• Natural Product Sciences
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• 제15권1호
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• pp.44-49
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• 2009

Seven monoterpenes, three sesquiterpenes, three phenolics and one flavonoid were isolated from the MeOH extract of Amomum xanthioides. Their structures were determined by spectroscopic methods to be caryophyllene oxide (1), bornyl acetate (2), nerolidol (3), spathulenol (4), (-)-borneol (5), (+)-5-endohydroxycamphor (6), vanillic acid (7), protocatechuic acid methyl ester (8), betulabuside A (9), (1R,4S,6R)-6-hydroxyfenchan-2-one-6-O-$\beta$-D-glucopyranoside (10), (1S,4R,6S)-6-hydroxybornan-2-one-6-O-$\beta$-D-glucopyranoside (11), (1R,2S,4S,5R)-angelicoidenol 2-O-$\beta$-D-glucopyranoside (12), 1-O-vanilloyl-$\beta$-D-glucopyranoside (13), and quercetin-3-rhamnopyranoside (14). Compounds 6-14 were isolated for the first time from this plant source. Compounds 3 and 4 exhibited moderate cytotoxicity against four human cancer cell lines in vitro using a SRB bioassay.

• 한국수산과학회지
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• 제45권5호
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• pp.523-526
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• 2012

This study evaluated the effects of the number of feeding days and feeding rate on the growth of growing-out flounder Paralichthys olivaceus. Three replicated groups of fish ($141{\pm}1.9g$) were hand-fed a commercial feed under different feeding regimes for 9 weeks. Fish in group 6F-1S were fed to satiation twice daily for 6 consecutive days and starved for 1 day. Fish in groups 4F-1S and 3F-1S were fed to satiation twice daily for 4 and 3 days, respectively, and starved for 1 day. Fish in group 6F-90% were fed a diet of 90% of 6F-1S twice daily for 6 consecutive days and starved for 1 day. The weight gain, feed efficiency and daily feed intake of the fish groups in 4F-1S and 3F-1S were not significantly different from those of group 6F-1S. The weight gain and feed efficiency of fish in group 6F-90% were not significantly different from those of group 6F-1S. The results of this study suggest that the growth of growing-out flounder fed to satiation twice daily for 4 or 3 days after starving 1 day was similar to that of fish fed to satiation for 6 days, and that the proper feeding rate for growth could be lowered to 90% of satiation without growth suppression.

• 대한화학회지
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• 제45권4호
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• pp.386-390
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• 2001

• 대한약리학회:학술대회논문집
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• 대한약리학회 2006년도 58th Annual Meeting of The Korean Society of Pharmacology
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• pp.68.2-68.2
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• 2006

• 대한전자공학회논문지TC
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• 제49권1호
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• pp.1-10
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• 2012

무선 통신에서 이동성과 서비스 품질(QoS)에 대한 요구는 점점 더 중요한 문제로 부각되고 있다. 종래의 인터넷 서비스는 새로운 접속매체들과 어플리케이선으로 확대되고 있는 중이며, 무선 통신 서비스는 원격 지점에서의 번번한 핸드오버를 수반하기 때문에 유비쿼터스 통신에서는 확장가능하고 빠른 핸드오버가 필요조건이 되고 있다. 본 논문에서는 QoS가 보장된 서비스와 빠른 핸드오버 요건을 만족시키고자 이 기종 프록시 이동 IPv6(PMIPv6) 네트워크에 차별화 서비스(Diffserv) 모형을 배치하고, QoS가 보장된 글로벌 로밍 작동 절차 뿐 아니라, 이동 단말의 이동 범위를 기반으로 한 QoS 관리와 핸드오버 비용평가 방식을 제안하였다. 또한 핸드오버 지연 감소를 네트워크 기반의 지역적 이동성 관리 구조 틀에서 분석하고, 통합된 이기종 무선 네트워크 사이의 무선 인터페이스에서 최소 신호 오버헤드를 유지하는 가운데 핸드오버 지연과 관련된 핸드오버 성능을 더 향상 시키고자, 네트워크 기반 개체인 글로벌 이동접속 게이트웨이(G-MAG)로 최적화된 PMIPv6를 제안하고 분석하였다. 핸드오버 지연 감소 정도를 보여주기 위해서 단말 기반 MIPv6에서의 핸드오버 신호 절차를 네트워크 기반 프록시 MIPv6(PMIPv6)와 G-MAG로 보조된 빠른 PMIPv6와 비교하였다. 분석 결과, 핸드오버 지연이 유의하게 감소되었음을 확인하였다.

