• Radiation Oncology Journal
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• v.30 no.4
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• pp.165-172
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• 2012

Purpose: To retrospectively evaluate the outcome and toxicity of total lymphoid irradiation (TLI) based conditioning regimen for allogeneic hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) patients who experienced an engraftment failure from prior HSCT or were heavily transfused. Materials and Methods: Between 1995 and 2006, 20 SAA patients received TLI for conditioning of HSCT. All patients were multi-transfused or had long duration of disease. Fifteen (75%) patients had graft failure from prior HSCT. In 18 (90%) patients, the donors were human leukocyte antigen identical siblings. The stem cell source was the peripheral blood stem cell in 15 (75%) patients. The conditioning regimen was composed of antithymocyte globulin plus TLI with a median dose of 750 cGy in 1 fraction. The graft-versus-host disease (GVHD) prophylaxis used cyclosporine with methotrexate. Results: With a median follow-up of 10.8 years, graft failures developed in 6 patients. Among them, 3 patients received their third HSCT to be engrafted finally. The Kaplan-Meier overall survival rate was 85.0% and 83.1% at 5 and 10 years, respectively. The incidence of acute and chronic GVHD was 20% and 20%, respectively. None of the patients have developed a malignancy after HSCT. Conclusion: In our study, TLI based conditioning in allogeneic HSCT was feasible with acceptable rates of GVHD in SAA patients who experienced graft failure from prior HSCT or was at a high risk of graft rejection. We achieved relatively better results of engraftment and survival with a long term follow-up.

• Journal of Advanced Navigation Technology
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• v.19 no.4
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• pp.288-298
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• 2015

For the commercialization of unmanned aircraft, we must validate the safety of the air/ground collision alert systems (CAS). The validation procedure of CAS requires the flight test which is not only expensive but also dangerous. To alleviate this problem, we need the simulation based validation process for the CAS. We developed an integrated UAV simulation (IUS) environment which interconnect the flight simulator, the Matlab/Simulink, and a target avionics simulation model. We developed the collision warning module of the TCAS and tested using IUS and flight encounter models. Using IUS, we can evaluate the performance and reliability of a target avionic system at the preliminary design stage of a development life cycle.

• Clinical and Experimental Pediatrics
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• v.58 no.7
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• pp.267-269
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• 2015

Antithymocyte globulin (ATG) is used as an immunosuppressive treatment (IST) to deplete clonal suppressor T cells in patients with severe aplastic anemia (SAA). The depletion of suppressor T cells by ATG may affect the activation of B cells, which results in an increased risk for autoimmune conditions. A 12-year-old boy was diagnosed with idiopathic SAA. As he did not have an human leukocyte antigen-matched sibling, he was treated with rabbit ATG (3.5 mg/kg/day for 5 days) and cyclosporine. Five months later, he became transfusion independent. However, 23 months after IST, he complained of mild hand tremors, sweating, weight loss, palpitations, and goiter. Results of thyroid function tests revealed hyperthyroidism (free thyroxine, 3.42 ng/dL; thyroid stimulating hormone [TSH], <0.01 nIU/mL; triiodothyronine, 3.99 ng/mL). Results of tests for autoantibodies were positive for the antimicrosome antibody and TSH-binding inhibitory immunoglobulin, but negative for the antithyroglobulin antibody and antinuclear antibody. He was treated with methimazole, and his symptoms improved. The patient has been disease free for 39 months after IST and 9 months after methimazole treatment. This case report suggests that although rare, rabbit ATG may have implications in the pathogenesis of autoimmune hyperthyroidism. Our findings suggest that thyroid function tests should be incorporated in the routine follow-up of SAA patients treated with ATG.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.6
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• pp.1375-1380
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• 2014

SaaS at a cloud computing is a framework to provide a software as a service. Depending on the difference of the tenant and the use, if the service provider re-establish a service, they are required resources In terms of costs and managerial. So we propose a technique for analysis of software structure using the process algebra to reuse existing software. A process algebra analyze the structure of the software, express in different languages and verify that it can be reused. CCS in a process algebra is useful to convert the business process or XML, by using this, we structure a process as process view and propose meta storage for comparison and management a structured document.

• Journal of Convergence for Information Technology
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• v.9 no.9
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• pp.33-37
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• 2019

According to the enforcement of the Cloud Computing Development and User Protection Act, a new paradigm called as Cloud Computing is coming to the fore among public and private domestic enterprises. Therefore, domestic companies should develop SaaS products specialized for the domestic market and try to preempt the IaaS market ahead of global companies. Now we are facing a necessity to combine all the cloud systems in Korean government to operate seamlessly in a harmony. In this paper, we will look at the prospect of future development of related industry through cloud computing concept and G-cloud's cloud management system (G-CMS). G-CMS can be seen as the first system to comprehensively manage heterogeneous Unix virtualization systems. G-CMS can also save costs by managing heterogeneous virtualization systems in data centers.

