• Smart Structures and Systems
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• v.19 no.5
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• pp.487-497
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• 2017

Semi-active devices use the building's own motion to produce resistive forces and are thus strictly dissipative and require little power. Devices that independently control the binary open/closed valve state can enable novel device hysteresis loops that were not previously possible. However, some device hysteresis loops cannot be obtained without active analog valve control allowing slower, controlled release of stored energy, and is presents an ongoing limitation in obtaining the full range of possibilities offered by these devices. This in silico study develops a proportional-derivative feedback control law using a validated nonlinear device model to track an ideal diamond-shaped force-displacement response profile using active analog valve control. It is validated by comparison to the ideal shape for both sinusoidal and random seismic input motions. Structural application specific spectral analysis compares the performance for the non-linear, actively controlled case to those obtained with an ideal, linear model to validate that the potential performance will be retained when considering realistic nonlinear behaviour and the designed valve control approach. Results show tracking of the device force-displacement loop to within 3-5% of the desired ideal curve. Valve delay, rather than control law design, is the primary limiting factor, and analysis indicates a ratio of valve delay to structural period must be 1/10 or smaller to ensure adequate tracking, relating valve performance to structural period and overall device performance under control. Overall, the results show that active analog feedback control of energy release in these devices can significantly increase the range of resetable, valve-controlled semi-active device performance and hysteresis loops, in turn increasing their performance envelop and application space.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.122-122
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• 1998

Propentofylline (PPF), a xanthine derivative, has been reported to be effective for the treatment of both vascular dementia and Alzheimer's disease. The elimination half-life of PPF was ranged from 15 to 45 min in rabbit and human, and PPF was rapidly disappeared from the blood. The objective of this experiment is to investigate whether xanthine analogues have effects on the profile of plasma concentration and metabolism of PPF. Caffeine (50 mg/kg, ip) was treated to Sprague-Dawley rats for consecutive 7 days and PPF was intravenously administered to rats 2 hr after the last dose of caffeine. In the other group, PPF was intravenously administered to rats 1 hr after a single dose of pentoxifylline (50 mg/kg, iv). Control group was treated with saline vehicle for the same period as in treatment groups. Blood was withdrawn at specific time intervals. PPF and one of its metabolite (POH) in plasma were determined by gas chromatography/nitrogen phosphorus detector. Plasma concentrations and pharmacokinetic parameters were compared between groups. The area under the curve (AUC) of PPF in rats treated sub chronically with caffeine was significantly decreased compared to control rats. Caffeine treatment results in a significant increase of total body clearance. The AUC of POH was significantly decreased in the caffeine-treated group. A single dose of pentoxifylline has no effect on the phramacokinetics of PPF. Reduction of the AUCs of PPF and POH both suggests that caffeine may increase the excretion of PPF with no affecting the metabolism of PPF to POH.

• Journal of IKEEE
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• v.18 no.2
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• pp.240-247
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• 2014

Intraocular pressure is measured after a cornea air puff by observing biomechanical properties such as thickness or displacement of the cornea. In this paper, we deal with a frequency domain analysis of corneal deformation in the air puff tonometry that is used to diagnose glaucoma or lasik. We distinguish the patient from the normal by measuring the oscillation frequency in the neighborhood of the central cornea section. A binary image was obtained from the video images, and cornea vertical oscillation profile was extracted from the difference between the vertical displacement data and the curve fitting. In terms of Fourier transform, a vibration frequency of 479.2Hz for the patient was obtained as well as more higher 702.8Hz for the normal due to stiffness. Hilbert-Huang transform's empirical mode decomposition generally describes local, nonlinear, and nonstationary data. After the data were decomposed into intrinsic mode functions, a spectrum and power were analysed. Finally, we confirm that the patient has 6 times more higher power ratio for the specific intrinsic mode function between the patient and the normal.

