• Molecules and Cells
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• v.42 no.11
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• pp.804-809
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• 2019

Oncogenic gain-of-function mutations are clinical biomarkers for most targeted therapies, as well as represent direct targets for drug treatment. Although loss-of-function mutations involving the tumor suppressor gene, STK11 (LKB1) are important in lung cancer progression, STK11 is not the direct target for anticancer agents. We attempted to identify cancer transcriptome signatures associated with STK11 loss-of-function mutations. Several new sensitive and specific gene expression markers (ENO3, TTC39C, LGALS3, and MAML2) were identified using two orthogonal measures, i.e., fold change and odds ratio analyses of transcriptome data from cell lines and tissue samples. Among the markers identified, the ENO3 gene over-expression was found to be the direct consequence of STK11 loss-of-function. Furthermore, the knockdown of ENO3 expression exhibited selective anticancer effect in STK11 mutant cells compared with STK11 wild type (or recovered) cells. These findings suggest that ENO3-based targeted therapy might be promising for patients with lung cancer harboring STK11 mutations.

• Journal of the Korean Mathematical Society
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• v.48 no.3
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• pp.655-667
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• 2011

A class of functions involving divided differences of the psi and tri-gamma functions and originating from Kershaw's double inequality are proved to be completely monotonic. As applications of these results, the monotonicity and convexity of a function involving the ratio of two gamma functions and originating from the establishment of the best upper and lower bounds in Kershaw's double inequality are derived, two sharp double inequalities involving ratios of double factorials are recovered, the probability integral or error function is estimated, a double inequality for ratio of the volumes of the unit balls in $\mathbb{R}^{n-1}$ and $\mathbb{R}^n$ respectively is deduced, and a symmetrical upper and lower bounds for the gamma function in terms of the psi function is generalized.

• Journal of applied mathematics & informatics
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• v.41 no.2
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• pp.373-386
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• 2023

In this paper we have obtained various forms of (p, q)-analogue of Aleph-Function satisfying Truesdell's ascending and descending F_p,q-equation. These structures have been employed to arrive at certain generating functions for (p, q)-analogue of Aleph-Function. Some specific instances of these outcomes as far as (p, q)-analogue of I-function, H-function and G-functions have likewise been obtained.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.4
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• pp.13-19
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• 2016

PURPOSE : The purpose of this study was to determine whether tredmill exercise increases pulmonary function and decreases body mass index of the 20s obesity. METHOD : Thirty obesity in their 20s were randomly assigned to on experimental group (n=15) or control group (n=15). Over the course of four weeks, the experimental group participated in tredmill exercise for 30 minutes three times per week and the control group participated in auto-med exercise for 30 minutes three times per week. Subjects were assessed pre-test and post-test by measurement of pulmonary function (tidal volume, inspiration reserve volume, expiratory reserve volume, vital capacity) and body mass index. RESULT : Our findings show that the experimental group had significant difference in expiratory reserve volume and vital capacity and body mass index (p<.05). In the comparison of the two groups, the experimental group had higher pulmonary function and lower body mass index than the control group. CONCLUSION : In this study, the experimental group showed greater improvement in pulmonary function than the control group, which indicates that the tredmill exercise is effective at increasing the pulmonary function and body mass index 20s obesity.

• Communications of the Korean Mathematical Society
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• v.35 no.1
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• pp.125-136
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• 2020

In this article, we discuss classes of generalized functions for certain modified integral operator of Bessel-type involving Fox's H-function kernel. We employ a known differentiation formula of Fox's H-function to obtain the definition and properties of the distributional modified Bessel-type integral. Further, we derive a smoothness theorem for its kernel in a complete countably multi-normed space. On the other hand, using an appropriate class of convolution products, we derive axioms and establish spaces of modified Boehmians which are generalized distributions. On the defined spaces, we introduce addition, convolution, differentiation and scalar multiplication and further properties of the extended integral.