• 대한의생명과학회지
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• 제8권3호
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• pp.137-142
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• 2002

The expression of CD44v is known as a marker of cancer progression and its metastasis in colorectal cancer. It has been known that CD44 variant containing sequences encoded by exon 11 (v6) confer metastatic potential to human colorectal cancer cells. The role of CD44 standard (CD44s) and CD44v6 in colorectal cancer was investigated in this study by immunohistochemical staining of the primary tumors obtained from the colorectal cancer patients. Immunohistochemical staining was performed in 40 patients with colorectal cancer who underwent curative surgery at Keimyung University hospital. The expression CD44s and CD44v6 was observed in 24/40 (60%) and 13/40 (32.5%) respectively. The expression of CD44v6 had correlation with TNM stage (P＜0.05), however CD44s had not any correlation with clinicopathological parameters. These results suggest that CD44v6 expression may give an information for tumor progression than decreased expression of CD44s in colorectal cancer cells.

• 한국식품과학회지
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• 제32권6호
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• pp.1331-1335
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• 2000

김치 젖산균인 WL6는 API kit 또는 Biolog system방법에 의하여 동정한 결과, Leuconostoc mesenteroides ssp. cremoris, Leu. mesenteroides ssp. dextranicum 또는 Lactobacillus bifermentans로 나타나 동정되지 않았다. 그러나, pepN gene과 16S rRNA gene으로부터 2개의 specific-sequence primer set을 제조하여 PCR 방법으로 증폭한 후에 표준균주들과 비교한 결과, WL6는 Lactobacillus bifermentans로 추정되었다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4589-4594
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• 2014

The mammalian target of rapamycin (mTOR) signaling pathway is upregulated in the pathogenesis of many cancers, including colorectal cancer (CRC). DEPTOR is an mTOR inhibitor whose expression is negatively regulated by mTOR. However, the role of DEPTOR in the development of CRC is not known. The aim of this study was to investigate the expression of DEPTOR and mTORC1 activity (P-S6) in a subset of CRC patients and determine their relation to tumor differentiation, invasion, nodal metastasis and disease-free survival. Here, Immunohistochemical expression of P-S6 (S235/236) and DEPTOR were evaluated in 1.5 mm tumor cores from 90 CRC patients and in 90 samples of adjacent normal mucosa by tissue microarray. The expression of P-S6 (S235/236) was upregulated in CRC, with the positive rate of P-S6 (S235/236) in CRC (63.3%) significantly higher than that in control tissues (36.7%, 30%) (p<0.05). P-S6 (S235/236) also correlated with high tumor histologic grade (p=0.002), and positive nodal metastasis (p=0.002). In contrast, the expression level of DEPTOR was correlated with low tumor histological grade (p=0.006), and negative nodal metastasis (p=0.001). Interestingly, P-S6 (S235/236) expression showed a significant negative association with the expression of DEPTOR in CRC (p=0.011, R= -0.279). However, upregulation of P-S6 (S235/236) (p=0.693) and downregulation of DEPTOR (p=0.331) in CRC were not significantly associated with overall survival. Thus, we conclude that expression of DEPTOR negatively correlates with mTORC1 activity and tumor progression in CRC. DEPTOR is a potential marker for prognostic evaluation and a target for the treatment of CRC.

• 대한소아신장학회:학술대회논문집
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• 대한소아신장학회 2006년도 제13차 추계학술대회 및 정기총회 초록집
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• pp.6-6
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• 2006

• 약학회지
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• 제60권3호
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• pp.101-106
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• 2016

Allylthiopyridazine derivatives were synthesized and evaluated for anti-proliferative activities in the previous study. In this study, selected two allylthiopyridazine derivatives (compound I, 3-heptylamino-6-allylthiopyridazine and compound II, 3-dipentylamino-6-allylthiopyridazine) were assessed for cytotoxicity and chronic proliferation in human colon carcinoma RKO cells. Two derivatives dose-dependently inhibited cell viability and proliferation. To elucidate the anticancer mechanism of two derivatives, we investigated the expression level of apoptosis-related proteins in RKO cells. Compound I induced the activation of JNK and expression of p53 and p21. On the other hand, compound II showed no change of p53 level. Interestingly, compound II inhibited the nuclear translocation of NF-${\kappa}B$. This result suggested that compound II suppressed cell proliferation. These different mechanisms of these compounds might have occurred through different steric conformation.