• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4451-4456
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• 2015

Background: The aim of our present study was to compare quality of life (QoL) between intermediate-stage (BCLC-B) HCC patients who had undergone either liver resection or transcatheter arterial chemoembolization (TACE). Materials and Methods: A total of 102 intermediate-stage HCC patients participated in our study, including 58 who had undergone liver resection and 44 who had undergone TACE. Baseline demographic characteristics, tumor characteristics, and long-term outcomes, such as tumor recurrence, were compared and analyzed. QoL was assessed using the Short Form (SF)-36 health survey questionnaire with the mental and physical component scales (SF-36 MCS and PCS). This questionnaire was filled out at HCC diagnosis and 1, 3, 6, 12, 24 months after surgery. Results: For the preoperative QoL evaluation, the 8 domains related to QoL were comparable between the two groups. The PCS and MCS scores were significantly decreased in both the TACE and resection groups at1 month after surgery, and this decrease was greater in the resection group. These scores were significantly lower in the resection group compared with the TACE group (P<0.05). However, these differences disappeared at 3 and 6 months following surgery. One year after surgery, the resection group showed much higher PCS scores than the TACE patients (P=0.018), and at 2 years after surgery, the PCS and MCS scores for the resection group were significantly higher than those for the TACE group (P<0.05). Eleven patients (19.0%) in the resection group and 17 (38.6%) in the TACE group suffered HCC recurrence (P<0.05). Univariate and multivariate analyses indicated that tumor recurrence (HR=1.211, 95%CI: 1.086-1.415, P=0.012) was a significant risk factor for poorpostoperative QoL in the HCC patients.Conclusions: Due to its effects on reducing HCC recurrence and improving long-term QoL, liver resection should be the first choice for the treatment of patients with intermediate-stage HCC.

• Journal of Korean Neurosurgical Society
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• 제61권6호
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• pp.716-722
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• 2018

Objective : Lateral interbody fusion (LIF) is attractive as a less invasive technique to address anterior spinal pathology in the treatment of adult spinal deformity. Its own uses and benefits in treatment of adult degenerative scoliosis are undefined. To investigate the radiographic and clinical outcomes of LIF, and staged LIF and posterior spinal fusion (PSF) for the treatment of adult degenerative scoliosis patients, we analyzed radiographic and clinical outcomes of adult degenerative scoliosis patients who underwent LIF and posterior spinal fusion. Methods : Forty consecutive adult degenerative scoliosis patients who underwent LIF followed by staged PSF at a single institution were retrospectively reviewed. Long-standing 36" anterior-posterior and lateral radiographs were taken preoperatively, at inter-stage, 3 months, 1 year, and 2 years after surgery were reviewed. Outcomes were assessed through the visual analogue scale (VAS), 36-Item Short Form Health Survey (SF-36), and Oswestry Disability Index (ODI). Results : Forty patients with a mean age of 66.3 (range, 49-79) met inclusion criteria. A mean of 3.8 levels (range, 2-5) were fused using LIF, while a mean of 9.0 levels (range, 3-16) were fused during the posterior approach. The mean time between stages was 1.4 days (range, 1-6). The mean follow-up was 19.6 months. Lumbar lordosis was significantly restored from $36.4^{\circ}$ preoperatively up to $48.9^{\circ}$ (71.4% of total correction) after LIF and $53.9^{\circ}$ after PSF. Lumbar coronal Cobb was prominently improved from $38.6^{\circ}$ preoperatively to $24.1^{\circ}$ (55.8% of total correction) after LIF, $12.6^{\circ}$ after PSF respectively. The mean pelvic incidence-lumbar lordosis mismatch was markedly improved from $22.2^{\circ}$ preoperatively to $8.1^{\circ}$ (86.5% of total correction) after LIF, $5.9^{\circ}$ after PSF. Correction of coronal imbalance and sagittal vertebral axis did not reach significance. The rate of perioperative complication was 37.5%. Five patients underwent revision surgery due to wound infection. No major perioperative medical complications occurred. At last follow-up, there were significant improvements in VAS, SF-36 Physical Component Summary and ODI scores. Conclusion : LIF provides significant corrections in the coronal and sagittal plane in the patients with adult degenerative scoliosis. However, LIF combined with staged PSF provides more excellent radiographic and clinical outcomes, with reduced perioperative risk in the treatment of adult degenerative scoliosis.

• 대한한의학회지
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• 제43권2호
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• pp.124-139
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• 2022

본 증례에서 COVID-19 백신 접종 후유증으로 각각 두통, 사지저림으로 내원한 환자 2명에 대하여 한의 치료를 시행한 결과 주소증 및 삶의 질이 호전되었으며, 향후 COVID-19 백신 접종 후유증이 장기간 지속되는 환자에 한의 치료를 활용할 수 있음을 확인하였기에 증례를 보고하는 바이다.

