• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.48 no.1
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• pp.19-26
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• 2016

In the consumer products industry, it has been highly desirable to develop objective test methods to replace subjective evaluation methods. In developing an objective test method, subjective evaluation data should be on a linear scale. According to Thurstone's theory of comparative judgment, a%-preference from a paired-comparison test can be converted to a linear-scale value. The required number (N) of paired-comparison tests increases dramatically as the number of products increases. This problem should be solved by classifying the total products into several subgroups consisting of 3-4 products in each group. By doing so, it can not only significantly reduce the number of required paired-comparison tests, but it can also obtain more reliable, reproducible data.

• Tuberculosis and Respiratory Diseases
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• v.59 no.5
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• pp.522-529
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• 2005

Background : Several national societies have published guidelines for empirical antimicrobial therapy in patients with severe community-acquired pneumonia (SCAP). This study investigated the etiologies of SCAP in the Asan Medical Center and assessed the relationship between the initial empirical antimicrobial regimen and 30 day mortality rate. Method : retrospective analysis was performed on patients with SCAP admitted to the ICU between March 2002 and February 2004 in the Asan Medical Center. The basic demographic data, bacteriologic study results and initial antimicrobial regimen were examined for all patients. The clinical outcomes including the ICU length of stay, the ICU mortality rate, and 30 days mortality rates were assessed by the initial antimicrobial regimen. Results : One hundred sixteen consecutive patients were admitted to the ICU (mean age 66.5 years, 81.9 % male, 30 days mortality 28.4 %). The microbiologic diagnosis was established in 58 patients (50 %). The most common pathogens were S. pneumoniae (n=12), P. aeruginosae (n=9), K. pneumonia (n=9) and S. aureus (n=8). The initial empirical antimicrobial regimens were classified as: ${\beta}$-lactam plus macrolide; ${\beta}$-lactam plus fluoroquinolone; anti-Pseudomonal ${\beta}$-lactam plus fluoroquinolone; Aminoglycoside combination regimen; ${\beta}$-lactam plus clindamycin; and ${\beta}$-lactam alone. There were no statistical significant differences in the 30-day mortality rate according to the initial antimicrobial regimen (p = 0.682). Multivariate analysis revealed that acute renal failure, acute respiratory distress syndrome and K. pneumonae were independent risk factors related to the 30 day mortality rate. Conclusion : S. pneumoniae, P. aeruginosae, K. pneumonia and S. aureus were the most common causative pathogens in patients with SCAP and K. pneumoniae was an independent risk factor for 30 day mortality. The initial antimicrobial regimen was not associated with the 30-day mortality.

• Proceedings of the KSR Conference
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• 2011.05a
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• pp.613-618
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• 2011

More than 7 million persons use Seoul Metropolitan Subways (SMS) everyday and the number has been in increasing trend. With the increasing trend of concerns on indoor air quality(IAQ), the management of IAQ has become an important issue, especially in case of subway operators, because most of subway lines are placed underground with poor ventilation condition. The ultimate object of study develop independent cleaning device that reduce efficient fine particle and $CO_2$. Urban subway has characteristics about proper clean air flow, must be installed in narrow space and maintenance cycle has enough time. Two layered electrically pre-charged filters were used for removing particulate matters and gas absorbers are packed between two layer filters for removing gases pollutants such $CO_2$, VOCs and HCHO. Urban subway has characteristics about proper clean air flow, must be installed in narrow space and maintenance cycle has enough time. SCAP prototype is producted as all in one method which decrease fine dust, $CO_2$ and noxious gas. and basic test carry out with quantity of wind, a gap of pressure, sampling efficiency.

