• Title/Summary/Keyword: S-acts

Search Result 1,191, Processing Time 0.029 seconds

The Study about Popularization of Gardening and Its Development Process in the UK - Focused on the Royal Horticultural Society in the 19th Century - (영국 정원문화의 대중화 전개 양상에 대한 연구 - 19세기 왕립원예협회(RHS)의 활동을 중심으로 -)

  • Cho, Hye-Ryeong;Sung, Jong-Sang
    • Journal of the Korean Institute of Landscape Architecture
    • /
    • v.44 no.3
    • /
    • pp.47-55
    • /
    • 2016
  • RHS is a core organization with huge influences on the expansion of the base for the garden culture and industry. This study aimed to examine the meaning and value of the professional charity's role through the appearance background and developmental process of RHS. The passion for plant collection in the Victorian Age of the $19^{th}$ century became the background of establishing the society. Such background of the times and the root of the society are deeply related to the British civil garden culture. The consideration of the forming process of RHS and the study can be summarized as below. First, the professional introduction of exotic plants by plant hunters was developed into an organization supporting professional plant research through collection, sampling, and records, which led to the development of horticulture techniques, growth of plant nursery businesses and established the foundation of the civil garden culture in the UK. Second, after John Loudon was involved in RHS, inspired by the press editing more practical information contents, middle-class and women became new patrons to gardening. Therefore, the care of gardens became a source of agreeable domestic recreation, especially to the female sex. Third, $19^{th}$ century plant collection and exhibition was seen in the Chelsea Flower Show which a key role beyond the UK garden culture. Fourth, those acts of RHS and modernity in $19^{th}$ developed British middle-class domestic gardens which have the character of the ordinary and national garden style in the UK. Such history and activities of RHS are connected to the national status as a country of gardens, which suggests clues to practical measures and values we should aim for in order to settle citizen-centered garden culture.

Kant on 'the Highest Good of a Possible World' (칸트에서 '가능한 세계의 최고선')

  • PAEK, CHONG-HYON
    • Journal of Korean Philosophical Society
    • /
    • no.96
    • /
    • pp.39-70
    • /
    • 2012
  • In order to locate Kant's concept of the highest good within ethics and the theory of moral religion, it needs to be approached with some qualifications: there are two rough ways to be suggested. The first way is to focus on the concept of the highest good that is explained in terms of the happiness in proportion to a rational being's virtue or to his/her worthiness to be happy. But the happiness determined in the sense outlined above would be (increasingly or decreasingly) changeable according to each one's individual morality-this is what is meant by each one's 'worthiness' here-, and would not be seen as the perfect one. It might even be said that this kind of happiness is possible in a sensible world generally taken, if the existence of God thought of as harmonizing natural phenomena and the moral order is successfully presupposed. The other way is to understand the concept of the highest good literally: in this view, the highest good shows that a rational being's character is completely appropriate to the moral law and for him/her, its corresponding idea, i.e., the perfect happiness, is considered with full justification. But the highest good in the sense sketched above-along with the existence of God and the immortality of the soul-is expected to be realized only in an intelligible world generally taken. This means that it should be appraised as an ideal of the highest good that includes the so-called 'physical happiness' specified in terms of the first way as its element. In this regard, it is seen to be somewhat restricted. Between the two concepts of the highest good already touched upon, the highest good of the possible world would be the one established in terms of the first way. In other words, it is not the highest good in an intelligible world, but the highest good in this world. Of course, it is true that we cannot help but assume the existence of God-a being as higher, as moral, as most holy, and as omnipotent-in order to explain the highest good in this world (namely, in order to establish the possibility of the combination of the happiness and the worthiness). For as long as both morally good acts and the happiness are considered to happen in a natural world, the cause of the nature (i.e., the existence of its creator), that is, God, must be able to be presupposed. In this vein, Kant interprets that most people view that the key of the Bible is to show that the best world which is characterized by an intelligible or heavenly kingdom is also actually feasible in this world. The wish of the people who have the morally good character is that God's kingdom comes and his will is properly achieved in this world. But we cannot know what God really does in order to realize his world in this world. Nonetheless, we are fully aware of what we should do in order to make ourselves a member of his world. It is specified like this: we should do our ethical duties and further proceed to establish an ethical community. Viewed this manner, it is concluded that an ethical community is not a merely ideal thing like the kingdom of the ends, but a human apparatus or institution that exists in this world.