• 한국콘텐츠학회논문지
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• 제20권11호
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• pp.511-524
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• 2020

연구목적은 혈액투석환자를 위한 혈액투석 중 자전거운동과 걷기운동을 개발하여 적용하고, 혈액투석환자의 신체 활동량이 건강관련 삶의 질과 영양섭취에 미치는 영향을 확인하기 위함이다. 연구방법은 혈액투석환자에게 적용한 유산소 운동 프로그램의 효과를 확인하기 위한 비동등성 대조군 전·후 실험연구이다. 연구대상자는 중재군과 대조군에 각각 30명이 배정되어 총 60명이었다. 운동중재는 두 종류의 유산소 운동이 포함되어 있으며, 총 8주간 진행되었다. 첫 번째 운동은 일주일에 세 번씩 혈액투석 중 수행되는 자전거운동이었고 두 번째 운동은 일주일에 최대 7 일 동안 실시되는 걷기운동이었다. 통계분석은 기술통계, 독립표본 t-test, 𝑥2-test와 Mann-Whitney U test를 사용하였다. 영양섭취는 CAN-2.0을 사용하여 평가하였다. 연구결과는 중재군이 중재 후 신체활동량 점수가 유의하게 높았으며, 신체적 건강관련 삶의 질도 중재 후 유의하게 개선되었다. 그러나 영양섭취는 중재 전 후 유의한 차이가 없었다. 비록 그룹 간의 차이는 없었지만, 총 칼로리 섭취는 중재 후에 중재군이 대조군보다 높은 것으로 나타났다. 신체적 건강관련 삶의 질은 동물성 단백질, 망간, 셀레늄과 비타민 C와 유의한 상관관계가 있었다. 본 연구는 혈액투석 중 자전거운동과 걷기운동은 신체활동량과 신체적 건강관련 삶의 질을 향상시키는데 효과적인 것으로 나타났다. 따라서, 본 연구결과는 혈액투석환자의 운동증진을 위한 지침으로 사용될 수 있을 것이다.

• Journal of Ginseng Research
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• 제33권2호
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• pp.115-126
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• 2009

홍삼의 여성성기능 장애 개선과 건강관련 삶의 질 개선 효과를 규명하기 위해 성기능 저하를 호소하는 만 30세 이상 45세 미만의 기혼여성을 대상으로 6주간의 기본 투약기간을 두 번 거친 총 20주 동안의 교차 임상시험을 진행한 결과 대상자들 모두에서 성기능 개선과 일반적 건강수준 향상, 삶의 질 개선 효과가 나타났으나 홍삼과 대조약의 통계적으로 유의한 차이는 나타나지 않았다. 특히 대부분의 유효성 평가 항목들이 대상약에 상관없이 1차 투약에서 좀 더 개선되는 양상을 보였고, 홍삼과 대조약의 효과가 크게 차이가 나타나지 않았다. 그러나 성욕 (desire)의 경우는 모든 대상자에서 홍삼을 복용한 경우가 대조약을 복용한 경우보다 좀 더 개선되는 양상을 보였으며, 일반적 건강수준과 삶의 질 개선에 있어서는 특히 신체적 기능 (PF)이 정신적 요소보다 홍삼을 복용한 경우에 좀 더 개선되는 양상을 보였다. 이러한 결과는 정서적 반응에 의해 높은 변동을 보일 수 있는 대상 질환의 특성 상대조약의 높은 위약효과에 의해 홍삼의 유의한 효과가 가려졌음에도 불구하고 홍삼의 보기온양 (補氣溫陽)하는 효과가 실제적으로 발휘된 것으로 생각되었으며, 신체적 건강수준 개선과 더불어 홍삼에 일정한 성기능 개선 효과가 있음을 유추할 수 있게 하였다. 따라서 본 연구 방법을 토대로 향후 성기능장애와 같은 기능성 장애에 대한 강한 위약 효과를 고려한 좀 더 많은 수의 대상자를 포함한 장기간의 추가 임상 시험 연구가 이루어진다면 신체적 건강과 삶의 질, 그리고 성기능 개선에 관한 홍삼의 유의한 효과를 규명할 수 있을 것이라 생각된다.

