• Title/Summary/Keyword: SEPT6

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Quantitative Expression Analysis of Functional Genes in Four Dog Breeds (개의 네 품종에서 기능 유전자들에 대한 정량적 발현 분석)

  • Gim, Jeong-An;Kim, Sang-Hoon;Lee, Hee-Eun;Jeong, Hoim;Nam, Gyu-Hwi;Kim, Min Kyu;Huh, Jae-Won;Choi, Bong-Hwan;Kim, Heui-Soo
    • Journal of Life Science
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    • v.25 no.8
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    • pp.861-869
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    • 2015
  • One of the domesticated species; the dog has been selectively bred for various aims by human. The dog has many breeds, which are artificially selected for specific behaviors and morphologies. Dogs contribute their life to human as working dogs for guide, rescue, detection or etc. Working dogs requires good personality, such as gentleness, robustness and patience for performing their special duty. Many studies have concentrated on finding genetic marker for selecting the high-quality working dog. In this study, we confirmed quantitative expression patterns of eight genes (ABAT; 4-Aminobutyrate Aminotransferase, PLCB1; Phospholipase C, Beta 1, SLC10A4; Solute Carrier Family 10, Member 4, WNT1; Wingless-Type MMTV Integration Site Family, Member 1, BARX2; BarH-Like Homeobox 2, NEUROD6; Neuronal Differentiation 6, SEPT9; Septin 9 and TBR1; T-Box, Brain, 1) among brains tissues from four dog breeds (Beagle, Sapsaree, Shepherd and Jindo), because these genes were expressed and have functions in brain mostly. Specially, BARX2, SEPT9, SLC10A4, TBR1 and WNT1 genes were highly expressed in Beagle and Jindo, and Sapsaree and German Shepherd were vice versa. The biological significance of total genes was estimated by database for annotation, visualization and integrated discovery (DAVID) to determine a different gene ontology (GO) class. In these analyses, we suppose to these eight genes could provide influential information for brain development, and intelligence of organisms. Taken together, these results could provide clues to discover biomarker related to functional traits in brain, and beneficial for selecting superior working dogs.

Limnological Characteristics and Influences of Free-floating Plants on the Woopo Wetland during the Summer (하계우포습지의 육수학적 특성 및 부유수생식물의 영향)

  • Joo, Gea-Jae;Kim, Gu-Yeon;Park, Sung-Bae;Lee, Chan-Woo;Choi, Sang-Ho
    • Korean Journal of Ecology and Environment
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    • v.35 no.4 s.100
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    • pp.273-284
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    • 2002
  • During January 1998-October 1999, the impact of free-floating plants (FFP) on limnology of the wetland ecosystem was evaluated through the investigation of physicochemical characteristics of the Woopo Wetland along with in situ manipulation experiments of aquatic plants. Flooding events occurred in the wetland during the summer period (Jun.-Aug.) and water levels rose to 2-3 m due to precipitation from the catchment and inflow from the main channel of the Nakdong River. Physicochemical parameters and plankton dynamics in the wetland during the summer were greatly influenced by floods and growth of free-floating plants. Dissolved oxygen (Jun.-Sept., 4.5${\pm}$2.5 mg/1; Oct.-May, 8,1 ${\pm}$4.0 mg/1) and pH (Jun.-Sept., 6.9${\pm}$0.4; Oct.-May,7.4${\pm}$0.8) levels were significantly lower during the summer than any other seasons. Three types of enclosure experiments (100 L, treatments with floating plants, screened and opened) were conducted under the presence and absence of sediment for 15 days in the 1999 summer. The treatments with sediment had higher levels of nutrient concentrations than those of the others. Among the treatments with sediment, nutrient concentrations in the treatments with free-floating plants were higher than the others. Zooplankton communities in each treatment showed a similar variation, although the scale of zooplankton densities differed. Rotifer community dominated the zooplankton at the initial phase of the experiment, but decreased drastically along with an increase of cladoceran and copepod communities. In conclusion, low levels of dissolved oxygen and pH in the Woopo Wetland during the summer seemed to be caused by a proliferation of free-floating plants and active decomposition process at the bottom of the sediment.