• Genomics & Informatics
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• v.19 no.1
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• pp.5.1-5.11
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• 2021

Head and neck squamous cell carcinoma (HNSCC) is the most frequent type of head and neck cancer that usually arises from the mucosal surfaces of several organs including nasal cavity, paranasal sinuses, oral cavity, tongue, pharynx, and larynx. The Wnt signaling pathway is a crucial mechanism for cellular maintenance and development. It regulates cell cycle progression, apoptosis, proliferation, migration, and differentiation. Dysregulation of this pathway correlates with oncogenesis in various tissues including breast, colon, pancreatic as well as head and neck cancers. The present study aims to assess the gene alterations in the Wnt family of genes so as to derive an association with HNSCC. Computational approaches have been utilized for the identification of gene alterations in the Wnt family of genes. Several databases such as cBioportal, STRING, and UALCAN were used for the purpose. The frequency of alteration was high in case of Wnt family member 11 (5%). Gene amplification, deep deletions, missense and truncating mutations were observed in HNSCC patients. There was a marked difference in the gene expression profile of WNT11 between grades as well as normal samples. The survival probability measured using the Kaplan-Meier curve also presented with a significant difference among male and female subjects experiencing a low/medium level expression. The female patients showed less survival probability when compared to the male subjects. This provides the prognostic significance of the WNT11 gene in HNSCC. Taken together, the present study provides clues on the possible association of WNT11 gene alterations with HNSCC, which has to be further validated using experimental approaches.

• Steel and Composite Structures
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• v.41 no.6
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• pp.831-850
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• 2021

Surface subsidence caused by mining subsidence has an impact on neighboring structures and utilities. In other words, subsurface voids created by mining or tunneling activities induce soil movement, exposing buildings to physical and/or functional destruction. Soil-structure is evaluated employing probability distribution laws to account for their uncertainty and complexity to estimate structural vulnerability. In this study, to investigate the displacement field and surface settlement profile caused by mining subsidence, on the basis of a Winklersoil model, analytical equations for the moment-rotation response ofsoil during mining induced ground movements are developed. To define the full static moment-rotation response, an equation for the uplift-yield state is constructed and integrated with equations for the uplift- and yield-only conditions. The constructed model's findings reveal that the inverse of the factor of safety (x) has a considerable influence on the moment-rotation curve. The maximal moment-rotation response of the footing is defined by X = 0:6. Despite the use of Winkler model, the computed moment-rotation response results derived from the literature were analyzed through the ELM-SVM hybrid of Extreme Learning Machine (ELM) and Support Vector Machine (SVM). Also, Monte Carlo simulations are used to apply continuous random parameters to assess the transmission of ground motions to structures. Following the findings of RMSE and R2, the results show that the choice of probabilistic laws of input parameters has a substantial impact on the outcome of analysis performed.

• Radiation Oncology Journal
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• v.11 no.2
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• pp.421-430
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• 1993

The calculation of dose distribution in multiple arc stereotactic radiotherapy is a three-dimensional problem and, therefore, the three-dimensional dose calculation algorithm is important and the algorithm's accuracy and reliability should be confirmed experimentally. The aim of this study is to verify the dose distribution of stereotactic radiosurgery experimentally and to investigate the effect of the beam quality, the number of arcs of radiation, and the tertiary collimation on the resulting dose distribution. Film dosimetry with phantom measurements was done to get the three-dimensional orthogonal isodose distribution. All experiments were carried out with a 6 MV X-ray, except for the study of the effects of beam energy on dose distribution, which was done for X-ray energies of 6 and 15 MV. The irradiation technique was from 4 to 11 arcs at intervals of from 15 to 45 degrees between each arc with various field sizes with additional circular collimator. The dose distributions of square field with linear accelerator collimator compared with the dose distributions obtained using circular field with tertiary collimator. The parameters used for comparing the results were the shape of the isodose curve, dose fall-offs fom $90\%$ to $50\%$ and from $90\%\;to\;20\%$ isodose line for the steepest and shallowest profile, and $A=\frac{90\%\;isodose\;area}{50\%\;isodose\;area-90\%\;isodose\;area}$(modified from Chierego). This ratio may be considered as being proportional to the sparing of normal tissue around the target volume. The effect of beam energy in 6 and 15 MV X-ray indicated that the shapes of isodose curves were the same. The value of ratio A and the steepest and shallowest dose fall-offs for 6 MV X-ray was minimally better than that for 15 MV X-ray. These data illustrated that an increase in the dimensions of the field from 10 to 28 mm in diameter did not significantly change the isodose distribution. There was no significant difference in dose gradient and the shape of isodose curve regardless of the number of arcs for field sizes of 10, 21, and 32 mm in diameter. The shape of isodose curves was more circular in circular field and square in square field. And the dose gradient for the circular field was slightly better than that for the square field.