• Proceedings of the KWS Conference
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• 2010.05a
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• pp.78-78
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• 2010

모바일 정보통신기기를 중심으로 패키지의 초소형화, 고집적화를 위해 플립칩 공법의 적용이 증가되고 있고 있으며 접속피치의 미세화에 따라 솔더 및 언더필을 사용하는 C4 공법보다 ACA(Anisotropic Conductive Adhesive), NCA (Non-conductive Adhesive) 등의 접착제를 이용하는 칩본딩 공법에 대한 요구가 증가하고 있다. 특히, NCA 공법의 경우 산업 현장의 대량생산에 대응하기 위해서는 접착제의 속경화 특성이 요구되어 진다. 일반적으로 접착제의 경화거동은 DSC(Differential Scanning Calorimeter)를 사용해 확인하지만, 수초 이내에 경화되는 접착제의 경우는 적용되기 어렵다. 본 연구에서는 이러한 전자패키지용 접착제의 속경화 거동을 효과적으로 평가할 수 있는 방법을 조사 하였다. 실험에서 사용된 접착제는 에폭시계 레진 기반에 이미다졸계 경화제를 사용한 기본적인 포뮬레이션을 사용하였고, 경화시간은 160^{\circ}C에서 1분 이내에 경화되는 특성을 가지고 있다. 경화 거동을 확인하기 위해서 isothermal DSC와 DEA(Dielectric Analysis)의 두가지 방법을 사용해 비교하였다. 두 실험 방법 모두 $160^{\circ}C$를 유지하며 경화 거동을 확인하였고, DoC(Degree of Cure)의 측정오차를 비교 분석하였다. DEA는 이온 모빌리티 변화에 따른 유전손실율을 측정하는 방법으로 80~90% 이후의 경화도는 측정되지 않았지만, 수초 이내에 경화되는 속경화 특성을 평가하기에 적합한 것으로 확인되었다.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.47 no.5
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• pp.80-84
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• 2015

Softness is considered one of the most important attributes of hygiene paper such as tissue and towel. Being subjective in nature, however, softness attribute has been generally believed to be impossible to evaluate using objective methods. Hallmark in his pioneering work proposed that tissue subjective softness should be mainly consisted of the bulk softness component and surface softness component. The bulk softness component can be determined by tensile stiffness; the surface softness component by surface tester. The surface friction turns out far more important than the surface roughness in determining the surface softness component. It cannot be too much emphasized that both results of the tensile stiffness and the surface friction should depend on measuring conditions such as an instrument used, sample sizes (e.g., basis weight, length, and width) and operating conditions of the instrument (e.g., gauge length, cross-head speed, size of stylus, and its scanning speed). This indicates that a direct comparison of the test results would be impossible or misleading unless they have been tested under the identical conditions. This may explain why the standard objective test method for tissue softness has not been available at present.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.47 no.6
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• pp.22-40
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• 2015

Cellulose fibers is one of the most abundant in nature. It has many distinctive features: abundant in nature, biodegradable, non-toxic, eco-friendly, sustainable, easy to fabricate, hydrophilic, and cost-effective. Cellulose fibers, known as pulp, is produced from cellulose-containing materials by the pulping process. As the raw material, wood has been most commonly used while recycled pulp has been also used to some degree. Thus, pulp usually refers to wood pulp. Generally, the pulp and paper industry is regarded as the commodity market where the cost should be much more important than the quality. It also belongs to a mature market where the growth is slow, or even in decline. Accordingly, technological development has been rather stagnant for the industry. Recently, however, the pulp and paper industry has faced very serious challenges. First, due to digital technology, there has been a steady decline in the need for pulp and paper products. The digital industry has continuously replaced printed products such as books, newspapers, and magazines. Second, there has been a trend initiated by developed countries to limit the use of wood as the raw material for the sake of environmental protection. This forces the industry to find a more efficient use of wood pulp as well as finding alternative, non-wood sources. Third, as an individual becomes wealthier and more conscious of health-care, the quality of a product becomes more important than the cost. Thus, a paradigm shift is needed from the cost-conscientious to the quality conscientious. The objective of this article is to review the technologies aimed at engineering cellulose fibers for producing high-value added paper products.