Effects of Natural Product on the Inhibition of $5{\alpha}-Reductase$ Type 2 for the Development of Chemopreventive Agents in LNCaP Cells

  • Lee, Sung-Jin;Kim, Kyeong-Ho;Cho, Myung-Haing;Lee, Sang-Kook;Mar, Woong-Chon
    • Natural Product Sciences
    • /
    • v.5 no.2
    • /
    • pp.97-103
    • /
    • 1999
  • The enzyme steroid $5{\alpha}-reductase$ is responsible for the conversion of testosterone into the most potent androgen dihydrotestosterone (DHT). In man, this steroid acts on a variety of androgen-responsive target tissues to mediate such diverse endocrine processes as male sexual differentiation in the fetus and prostatic growth in men. Androgen levels in the prostate may influence carcinogenesis in this organ. The use of a $5{\alpha}-reductase$ inhibitor, finasteride, in the chemoprevention of prostate cancer is being evaluated in a clinical trial and have been used successfully for treatment of benign prostatic hyperplasia. Therefore, for the discovery of $5{\alpha}-reductase$ type 2 inhibitors, we have evaluated the inhibitory effects of solvent fractionated extracts of natural products on $5{\alpha}-reductase$ type 2 activity. We have tested approximately 80 kinds of natural products after partition into n-hexane, ethyl acetate and aqueous layers from 100% methanol extracts of plants. The ethyl acetate fractions of Perilla sikokiana $(seed,\;IC_{50}\;:\;6.2\;ug/ml)$, Sophora flavescens $(root,\;IC_{50}\;:\;8.9\;ug/ml)$, and Angelica tenuissima $(root,\;IC_{50}\;:\;11.7\;ug/ml)$ revealed inhibitory effects on $5{\alpha}-reductase$ 2 activity in LNCaP cells. The effective ethyl acetate fractions of Perilla sikokiana, Sophora flavescens, Hydnocarpus anthelmintica, and Angelica tenuissima were subfractionated by column chromatography and tested. The subfractions $F4\;(IC_{50}\;:\;1.1\;ug/ml),\;F5\;(IC_{50}\;:\;2.0\;ug/ml),\;and\;F6\;(IC_{50}\;:\;5.8\;ug/ml)$ of the ethyl acetate fraction of Perilla sikokiana and the subfraction $F8\;(IC_{50}\;:\;5.3\;ug/ml)$ of the ethyl acetate fraction of Sophora flavescens displayed greater inhibition of $5{\alpha}-reductase$ type 2 than did finasteride in LNCaP cells. These active fractions are under the process of further sequential fractionation to find the effective pure compounds against $5{\alpha}-reductase$ 2 activity.

  • PDF

FE analysis of RC structures using DSC model with yield surfaces for tension and compression

  • Akhaveissy, A.H.;Desai, C.S.;Mostofinejad, D.;Vafai, A.
    • Computers and Concrete
    • /
    • v.11 no.2
    • /
    • pp.123-148
    • /
    • 2013
  • The nonlinear finite element method with eight noded isoparametric quadrilateral element for concrete and two noded element for reinforcement is used for the prediction of the behavior of reinforcement concrete structures. The disturbed state concept (DSC) including the hierarchical single surface (HISS) plasticity model with associated flow rule with modifications is used to characterize the constitutive behavior of concrete both in compression and in tension which is named DSC/HISS-CT. The HISS model is applied to shows the plastic behavior of concrete, and DSC for microcracking, fracture and softening simulations of concrete. It should be noted that the DSC expresses the behavior of a material element as a mixture of two interacting components and can include both softening and stiffening, while the classical damage approach assumes that cracks (damage) induced in a material treated acts as a void, with no strength. The DSC/HISS-CT is a unified model with different mechanism, which expresses the observed behavior in terms of interacting behavior of components; thus the mechanism in the DSC is much different than that of the damage model, which is based on physical cracks which has no strength and interaction with the undamaged part. This is the first time the DSC/HISS-CT model, with the capacity to account for both compression and tension yields, is applied for concrete materials. The DSC model allows also for the characterization of non-associative behavior through the use of disturbance. Elastic perfectly plastic behavior is assumed for modeling of steel reinforcement. The DSC model is validated at two levels: (1) specimen and (2) practical boundary value problem. For the specimen level, the predictions are obtained by the integration of the incremental constitutive relations. The FE procedure with DSC/HISS-CT model is used to obtain predictions for practical boundary value problems. Based on the comparisons between DSC/HISS-CT predictions, test data and ANSYS software predictions, it is found that the model provides highly satisfactory predictions. The model allows computation of microcracking during deformation leading to the fracture and failure; in the model, the critical disturbance, Dc, identifies fracture and failure.