• Journal of the Korean Home Economics Association
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• v.47 no.4
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• pp.25-35
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• 2009

The purpose of this study is to examine the effect of group game play program on ADHD-liked children’s executive function. The game play program was implemented for children in experiment group to find out the effect of the group game play program on ADHD-liked executive function. The subjects of this study were 12 children (4th year elementary students), showing ADHD characteristics. 6 were put in experiment group and other 6 were put in control group randomly. The effectiveness of group game play on ADHD children’s executive function are as followings: The attention ability, behavior inhibition ability, cognitive flexibility of children in experiment group was improved more than in control group. It is concluded that group game play program is effective for ADHD-liked children’s executive function.

• 한국전산유체공학회:학술대회논문집
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• 2008.03b
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• pp.176-179
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• 2008

In a numerical simulation of open channel turbulent flows, the determination of wall roughness height for wall function was studied. The roughness constant, based on the law-of-the -wall for flow on rough walls, obtained by experimental works for pipe flows is employed in general wall functions. However, this constant of wall function is the function of Froude number in open channel flows. Thus, the wall roughness should be determined by taking into account the effect of Froude number. In addition, the wall roughness should be corresponding to Manning's roughness coefficient widely used for open channels. In this study, the relation between wall roughness height as an input condition and Manning's roughness coefficient was investigated, and an equation for effective wall roughness height considering the characteristics of numerical models was proposed as a function of Manning's roughness coefficient.

• Kyungpook Mathematical Journal
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• v.48 no.2
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• pp.165-171
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• 2008

The aim of this paper is to evaluate four finite integrals involving the product of Srivastava's polynomials, a generalized hypergeometric function and $\bar{H}$-function proposed by Inayat Hussian which contains a certain class of Feynman integrals. At the end, we give an application of our main findings by connecting them with the Riemann-Liouville type of fractional integral operator. The results obtained by us are basic in nature and are likely to find useful applications in several fields notably electric networks, probability theory and statistical mechanics.

• Bioinformatics and Biosystems
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• v.1 no.2
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• pp.123-127
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• 2006

TIM barrel domain is widely studied since it is one of most common structure and mediates diverse function maintaining overall structure. TIM barrel domain's function is determined by local structural environment at the C-terminal end of barrel structure. We classified TIM barrel domains by local structural alignment tool, LSHEBA, to understand characteristics of TIM barrel domain's functionalvariation. TIM barrel domains classified as the same cluster share common structure, function and ligands. Over 80% of TIM barrels in clusters share exactly the same catalytic function. Comparing clustering result with that of SCOP, we found that it's important to know local structural environment of TIM barrel domains rather than overallstructure to understand specific structural detail of TIM barrel function. Non TIM barrel domains were associated to make different domain combination to form a different function. The relationship between domain combination, we suggested expected evolutional history. We finally analyzed the characteristics of amino acids around ligand interface.

• Communications of the Korean Mathematical Society
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• v.30 no.3
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• pp.239-252
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• 2015

Motivated mainly by certain interesting extensions of the ${\tau}$-hypergeometric function defined by Virchenko et al. [11] and some ${\tau}$-Appell's function introduced by Al-Shammery and Kalla [1], we introduce here the ${\tau}$-Lauricella functions $F_A^{(n),{\tau}_1,{\cdots},{\tau}_n}$, $F_B^{(n),{\tau}_1,{\cdots},{\tau}_n}$ and $F_D^{(n),{\tau}_1,{\cdots},{\tau}_n}$ and the confluent forms ${\Phi}_2^{(n),{\tau}_1,{\cdots},{\tau}_n}$ and ${\Phi}_D^{(n),{\tau}_1,{\cdots},{\tau}_n}$ of n variables. We then systematically investigate their various integral representations of each of these ${\tau}$-Lauricella functions including their generating functions. Various (known or new) special cases and consequences of the results presented here are also considered.