• Journal of Animal Science and Technology
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• v.62 no.3
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• pp.293-305
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• 2020

The difference in the breeding programs and population history may have diversely shaped the genomes of Korean native cattle breeds. In the absence of phenotypic data, comparisons of breeds that have been subjected to different selective pressures can aid to identify genomic regions and genes controlling qualitative and complex traits. In this study to decipher genetic variation and identify evidence of divergent selection, 3 Korean cattle breeds were genotyped using the recently developed high-density GeneSeek Genomic Profiler F250 (GGP-F250) array. The three Korean cattle breeds clustered according to their coat color phenotypes and breeding programs. The Heugu breed reliably showed smaller effective population size at all generations considered. Across the autosomal chromosomes, 113 and 83 annotated genes were identified from Hanwoo-Chikso and Hanwoo-Heugu comparisons, respectively of which 16 genes were shared between the two pairwise comparisons. The most important signals of selection were detected on bovine chromosomes 14 (24.39-25.13 Mb) and 18 (13.34-15.07 Mb), containing genes related to body size, and coat color (XKR4, LYN, PLAG1, SDR16C5, TMEM68, CDH15, MC1R, and GALNS). Some of the candidate genes are also associated with meat quality traits (ACSF3, EIF2B1, BANP, APCDD1, and GALM) and harbor quantitative trait locus (QTL) for beef production traits. Further functional analysis revealed that the candidate genes (DBI, ACSF3, HINT2, GBA2, AGPAT5, SCAP, ELP6, APOB, and RBL1) were involved in gene ontology (GO) terms relevant to meat quality including fatty acid oxidation, biosynthesis, and lipid storage. Candidate genes previously known to affect beef production and quality traits could be used in the beef cattle selection strategies.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.36 no.3
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• pp.186-196
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• 2010

Introduction: The first aim of this study was to isolate the dental tissue-derived stem cells from the dental follicle (DF), dental pulp (DP), and root apical papilla (RAP) of the extracted wisdom teeth. Second was to evaluate their characterization with the expressions of transcription factors and cell surface markers. Finally, their ability of the in vitro multi-lineage differentiations into osteogenic and adipogenic cells were compared, respectively. Materials and Methods: Dental tissues, including dental follicle, dental pulp, and root apical papilla, were separated in the extracted wisdom teeth. These three dental tissues were cultured in Dulbecco’s modified Eagle’s medium (DMEM) with supplements, respectively. After passage 3, the homogeneous shaped dental tissue-derived cells were analyzed the expression of transcription factors (Oct-4, Nanog and Sox-2) and cell surface markers (CD44, CD90 and CD105) with reverse transcription polymerase chain reaction (RT-PCR) and fluorescence-activated cell sorting (FACS) analysis. In order to evaluate in vitro multi-lineage differentiations, the culture media were changed to the osteogenic and adipogenic induction mediums when the dental tissue-derived cells reached to passage 3. The characteristics of these three dental tissue-derived cells were compared with immunohistochemistry. Results: During primary culture, heterogenous and colony formatted dental tissue-derived cells were observed in the culture plates. After passage 2 or 3, homogenous spindle-like cells were observed in all culture plates. Transcription factors and mesenchymal stem cell markers were positively observed in all three types of dental tissue-derived cells. However, the quantity of expressed transcription factors was most large in RAP-derived cells. In all three types of dental tissue-derived cells, osteogenic and adipogenic differentiations were observed after treatment of specific induction media. In vitro adipogenic differentiation was similar among these three types of cells. In vitro osteogenic differentiation was most strongly and frequently observed in the RAP-derived cells, whereas rarely osteogenic differentiation was observed in the DP-derived cells. Conclusion: These findings suggest that three types of human dental tissue-derived cells from extracted wisdom teeth were multipotent mesenchymal stem cells, have the properties of multi-lineage differentiations. Especially, stem cells from root apical papilla (SCAP) have much advantage in osteogenic differentiation, whereas dental follicle cells (DFCs) have a characteristic of easy adipogenic differentiation.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.47 no.4
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• pp.177-186
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• 2015