Growth and Contents of Inorganic Nutrient during Cultivation of Zoysiagrass (한국잔디의 재배기간 중 생육과 무기성분 함량 변화)

  • Bae, Eun-Ji;Lee, Kwang-Soo;Park, Yong-Bae;Lee, Sang-Myeong;Yang, Geun-Mo;Huh, Moo-Ryong
    • Weed & Turfgrass Science
    • /
    • v.2 no.1
    • /
    • pp.82-87
    • /
    • 2013
  • This research will be utilized as a base line data by researching on growth and the accumulation of inorganic nutrients during the cultivation period of zoysiagrass and also to establish a cultivation strategy of zoysiagrass. It involves the management such as fertilizer and mowing which ultimately led to the difference of growth and accumulation of inorganic nutrients. The accumulation of inorganic nutrients after mowing, the amount of accumulation was small when compared to the amount lost for the shoot, rhizome and root. Difference in the accumulation of inorganic nutrients, but as for K, Ca and Mg accumulation it shows similar aspects to N accumulation. The orders of inorganic nutrients in zoysiagrass were N > K > P > Ca > Mg. The characteristics of inorganic nutrients absorption of such zoysiagrass acts as the foundation of cultivation, and in the aspect of making decisions on the fertilization amount and soil management, it is closely related to the requirement on nutrients. In order to increase the productivity based on the zoysiagrass's growth and density rate improvement, accumulation of inorganic nutrients per growth period needs to be analyzed, and supplying nutrients in an efficient method suitable to the growth period is advisable, so such basic research was necessary.

Interdependence of Corporate Control Mechanisms and Firm Performance in Korea (기업지배구조의 상호관계 및 기업성과에 관한 연구)

  • Cho, Sungbin
    • KDI Journal of Economic Policy
    • /
    • v.28 no.2
    • /
    • pp.131-177
    • /
    • 2006
  • This paper examines a simultaneous determination of corporate control mechanisms, and its effects on firm performance. The corporate control mechanisms considered include the following; insider shareholding, institutional shareholding, the board of directors, dividend policy, and capital structure. This paper applies a simultaneous equation methodology and investigates the interdependence among the corporate control mechanisms. In the first part, the paper finds that firm-level variations of control mechanisms are large across time although average variations are relatively small. These variations are related to one another, which is confirmed by Granger causality test based on dynamic panel autoregression model. More specifically insider shareholding, institutional shareholding and outside director ratio cause each other. With regard to interdependence among the control mechanisms, 2SLS(two stage least squares) regression results show that insider shareholding and institutional shareholding are substitutes while institutional shareholding acts as complements to the ratio of outside members in the board of directors. Then in the second part, the paper examines the relationship between firm performance and corporate governance. Firm performance, measured by Tobin's Q, has a positive association with leverage ratio while that has a negative relation to outside director ratio. This suggests that there may be a room for reforming corporate governance in Korea. Specifically it is necessary to enhance the independence of the outside directors.