• The Korean Journal of Pain
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• 제29권3호
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• pp.172-178
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• 2016

Background: This study was designed to assess serum vitamin D status (25-OHD) in the fibromyalgia (FM) patients and to compare it with a healthy control group. It also aimed to investigate the correlation of serum vitamin D level with FM symptom severity and invalidation experiences. Methods: A total of 74 consecutive patients with FM and 68 healthy control participants were enrolled. The eligible FM patients completed the Illness Invalidation Inventory (3*I), the Revised Fibromyalgia Impact Questionnaire (FIQR) and a short-form health survey (SF-12). Venous blood samples were drawn from all participants to evaluate serum 25-OHD levels. Mann-Whitney tests and multiple logistic regression analyses were performed and Spearman's correlations were calculated. Results: 88.4% of FM patients had low levels of serum 25-OHD. FM patients had significantly higher level of serum 25-OHD than the control group ($17.24{\pm}13.50$ and $9.91{\pm}6.47$ respectively, P = 0.0001). There were no significant correlations between serum 25-OHD levels and the clinical measures of disease impact, invalidation dimensions, and health status. Multiple logistic regression analyses revealed that an increased discounting of the disease by the patient's spouse was associated with a 4-fold increased risk for vitamin D deficiency (OR = 4.36; 95% CI, 0.95-19.87, P = 0.05). Conclusions: This study showed that although high rates of vitamin D insufficiency or deficiency were seen among FM patients and healthy non-FM participants, but it seems there was no intrinsic association between FM and vitamin D deficiency. Addressing of invalidation experience especially by the patient's spouse is important in management of FM.

• Journal of Korean Neurosurgical Society
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• 제59권4호
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• pp.363-367
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• 2016

Objective : To compare the fusion rate of a hydroxyapatite demineralized bone matrix (DBM) with post-laminectomy acquired autograft in lumbar interbody fusion surgery and to evaluate the correlation between fusion rate and clinical outcome. Methods : From January 2013 to April 2014, 98 patients underwent lumbar interbody fusion surgery with hydroxyapatite DBM (HA-DBM group) in our institute. Of those patients, 65 received complete CT scans for 12 months postoperatively in order to evaluate fusion status. For comparison with autograft, we selected another 65 patients who underwent lumbar interbody fusion surgery with post-laminectomy acquired autograft (Autograft group) during the same period. Both fusion material groups were matched in terms of age, sex, body mass index (BMI), and bone mineral density (BMD). To evaluate the clinical outcomes, we analyzed the results of visual analogue scale (VAS), Oswestry Disability Index (ODI), and Short Form Health Survey (SF-36). Results : We reviewed the CT scans of 149 fusion levels in 130 patients (HA-DBM group, 75 levels/65 patients; Autograft group, 74 levels/65 patients). Age, sex, BMI, and BMD were not significantly different between the groups (p=0.528, p=0.848, p=0.527, and p=0.610, respectively). The HA-DBM group showed 39 of 75 fused levels (52%), and the Autograft group showed 46 of 74 fused levels (62.2%). This difference was not statistically significant (p=0.21). In the HA-DBM group, older age and low BMD were significantly associated with non-fusion (61.24 vs. 66.68, p=0.027; -1.63 vs. -2.29, p=0.015, respectively). VAS and ODI showed significant improvement after surgery when fusion was successfully achieved in both groups (p=0.004, p=0.002, HA-DBM group; p=0.012, p=0.03, Autograft group). Conclusion : The fusion rates of the hydroxyapatite DBM and Autograft groups were not significantly different. In addition, clinical outcomes were similar between the groups. However, older age and low BMD are risk factors that might induce non-union after surgery with hydroxyapatite DBM.

• Korean Journal of Acupuncture
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• 제28권4호
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• pp.1-15
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• 2011

Objectives : The purpose of this study is to evaluate the feasibility of massive clinical research and to make a basic analysis on the effectiveness and safety of moxibustion treatment on knee osteoarthritis compared to usual care. Methods and Results : This study is a protocol for a pilot randomized controlled trial. Forty participants are assigned to the moxibustion group (n=20) and usual care group (n=20). Participants assigned to the moxibustion group receive moxibustion treatment on the affected knee(s) at six standard acupuncture points (ST36, ST35, ST34, SP9, Ex-LE04 and SP10) three times per week for four weeks (total of 12 sessions). Participants in the usual care group don't receive moxibustion treatment during the study period and follow-up are made on the 5th, 9th and 13th weeks after random allocation. Both groups are allowed to use any kind of treatment, including surgery, conventional medication, physical treatment, acupuncture, herbal medicine, over-the-counter drugs and other active treatments. Education material that explains knee osteoarthritis and current management options and self-exercise is provided for each group. The pain scale of the Korean Western Ontario and McMaster Universities Questionnaire (K-WOMAC) is the primary outcome measurement used in this study. Other subscales of the K-WOMAC, the Short-Form 36 Health Survey (SF-36), Beck Depression Inventory (BDI), Physical Function test, Patient Global Assessment, and Pain Numeric Rating Scale (NRS) are used as outcome variables to evaluate the effectiveness of acupuncture. Safety is assessed at every visit. Conclusions : The result of this trial will provide a basis for the effectiveness and safety of acupuncture treatment for knee osteoarthritis.