F10 cells. SFKLRY-$NH_2$ induced no skin irritation at low concentration ($10{\mu}m$), mild irritation at high concentration (10mM). We consider that this result is helpful for saying about the safety of SFKLRY-$NH_2$ in clinical use.