Surgical Treatment of Thoracic Aortic Aneurysm - Surgical Approach and Perioperative Problems - (흉부 대동맥류의 외과적 치료외과적 접근 및 술후 문제점)

  • 이준영
    • Journal of Chest Surgery
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    • v.21 no.1
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    • pp.158-163
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    • 1988
  • 12 Patients with thoracic aortic aneurysm were operated between May 1985 to Sept. 1987 at the our department, Hanyang University Hospital. We retrospectively evaluated the surgical results and considered diagnosis, surgical approach and perioperative problems of thoracic aortic aneurysm. There are 9 males and 3 females in the patients. The age ranged from 23 to 61 years with the mean age at 40.6 years. The cause of the aneurysm was atherosclerosis in 5, Marfan`s syndrome in 4, syphilis In 1, trauma in 1 and annuloaortic ectasia in 1 case. According to DeBakey`s classification, Type I was 1 case, Type II was 5 cases and Type III was 6 cases. Among 6 patients with ascending aortic aneurysm, Bentall`s operation in 4 cases and ascending aorta reconstruction using to Dacron Tube Graft in 2 cases were performed successfully. 6 cases with descending aortic aneurysm were managed by prosthetic graft replacement. Chylothorax was observed in 1 patient and postoperative hemorrhage necessitating reopening of the chest occurred in 4 of operative survivors. There were 2 hospital deaths; one patient was dead during the operation and one patient was dead during the post-operative course due to low cardiac output syndrome

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The Correlational Analysis between Perceived Heath Status, Self-Esteem, and Self-Care Agencies among Adolescents (청소년이 지각한 건강상태, 자아존중감, 자가간호역량간의 관계분석)

  • 장희정;신윤희
    • Journal of Korean Academy of Nursing
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    • v.32 no.2
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    • pp.186-195
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    • 2002
  • This study was to identify and clarify the relationship between perceived health, self-esteem, and self-care agencies for promoting self care among Korean adolescents. Method: Data were collected from 817 adolescents in schools located in Seoul, Kyungki-do, and Chuncheon from Sept, 16th to Sept, 28th, 1999, and from Mar 10th to Mar 25th, 2000. The instruments used for this study were the Health Self-Rating Scale, Self-Care Agency Assessment Questionnaire (Denyes, 1981), the Self-Esteem Questionnaire (Rosenberg, 1971). Result: 1) The mean perceived health status among Korean adolescents was 8.75 (SD=1.72) 2) The mean self-esteem was 27.27 (SD=4.64). 3) The mean self-care agency was 99.64 (SD=21.02) and the average self-care agency score was 3.99 (SD=0.84). In the subcategories, the highest degree was feelings towards health (4.15), followed by ego strength (4.06), attending to health (3.87), general health knowledge (3.56), and the lowest degree was specific health knowledge (3.20) 4) There was statistical significant differences between demographic factors and self-care agencies, expecially, gender (t=28.65), grade (F=3.79), pocket money (t=5.72), and height (F=9.82) 5) The statistical relationship between perceived health status, self-esteem, and self-care agencies were found to have a positive correlation. 6) Self-care agencies among adolescents was the highest factor predicting self-esteem (15%). Conclusion: The relationship between perceived health status, self-esteem, and self-care agencies revealed a significant positive correlation among adolescents. Therefore, nursing intervention for adolescents needs to develop self-esteem programs to increase self-care agencies

Role Stress, Organizational Commitment and Job Involvement in Clinical Nurses (임상간호사의 역할스트레스, 조직몰입, 직무몰입의 관계)