• Clinical and Experimental Pediatrics
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• v.59 no.4
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• pp.190-195
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• 2016

Purpose: Severe aplastic anemia (SAA), a fatal disease, requires multiple transfusion, immunosuppressive therapy, and finally, hematopoietic stem cell transplantation (HSCT) as the definitive treatment. We hypothesized that iron overloading associated with multiple transfusions and HSCT-related complications may adversely affect cardiac function. Left ventricular (LV) function was assessed in children after HSCT for SAA. Methods: Forty-six consecutive patients with a median age of 9.8 years (range, 1.5-18 years), who received HSCT for SAA and who underwent comprehensive echocardiography before and after HSCT, were included in this study. The data of LV functional parameters obtained using conventional echocardiography, tissue Doppler imaging (TDI), and speckle-tracking echocardiography (STE) were collected from pre- and post-HSCT echocardiography. These data were compared to those of 40 age-matched normal controls. Results: In patients, the LV ejection fraction, shortening fraction, end-diastolic dimension, mitral early diastolic E velocity, TDI mitral septal E' velocity, and STE LV longitudinal systolic strain rate (SSR) decreased significantly after HSCT. Compared to normal controls, patients had significantly lower post-HSCT early diastolic E velocity and E/A ratio. On STE, patients had significantly decreased LV deformational parameters including LV longitudinal systolic strain (SS), SSR, and diastolic SR (DSR), and circumferential SS and DSR. Serum ferritin levels showed weak but significant correlations (P<0.05) with LV longitudinal SS and SSR and circumferential SS and DSR. Conclusion: Subclinical LV dysfunction is evident in patients after HSCT for SAA, and was associated with increased iron load. Serial monitoring of cardiac function is mandatory in this population.

• Journal of Korea Society of Industrial Information Systems
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• v.18 no.1
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• pp.47-58
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• 2013

This study offers a $3{\times}2$ matrix on the development method pursuant to the level of readiness and necessity for IS of SMEs, and the Delphi method survey through the assistance of a panel of IT experts was employed. Upon analyzing the results, in all rounds, the 1st quadrant and 2nd quadrant resulted in a preference for leasing methods (ASP/SaaS) and the other quadrants resulted in a preference for outsourcing. Quadrants closer to the 1st quadrant showed a preference for leasing methods (ASP/SaaS) and quadrants closer to the 6th quadrant showed a preference for outsourcing. In the case of the IS implementation for the entire company, all three levels of readiness resulted in a preference for outsourcing. The point in which the implementation method changed depending on the level of readiness was when unit systems were implemented, and among the implementation methods, in-house development showed the lowest results.

• KIPS Transactions on Software and Data Engineering
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• v.8 no.1
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• pp.45-50
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• 2019

With the gradual advancement of IT, passive work processes are automated and the overall quality of life has greatly improved. This is made possible by the formation of an organic topology between a wide variety of real-life smart devices. To serve these diverse smart devices, businesses or users are using the cloud. The services in the cloud are divided into Infrastructure as a Service (IaaS), Platform as a Service (PaaS) and Software as a Service (SaaS). SaaS runs on PaaS, and PaaS runs on IaaS. Since IaaS is the basis of all services, an algorithm is required to operate virtualization resources efficiently. Among them, desktop resource virtualization is used for resource high availability of unused state time of existing desktop PC. Clustering of hierarchical structures is important for high availability of these resources. In addition, it is very important to select a suitable algorithm because many clustering algorithms are mainly used depending on the distribution ratio and environment of the desktop PC. If various attempts are made to find an algorithm suitable for desktop resource virtualization in an operating environment, a great deal of power, time, and manpower will be incurred. Therefore, this paper proposes a resource clustering simulator for cluster selection of desktop virtualization. This provides a clustering simulation to properly select clustering algorithms and apply elements in different environments of desktop PCs.

• 프린팅코리아
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• v.11 no.7
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• pp.154-157
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• 2012

클라우드 프린팅 서비스는 지난 5월에 개최된 드루파2012에서 인쇄시장의 지속적인 성장 동력임을 아주 명확히 보여줬다. 애플리케이션 소프트웨어 제공업체(ASP) 및 소프트웨어 서비스업체(SaaS)에게 있어 오늘날의 주요 과제는 웹 접속성으로 대변된다. 사이버 공간을 활용하는 프린팅 인프라는 보다 빠른 작업을 실현한다.

• Proceedings of the Safety Management and Science Conference
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• 2012.11a
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• pp.343-353
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• 2012

오늘날 경영환경은 운송수단의 발달과 정보통신 혁명 등으로 기업들의 급격한 글로벌화가 진행되고 있다. 글로벌한 환경속에서 다양한 고객의 요구를 대응하기 위해 다양한 상품과 서비스를 원하는 시간에 정확하고 합리적인 비용으로 고객에게 전달하기 위하여 많은 물류기업들이 끊임없는 노력을 경주하고 있다. 물류기업은 물류경쟁력을 확보하기 위해 여러 화주의 물량을 공동으로 보관 및 운송 서비스를 수행하는 물류공동화를 수행하거나 관련 물류기업간의 전문화를 통한 다양한 협업 모델을 도입하여 적용하고 있다. 그러나 IT부문의 관점에서 보면 일부 국제물류 등의 수출입 EDI 시스템을 공동으로 활용하거나 운송시스템을 대기업의 서비스사업자를 중심으로 시스템을 공유하는 것을 제외하며 IT시스템 관점에서의 협업 또는 IT공동화 체계는 거의 없는 실정이며, 오히려 물류기업간의 경쟁이 심화되면서 물류기업간의 상호 정보유출 등을 우려하여 매우 폐쇄적으로 운영하고 있는 실정이나 상대적으로 중소물류기업의 입장에서 보면 기업의 영세성 등으로 인해 거의 IT부문에 대한 투자나 활용이 거의 진행되지 못하는 문제점 또한 발생하고 있다. IT시스템을 공동으로 구축 및 활용함으로써 상호간의 비용 절감하고 IT시스템의 전략적 활용을 극대화 하기 위한 방안으로서 물류기업에서 IT공동화의 도입 방안을 제시하고자 한다. 먼저 금융권의 IT공동화 사례 및 국내외 물류관련 사례를 살펴보고, 물류IT공동화의 유사개념인 제4자 물류와 소프트웨어를 필요한 만큼을 필요한 시점에 서비스를 활용할 수 있는 모델인 ASP, SaaS, 클라우드 서비스 등을 비교함으로써 물류IT공동화의 도입 방안과 활용 방안을 제시 하였다.