  • PDF

A Study on the Ultrastructural Changes of Cardiac Muscle in Dichlorvos Treated Albino Rat (Dichlorvos가 흰쥐 심근의 미세구조에 미치는 영향)

  • Baik, Tai-Kyoung;Lee, Wha-Mo;Chung, Ho-Sam
    • Applied Microscopy
    • /
    • v.24 no.3
    • /
    • pp.23-33
    • /
    • 1994
  • It is well known that dichlorvos (DDVP), an organophosphate insecticide in common use, is so easily and rapidly hydrolyzed and excreted that it has usually little toxic effect on human body. In these days, however, it is widely used as an industrial and domestic insecticide and as an anthelmintic agent for animals, so that the accident of chemical poisoning occurs frequently. DDVP acts as a powerful inhibitor of carboxylic esterase, which can cause accumulation of acetylcholine at the synapses so paralysis of muscle and the transmission failure in cholinergic synapses dueing to desensitization of acetylcholin receptor may occure. Moreover accumulation of the acetylcholine brings about the elevation of the cyclic-AMP, which alters the cellular metabolisms of nucleic acid, carbohydrate, protein and lipid. Present study has undertaken to investigate the cardiotoxic effect of DDVP by electron microscopic study. A total of 30 Sprague-Dawley strain rats, weighing about 250gm were used as experimental animals. 2mg/kg/day of DDVP is intraperitonealy injected 3 times with intervals of every other day. On 1 day, 3 days, 5 days, 7 days and 14 days after drug administration, the animals were sacrified by cervical dislocation. Left ventricular cardiac muscles were resected and sliced into $1mm^3$. The specimens were embedded with Epon 812 and prepared by routine methods for electron microscopical observation. All preparations were stained with lead citrate and uranyl acetate and then observed with Hitachi-600 transmission electron microscope. The results were as follows: 1. In the cardiac muscle of DDVP treated rats, mitochondria with disorganized double membrane and mitochondrial crista, and vacuole formation in mitochondrial matrix were observed. But structures of mitochondria were recovered to normal in 14 days group. 2. In the cardiac muscle of DDVP treated rats, cisternae of sarcoplasmic reticulum were dilated and sacculated. But these changes were recovered to normal in 14 days group. 3. In the cardiac muscle of DDVP treated rats, glycogen particles around damaged myofibrils were decreased. But amount of glycogen particles were restored in 14 days group. 4. In the cardiac muscle of DDVP treated rats, disruption and discontinuation of myofilaments and disorganization of Z-disc were observed. But the structures of myofibrils were recovered to normal in 14 days group. It is consequently suggested that DDVP would induce the reversible degenerative changes on the ultrastructures in cardiac muscle of rat.

  • PDF

Development on Antibiotic Concrete Mixed with Antibacterial Metals and Metallic Salts (금속 및 금속염계 항균제가 혼입된 항균 콘크리트 개발)

  • Choi, Hong-Shik;Heo, Kwon;Lee, Ho-Beom;Lee, Si-Woo;Kwak, Hong-Shin
    • Journal of the Korean Recycled Construction Resources Institute
    • /
    • v.1 no.2
    • /
    • pp.136-143
    • /
    • 2013
  • In the sewage structures and wastewater facilities, concrete is exposed to hydrogen sulfide ($H_2S$) which acts as an acid material in a solution, and a strongly acidic sulfate ion ($SO{_4}^{-2}$) is generated by a sulfuric bacteria. Hence, a degradation of concrete with biochemical corrosion would be accelerated. Finally, durability of concrete and concrete structures may be greatly reduced. In this study, in order to remove the hydrogen sulfide which is used by the sulfuric bacteria organic-biologically, the antibiotic metal and metallic salt powders were mixed to concrete, and a suppressing performance of the sulfate ion was assessed. For the sulfuric acid bacteria, a comparative evaluation of antimicrobial performance on neutralized concrete specimens were carried out, also by a rapid chloride penetration test, chloride penetration depths and diffusion coefficients were measured for antibiotic concrete in accordance with the amount of metal and metallic salt-based antibacterial agents. Eventually, by an observation of the biochemical state of the surface of concrete specimens exposed outdoors, the performance and applicability of antibiotic concrete were confirmed.