  • 이명하
    • Journal of Korean Academy of Nursing
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    • v.26 no.2
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    • pp.467-482
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    • 1996
  • This study was carried out to measure the degree of organizational commitment, job involvement, and role stress of clinical nurses, and to identify the relationships among personal characteristics, role stress, organizational commitment and job involvement in clinical nurses. The subjects were consisted of 412 nurses who were working at three General Hospitals in Chonbuk. The data were collected by self-reporting questionnaire from Sept. 20 to Sept. 31, 1995. The instruments used in this study were Organizational Commitment Scale developed by Mowday et al. and Job Involvement Scale developed by Kanungo. The role stress was measured by the scale developed by Rizzo( : role conflict, role ambiguity) and Beehr( : role overload). T-test, one-way ANOVA, Scheffe test and pearson's correlation coefficient were used for data ana1isis. Major findings were as follows : 1. Mean scores for organizational commitment were 3.008, job involvement 3.074, and role stress 2. 815( :role conflict 2.802, role ambiguity 2.253, role overload 3.294) on a 5 point scale. 2. All of personal characteristics were significantly related to the level of organizational commitment : age(r=.481, p=.000), clinical experience(r= .479, p=.000), educational level(t=4.11, p= .000), position(F=30.867, p=.000), marital status(t=-5.63, p=.000) and hospital agency (F=21.374, p=.000). 3. All of personal characteristics were significantly related to the level of job involvement : age(r= .381, p=.000), clinical experience(r=.393, p= .000), educational level(t=3.72, p=.000), position(F=18.004, p=.000), marital status(t=-4. 91, p=.000) and hospital agency(F=39.441, p= .000). 4. There was a negative relationship between role stress and organizational commitment(r=-.519, p=.000). 5. There was a negative relationship between role stress and job involvement(r=-.256, p=.000). 6. There was a positive relationship between organizational commitment and job involvement (r=.591, p=.000).

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A Study on the Factors Influencing Alienation of the Aged (노인의 소외감에 영향을 미치는 관련변인 연구 - 서울시 거주 노인들을 대상으로)

  • 박의연;유영주
    • Journal of Families and Better Life
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    • v.7 no.2
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    • pp.199-212
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    • 1989
  • The main purpose of this paper is to investigate the factors which affect the alienation of the aged, and to study the relative importance of these factors. This study focused on the following research questions: 1) How do the demographic variables(sex, marital status, family structure, religion, economics, prior occupation, education level) affect the alienation of the aged? 2) How the alienation of the aged is affected by their involvement in social activities? 3) Does the degree of satisfaction with family relationship have a perceivable impact on the alienation of the aged? 4) How does the self-rated senescence affect the alienation of the aged? The research was practiced from the 18th Sept. 1999 to the 30th Sept. 1988, through individual interviews with 300 elderly people, all living in Seoul area. Among them only 285 were used in the analysis. The major findings of the study are as follows; 1) The sex of the respondents makes no difference in the alienation of the age . 2) Marital status is found to be relatively significant in determining the alienation. The degree of alienation of old people with spouse is substantially lower than that of those without spouse. 3) Family structure was found to have no significantly effect on the alienation of the aged. 4) Involvement in religion was found to significantly reduce the alienation of the aged. 5) Econimic factors seems to be critical in defermining the aged. The amount of pocket money avaliable for daily use has direct relationship with alienation. 6) Prior occupation was found to be another significant factor affecting alienation professionals experience far lower alienation than nonprofessionals. 7) The higher is education level, the lower is the alienation of the aged. 8) Active participation in social activities and good relationship with other family members were founded to contribute to lowering the alienation of the aged. Whereas, too much concern over one's senescence appears to hav negative effects on the alienation. The regression analysis shows that the satisfaction with the family relationship has the most important influence upon the alienation of the aged. Following are the factors of self-rated senescence, pocket money in a descending order. All these factors, which explain 42.65% of the total variance of alienation variable are statistically significant(p<.001)

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The Study About The QSCC II For The Diagnosis Of Sasang Constitution (Around The Analysis of subjects) (사상체질진단을 위한 사상체질분류검사지II (QSCCII)의 연구 (문항분석을 중심으로))

  • Lee, Eui-Ju;Choi, Sun-Mi;Kim, Jung-Hwa;Jung, Sung-Il;Lee, Hyun-Min;Kim, Jong-Won;Kim, Young-Woo
    • Journal of Sasang Constitutional Medicine
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    • v.15 no.3
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    • pp.11-21
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    • 2003
  • Purpose: This study had focused on evaluating the QSCC II for the elevating accuracy and the designing new Questionnaire. Methods : QSCC II was administered to 1051 patients who had been treated in Hospital and Kyung Hee Oriental Medical Hospital during 19 months from sept. 2000 to mar. 2002. We analyzed all subjects of the QSCC II. Result: 1. In the analysis with all subjects of the QSCC II , 1-1. 75 subjects had a significance between the Sasang Constitution groups. 1-2. In each Sasang Constitution group, we was able to select some significant subjects. I had selected 34 subjects in the Taeyang scale, 33 subjects in the Soyang scale, 28 subjects in the Taeeum scale, and 23 subjects in the Soeum scale. 1-3. When I applied the new intensifying value and calculation, the diagnostic discrimination abilities of the QSCCII was 61.8% about Taeyangin, 55.9% about Soyangin, 63.8% about Taeeumin, 63.6% about Soeumin, and total average was 61.8%. the Dong Eui Oriental Medical from sept. 2000 to mar. 2002.