Until Mandelbrot introduced the concept of fractal geometry and fractal dimension in early 1970s, it has been generally considered that the geometry of nature should be too complex and irregular to describe analytically or mathematically. Here fractal dimension indicates a non-integer number such as 0.5, 1.5, or 2.5 instead of only integers used in the traditional Euclidean geometry, i.e., 0 for point, 1 for line, 2 for area, and 3 for volume. Since his pioneering work on fractal geometry, the geometry of nature has been found fractal. Mandelbrot introduced the concept of fractal geometry. For example, fractal geometry has been found in mountains, coastlines, clouds, lightning, earthquakes, turbulence, trees and plants. Even human organs are found to be fractal. This suggests that the fractal geometry should be the law for Nature rather than the exception. Fractal geometry has a hierarchical structure consisting of the elements having the same shape, but the different sizes from the largest to the smallest. Thus, fractal geometry can be characterized by the similarity and hierarchical structure. A process requires driving energy to proceed. Otherwise, the process would stop. A hierarchical structure is considered ideal to generate such driving force. This explains why natural process or phenomena such as lightning, thunderstorm, earth quakes, and turbulence has fractal geometry. It would not be surprising to find that even the human organs such as the brain, the lung, and the circulatory system have fractal geometry. Until now, a normal frequency distribution (or Gaussian frequency distribution) has been commonly used to describe frequencies of an object. However, a log-normal frequency distribution has been most frequently found in natural phenomena and chemical processes such as corrosion and coagulation. It can be mathematically shown that if an object has a log-normal frequency distribution, it has fractal geometry. In other words, these two go hand in hand. Lastly, applying fractal principles is discussed, focusing on pulp and paper industry. The principles should be applicable to characterizing surface roughness, particle size distributions, and formation. They should be also applicable to wet-end chemistry for ideal mixing, felt and fabric design for papermaking process, dewatering, drying, creping, and post-converting such as laminating, embossing, and printing.

• Tuberculosis and Respiratory Diseases
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• v.41 no.5
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• pp.537-545
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• 1994

Background: In 1987, the British Thoracic Society (BTS) subjected an extensive list of patient variables to statistical analysis in a prospective study of prognosis in 453 adults with community-acquired pneumonia and, subsequently published guidelines for management of severe community acquired pneumonia. It was hoped that those at risk of dying from community acquired pneumonia could be easily identified and treated appropriately, thereby reducing mortality. To date, severe community acquired pneumonia has not been well studied in Korea. Therefore, we studied retrospectively 10 patients dying of severe community acquired pneumonia in Dongsan Hospital to see clinical manifestations of dying of severe community-acquired pneumonia. Methods: Between July 1987 and july 1993, 498 patients were admitted to Keimyung University Dongsan Hospital with community acquired pneumonia, and 77 of them received intensive care. Of the 77 patients, 10 patients died. We reviewed medical records of these patients. Results: 1) The mean age of the patients was 56.2 years(range, 25 to 75 years). There were 7 men and 3 women. Seven patients(70%) were older than 60years of age. 2) The clinical features on admission were as follows: tachypnca, hypoxemia, mental change, cyanosis, leukopenia, leukocytosis, azotemia, hypotension, hypoalbuminemia in order of frequency. Three patients had one abnormal physical finding, 3 patients had 2, 2 patients had 3, and 2 patients had none of these abnormal physical findings. All patients had at least one of the abnormal laboratory findings. 3) A potential bacterial pathogen was isolated in sputum culture from 2 patients. One was E.coli, the other Enterobacter species. Sputum stain were positive in eight cases (G(+)cocci in six, G(+) cocci and G(-)bacilli in two). 4) Features of respiratory failure were the main reasons for ICU transfer, but two patients were transferred only following a cardiac or respiratory arrest in the general ward. 5) The mean of 2.7 different antibiotics were given to the patients. The aminoglycoside and first generation cephalosporin were the most frequently prescribed antibiotics, followed by the third generation cephalosporin and vancomycin. The most frequently prescribed antibiotics combination was a 1st generation cephalosporin plus an aminoglycoside. 6) Seven patients death(70%) occured after admission within the first five days, and a mean duration of hospitaliztion was 11.2 days. Conclusion: As the results show most death occured within the first five days after admission and aged patients; consequently, an aggressive intensive treatment should be provided early to the patients with severe community acquired pneumonia, and we should pay more attention to the aged patients.