• Journal of Korea Water Resources Association
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• v.36 no.6
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• pp.925-936
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• 2003

The objective of this study is to suggest new drawing methods of isochrones using GIS. For this purpose the Unit Hydrograph (UH) of studied watershed for instantaneous rainfall suggested by Clark have been determined by routing the time-area curve through a single linear reservoir. To evaluate constructing methods of isochrones three methods has been examined; Channel Profile and Clark-kict method; Laurenson method; Average velocity method of S.C.S. Also, these methods have been recomposed by GIS in this study. To apply first method, spatial modeling, the vector based on the stream network and Route_System measuring a distance between points has been used. A raster based on the flow direction grid from burn DEM and the slope grid from original DEM has been applied for the second method. The third method has been applied by a raster based on the landuse grid and a velocity function expressed by slope. Results by these three methods have been evaluated with observed hydrograph, and the method using average velocity method of S.C.S shows more reasonable results comparatively.

• Journal of the Korean Society of Food Science and Nutrition
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• v.44 no.5
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• pp.752-760
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• 2015

Effects of maltogenic amylase on textural properties of dough and quality characteristics of white pan bread were investigated. White pan bread was prepared with four different levels of maltogenic amylase contents (M-1: 0.048 U/g, M-2: 0.060 U/g, M-3: 0.072 U/g, M-4: 0.084 U/g). The setback by amylograph for the control was $480.0{\pm}12.25$ Brabender Unit (B.U.) while M-4 showed the a setback of $215.0{\pm}5.00B.U.$ The absorption, mixing tolerance index, and stability by farinogram were not significantly different (P>0.05) for across all treatments. The area under the curve (135 min) by extensogram was higher than all samples. The texture profile analysis results showed that there was significant decreasing in hardness for the maltogenic amylase infused bread (P<0.05). M-3 and M-4 showed higher springiness and cohesiveness but lower hardness than control over 1 to 3 days, indicating possibly extended shelf-life. Imaging scan showed that air cell size less than $0.4mm^2$ for the control and M-4 were at rates of 94.90% and 95.70%, respectively. For sensory evaluation, M-3 and M-4 showed higher intensities than the control for taste, flavor, texture, mouthfeel, and moistness quality. These results imply that the quality of white pan bread could be improved by adding maltogenic amylase without the use of chemical additives.

• Journal of the Korean Vacuum Society
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• v.18 no.2
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• pp.108-115
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• 2009

The superlattice infrared photodetector (SLIP) with an active layer of 8/8-ML InAs/GaSb type-II strained-layer superlattice (SLS) of 150 periods was grown by MBE technique, and the proto-type discrete device was defined with an aperture of $200-{\mu}m$ diameter. The contrast profile of the transmission electron microscope (TEM) image and the satellite peak in the x-ray diffraction (XRD) rocking curve show that the SLS active layer keeps abrupt interfaces with a uniform thickness and a periodic strain. The wavelength and the bias-voltage dependences of responsivity (R) and detectivity ($D^*$) measured by a blackbody radiation source give that the cutoff wavelength is ${\sim}5{\mu}m$, and the maximum Rand $D^*$ ($\lambda=3.25{\mu}m$) are ${\sim}10^3mA/W$ (-0.6 V/13 K) and ${\sim}10^9cm.Hz^{1/2}/W$ (0 V/13 K), respectively. The activation energy of 275 meV analyzed from the temperature dependent responsivity is in good agreement with the energy difference between two SLS subblevels of conduction and valence bands (HH1-C) involving in the photoresponse process.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.16 no.3
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• pp.73-82
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• 2017

As of December 2016, the number of registered automobiles in Korea exceeds 21million. As a result, greenhouse gas emission by transportation sector are increasing every year. It was concluded that the development of the driving strategy considering the driving behavior and the road conditions, which are known to affect the fuel efficiency and the greenhouse gas emissions, could be the most effective fuel economy improvement. Therefore, this study aims to develop a fuel efficient driving strategy in a complex linear section with uphill and curved sections. The road topography was designed according to 'Rules about the Road Structure & Facilities Standards'. Various scenarios were selected. After generating the speed profile, it was applied to the Comprehensive Modal Emission Model and fuel consumption was calculated. The scenarios with the lowest fuel consumption were selected. After that, the fuel consumption of the manual driver's driving record and the selected optimal driving strategy were compared and analyzed for verification. As a result of the analysis, the developed optimal driving strategy reduces fuel consumption by 21.2% on average compared to driving by manual drivers.