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Clinical Statistics on the Allergic Skin Tests in Seoulites (서울지역 일반인의 알레르기 피부시험에 관한 고찰)

  • 조재훈;김찬중;남봉수;한은정;김윤범
    • The Journal of Korean Medicine
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    • v.22 no.4
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    • pp.29-36
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    • 2001
  • Objectives: This study attempted to investigate the allergic histories and the distribution of offending allergens in the general public and further to help their diagnosis and treatment with Oriental Medicine. Methods: Allergic skin tests (AST) were performed and allergic histories were taken of 359 members of the general public who visited the International Exhibition on Oriental Medicine from Sept. 1 to Sept. 5, 2000. The allergen reagents for AST were three (House dust, D. farinae, Dog hair) and the control reagent was histamine solution. Results: 1.50.1 % of the subjects (n=359) were positive to AST. The ratio between males' positivity and females' was 1.06:1. 2. The younger the subjects were, the higher the positivity was. 3. The positive subjects' (n=180) positivity to three allergens was as follows: D. farinae 98.9%, House dust 30.0%, Dog hair 1.7%. 4. The younger the positive subjects were, the higher the positivity to House dust was. In contrast, the positivity to D. farinae was high in all age groups. 5.71.1 % of the positive subjects reacted positively to monotype allergen and 28.9% reacted positively to multiple allergens (2.46:1). The most common monotype allergen was D. farinae (98.4%) and the most common combination of multiple allergens was House dust and D. farinae (94.2%). 6.52.8% of the positive subjects (n=180) and 51.4% of the negative subjects (n=179) represented the history of allergic diseases. There was no relationship between allergic skin test and allergic diseases. Conclusion: To help in diagnosis and treatment with oriental medicine, research to analyze the relationship between allergic skin test and allergic diseases should be continued on the basis of Oriental medical theories.

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Study on Seismic Load Characteristics of Regulations and Integrity Evaluation of Wind Turbine (풍력발전기의 규정에 대한 지진 하중 특성 연구 및 건전성 평가)

  • Kim, Miseon;Kim, Jeonggi;Park, Sunho;Bang, Johyug;Chung, Chinwha
    • Journal of the Earthquake Engineering Society of Korea
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    • v.21 no.6
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    • pp.295-301
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    • 2017
  • This paper relates to the study of load characteristics applicable to wind turbine generators induced by earthquakes. An artificial design earthquake wave generated through the target spectrum and the envelope function of Richter Magnitude Scale (ML) 7.0 as in ASCE4-98 was created. A simulation of earthquake loads were performed according to the design load cases (DLC) 9.5~9.7 of GL guidelines. Additionally, simulation of seismic loads experienced by Wind Turbines installed in the Gyeongju region were carried out utilizing artificial earthquakes of ML 5.8 simulating the real earthquakes during the Gyeongju Earthquakes of Sept. 2016.

Analysis of Factors Affecting Family Function (일부지역 주민의 가족기능과 관련요인 분석연구)

  • 정영숙
    • Journal of Korean Academy of Nursing
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    • v.20 no.1
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    • pp.5-15
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    • 1990
  • The purpose of this study was to identify the degree of family function and to determine factors influencing family function. The subjects for this study were 451 adults and high school students among the general population from J city. Data were collected by questionnaire from Sept. 1 to Nov. 30, 1989. The measurement tool was the Family Function Questionnaire(APGAR) developed by Smilkstein. Data were analysed by statistical methods including Mean, S.D. t-test and ANOVA. The following results were obtained : 1. The mean Family APGAR score was 5.70$\pm$0.11, in a range from 0-10. 2. Scores from 0 to 6, which fall into the dysfunctional family range, were recorded for 266 families(59.6%) 3. Significant variables among general characterisics influencing family function were age, sex, marital status, educational levels. monthly income and occupation(p<.001). 4. Significant variables among family characteristics influencing family function were family life cycle (p<.01), utilization of family resources(p<.01) and family atmosphere( p<.001).

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