Comparison of Level of Knowledge and Attitude towards Sex between General and Industrial High School Students (인문계와 산업체 고교생들의 성에 대한 태도 및 지식수준 비교)

  • 장정희;맹광호
    • Korean Journal of Health Education and Promotion
    • /
    • v.12 no.2
    • /
    • pp.73-89
    • /
    • 1995
  • This study was planned to investigate indirectly the effects of study environments of high school students such as family characteristics, availability of sex education, and possibility of exposure to unhealthy sexual environments. For this purpose, the level of knowledge and attitude towards sex of general and industrial high school students were compared because these two groups of students were believed to be different in those study variables. For this study, 600 students (300 male and 300 female students) from a general high school students and 400 (200 male and 200 female) from an industrial high school in one industrial city in Korea were surveyed with a structured questionnaire. The study results were as follows: 1. There were significant differences in selected family condition variables between general and industrial high school students. Proportions of students with single parents, those who live in houses other than their own, and those father's occupations were farming and manufacturing were higher in industrial high school students than in general high school students. 2. Female students wanted to have more knowledge on sex whereas male students were interested in things related to sexual acts in both general and industrial high school students. The largest proportion of students wanted to discuss their sex problems with their friends not with their parents. 3. More students in general high school thought that the sexual intercourse is natural and pretty than those in industrial high school, whereas more industrial high school students insisted on the sexual purity before marriage than general high school students. 4. About 65% of students surveyed agreed to making friends with opposite sex and, in fact, more than half either had experiences or were having friends of opposite sex. More students in industrial high school wanted to choose their marital partners based on advices of their parents than students in general high school. 5. More female students than male and more industrial high school students than general high school students were embarrassed with first wet dream or menstruation and felt guilty about the masturbation. 6. Level of knowledge on reproductive physiology, sex transmitted disease and contraception was higher in general high school students than in industrial high school students. These study results suggest that simple knowledge on sex of the general high school students does not seem to affect positively the students attitude towards sex and the unfavorable living conditions of industrial high school students seem to influence the students to become more sincere and healthy in their attitude towards sex and life. Therefore, more thoughtful consideration in contents and methods should be given when the sex education is provided to the high school students.

  • PDF

New Method of Computing the Stokes Drift Including Shear Effect in the Cross-Sectional Flow Field (유수단면 흐름장에서 Shear 효과를 갖는 Stokes Drift의 계산법)

  • Kim, Jong-Hwa;Park, Byong-Su
    • Journal of the Korean Society of Fisheries and Ocean Technology
    • /
    • v.33 no.1
    • /
    • pp.9-26
    • /
    • 1997
  • Stokes drift(SD) and Lagrangian discharge(LD) are important factors for analysis of flushing time, tidal exchange, solute transport and pollutant dispersion. The factors should be calculated using the approached method to flow phenomena. The aim of this paper re-examines the previous procedures for computing the SD and LD, and is to propose the new method approached to stratified flow field in the cross-section of coastal region, e.g. Masan Bay. The intensity of velocity near the bottom boundary layer(BBL) depends on the sea-bed irregularity in the coastal estuaries. So we calculated the depth mean velocity(DMV) considering that of BBL omitted in Kjerfve's calculation method. It revealed that BBL effect resulting in application of the bay acts largely on DMV in half more among 1l stations. The new expression of SD and LD per unit width in the cross-section using the developed DMV and proposed decomposition procedure of current were derived as follow : $$Q=u_0+\frac{1}{2}H_1{U_1cos(\varphi_h-\varphi_u)+U_3cos(\varphi_h-\varphi{ud})} LD ED SD$(Q_{skim}+Q_{sk2}) The third term, $Q_{sk2}$, on the right-hand of the equation is showed newly and arise from vertical oscillatory shear. According to the results applied in 3 cross-sections including 11 stations of the bay, the volume difference between proposed and previous SD was founded to be almost 2 times more at some stations. But their mean transport volumes over all stations are 18% less than the previous SD. Among two terms of SD, the flux of second term, $Q_{skim}$, is larger than third term, $Q_{sk2}$, in the main channel of cross-section, so that $Q_{skim}$ has a strong dependence on the tidal pumping, whereas third term is larger than second in the marginal channel. It means that $Q_{sk2}$ has trapping or shear effect more than tidal pumping phenomena. Maximum range of the fluctuation in LD is 40% as compared with the previous equations, but mean range of it is showed 11% at all stations, namely, small change. It mean that two components of SD interact as compensating flow. Therefore, the computation of SD and LD depend on decomposition procedure of velocity component in obtaining the volume transport of temporal and spacial flow through channels. The calculation of SD and LD proposed here can separate the shear effect from the previous SD component, so can be applied to non-uniform flow condition of cross-section, namely, baroclinic flow field.

  • PDF